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1 and TTC-SOD-1 were distributed in a punctate perineuronal and intraneuronal pattern similar to that s
3 the cortex, a subset of microglia (sometimes perineuronal) consists of cells that are probably phagoc
4 ast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral c
6 These included increases in the number and perineuronal location of CX3CR1-expressing microglia, de
9 etzincin proteases involved in reshaping the perineuronal net (PNN) and Mme encoding for Neprilysin,
11 zation leads to dynamic turnover of selected perineuronal net (PNN) components well beyond the normal
12 te proteoglycans (CSPGs) associated with the perineuronal net (PNN) is upregulated around the phrenic
13 In rodents, degradation of the hippocampal perineuronal net (PNN) replicates this overactivity, but
14 d closure is marked by the condensation of a perineuronal net (PNN) tightly enwrapping subsets of PV+
15 g, are stored as the pattern of holes in the perineuronal net (PNN), a specialized ECM that envelops
16 ycosaminoglycans, dense core granules (DCG), perineuronal net (PNN), mucin, central nervous system (C
17 wave induced cavitation collapse within the perineuronal net (PNN), which is the near-neuron domain
18 llular matrix genes associated with synaptic perineuronal net and alterations in spontaneous electrop
21 teoglycans (CSPGs) within the glial scar and perineuronal net creates a barrier to axonal regrowth an
22 sion exhibited by the Cat-315 CSPG and other perineuronal net CSPGs imparts a distinct molecular surf
23 ct a balance between the oxidative burden on perineuronal net degradation and the capacity of the sys
26 entially programs synaptic plasticity and PV/perineuronal net development in the left and right BLA.
27 dysregulation was recapitulated by enzymatic perineuronal net digestion in the TRN of normal rats.
31 ier formation, perinodal ECM deposition, and perineuronal net formation, all of which depend on the E
37 r local remodeling.SIGNIFICANCE STATEMENTThe perineuronal net is an extracellular matrix, which accum
39 enriched brevican (Bcan), a component of the perineuronal net matrix that ensheaths principal neurons
43 ory neurons and concomitantly attenuates the perineuronal net to potentially reduce inhibitory input
46 on of monocytic influx significantly reduced perineuronal net-enwrapped parvalbumin neurons and autis
50 ons have also been shown to be ensheathed by perineuronal nets (PNN), extracellular matrix envelopes
51 d with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack th
52 etwork of macromolecules which has two forms-perineuronal nets (PNNs) and a diffuse ECM (dECM)-both i
53 as well as specific ECM structures, such as perineuronal nets (PNNs) and interstitial matrix, are di
54 ry was performed in rat's brains to evaluate perineuronal nets (PNNs) and parvalbumin GABA interneuro
73 radation of protective ECM structures called perineuronal nets (PNNs) around fast-spiking inhibitory
75 can be divided into aggregated ECM, such as perineuronal nets (PNNs) around neurons, and diffuse ECM
76 he adult visual cortex through disruption of perineuronal nets (PNNs) by chondroitinase treatment, or
77 he adult visual cortex through disruption of perineuronal nets (PNNs) by chondroitinase treatment, or
80 EMENT: Emerging evidence suggests a role for perineuronal nets (PNNs) in learning and regulation of p
82 as associated with a progressive build-up of perineuronal nets (PNNs) in the contralateral somatosens
83 mmatory pain in mice enhances the density of perineuronal nets (PNNs) in the somatosensory cortex and
86 -rich extracellular matrix structures called perineuronal nets (PNNs) restrict plasticity and regener
87 pearance of honeycomb-like structures called perineuronal nets (PNNs) that surround a subset of neuro
89 ce forming a macromolecular structure called perineuronal nets (PNNs) which regulate neuroplasticity.
92 ensed extracellular matrix structures called perineuronal nets (PNNs), and it has been suggested that
94 ippocampus, some of which are enwrapped with perineuronal nets (PNNs), extracellular matrix structure
95 the central nervous system, ACAN is found in perineuronal nets (PNNs), honeycomb-like structures that
96 lia degrade extracellular matrix structures, perineuronal nets (PNNs), in lamina I of the spinal cord
97 uronal and glial elements, we found atypical perineuronal nets (PNNs), specialized ECM structures tha
98 ed structures of extracellular matrix called perineuronal nets (PNNs), which are integral to the main
99 component in extracellular structures called perineuronal nets (PNNs), which surround parvalbumin-exp
107 ning for two types of extracellular markers--perineuronal nets (PNs) and perisomatic rings of termina
109 nspicuous manifestation in the brain are the perineuronal nets (PNs) which surround somata and proxim
110 iated Wisteria floribunda agglutinin-labeled perineuronal nets (WFA/PNNs) are altered in SZ and BD, a
112 ectin histochemistry resulted in labeling of perineuronal nets and cells with clear glial morphology,
113 t rather may be extrasynaptically located in perineuronal nets and concerned with the modulation of n
115 jor component of the extracellular matrix of perineuronal nets and is highly enriched in the perisyna
116 escribe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement
118 ur knowledge of the presence of lecticans in perineuronal nets and their importance in regulating syn
119 lel, parvalbumin cells enwrapped with mature perineuronal nets are better protected than immature par
124 e relationship between the robustness of the perineuronal nets around parvalbumin cells and the degre
125 in the extracellular space or aggregated as perineuronal nets around specific classes of neurons.
126 lular matrices form around mature neurons as perineuronal nets containing chondroitin sulfate proteog
128 found that staining for GABAergic cells and perineuronal nets differentiates these intercollicular n
129 hich is up-regulated in the visual cortex as perineuronal nets form during development and after dark
131 prevented this but also strikingly increased perineuronal nets in the brains of naive littermates, su
132 acterization revealed enhanced deposition of perineuronal nets in the dentate gyrus of the hippocampu
133 lular staining of brevican resembled that in perineuronal nets in which tenascin-R has been localized
135 on of chondroitin sulphate proteoglycan into perineuronal nets is therefore the key event in the cont
137 s of similar sizes, each antibody recognizes perineuronal nets on distinct but overlapping sets of ne
139 me of these "brakes" are structural, such as perineuronal nets or myelin, which inhibit neurite outgr
142 of the neural cell adhesion molecule and in perineuronal nets surrounding parvalbumin expressing int
143 creased ECM coverage, specifically targeting perineuronal nets surrounding parvalbumin interneurons,
144 A concurrent loss of proteoglycan-containing perineuronal nets was also evident in R6/2 mice, and mic
147 mesh-like extracellular structures known as perineuronal nets whose maturation is associated with th
148 xtracellular matrix pericellular aggregates (perineuronal nets) in the amygdala and entorhinal cortex
149 ity and proportion of PV cells surrounded by perineuronal nets, a marker of mature PV cells, in adult
151 nthetic enzymes, vesicular GABA transporter, perineuronal nets, and enhanced GABA transmission among
155 n and wisteria floribunda agglutinin-labeled perineuronal nets, correlating with increased markers of
157 by increase in ECM molecules associated with perineuronal nets, increased sprouting of serotonergic f
160 these extracellular matrix glycoproteins are perineuronal nets, specialized lattice-like structures t
161 ical variation in basolateral amygdala (BLA) perineuronal nets, which are developmentally implicated
162 imbalance, we demonstrate that extracellular perineuronal nets, which constitute a specialized polyan
164 ess was accompanied by a significant loss of perineuronal nets, which normally enwrap mature fast-spi
165 cid (GABA) interneurons and volumes of their perineuronal nets, white matter abnormalities, and micro
182 -induced protein 6 (TSG6), remodeling of the perineuronal network, and a beta1-integrin/ERK pathway.
183 anglia of transgenic mice; these fibers form perineuronal plexi around a subpopulation of sensory som
188 c), atypical PrPres did not show significant perineuronal, vascular, or perivascular immunoreactivity