ライフサイエンスコーパス: pericentric

1 that bw can be simultaneously acted upon by pericentric and distal blocks of heterochromatin.

2 the functional centromere within an enlarged pericentric and heterochromatic region.

3 illustrated by the formation of concentric, pericentric and multicompartment liposomes.

4 eads locally at centromere junctions on both pericentric and telocentric sides.

5 g from canonical heterochromatic function at pericentric and telomeric regions to exclusive localizat

6 and establish ATRX as a major determinant of pericentric beta-heterochromatin identity.

7 85 but not ATRX125 is highly concentrated in pericentric beta-heterochromatin of the X chromosome in

8 , ATRX185 is required for HP1a deposition in pericentric beta-heterochromatin of the X chromosome.

9 of inner kinetochores contract, whereas the pericentric chromatin and cohesin that encircle spindle

10 rochromatin-associated HP1beta and Ikaros at pericentric chromatin and expressed low levels of Ezh2 a

11 domain also reduces cohesin turnover within pericentric chromatin and permits establishment of Wapl-

12 Pericentric chromatin forms an intramolecular loop that

13 the kinetochore promotes the organization of pericentric chromatin into a cruciform in mitosis such t

14 ritical features of how these complexes mold pericentric chromatin into a functional spring.

15 pite its increased spatial distribution, the pericentric chromatin is less dynamic.

16 To understand how pericentric chromatin is packaged and resists tension, w

17 ntromere DNA-looping complexes positions the pericentric chromatin loops and stabilizes the dynamic p

18 metric alteration of all 16 kinetochores and pericentric chromatin reflect global changes in the peri

19 er chromatids toward opposite poles, whereas pericentric chromatin resists with contractile springlik

20 Linking of pericentric chromatin through cohesin, condensin, and ki

21 eometry and dynamics of kinetochores and the pericentric chromatin upon reduction of microtubule dyna

22 hese findings indicate that H2A.Z-containing pericentric chromatin, as in higher eukaryotes with regi

23 rotein complexes are concentrated within the pericentric chromatin, but whether they contribute to te

24 phosphorylation and Sgo1 recruitment to the pericentric chromatin, rather than microtubule dynamics.

25 or the increased association of cohesin with pericentric chromatin, which is required to resist micro

26 th are governed in part by the stretching of pericentric chromatin.

27 e4-containing centromeric nucleosome, but in pericentric chromatin.

28 activity also reduce turnover of cohesin on pericentric chromatin.

29 displaced from the spindle axis and confines pericentric chromatin.

30 s and is responsible for axial compaction of pericentric chromatin.

31 al studies that, in animals heterozygous for pericentric chromosomal inversions, loop formation is gr

32 pericentric non-satellite repeat islands and pericentric-chromosomal junctions.

33 ts in the eu-heterochromatin junction in the pericentric chromosome regions.

34 ereas coordinated stretching is dependent on pericentric cohesin and Cin8.

35 Pericentric cohesin and condensin contribute to spindle

36 Depletion of pericentric cohesin or condensin has been shown to incre

37 are partially rescued by mutants that weaken pericentric cohesion or mutants that decrease constricti

38 Pericentric condensin contributes to chromatin compactio

39 e results also show a down-regulation of the pericentric constitutive heterochromatin mark, histone H

40 gene regulation, beyond its accumulation on pericentric constitutive heterochromatin.

41 Pericentric DNA is related to heterochromatin and gene i

42 r kinetochore complex (CBF3) is required for pericentric DNA looping at the Cse4p-containing nucleoso

43 ng kinetochore complexes are not involved in pericentric DNA looping but are required for the geometr

44 microtubules, the kinetochore, and organized pericentric DNA loops.

45 We demonstrate that pericentric enrichment of condensin is mediated by inter

46 Reinstating the pericentric enrichment of Sgo1p alleviates the mitotic d

47 HP1 binds predominantly to pericentric genes and transposable elements.

48 report on the role of KLLN in maintenance of pericentric H3K9 trimethylation (H3K9me3) and genomic st

49 ualization shows Arp2/3 inhibition decreases pericentric H3K9me3 marks.

50 lation of histone H3K9 trimethylation at the pericentric HC after DNA damage.

51 As anticipated, the pericentric heterochromatin and chromosome 4 are on aver

52 r second chromosome, at the boundary between pericentric heterochromatin and euchromatin.

53 on, there is increased nuclear clustering of pericentric heterochromatin and extensive changes in pri

54 maintenance of transcriptional silencing in pericentric heterochromatin and in the chromatin-depende

55 on of telomere shelterin components restores pericentric heterochromatin and its functions in RNAi mu

56 protein that is prominently associated with pericentric heterochromatin and mediates the concomitant

57 in replication-linked maintenance of centric/pericentric heterochromatin and suggest a novel means wh

58 ation, and altered chromatin interactions of pericentric heterochromatin and surrounding regions, ind

59 osomal protein primarily associated with the pericentric heterochromatin and telomeres in Drosophila.

60 , we found that MeCP2 induced aggregation of pericentric heterochromatin and that its chromatin accum

61 euchromatic genes brought to the vicinity of pericentric heterochromatin and the activation of hetero

62 duce silencing, suggesting that proximity to pericentric heterochromatin and/or a high local TE densi

63 WSTF accumulates in pericentric heterochromatin coincident with the replicat

64 assess mechanistically relevant features of pericentric heterochromatin compaction in mouse fibrobla

65 native pathway that loss of CBP leads to the pericentric heterochromatin condensation through ESET ex

66 romocenters are clusters of late-replicating pericentric heterochromatin containing HP1 bound to trim

67 In fission yeast, loss of RNAi causes pericentric heterochromatin defects, compromising gene s

68 ocalization towards spindle poles as well as pericentric heterochromatin domains at the metaphase II

69 me, where it confers epigenetic asymmetry to pericentric heterochromatin during the transition to the

70 chromosome translocations containing ectopic pericentric heterochromatin embedded in euchromatin disp

71 A transposition of the 59E-60A region into pericentric heterochromatin ensnares distal 59E-60A via

72 asmate chromosomes with the normal amount of pericentric heterochromatin exhibit increased nondisjunc

73 On human and fly chromosomes, for example, pericentric heterochromatin flanks single centromeres, w

74 al role for KLLN as a potential regulator of pericentric heterochromatin formation, genomic stability

75 finger proteins ZNF518A and ZNF518B in human pericentric heterochromatin formation.

76 the RNAi machinery is no longer required for pericentric heterochromatin functions.

77 We suggest that late-replicating pericentric heterochromatin helps to maintain embedded c

78 ient cells fail to deacetylate and methylate pericentric heterochromatin histones and to recruit esse

79 , it also displays a strong association with pericentric heterochromatin in diploid cells, where it a

80 ind to methylated H3K9 (H3K9me) and regulate pericentric heterochromatin in fission yeast.

81 Me3K9H3 decorated late-replicating pericentric heterochromatin in mouse cells and sites of

82 The localization of Lrwd1 and Orc2 at pericentric heterochromatin in mouse cells is lost in ce

83 Pericentric heterochromatin is a highly compacted struct

84 e mechanism for transcriptional silencing of pericentric heterochromatin is conserved from fission ye

85 Pericentric heterochromatin is critical for silencing re

86 pose that BRCA1-dependent establishment of X-pericentric heterochromatin is critical for XY body morp

87 K9me3 and that the association of Lrwd1 with pericentric heterochromatin is required for heterochroma

88 Furthermore, we observe defects in pericentric heterochromatin maintenance and assembly.

89 e find that targeting of the Sin3 complex to pericentric heterochromatin may also follow this model.

90 nary gene relocation between euchromatin and pericentric heterochromatin occurred with preservation o

91 function in concert to methylate H3K9 in the pericentric heterochromatin of all chromosomes, with dG9

92 ele and a yellow transgene inserted into the pericentric heterochromatin of chromosome 2R, while a th

93 nd its murine homologue Np95 are enriched in pericentric heterochromatin of interphase nuclei, and th

94 how that a hybrid lethality factor(s) in the pericentric heterochromatin of the D. mauritiana X chrom

95 reconstructions of the histone locus and the pericentric heterochromatin of the X Chromosome, spannin

96 een mapped at position 1q21, adjacent to the pericentric heterochromatin on the long arm of chromosom

97 hromosome axes and promotes establishment of pericentric heterochromatin on the X chromosome.

98 SUV39H1 methylates H3K9 at the pericentric heterochromatin region and participates in t

99 MT1 complexes are recruited independently to pericentric heterochromatin regions, they are both requi

100 entify a new compaction pathway of mammalian pericentric heterochromatin relying on Tip60 that might

101 DNA in pericentric heterochromatin replicates late in S phase,

102 activity is required for the fine-tuning of pericentric heterochromatin replication relative to othe

103 during mid S phase, which is coincident with pericentric heterochromatin replication.

104 ctivity, splitting an F-box and relocating a pericentric heterochromatin segment in juxtaposition wit

105 hylation, and DNA methylation in maintaining pericentric heterochromatin structure throughout cell di

106 ite repeat sequence-derived transcripts from pericentric heterochromatin that accumulate at different

107 MeCP2 at chromocenters, regions of extensive pericentric heterochromatin that can be imaged by fluore

108 led to reduced accumulation of H4K20me3 onto pericentric heterochromatin that coincided with abnormal

109 ults indicate that the Lrwd1 is recruited to pericentric heterochromatin through binding to H3K9me3 a

110 Pericentric heterochromatin transcription has been impli

111 We demonstrate that mammalian pericentric heterochromatin transcription is linked to c

112 ce and are disproportionately represented in pericentric heterochromatin, a feature potentially explo

113 of the A- and B-type lamins, alterations in pericentric heterochromatin, abnormally clustered centro

114 of satellite transcription, decompaction of pericentric heterochromatin, and defects in chromosome s

115 es an essential role in the establishment of pericentric heterochromatin, and genetic ablation of mSd

116 with mitotic chromosomes is concentrated at pericentric heterochromatin, and is encoded, in part, by

117 proteins are preferentially targeted to the pericentric heterochromatin, and mice lacking both Suv39

118 s reveals distinct profiles for euchromatin, pericentric heterochromatin, and the 4th chromosome.

119 SMARCAD1 ensures that silenced loci, such as pericentric heterochromatin, are correctly perpetuated.

120 transposable elements and tandem repeats at pericentric heterochromatin, as well as incomplete chrom

121 BMI1 was highly enriched at intergenic and pericentric heterochromatin, co-immunoprecipitated with

122 domains surrounding the centromere, known as pericentric heterochromatin, histone modifications, part

123 exts, PTRs confer no targeting, targeting to pericentric heterochromatin, or targeting to the periphe

124 are essential for targeting these enzymes to pericentric heterochromatin, probably via a mechanism ot

125 NAi pathway is required for the formation of pericentric heterochromatin, proper chromosome segregati

126 meiosis, ATF7IP2 amasses on autosomal and X-pericentric heterochromatin, spreads through the entiret

127 tightly associates with actively replicating pericentric heterochromatin, suggesting a role in its as

128 la melanogaster localized principally in the pericentric heterochromatin, telomeres, and fourth chrom

129 gaster, carrying a silenced transgene in the pericentric heterochromatin, to investigate in detail th

130 amage response pathway recruits ATF7IP2 to X-pericentric heterochromatin, where it facilitates the re

131 tone acetyltransferase Tip60 is recruited to pericentric heterochromatin, where it mediates acetylati

132 Pericentric heterochromatin, while often considered as "

133 h loss of KLLN resulting in dysregulation of pericentric heterochromatin, with consequent chromosomal

134 es such as the initiation and maintenance of pericentric heterochromatin, X-inactivation, and germ ce

135 y and the deposition or maintenance of major pericentric heterochromatin-associated histone marks, in

136 a central role in initiating the cascade of pericentric heterochromatin-specific modifications neces

137 aused aberrant HP1alpha distribution only to pericentric heterochromatin-surrounding nucleoli.

138 ionary and functional genomics of satDNAs in pericentric heterochromatin.

139 ted CenH3, and transcriptional quiescence of pericentric heterochromatin.

140 Lys-9 were both selectively enriched within pericentric heterochromatin.

141 me that harbors large amounts of centric and pericentric heterochromatin.

142 centromere-kinetochore complexes, including pericentric heterochromatin.

143 (alphoid) DNA array, where it is flanked by pericentric heterochromatin.

144 to methylate the major satellite repeats at pericentric heterochromatin.

145 ains are required for their association with pericentric heterochromatin.

146 and Dnmt3b are particularly concentrated in pericentric heterochromatin.

147 as used to show enrichment of the protein in pericentric heterochromatin.

148 ected H3 Lys9 trimethylation specifically at pericentric heterochromatin.

149 trast, trimethylated H3 Lys9 was enriched at pericentric heterochromatin.

150 and heterochromatin protein 1 binding at the pericentric heterochromatin.

151 2 (HP2), which codistributes with HP1 in the pericentric heterochromatin.

152 an promote genetic instability via defective pericentric heterochromatin.

153 lization is preferentially within Drosophila pericentric heterochromatin.

154 for Prod protein to its target satellite in pericentric heterochromatin.

155 20 of histone H4 (H4K20me3)) and localize to pericentric heterochromatin.

156 ittle impact on the localization of Lrwd1 on pericentric heterochromatin.

157 alleles at levels comparable to that seen on pericentric heterochromatin.

158 similar to that involved in the formation of pericentric heterochromatin.

159 s well known as a silencing protein found at pericentric heterochromatin.

160 In contrast, pericentric human satellite II (HSATII) repeats formed a

161 ontributes to HP1-dependent variegation at a pericentric insertion site, as demonstrated by a decreas

162 d chromosome fusion events, each marked by a pericentric inversion and centromere loss.

163 mates (now found in the Bornean orangutan) a pericentric inversion and centromere shift leads to the

164 a model where an ancestral human-chimpanzee pericentric inversion and the ancestral chromosome 2 fus

165 A large pericentric inversion associated with early flowering ex

166 nce in situ hybridization, five evolutionary pericentric inversion breakpoints present on the chimpan

167 n Genome Project, have been used to identify pericentric inversion breakpoints seen when comparing th

168 The pericentric inversion disrupts a gene (ACOD4) on chromos

169 n 5AL/4AL translocation and a putative small pericentric inversion in chromosome 5A.

170 A possible pericentric inversion in chromosome 7D was detected.

171 omolog, and a fission of chromosome 21 and a pericentric inversion is needed to derive the Bornean or

172 r Great Apes, that a cytogenetically cryptic pericentric inversion may have been involved in the form

173 GLI mapping reveals that a pericentric inversion occurred in the HSA chromosome 12

174 describe an 8-year-old boy who has a de novo pericentric inversion of chromosome 12, with breakpoints

175 We identified a pericentric inversion of chromosome 4, inv(4)(p13q21) th

176 signs of PMD, cytogenetic analysis showed a pericentric inversion of the X chromosome.

177 ification of a > 10-My-old, 11-megabase-long pericentric inversion on chromosome 1.

178 s indicated the possible presence of a small pericentric inversion on chromosome 2B.

179 Crossover within a pericentric inversion produces reciprocal recombinant ch

180 A pericentric inversion specific to the rice lineage was d

181 rly-maturing haplotype derived from an 11 Mb pericentric inversion that evolved early during G. hirsu

182 haracterize the breakpoints defining a large pericentric inversion that occurred some time after the

183 ts confirm the earlier putative claim that a pericentric inversion took place in HSA chromosome 11 an

184 nding in which it was proposed that only one pericentric inversion was needed.

185 omic changes in B. stricta likely involved a pericentric inversion, a chromosomal fusion, and two rec

186 equent chromosomal rearrangement, especially pericentric inversion, increases the probability of gene

187 (p23.1q22.1), and is derived from a parental pericentric inversion, inv(8)(p23.1q22.1).

188 s from its homologues in the great apes by a pericentric inversion.

189 and (3) in this family DMD is caused by the pericentric inversion.

190 in structural variants, including a putative pericentric inversion.

191 group through centromere repositioning and a pericentric inversion.

192 o be important in the origin of species, and pericentric inversions account for the majority of evolu

193 ue to 16 fusion events, 2 fission events, 10 pericentric inversions and 1 centromeric repositioning,

194 Paracentric and pericentric inversions are easily recovered when two ele

195 repeated events of unequal crossing over and pericentric inversions during chromosome 9 evolution.

196 The use of loci-specific probes to decipher pericentric inversions has proved to be a formidable app

197 anges (both involving centromeres) and three pericentric inversions have been identified between chic

198 Cases of AS resulting from translocations or pericentric inversions have been observed to be associat

199 oidization, highlighted by large paracentric/pericentric inversions in 14 chromosomes.

200 enerates strictly allele-specific indels and pericentric inversions in CD34(+) hematopoietic stem and

201 These pericentric inversions in PTR and GGO may have occurred

202 Pericentric inversions may have been important for the e

203 is heteromorphic in 6-8% of humans, whereas pericentric inversions occur in more than 1% of the popu

204 ylogenotic markers, was used to decipher the pericentric inversions of human chromosomes 11 and 12.

205 AL2 and ZAL2(m) differ by a pair of included pericentric inversions that we estimate span at least 98

206 No pericentric inversions were detected.

207 rrangements producing this diversity were 15 pericentric inversions, 12 centric fusions, 11 fissions,

208 translocations, 10 paracentric inversions, 2 pericentric inversions, and 4 disassociations or associa

209 mating the frequency of recombination within pericentric inversions.

210 changes in heterochromatin distribution and pericentric inversions.

211 (n = 7) through an unusually high number of pericentric inversions.

212 esis, intrachromatid crossing-over generated pericentric inversions.

213 or and major satellites spanning centromeric-pericentric junctions and a low yet significant amount o

214 MiSat length variants localize at centromere-pericentric junctions.

215 ion of cohesin (SMC3), condensin (SMC4), and pericentric LacO arrays within the spindle.

216 f heterochromatic genes that depend on their pericentric localization for maximal transcriptional act

217 To account for the ubiquity and pericentric localization of satellites, we propose that

218 DNA within the pericentric loop occupies a spatially confined area that

219 er chromosome segregation, and repression of pericentric meiotic recombination.

220 ts), with divergent MaSats concentrated near pericentric non-satellite repeat islands and pericentric

221 ation increases Chp1 and decreases Chp2/Swi6 pericentric occupancy and exhibits centromeric desilenci

222 specifically regulating interactions between pericentric origins.

223 ripped satellite galaxies on their first few pericentric passages around massive galaxies(23).

224 o sympatric speciation models facilitated by pericentric recombination suppression in this important

225 ttenuated H3-Sgo1p interaction essential for pericentric recruitment of Sgo1p.

226 is pigmentosa (adRP) phenotype linked to the pericentric region of chromosome 8 is associated with mu

227 der branchio-oto-renal syndrome (BOR) to the pericentric region of chromosome 8q.

228 ported an insertion of 270-kb mtDNA into the pericentric region on the short arm of chromosome 2.

229 phase cells prevents cohesin accumulation at pericentric regions and causes reduced binding on chromo

230 hl4 are necessary for Sgo1 to associate with pericentric regions but less so for Sgo1 to associate wi

231 merase II in euchromatin but its increase in pericentric regions in piwi mutants.

232 at reducing RNA polymerase II recruitment to pericentric regions is essential for maintaining heteroc

233 RNA polymerase II (RNAPII) occupancy at the pericentric regions is only modestly increased, while pr

234 Finally, H1 is essential for organization of pericentric regions of all polytene chromosomes into a s

235 ar position or replication timing of any non-pericentric regions of the genome, nor did it affect pro

236 reveals a preferential binding of cohesin to pericentric regions over cohesin-associated regions (CAR

237 rossovers between markers in heterochromatic pericentric regions that underwent demethylation.

238 atin protein Swi6, which is redistributed to pericentric regions through RNAi-independent heterochrom

239 regions and less abundant in crossover-poor pericentric regions were identified.

240 ated in mutant germ cells, tandem repeats in pericentric regions were methylated normally.

241 of the heterochromatin is distributed in the pericentric regions with some rice chromosomes containin

242 1 onto heterochromatin or the methylation of pericentric regions, possibly owing to a compensating in

243 P-A and H3K9me3 chromatin at centromeric and pericentric regions, respectively, is associated with in

244 We also found KLLN to localize to pericentric regions, with loss of KLLN resulting in dysr

245 s more frequent in telomeric regions than in pericentric regions.

246 nsition of the cell cycle and is enriched at pericentric regions.

247 ced affect on histone modification status at pericentric repeats or methylation of centromeric DNA.

248 enome including telomeres, ribosomal DNA and pericentric repeats, many of which are putative G-quadru

249 histone H3K9 dimethylation at the endogenous pericentric repeats.

250 omatin is accompanied by an up-regulation of pericentric satellite III repeat transcripts.

251 enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1(Su(

252 ergistic interaction displaces HP1gamma from pericentric sites, inducing changes in chromatin structu

253 omal telomere-telomere fusion resulting in a pericentric translocation of a chromosome segment or an

254 within an HBB BAC bias a competition between pericentric versus peripheral heterochromatin targeting

255 ar, six inversions, five paracentric and one pericentric, were revealed in chromosomes 4, 5 and 7.

256 on in a three-generation family with a large pericentric X chromosome inversion, inv(X)(p21.1q26), in

257 Our results indicate that (1) pericentric X chromosome inversions result in reduction