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1  blocked by treatment with the AKT inhibitor perifosine.
2 to assess the role of p21(WAF1) induction by perifosine.
3 s in nude mice was dramatically inhibited by perifosine.
4 nes lacking p21(waf1/cip1) are refractory to perifosine.
5 nized HN12 cells released in the presence of perifosine (10 microM) demonstrated increased expression
6                                              Perifosine + 10 Gy did not result in a significantly inc
7 The dose selected for the phase II study was perifosine 50 mg/d plus bortezomib 1.3 mg/m(2), with the
8 In this study, we investigated the effect of perifosine, a p.o.-bioavailable ALK, on the cell cycle k
9 pands our understanding of the mechanisms of perifosine action in neuroblastoma.
10 ciferase reporter plasmids, we observed that perifosine activates the 2.4-kb full-length p21(waf1/cip
11                     Moreover, we showed that perifosine activates the mitogen-activated protein/extra
12 t lacking p53-binding sites, suggesting that perifosine activates the p21(waf1/cip1) promoter indepen
13 72-h exposure of the MDA468 and PC3 cells to perifosine alone resulted in cell death in a dose-depend
14   Additional ATLs, including miltefosine and perifosine, also displaced Pma1p from rafts to the vacuo
15                                              Perifosine, an Akt inhibitor, has been shown to be effec
16                                              Perifosine, an AKT inhibitor, reduced over-activated AKT
17                                              Perifosine, an inhibitor of AKT signaling, significantly
18                 Akt is strongly inhibited by perifosine, an orally active alkyl-lysophospholipid curr
19  data were obtained using the AKT inhibitors perifosine and 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-
20 sm accounting for the anticancer activity of perifosine and a potential strategy to enhance the antic
21                         We demonstrated that perifosine and bortezomib both targeted NF-kappaB throug
22 cells (in which the PTEN gene is deleted) to perifosine and cetuximab, alone and in combination.
23 ersed by cotreatment with the Akt inhibitors perifosine and GSK69069 or by the addition of neutralizi
24              With these results, we combined perifosine and temozolomide as treatment of platelet-der
25                   Animal studies showed that perifosine and temozolomide combination therapy was more
26 A mutants greatly sensitized SW1736 cells to perifosine and temsirolimus.
27 MK-2206 and GSK690693 but not the compounds (perifosine and triciribine) targeting the PH domain of A
28                         To gain insight into perifosine anti-tumor activity in neuroblastoma we have
29             Novel agents such as bortezomib, perifosine, atacicept, oblimersen sodium, and tositumoma
30                                 Furthermore, perifosine augments dexamethasone, doxorubicin, melphala
31         These data, therefore, indicate that perifosine blocks cell cycle progression of head and nec
32                                              Perifosine-bortezomib +/- dexamethasone demonstrated enc
33      A phase III trial is underway comparing perifosine-bortezomib plus dexamethasone with bortezomib
34 rategy to enhance the anticancer efficacy of perifosine by preventing autophagy.
35  signal-related kinase (ERK) is increased by perifosine; conversely, MEK inhibitor synergistically en
36                                     Finally, perifosine demonstrates significant antitumor activity i
37 y prolonged survival by 27% (P = 0.0002) but perifosine did not (P = 0.92).
38                                              Perifosine does not induce cytotoxicity in peripheral bl
39         Taken together, the data showed that perifosine enhances the antitumor activity of cetuximab
40 hat the novel signal transduction modulator, perifosine, enhances the cytotoxicity of dexamethasone a
41 romigratory/proinvasive cells present in the perifosine-free areas, decrease of their abundance in th
42 but was ultimately ineffective in preventing perifosine/HDACI-mediated apoptosis.
43   Genetic-dependent apoptosis was induced by perifosine in cells selectively tested.
44                   Clinical data suggest that perifosine in combination with dexamethasone has activit
45 nt of gliomas, we investigated the effect of perifosine in combination with temozolomide.
46                     However, the efficacy of perifosine in human gliomas has not been established.
47 ndicate that coadministration of HDACIs with perifosine in human leukemia cells leads to Akt and MEK/
48 ide the framework for clinical evaluation of perifosine in WM patients.
49                                              Perifosine induced significant reduction in WM tumor gro
50 ggesting that JNK plays an essential role in perifosine-induced apoptosis.
51  SP600125) did not attenuate sodium butyrate/perifosine-induced apoptosis.
52  of xenografts in nude mice, suggesting that perifosine-induced autophagy protects cells from undergo
53 uction of p21(waf1/cip1) is required for the perifosine-induced cell cycle arrest because cell lines
54 sely, MEK inhibitor synergistically enhances Perifosine-induced cytotoxicity in MM cells.
55 tingly, MEK inhibitor significantly enhanced perifosine-induced cytotoxicity in WM cells.
56                  Inhibition of JNK abrogates perifosine-induced cytotoxicity, suggesting that JNK pla
57 nsulinlike growth factor 1 (IGF-1) overcomes Perifosine-induced cytotoxicity.
58 The minimal p21 promoter region required for perifosine-induced p21 promoter activation contains four
59  Mutations in each particular Sp1 site block perifosine-induced p21(waf1/cip1) expression.
60                                 Importantly, Perifosine induces apoptosis even of MM cells adherent t
61 ribose) polymerase cleavage, suggesting that perifosine induces both apoptosis and autophagy.
62                We have shown previously that perifosine induces p21(waf1/cip1) in a p53-independent f
63 port, we investigated the mechanism by which perifosine induces p21(waf1/cip1) protein expression.
64                                              Perifosine induces significant cytotoxicity in both MM c
65                             We observed that perifosine induces the accumulation of p21(waf1/cip1) mR
66            In addition to inhibition of Akt, perifosine inhibited the assembly of both mTOR/raptor an
67 ent study reveals a novel mechanism by which perifosine inhibits Akt and the mTOR axis.
68               Collectively, we conclude that perifosine inhibits mTOR signaling and induces autophagy
69              These results thus suggest that perifosine inhibits the mTOR axis through a different me
70 ed penetration of the clinically tested drug perifosine into spheroids during a 24 h period, revealin
71                                              Perifosine is a synthetic novel alkylphospholipid, a new
72                                              Perifosine is an alkylphospholipid exhibiting antitumor
73                  These results indicate that perifosine is an effective drug in gliomas in which Akt
74                                              Perifosine is an oral Akt inhibitor which exerts a marke
75 egulation by Akt knockdown and the inhibitor perifosine leads to significant inhibition of proliferat
76 both conventional (dexamethasone) and novel (perifosine, lenalidomide, and bortezomib) therapies.
77                        Some examples include perifosine, lovastatin, and UCN-01.
78                         To determine whether perifosine may enhance the antitumor activity of the ant
79 inase inhibitor desipramine attenuated HDACI/perifosine-mediated ceramide and ROS production as well
80 e (MEK) 1 or myristoylated Akt blocked HDACI/perifosine-mediated ceramide production and cell death,
81 yeloma (MM) cells is completely inhibited by perifosine [octadecyl-(1,1-dimethyl-piperidinio-4-yl)-ph
82 glioblastomas, we investigated the impact of perifosine on glia in culture and on a mouse glioma mode
83             This study details the impact of perifosine on proteome and lysine acetylome in SK-N-AS c
84  Ectopic Mcl-1 expression potently inhibited perifosine/PD184352-induced apoptosis, as did Bak or Bax
85 shed Bax/Bak binding, and sharply attenuated perifosine/PD184352-induced apoptosis.
86 pathways plays a critical functional role in perifosine/PD184352-mediated lethality.
87 ethasone at 20 mg if progression occurred on perifosine plus bortezomib alone.
88 rial, we compared the efficacy and safety of perifosine plus capecitabine (P-CAP) with placebo plus c
89 ee areas, decrease of their abundance in the perifosine-positive regions, and distinguishing between
90                  Treatment of the cells with perifosine reduced baseline levels of phosphorylated Akt
91                                  Strikingly, perifosine reduced the levels of Akt and other major com
92  inhibit Akt, other mechanisms contribute to perifosine's anti-tumor activity.
93 PD184352 or U0126 and the PI3K/Akt inhibitor perifosine strikingly induced apoptosis in multiple mali
94                            Here we show that perifosine strongly reduces phosphorylation levels of Ak
95                                    Moreover, perifosine substantially increased the levels of type II
96 tified other signaling pathways modulated by perifosine, such as activation of ERK MAPK pathway, whic
97 hydroxamic acid (SAHA), or trichostatin with perifosine synergistically induced mitochondrial dysfunc
98                                              Perifosine, the only available oral ALK, is being studie
99                Addition of subtoxic doses of perifosine to cetuximab treatment also enhanced the cetu
100 provide the rationale for clinical trials of perifosine to improve patient outcome in MM.
101 horylation of SAPK/JNK that was activated by perifosine treatment alone.
102  changes in the proteome and acetylome after perifosine treatment in SK-N-AS neuroblastoma cells usin
103                                              Perifosine triggers c-Jun N-terminal kinase (JNK) activa
104  of cdk complexes in vitro demonstrated that perifosine, up to 20 microM, did not directly interfere
105  effect, rather than feedback activation, of perifosine upstream ERK pathway.
106         Inhibition of Akt phosphorylation by perifosine was seen in these cells.
107 tors (HDACIs) and the alkyl-lysophospholipid perifosine were examined in human leukemia cells.
108  was potently inhibited by the Akt inhibitor perifosine, whereas SW1736, Hth74, WRO, KAT18, and TAD2
109                           The combination of perifosine with a lysosomal inhibitor enhanced apoptosis
110 itive to the antiproliferative properties of perifosine with an IC(50) of similar0.6-8.9 microM.

 
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