ライフサイエンスコーパス: pericentromeric

1 ident with losses in cytosine methylation at pericentromeric 5S gene clusters and AtSN1 retroelements

2 role of shugoshins appears to be to serve as pericentromeric adaptor proteins that recruit several di

3 Here, we show that shugoshin acts as a pericentromeric adaptor that plays dual roles in biorien

4 usly shown that duplication of chromosome 17 pericentromeric alpha satellite as measured with a centr

5 mapped cohesin-associated regions (CARs) in pericentromeric and arm regions, and that Scc2/Scc4-cohe

6 L.) mitotic cells, H3T3ph is concentrated at pericentromeric and centromeric regions.

7 ntiation between the two genome sequences in pericentromeric and peritelomeric regions.

8 ch loads cohesin at specific sites including pericentromeric and subtelomeric domains, is dispensable

9 genes in T. thermophila are concentrated in pericentromeric and subtelomeric regions of the 5 micron

10 Susceptible patterns (pericentromeric and telomeric exchanges) accounted for 3

11 static form of heterochromatin that silences pericentromeric and telomeric repeats in a cell cycle- a

12 ing segmental duplications and subtelomeric, pericentromeric, and acrocentric areas.

13 Concomitantly, the levels of pericentromeric aurora B kinase, known to phosphorylate

14 n of the gene RanGAP, whereas Rsp is a large pericentromeric block of satellite DNA.

15 n is reinforced within 3-Mb regions flanking pericentromeric boundaries, and this effect appears to b

16 Stretching of the pericentromeric chromatin during metaphase is thought to

17 BEND3, a protein enriched on pericentromeric chromatin in the absence of DNA methylat

18 dle dynamics fail to predict the behavior of pericentromeric chromatin in wild-type and mutant spindl

19 read chromatin changes, we hypothesized that pericentromeric chromatin structure could also be affect

20 n increase in ploidy associated with altered pericentromeric chromatin structure, suggesting a role f

21 The cell must adjust the pericentromeric chromatin to accommodate the changing te

22 rification method to characterize changes in pericentromeric chromatin-associated proteins in mouse e

23 the mitotic spindle exerts physical force on pericentromeric chromatin.

24 ibutes to an efficient release of HELLS from pericentromeric chromatin.

25 On pericentromeric chromosome 8 within our previously repor

26 in the frequency of associations between the pericentromeric clusters, chromosomal territory 3, and n

27 tochore-associated Ctf19 complex (Ctf19c) in pericentromeric CO suppression.

28 eloped a technique that specifically reduced pericentromeric cohesin association on a single chromoso

29 The magnitude of pericentromeric cohesin association was negatively corre

30 quencies of chromosome loss, suggesting that pericentromeric cohesin enrichment is essential for high

31 re components suggests that this pathway for pericentromeric cohesin enrichment may have been retaine

32 I, sister kinetochores are monooriented and pericentromeric cohesin is protected.

33 Together, these observations suggest that pericentromeric cohesin levels reflect the balance of op

34 Pericentromeric cohesin recruitment required evolutionar

35 Enriched pericentromeric cohesin requires the Ctf19 kinetochore s

36 romatids remain attached through centromeric/pericentromeric cohesin.

37 ave not clearly defined the roles of arm and pericentromeric cohesion in chromosome segregation.

38 ances cohesin loading and facilitates robust pericentromeric cohesion in S phase.

39 The failure to resolve pericentromeric cohesion is under the control of the B-s

40 nd this appears to be related to its role in pericentromeric cohesion.

41 o recruit Scc2/4 to centromeres and to build pericentromeric cohesion.

42 remature Sgo1 removal and precocious loss of pericentromeric cohesion.

43 would recruit these genes to the restrictive pericentromeric compartment, resulting in their repressi

44 Pericentromeric condensin biases sister kinetochores tow

45 Trimethylated H3(K9) marks pericentromeric constitutive heterochromatin and the mal

46 In organisms ranging from yeast to humans, pericentromeric COs are repressed.

47 ver remodeling at the chromosome scale, with pericentromeric decreases and euchromatic increases in r

48 We have identified a recurrent de novo pericentromeric deletion in 16p11.2-p12.2 in four indivi

49 In fission yeast, the pericentromeric dg and dh repeats are transcribed and gi

50 Pericentromeric DNA hypermethylation occurs in a subset

51 Heterochromatic gene silencing at the pericentromeric DNA repeats in fission yeast requires th

52 pendent co-transcriptional gene silencing at pericentromeric DNA repeats.

53 ing compact, hypermethylated centromeric and pericentromeric DNA.

54 ited in heterochromatic regions encompassing pericentromeric DNA.

55 ite DNA, is hypomethylated compared with the pericentromeric domains.

56 Subsequent phylogenetic analysis of a pericentromeric endogenous retrovirus amplified by PCR r

57 iotic gene promoters and is required for the pericentromeric enrichment of 5hmC.

58 These data indicate that defects in pericentromeric epigenetic heterochromatin modifications

59 epiRILs, we discuss mechanisms by which the pericentromeric epiQTLs could regulate the defence-relat

60 maging and tracking the thermal movements of pericentromeric fluorescent markers in Saccharomyces cer

61 Many cryptic, pericentromeric genes are expressed at the RNA level and

62 Human subtelomeric, but not pericentromeric, genes also exhibit these elevations.

63 results in equivalent partial reductions of pericentromeric H3K9me levels, but a double mutation eli

64 of nucleoli; (iv) increase in the number of pericentromeric heterochromatic clusters; and (v) increa

65 e dramatic reduction of recombination in the pericentromeric heterochromatic region.

66 By contrast, the pericentromeric heterochromatic regions of these chromos

67 In hematopoietic cells, Ikaros localizes to pericentromeric heterochromatin (PC-HC) where it recruit

68 The majority of Ikaros localizes at pericentromeric heterochromatin (PC-HC) where it regulat

69 Ikaros complexes to bind DNA motifs found in pericentromeric heterochromatin (PC-HC).

70 e-based physical map that spans 13 Mb of the pericentromeric heterochromatin and a cytogenetic map th

71 Assembly of fission yeast pericentromeric heterochromatin and generation of small

72 finity for methylated CpGs that localizes at pericentromeric heterochromatin and is frequently downre

73 CapA is associated with non-pericentromeric heterochromatin and its distribution var

74 enes and provide spring-like tension between pericentromeric heterochromatin and microtubules.

75 ites, and for the association of CENP-B with pericentromeric heterochromatin and tandem satellite rep

76 ilizes epigenetic heterochromatin markers on pericentromeric heterochromatin and the Y chromosome thr

77 terochromatin, and H2A.Z becomes enriched at pericentromeric heterochromatin and the Y chromosome.

78 genetic positions of the centromere and the pericentromeric heterochromatin and to relate chromatin

79 Nucleosome occupancy and HP1a binding at pericentromeric heterochromatin are markedly decreased i

80 rrier sequences result in the propagation of pericentromeric heterochromatin beyond its normal bounda

81 ATRXt isoforms are colocalized at blocks of pericentromeric heterochromatin but unlike full length A

82 These data suggest a role for nucleoli and pericentromeric heterochromatin clusters as organizers o

83 at all tRNA genes, many of which cluster at pericentromeric heterochromatin domain boundaries.

84 of the Brg1 ATPase results in dissolution of pericentromeric heterochromatin domains and a redistribu

85 unctions in limiting Pol II occupancy across pericentromeric heterochromatin domains.

86 Dozens of genes were embedded into pericentromeric heterochromatin during evolution of Dros

87 Here, we show that Brc1 localizes in pericentromeric heterochromatin during S phase, where it

88 H2A on serine-128/-129 to create gammaH2A in pericentromeric heterochromatin during S phase, which re

89 Dntt), which is silenced and repositioned to pericentromeric heterochromatin during thymocyte maturat

90 Pericentromeric heterochromatin formation is mediated by

91 ecognition by HP1 proteins are necessary for pericentromeric heterochromatin formation.

92 the cell cycle as well as chromatin context.Pericentromeric heterochromatin forms a distinct nuclear

93 dynamic HP1-dependent response that rescues pericentromeric heterochromatin function and is essentia

94 In contrast, BACs assigned to the pericentromeric heterochromatin had a gene density 10-10

95 be ChIP analysis revealed that Vgl1 binds to pericentromeric heterochromatin in an RNA-dependent mann

96 gional centromeres, there was no evidence of pericentromeric heterochromatin in C. lusitaniae.

97 ically associate with the nuclear lamina and pericentromeric heterochromatin in CD4(-)CD8(-) thymocyt

98 gh frequency with the nuclear lamina or with pericentromeric heterochromatin in developing thymocytes

99 interference (RNAi)-mediated transmission of pericentromeric heterochromatin in fission yeast, which

100 CEN chromatin is embedded within pericentromeric heterochromatin in most higher eukaryote

101 D3 and is recruited to 5-methylcytosine-rich pericentromeric heterochromatin in mouse cells.

102 tedly enriched at transcriptionally inactive pericentromeric heterochromatin in P. falciparum, a regi

103 compositional differences of euchromatin and pericentromeric heterochromatin in this model dicot spec

104 Nonetheless, they have spread throughout the pericentromeric heterochromatin in tomato and wild tomat

105 Pericentromeric heterochromatin is generally composed of

106 on, we concluded that stable localization at pericentromeric heterochromatin is neither necessary nor

107 indings suggest that impaired maintenance of pericentromeric heterochromatin may contribute to CIN in

108 kage group L, has sequences conserved in the pericentromeric heterochromatin of all 20 chromosomes.

109 We show that silencing of transposons in the pericentromeric heterochromatin of Arabidopsis thaliana

110 Dictyostelium discoideum and constitutes the pericentromeric heterochromatin of the six chromosomes i

111 We mapped a recessive factor to the pericentromeric heterochromatin of the X chromosome in D

112 f linkage and cytological maps revealed that pericentromeric heterochromatin of these sorghum chromos

113 pes, which include an abnormal appearance of pericentromeric heterochromatin on metaphase chromosomes

114 nd INM proteins, but not to association with pericentromeric heterochromatin or nuclear pore complexe

115 maternal mutant zygotes, suggesting that the pericentromeric heterochromatin regions are protected fr

116 origins of replication and non-coding RNA in pericentromeric heterochromatin results in competition b

117 ation of histone H3 (K9) and condensation of pericentromeric heterochromatin structure in neurons.

118 ion of recombination was associated with the pericentromeric heterochromatin that accounts for approx

119 linked directed monoallelic association with pericentromeric heterochromatin to the initiation or mai

120 sion of CENP-V leads to hypercondensation of pericentromeric heterochromatin, a phenotype that is abo

121 on of the H4K20me3 histone modification into pericentromeric heterochromatin, a territory occupied no

122 cytes, the SMC5/6 complex is enriched at the pericentromeric heterochromatin, and also localizes alon

123 ialized chromatin at the kinetochore itself, pericentromeric heterochromatin, and flanking euchromati

124 riant centromere protein A (CENP-A), and the pericentromeric heterochromatin, considered important fo

125 rtmentalization and the concentric shells of pericentromeric heterochromatin, facultative heterochrom

126 1 and atmorc6 mutants show decondensation of pericentromeric heterochromatin, increased interaction o

127 ore resistant to unfolding than sur-rounding pericentromeric heterochromatin, mitotic kinetochores ar

128 We find that pericentromeric heterochromatin, repetitive sequences, a

129 monomethylation, a modification enriched at pericentromeric heterochromatin, was observed broadly di

130 q21 CNAs and DNA hypomethylation of the 1q12 pericentromeric heterochromatin, we treated in vitro per

131 breaks (DSBs) is particularly challenging in pericentromeric heterochromatin, where the abundance of

132 in striking contrast to Chp1, a component of pericentromeric heterochromatin, which binds H3K9me-rich

133 umulates replicative damage at telomeres and pericentromeric heterochromatin, which is exacerbated by

134 ecessary for fully efficient transmission of pericentromeric heterochromatin, which is required for a

135 hosphorylation of histone H3 at serine 10 in pericentromeric heterochromatin, which normally occurs i

136 n stress at late-replicating regions such as pericentromeric heterochromatin.

137 sed Rag expression and Rag relocalization to pericentromeric heterochromatin.

138 pendent repositioning of the other allele to pericentromeric heterochromatin.

139 led replication forks, preferentially around pericentromeric heterochromatin.

140 ed by Dcr-2 into small RNAs to help maintain pericentromeric heterochromatin.

141 cers and positioned a kappa allele away from pericentromeric heterochromatin.

142 e transcripts were from genes located in the pericentromeric heterochromatin.

143 rs C/EBPalpha in the transcriptionally inert pericentromeric heterochromatin.

144 tive cells, one Tcrb allele was recruited to pericentromeric heterochromatin.

145 y located in euchromatin are now embedded in pericentromeric heterochromatin.

146 binant inbred mapping within centromeres and pericentromeric heterochromatin.

147 recruiting HP1 proteins to sites of altered pericentromeric heterochromatin.

148 anking centromeres to restrain the spread of pericentromeric heterochromatin.

149 not influence its nuclear localization into pericentromeric heterochromatin.

150 arly mitotic phases at inner centromeres and pericentromeric heterochromatin.

151 t known whether regional centromeres require pericentromeric heterochromatin.

152 tinct type of regional centromere that lacks pericentromeric heterochromatin.

153 Pericentromeric, higher-order repeat substructure exists

154 Pericentromeric histone dynamics are influenced by the c

155 alance between displacement and insertion of pericentromeric histones provides a mechanism to accommo

156 inetochore capture and expose shugoshin as a pericentromeric hub controlling chromosome biorientation

157 Pericentromeric human satellite II (HSATII) repeats are

158 e involved in the phosphorylation of H3T3 in pericentromeric/knob regions and that this repressive ep

159 a modest decrease in histone H3 occupancy in pericentromeric/knob regions of wild-type plants under o

160 ether, these data reveal a specific role for pericentromeric linkage in ensuring kinetochore biorient

161 he S. pombe ortholog Seb1 is associated with pericentromeric lncRNAs.

162 Thus, pericentromeric localization, per se, does not result in

163 f an interspecific cross for mapping and the pericentromeric location of the QTL, we observed no supp

164 gene conversion events occurring at numerous pericentromeric loci in the setting of malignancy.

165 ntitative reductions in centromeric core and pericentromeric markers (alpha-satellite units and HERV-

166 equired for RNAi complexes to associate with pericentromeric noncoding RNAs.

167 firing but interferes specifically with the pericentromeric origin activation.

168 is reminiscent of the recruitment of Dbf4 to pericentromeric origins by Ctf19.

169 Conversely, disassembly of the shugoshin pericentromeric platform may provide a signal that siste

170 Shugoshins form a pericentromeric platform that integrates multiple functi

171 Cuff accumulates at centromeric/pericentromeric positions in germ-cell nuclei and strong

172 amily elements is reduced in centromeric and pericentromeric positions, while others do not show a si

173 a recent issue of The EMBO Journal that the pericentromeric protein, SGO2, serves as a novel transcr

174 ulation of these important tension-sensitive pericentromeric proteins are discussed.

175 We uncover multi-layered suppression of pericentromeric recombination by the Ctf19 complex, oper

176 mes, apparently because rare centromeric (or pericentromeric) recombination events, when they do occu

177 sociation of the Igh and Igk loci, inhibited pericentromeric recruitment and locus 'decontraction' of

178 Hence, pericentromeric recruitment and locus 'decontraction' se

179 ng events of new material to this particular pericentromeric region abruptly ceased after this time p

180 tric chromatin reflect global changes in the pericentromeric region and provide mechanisms for mechan

181 lopmental RNA specificity between the barley pericentromeric region and the rest of the genome.

182 tion-dependent function for cyclin A1 in the pericentromeric region in late diplotene of meiosis, per

183 Third, local gene duplication in the pericentromeric region is reduced by 29% relative to the

184 Thus, the pericentromeric region of barley is a permissive environ

185 calization of a novel modifier, Mom7, to the pericentromeric region of chromosome 18.

186 rom patients with copy number changes in the pericentromeric region of chromosome 22q.

187 repeat is mapped to a single location in the pericentromeric region of chromosome 7.

188 results in alpha-E2 proteins binding to the pericentromeric region of metaphase chromosomes, as obse

189 The low-recombining pericentromeric region of the barley genome contains rou

190 Wheat ESTs that mapped to the pericentromeric region of the group-5 long arm anchored

191 Previous studies of the pericentromeric region of the human X chromosome short a

192 abase of heterochromatic sequence within the pericentromeric region of the short and long arm of the

193 Hypothesizing that this pericentromeric region of the X chromosome may be accumu

194 The pericentromeric region of this homeologous chromosome pa

195 First, genes within the pericentromeric region of wild barley show reduced diver

196 tant plants, a cluster of EPSPS genes on the pericentromeric region on one pair of homologous chromos

197 We have investigated the effects of pericentromeric region residency upon the expression, di

198 (EEGS) was identified that localized to the pericentromeric region with high homology to satellite 2

199 e been completely eliminated from the barley pericentromeric region.

200 venting heterochromatin spreading beyond the pericentromeric region.

201 s of the structure and assembly of all human pericentromeric regions (5 megabases).

202 ns of gene divergence and expression between pericentromeric regions and chromosomal arms in differen

203 repressive chromatin in aged males away from pericentromeric regions and the Y.

204 Centromeric and pericentromeric regions are essential for chromosome con

205 These results are surprising, because the pericentromeric regions are hypermethylated and were exp

206 A that were duplicatively transposed towards pericentromeric regions at a rate of six-seven events pe

207 During development or in cancer, pericentromeric regions can adopt either epigenetic stat

208 rucial for the control of heterochromatin at pericentromeric regions consisting of satellite repeats.

209 Lastly, H3K27me3-depleted pericentromeric regions contain gene islands with active

210 regions including the inner centromeric and pericentromeric regions during (pro)metaphase.

211 tant, which exhibited lower H3T3ph levels in pericentromeric regions even under normal environmental

212 esults show that hypomethylation at selected pericentromeric regions is sufficient to provide quantit

213 This implies that pericentromeric regions may contribute disproportionally

214 region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q

215 monstrate that the suppression of COs within pericentromeric regions of chromosomes persists in this

216 in structures at telomeres, centromeres, and pericentromeric regions of chromosomes, leading to mitot

217 8) E2 protein binds as large speckles at the pericentromeric regions of chromosomes.

218 Distal regions of euchromatin and pericentromeric regions of heterochromatin were delimite

219 The betapapillomavirus E2 proteins bind to pericentromeric regions of host mitotic chromosomes, inc

220 iven our discovery of gamma-satellite DNA in pericentromeric regions of most human chromosomes and a

221 he suppression of COs within the repeat-rich pericentromeric regions of plant and mammalian chromosom

222 otic chromosomal exchange in centromeric and pericentromeric regions of rice, the centromere core sho

223 The pericentromeric regions of soybean (Glycine max) chromos

224 quenced regions of the genome, including the pericentromeric regions of the acrocentric chromosomes a

225 nts which were mapped to the centromeric and pericentromeric regions of the Arabidopsis chromosomes t

226 dog genomes, suppression of recombination in pericentromeric regions of the metacentric fox chromosom

227 ridization analysis mapped the EPSPS gene to pericentromeric regions of two homologous chromosomes in

228 e and recombination is suppressed within the pericentromeric regions of wheat chromosomes, thus, prec

229 primarily by preferential TE insertions into pericentromeric regions or by selection against TE inser

230 osons (LTR-RTs), in recombination-suppressed pericentromeric regions seems to be a general pattern of

231 igh content of repetitive elements and large pericentromeric regions that are virtually devoid of mei

232 entially retained in recombination-repressed pericentromeric regions that exhibit lower gene densitie

233 ification as a signal for Top2p targeting to pericentromeric regions was suggested by an analysis of

234 of lncRNA transcription also takes place at pericentromeric regions where it contributes to heteroch

235 Most chromosomes have pericentromeric regions with highly suppressed recombina

236 The role of repetitive DNA sequences in pericentromeric regions with respect to kinetochore/hete

237 ic heterochromatin, increased interaction of pericentromeric regions with the rest of the genome, and

238 model for the formation of highly duplicated pericentromeric regions within the human genome.

239 ctural variants (inversions, centromeres and pericentromeric regions).

240 deleterious mutation rate is observed in the pericentromeric regions, and might be caused by differen

241 f transposons that are largely restricted to pericentromeric regions, barley MORC mutants did not sho

242 an genome that is highly concentrated in the pericentromeric regions, consisting of rapidly evolving

243 esin association on chromosome arms, but not pericentromeric regions, is reduced in the phosphomimeti

244 dog genes located either in subtelomeric and pericentromeric regions, or in short synteny blocks, pos

245 and S that was largely confined to gene-poor pericentromeric regions, prompting a speciation-with-ong

246 Crossovers were elevated in the diverse pericentromeric regions, showing a local preference for

247 these duplicated segments is nonrandom among pericentromeric regions, suggesting that some regions ha

248 ing the biased accumulation of singletons in pericentromeric regions, suggests that distinct genomic

249 nts were located in recombination-suppressed pericentromeric regions, where the ratio (1.26) of solo

250 e observed excess residual heterozygosity in pericentromeric regions, which suggested that selection

251 sity was greatest in the proximal and distal pericentromeric regions, with only a slightly preferenti

252 es are particularly informative within human pericentromeric regions--areas of particularly rapid cha

253 Intriguingly, the genes in pericentromeric regions-the cold spots for meiotic recom

254 e genome's heterochromatin, particularly its pericentromeric regions.

255 s that are embedded within highly repetitive pericentromeric regions.

256 ting in reduced crossover suppression across pericentromeric regions.

257 t are largely restricted to loci residing in pericentromeric regions.

258 is gained at new CHH positions, primarily in pericentromeric regions.

259 low Ks and low levels of gene expression in pericentromeric regions.

260 which are enriched within recombination-poor pericentromeric regions.

261 lation levels compared with sequences in the pericentromeric regions.

262 ith the same repeats located in the flanking pericentromeric regions.

263 ersion of a segment spanning centromeric and pericentromeric regions.

264 s is significantly enlarged in non-genic and pericentromeric regions.

265 ched at rRNA gene cluster, subtelomeric, and pericentromeric regions.

266 cative transposition from the euchromatin to pericentromeric regions.

267 ons and increased recombination rates across pericentromeric regions.

268 lomeric regions and reduced recombination in pericentromeric regions.

269 e with several major diversity losses in the pericentromeric regions.

270 n across the entire chromosome(s), including pericentromeric regions.

271 ormerly euchromatic regions into repeat-rich pericentromeric regions.

272 on and chromatin features at centromeric and pericentromeric repeats and identified mutant contexts w

273 several cases, LCRs, AT-rich palindromes and pericentromeric repeats are located at such rearrangemen

274 ssion was required to attach centromeric and pericentromeric repeats but not LINE-1 elements to the l

275 coordinated replication and transcription of pericentromeric repeats enable RNA interference (RNAi)-m

276 ochromatin assembly on transcribed noncoding pericentromeric repeats requires both RNAi and RNAi-inde

277 etitive regions, we show that in contrast to pericentromeric repeats, which reacquire normal methylat

278 on between the unique chromosome arm and the pericentromeric repeats.

279 lences transcription, and retains cohesin at pericentromeric repeats.

280 Sld3-Sld7 replication initiator proteins to pericentromeric replication origins so that they initiat

281 ions within Cd4 modulated CD8 expression and pericentromeric repositioning of Cd8.

282 Deacetylation at H3-Lys9 coincided with pericentromeric repositioning, and neither of these earl

283 rtilization is catalysed by SUV39H2 and that pericentromeric RNAs inhibit SUV39H2 activity and reduce

284 racterized by immune defects, instability of pericentromeric satellite 2-containing heterochromatin,

285 ple underlying the ubiquity and abundance of pericentromeric satellite DNA repeats in eukaryotes has

286 nd minor satellite RNAs from centromeric and pericentromeric satellite repeats accumulate in excess.

287 thylation and DNMT3B to both centromeric and pericentromeric satellite repeats and that CENP-C and DN

288 maintenance of transcriptional silencing at pericentromeric satellite sequences (constitutive hetero

289 e pancreatic ductal adenocarcinomas (PDACs), pericentromeric satellites accounted for a mean 12% (ran

290 Pericentromeric Scc2/Scc4 enrichment is kinetochore-depe

291 ncluding the first autosomal transition from pericentromeric sequence to higher-order alpha-satellite

292 b) of genomic sequence, including 0.87 Mb of pericentromeric sequence, uncovered 45 intact long termi

293 widespread heterogeneity of centromeric and pericentromeric sequences in cancer cells and tissues as

294 A pericentromeric SNP on chromosome 1p11.2 (rs11249433; P

295 ive the linear order of sequences across the pericentromeric space and to investigate the spatial org

296 karyotic chromosomes, mostly at centromeric, pericentromeric, telomeric and subtelomeric regions(1).

297 Snail1 transcription factor represses mouse pericentromeric transcription, acting through the H3K4 d

298 Mkt1 physically associates with pericentromeric transcripts, and is additionally require

299 unced in genomic regions that are non-genic, pericentromeric, transposable elements; methylated; and

300 erns, but with most of the changes affecting pericentromeric transposons.