ライフサイエンスコーパス: pericentriolar

1 riate number of centrioles inside a cloud of pericentriolar and fibrogranular material.

2 omprises a reticulum of linked stacks in the pericentriolar and often in the juxtanuclear regions of

3 ate how the organization and function of the pericentriolar architecture are altered by disease-assoc

4 Tfn then accumulated in the pericentriolar cluster of recycling vesicles (RVs).

5 f recycling cargo typically accumulates in a pericentriolar cluster of tubules and vesicles.

6 7 has been characterized as a component of a pericentriolar complex containing Cep63 and Cep152.

7 by which the duplicated centrosomes recruit pericentriolar components and increase their microtubule

8 s possess increased levels of centriolar and pericentriolar components including gamma-tubulin and th

9 The pericentriolar components, gamma tubulin and dynactin, a

10 rotein vimentin to form a cage surrounding a pericentriolar core of aggregated, ubiquitinated protein

11 ingly, Cep63 and Cep152 self-assemble into a pericentriolar cylindrical architecture, and this event

12 le formation, and lysosomes are recruited to pericentriolar cytoplasmic inclusion bodies by a process

13 n epithelia converge in an apically located, pericentriolar endosomal compartment termed the apical r

14 (MDCK), antibodies to Rab11a label an apical pericentriolar endosomal compartment that is dependent o

15 lls has been shown to be concentrated in the pericentriolar endosomal recycling compartment and to pl

16 To better characterize this pericentriolar endosome population, we determined the di

17 However, although these pericentriolar endosomes contained Cbvn, they were strik

18 istributed along centriolar cylinders and on pericentriolar fibers, at least some of which constitute

19 Current models indicate that pericentriolar fibres termed rootlets, also known as the

20 At the onset of mitosis, the pericentriolar Golgi apparatus of mammalian cells is con

21 or without lethal factor, converts stacks of pericentriolar Golgi membranes into smaller fragments co

22 Based on our findings, we suggest that the pericentriolar Golgi organization is a sensor for contro

23 The pericentriolar Golgi stacks are fragmented and found dis

24 ivated protein kinase 1 (MEK1) fragments the pericentriolar Golgi stacks in mammalian cells.

25 ed P23H accumulates in aggresomes, which are pericentriolar inclusion bodies that require an intact m

26 Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a means t

27 l) binding proteins (SAS-6 and CPAP) and the pericentriolar localization of gamma-tubulin.

28 d by nocodazole, although the characteristic pericentriolar location of the population was not mainta

29 as is common for JBTS proteins, and also in pericentriolar locations.

30 dc14A overexpression induces the loss of the pericentriolar markers pericentrin and gamma-tubulin fro

31 nherited centrioles and maternally inherited pericentriolar material (PCM) [1].

32 d by a protein-rich matrix of electron-dense pericentriolar material (PCM) [4].

33 a coiled-coil protein that localizes within pericentriolar material (PCM) and in the immediate vicin

34 nd functionally segregate Nup188 between the pericentriolar material (PCM) and NPCs.

35 centrioles start to recruit large amounts of pericentriolar material (PCM) around themselves in prepa

36 es are formed when mother centrioles recruit pericentriolar material (PCM) around themselves.

37 Centrosomes form when centrioles assemble pericentriolar material (PCM) around themselves.

38 ble when centrioles recruit large amounts of pericentriolar material (PCM) around themselves.

39 hat the centrioles play instructive roles in pericentriolar material (PCM) assembly and that the PCM

40 nherent capacity to duplicate or to organize pericentriolar material (PCM) but acquired both after mi

41 pproximately 5-8 h after ablation, clouds of pericentriolar material (PCM) containing gamma-tubulin a

42 cle, wherein mitotic centrosomes with mature pericentriolar material (PCM) embed in the NL and interp

43 which the centriole forms but the centrosome pericentriolar material (PCM) fails to assemble, actin m

44 Furthermore, pericentriolar material (PCM) formation is abnormal in s

45 cells depleted of Asl, we found that, while pericentriolar material (PCM) function is mildly affecte

46 centrosomal protein required for organizing pericentriolar material (PCM) in mitosis.

47 omposed of a centriolar core surrounded by a pericentriolar material (PCM) matrix that docks microtub

48 Pericentriolar material (PCM) mediates the microtubule (

49 in-like protein (PLP) directs formation of a pericentriolar material (PCM) scaffold required for PCM

50 ucture includes core centrioles that recruit pericentriolar material (PCM) that anchors gamma-tubulin

51 pair of centrioles surrounded by a matrix of pericentriolar material (PCM) that assembles from cytopl

52 onsist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically

53 entrioles surrounded by a protein network of pericentriolar material (PCM) that is essential for the

54 on of pericentrin-like protein (PLP) and the pericentriolar material (PCM) to the proximal end of the

55 activity of centrosomes is conferred by the pericentriolar material (PCM), a composite of numerous p

56 iole assembly and found that proteins of the pericentriolar material (PCM), and in particular y-tubul

57 centrosome is driven by proteins within the pericentriolar material (PCM), however the molecular com

58 The outermost layer of centrosomes, called pericentriolar material (PCM), organizes microtubules fo

59 Centrioles are surrounded by pericentriolar material (PCM), which is proposed to prom

60 comprises a pair of centrioles surrounded by pericentriolar material (PCM), which nucleates and ancho

61 air of centrioles surrounded by an amorphous pericentriolar material (PCM).

62 ir core is a pair of centrioles that recruit pericentriolar material (PCM).

63 tubules into the mitotic spindle through its pericentriolar material (PCM).

64 ation of multipolar spindles with fragmented pericentriolar material (PCM).

65 They consist of centrioles surrounded by pericentriolar material (PCM).

66 ioles surrounded by a microtubule-nucleating pericentriolar material (PCM).

67 bules (MTs) is a property of the surrounding pericentriolar material (PCM).

68 two centrioles embedded in the proteinaceous pericentriolar material (PCM).

69 nded by an amorphous protein mass called the pericentriolar material (PCM).

70 amma-TuRCs) embedded within the centrosome's pericentriolar material (PCM).

71 ther' and 'daughter' centriole surrounded by pericentriolar material (PCM).

72 ists of a pair of centrioles and surrounding pericentriolar material (PCM).

73 comprise a pair of centrioles surrounded by pericentriolar material (PCM).

74 localizes to centrosomes and stabilizes the pericentriolar material (PCM).

75 rioles surrounded by an amorphous network of pericentriolar material (PCM).

76 air of centrioles surrounded by an amorphous pericentriolar material (PCM).

77 ments of two centrosome-associated proteins, pericentriolar material 1 (PCM-1) and pericentrin, in pr

78 ariation in brain morphology associated with pericentriolar material 1 (PCM1) alleles was examined us

79 Here, we identify Pericentriolar material 1 (Pcm1) as a key player in this

80 ed the extent of centrosomal localization of pericentriolar material 1 (PCM1) in SH-SY5Y cells.

81 eover, SDCCAG8 interacts and cotraffics with pericentriolar material 1 (PCM1), a centriolar satellite

82 dynamic multiprotein assemblies nucleated by Pericentriolar material 1 (PCM1).

83 on and differentiation of NPCs by repressing pericentriolar material 1 (PCM1).

84 s requires the interaction between Hook3 and Pericentriolar Material 1 (PCM1).

85 We show that ablation of pericentriolar material 1 in the mouse leads to progress

86 e also find that the targeting protein PCM1 (pericentriolar material 1) localizes CaMKIIbeta to the c

87 aside from their role as an anchor point for pericentriolar material and as basal bodies of flagella

88 ls, SSX2IP knockdown caused fragmentation of pericentriolar material and chromosome segregation error

89 separate, but only one is active, retaining pericentriolar material and forming a "dominant centroso

90 osomes consist of two centrioles embedded in pericentriolar material and function as the main microtu

91 ves asymmetric, organizing varying levels of pericentriolar material and microtubules.

92 DCCAG8 regulates centrosomal accumulation of pericentriolar material and neuronal polarization and mi

93 embedded centrosomes carry large amounts of pericentriolar material and nucleate astral microtubules

94 Such MTOCs had pericentriolar material and the centriolar protein Sas-4

95 Gle1 assembles into the toroid-shaped pericentriolar material around the mother centriole.

96 ancer target that is critical for regulating pericentriolar material cohesion during bipolar spindle

97 rmed maturation, involves the recruitment of pericentriolar material components via an as-yet unknown

98 ma-tubulin ring complex and, possibly, other pericentriolar material components, thus promoting their

99 Moreover, the centrosome and the pericentriolar material form condensates that share comp

100 ucleus, also preferentially localizes to the pericentriolar material in interphase cells.

101 ion led unexpectedly to fragmentation of the pericentriolar material in metaphase cells and delayed m

102 Our data emphasize a role for the pericentriolar material in the postnatal brain, with pro

103 a novel role of TACC3-ch-TOG in maintaining pericentriolar material integrity during mitosis to ensu

104 kely microtubule nucleation sites within the pericentriolar material of isolated centrosomes.

105 human centrioles, but not for recruitment of pericentriolar material on already assembled centrioles.

106 mma-tubulin and other proteins that form the pericentriolar material on centrosomes during G2/prophas

107 s during interphase promote fragmentation of pericentriolar material once cells enter mitosis due to

108 Because pericentriolar material organization is evolutionarily c

109 We propose that Gle1 assembly into the pericentriolar material positions the DEAD-box protein r

110 Our results suggest that the pericentriolar material promotes daughter centriole form

111 at brain-8A, centrosomal protein of 290 kDa, pericentriolar material protein 1, and polycystin-2, as

112 We link Cdk5rap2 function to the pericentriolar material protein pericentrin, loss of fun

113 s in various organisms revealed that diverse pericentriolar material proteins are concentrically loca

114 Thus, both centriolar and pericentriolar material proteins contribute to centriole

115 uring G2/M, where it associates with various pericentriolar material proteins, including Polo-like ki

116 rgo maturation characterized by expansion of pericentriolar material proteins, which facilitates spin

117 assembly assay to examine the roles of three pericentriolar material proteins: SPD-5, the kinase auro

118 We also find that Asl is not essential for pericentriolar material recruitment or centrosome functi

119 Here we show that two human pericentriolar material scaffolds, Cep63 and Cep152, coo

120 composed of a centriolar core surrounded by pericentriolar material that nucleates microtubules.

121 composed of a single centriole surrounded by pericentriolar material that was studded with ring-shape

122 Centrioles organize pericentriolar material to form centrosomes and also tem

123 ase activity caused premature recruitment of pericentriolar material to the sperm-provided centrioles

124 The KASH protein Nesprin-1alpha recruits pericentriolar material to the surface of myotube nuclei

125 These structures and associated pericentriolar material undergo fragmentation.

126 Significantly, the presence of excess pericentriolar material was associated with the highest

127 luded 1) supernumerary centrioles, 2) excess pericentriolar material, 3) disrupted centriole barrel s

128 a pair of centrioles surrounded by amorphous pericentriolar material, and centrosome duplication is c

129 5L is a centrosome protein localizing to the pericentriolar material, and knockdown of Cep85l causes

130 poles of dd4 cells have irregular amounts of pericentriolar material, but also that they can have abn

131 Together with the pericentriolar material, centrioles form the major micro

132 tubule walls, cartwheel, inner scaffold, and pericentriolar material, contribute to the long-term sta

133 In addition to residing on the pericentriolar material, GABARAP marks a subtype of PCM1

134 me, composed of two centrioles surrounded by pericentriolar material, is the cell's central microtubu

135 nsists of two centrioles and the surrounding pericentriolar material, is the primary microtubule-orga

136 -inflammatory stimuli lead to recruitment of pericentriolar material, specifically pericentrin and ga

137 ericentrin antibodies decorate the amorphous pericentriolar material, while the Cdc2 antibodies also

138 ression in both the Wee1 mRNA 3' UTR and the pericentriolar material-1 (Pcm-1) mRNA 3' UTR in immatur

139 37 block the formation of foci that comprise pericentriolar material-these foci are structures with a

140 nsists of a pair of centrioles surrounded by pericentriolar material.

141 nsists of a pair of centrioles and amorphous pericentriolar material.

142 binding occurs at the outer boundary of the pericentriolar material.

143 oles surrounded by an ill-defined "cloud" of pericentriolar material.

144 ves the interaction of tubulin subunits with pericentriolar material.

145 pair of centrioles surrounded by a cloud of pericentriolar material.

146 of a pair of centrioles and the surrounding pericentriolar material.

147 which each contain a centrosome, embedded in pericentriolar material.

148 odel involving autocatalytic assembly of the pericentriolar material.

149 s called centrioles and an amorphous mass of pericentriolar material.

150 regulates the recruitment of GABARAP to the pericentriolar material.

151 ng a protective role for Polo kinase and the pericentriolar material.

152 RIM37 as a negative regulator of centrosomal pericentriolar material.

153 ication of the centriole and organization of pericentriolar material.

154 consists of a pair of centrioles embedded in pericentriolar material.

155 s on assembly of protein components into the pericentriolar material.

156 We tested multiple anti-centriole and pericentriolar-material antibodies to identify bona fide

157 f CDK5RAP2, centrosomin (Cnn), maintains the pericentriolar matrix (PCM) around centrioles during mit

158 ent required for assembly of all other known pericentriolar matrix (PCM) proteins to achieve microtub

159 of two centrioles surrounded by an amorphous pericentriolar matrix (PCM), but it is unknown how centr

160 Human Cep57 is a coiled-coil scaffold at the pericentriolar matrix (PCM), controlling centriole dupli

161 pair of centrioles surrounded by an ordered pericentriolar matrix (PCM).

162 hair bundles, accompanied by defects in the pericentriolar matrix and microtubule organization.

163 centriole (DC) and its surrounding atypical pericentriolar matrix form a dynamic basal complex (DBC)

164 at pericentrin, an integral component of the pericentriolar matrix of the centrosome that has been sh

165 GABARAP is on the pericentriolar matrix, and this dynamic pool contributes

166 ioles surrounded by a relatively ill-defined pericentriolar matrix, provide the ciliary centriole-kin

167 e, in a microtubule-dependent manner, to the pericentriolar matrix.

168 n to the centrosome center creates a dynamic pericentriolar matrix.

169 We find that ZW10 localizes to pericentriolar membranous structures during interphase a

170 cell whole mounts show the centrioles and a pericentriolar network of filaments.

171 a small GTP-binding protein enriched in the pericentriolar plasma membrane recycling systems.

172 tosis and may provide an explanation for the pericentriolar position of the mammalian Golgi apparatus

173 n by RNA interference led to the loss of the pericentriolar positioning and dispersal of the Golgi ap

174 y the p150 Glued subunit of dynactin and the pericentriolar protein PCM-1.

175 MGC1203 encodes a pericentriolar protein that interacts and colocalizes wi

176 ) lack cilia, although mother centrioles and pericentriolar proteins are detected.

177 ype Caenorhabditis elegans zygotes, maternal pericentriolar proteins are not recruited to the sperm c

178 Kinesin prevents recruitment of pericentriolar proteins by coating the sperm DNA and cen

179 In the zygote, the centrioles recruit pericentriolar proteins from the egg to form a mature ce

180 ssemble gamma-tubulin, pericentrin, or other pericentriolar proteins into an organized PCM.

181 rt mitochondria to MTOCs independent of core pericentriolar proteins that regulate MT assembly at cen

182 r, GFP-AKAP350A(2691-3907) recruited several pericentriolar proteins to MTNCs, including gamma-tubuli

183 domain decreases LRRK2 membrane association, pericentriolar recruitment, and ability to phosphorylate

184 expressed kinase-active LRRK2 shows striking pericentriolar recruitment, which is dependent on the pr

185 ion of the trans-Golgi network (TGN) and the pericentriolar recycling compartment (PRC).

186 at the TR and GLUT4 are transported from the pericentriolar recycling compartment in separate vesicle

187 report that PI3K-C2alpha is enriched in the pericentriolar recycling endocytic compartment (PRE) at

188 king of beta-catenin/E-cadherin complexes to pericentriolar recycling endosomes (PCREs).

189 ndosomes, and subsequently with Rab11-GFP in pericentriolar recycling endosomes.

190 mbrane trafficking through early/sorting and pericentriolar recycling endosomes.

191 early/sorting endosomes, as well as Rab11 on pericentriolar recycling endosomes.

192 somes and tubular recycling endosomes in the pericentriolar region followed by their reappearance at

193 antly to an intracellular compartment at the pericentriolar region of the cell.

194 n-Ig, which at steady state accumulated in a pericentriolar region similar to rhodamine-transferrin.

195 to produce fragmented Golgi membranes in the pericentriolar region that is characteristic of macfarla

196 embranes are subsequently dispersed from the pericentriolar region.

197 d that protein 4.1 epitopes localized in the pericentriolar region.

198 ollapse of the lysosomal population into the pericentriolar region.

199 ance of the resulting Golgi fragments in the pericentriolar region.

200 es, associates with centrosome/centriole and pericentriolar satellites in human cells and forms a com

201 Here we demonstrate that trafficking of pericentriolar satellites requires the interaction betwe

202 d the nucleus in C. elegans, is recruited to pericentriolar satellites through interaction with PCM1,

203 BBSome is nucleated by BBS4 and assembled at pericentriolar satellites, followed by the translocation

204 c assembly is mediated by the trafficking of pericentriolar satellites, which are comprised of centro

205 s inclusions or virus factories that form at pericentriolar sites close to the microtubule organizing

206 mation underneath the plasma membrane and at pericentriolar sites, concurrent with decreased particle

207 The pericentriolar stacks of Golgi cisternae undergo extensi

208 croscopy suggest that Skp1 forms an extended pericentriolar structure that may function to organize t

209 aded CFTR molecules accumulate at a distinct pericentriolar structure which we have termed the aggres

210 stering aggregation-prone proteins in large, pericentriolar structures termed aggresomes.

211 constitutively active form of Arl3 (Q71L) on pericentriolar vesicle transport.