ライフサイエンスコーパス: perinuclear

1 iquitination site, FOXP3 displayed aberrant, perinuclear accumulation and disrupted regulatory functi

2 EXPH5-mutant KCs also showed increased perinuclear accumulation and significantly reduced traff

3 However, both the perinuclear accumulation and the activation of GEF-H1 we

4 ence was greatly attenuated with evidence of perinuclear accumulation in astrocytes.

5 namics by enhancing fusion and induced their perinuclear accumulation in HEK293 cells and rat primary

6 ZCL278 reduces the perinuclear accumulation of active Cdc42 in contrast to

7 ximately 0.5%) led to impaired mitophagy and perinuclear accumulation of damaged mitochondria associa

8 n of tubular membrane carriers from the TGN, perinuclear accumulation of early endosomes and impaired

9 utants, we define the mechanisms involved in perinuclear accumulation of PKCalpha and identify the no

10 These animals developed perinuclear accumulation of ubiquitin and the E3 ubiquit

11 Abnormal perinuclear accumulation of vimentin filaments, which so

12 tion both in vitro and in vivo and maintains perinuclear accumulations of capsids, facilitating produ

13 tic diseases), was found to be important for perinuclear actin assembly.

14 ar envelope did not abolish Ca(2+)-dependent perinuclear actin assembly.

15 N) lines, which couple the nucleus to dorsal perinuclear actin cables undergoing retrograde flow.

16 ispensable for the retrograde flow of dorsal perinuclear actin cables, supporting the recently propos

17 We show that the presence of the perinuclear actin cap (apical stress fibers), such as th

18 ll subset of actin fibers, those forming the perinuclear actin cap that wraps around the nucleus, for

19 pond rapidly to external force by remodeling perinuclear actin in a unique Ca(2+)- and INF2-dependent

20 Our data suggest that a perinuclear actin meshwork connects actin cables to nucl

21 phore A23187 recapitulated the force-induced perinuclear actin remodeling.

22 The perinuclear actin rim structure colocalized with INF2 on

23 ate a critical role for FMN2 in generating a perinuclear actin/FA system that protects the nucleus an

24 cleator FMN2 associates with and generates a perinuclear actin/focal adhesion (FA) system that is dis

25 ptin 7 knockdown lead to a disruption of the perinuclear actomyosin and persistent directional migrat

26 er investigate the effect of LINC-associated perinuclear actomyosin complex on mechanoresponsive gene

27 I and PP2A A subunit, which was observed as perinuclear aggregates in the somata of the frontal cort

28 ic misfolded protein species that present as perinuclear aggregates known as aggresomes.

29 ear export, promoting the formation of large perinuclear aggregates of RNPs along with cellular Rab11

30 The presence of large perinuclear aggregates profoundly affects the behavior a

31 We present evidence that, as perinuclear aggresomes accumulate, they are associated w

32 enter and thereby initiated the formation of perinuclear aggresomes.

33 utation of met-2 or lin-65 also disrupts the perinuclear anchoring of genomic heterochromatin.

34 Sti1-inducible foci are perinuclear and contain proteins that are bound by the a

35 P1 together with polyglutamine is shifted to perinuclear and cytoplasmic areas.

36 es increased mitochondrial oxidant stress in perinuclear and dendritic compartments.

37 d productive uptake, distribution of ASO was perinuclear and in those with poor productive uptake dis

38 nnected network throughout the parasite with perinuclear and peripheral localizations.

39 dation intermediates being concentrated into perinuclear and peripheral puncta.

40 RC3 prevented proper trafficking of STING to perinuclear and punctated region, known to be important

41 nized smooth ER with pronounced expansion at perinuclear- and peripheral positions.

42 ir1, anti-flagellin 2, anti-flagellin X, and perinuclear anti-neutrophil cytoplasmic antibodies) and

43 nuclear lamin A/C-mediated formation of the perinuclear apical actin cables protects the nuclear str

44 the dynamic formation of a highly organized perinuclear apicosome structure.

45 arned that Vasa interacted with mRNAs in the perinuclear area and at the spindle in an Importin-depen

46 mostly cytoplasmic protein localizing in the perinuclear area and forms highly stable dimers/oligomer

47 opy of YC-36 showed drug distribution in the perinuclear area and plasma membrane.

48 ndent localization of NMIIA and NMIIB at the perinuclear area and tip of the filopodia and affect cel

49 Strategically located NMIIs at the perinuclear area colocalize with the linker of nucleoske

50 translocation of ASC from the nucleus to the perinuclear area during inflammasome activation.

51 remains under the control of IKKalpha in the perinuclear area following translocation of the ASC/IKKa

52 icroscopy, but their location in the crowded perinuclear area has hampered their analysis via optical

53 ant accumulation of these TG6 mutants in the perinuclear area led to activation of the unfolded prote

54 nsport of PIP2 rich organelles from the cell perinuclear area to the edge, along actin fibers.

55 ear depletion, increased accumulation in the perinuclear area, insolubility and loss of enzymatic fun

56 protein mainly localized to the nucleus and perinuclear area, whereas five TG6 mutations showed nucl

57 ork in Miro1(-/-) MEFs was restricted to the perinuclear area, with few mitochondria present at the c

58 ally, the ratio of ATP to ADP was highest at perinuclear areas of dense mitochondria and gradually de

59 is suppressed by vesicular recycling through perinuclear areas with high PTP1B activity.

60 constraints imposed by chromosome length and perinuclear attachment determine the amount of SCI that

61 n C. elegans is regulated both by the direct perinuclear attachment of silent chromatin, and by an ac

62 es linked to lamin A mutations suggests that perinuclear binding of chromatin contributes to cell-typ

63 aused relocalization of these two enzymes to perinuclear bodies (A3B) and to oblong cytoplasmic struc

64 amatic relocalization of nuclear APOBEC3B to perinuclear bodies.

65 Rab8A colocalizes with GLUT4 in perinuclear but not submembrane regions visualized by co

66 er sustained oscillations of the nuclear and perinuclear Ca(2+) concentration (Ca(2+) spiking), which

67 -microbe symbioses by generating nuclear and perinuclear Ca(2+) spiking.

68 We conclude that in early TAC perinuclear CaMKIIdeltaC activation promotes adaptive in

69 is study, we provide evidence for a neuronal perinuclear cAMP compartment organized by the scaffold p

70 tent with this, microtubules extend from the perinuclear centrosome to the plasma membrane and allow

71 ls nucleate or form new microtubules off the perinuclear centrosome.

72 A perinuclear clear halo was visible within the epithelial

73 nd relocalizes the transcription factor to a perinuclear cluster of mitochondria.

74 ingly, knocking down SNCA reversed lysosomal perinuclear clustering caused by CLN5 deficiency.

75 lysosome-positioning machinery, we show that perinuclear clustering of lysosomes delays reactivation

76 d microtubule/dynein-dependent mitochondrial perinuclear clustering, and translocation towards the mi

77 ylation with mitochondrial fragmentation and perinuclear clustering, considered a protective posture

78 unofluorescence images indicated a potential perinuclear co-localization between IGFBP-1 and CSNK-2be

79 in the case of overexpressed Cav1-GFP, this perinuclear compartment consists of cytoplasmic inclusio

80 trafficking, including its accumulation in a perinuclear compartment previously identified as the Gol

81 ains, and correlated with movement between a perinuclear compartment, adhesions, and the plasma membr

82 anslocates from the endoplasmic reticulum to perinuclear compartments.

83 vitro but was necessary for the genesis of a perinuclear-concentrated network of keratin filaments, n

84 P granules are perinuclear condensates in C. elegans germ cells propose

85 Thus, our data suggests a role for multiple perinuclear condensates in organizing the piRNA pathway

86 mal cadherin-catenin complex assembly in the perinuclear cytoplasm and subsequent localization to the

87 C2 in sciatic nerves and lumbar roots in the perinuclear cytoplasm of a subset of Schwann cells, in a

88 . gingivalis-NDK transfected GECs revealed a perinuclear/cytoplasmic localization of NDK.

89 discriminant of mechanical properties in the perinuclear cytoskeleton (pnCSK) of various stem cell ty

90 -MyoVa-CT collapses the GTPase into enlarged perinuclear depots.

91 The tgDISC1 rat displayed mainly perinuclear DISC1 aggregates in neurons.

92 ular localization of altered ELOVL5 showed a perinuclear distribution with a signal increase in the G

93 We determined the crystal structure of the perinuclear domain of human LAP1.

94 localized AAA+ ATPases, through a conserved, perinuclear domain.

95 In addition, strongly positive perinuclear dots were observed in 30 of 36 specimens (83

96 tion sequence blocks its capacity to restore perinuclear dynein in both cultured human cells lacking

97 his paper, we reveal the passage of LDs from perinuclear endoplasmic reticulum association to entry i

98 Rather, our data suggest that the perinuclear endoplasmic reticulum, accumulated through d

99 islocalization of R-opsin and S-opsin to the perinuclear endoplasmic reticulum.

100 endosomes (PEs), c-Met needs to traffic to a perinuclear endosome (PNE) to sustain Rac1 signalling, t

101 l symmetry between the cortical ER (cER) and perinuclear ER (pnER).

102 lear size scaling by the amount of inherited perinuclear ER and duration of interphase.

103 skeletal muscle cells, one localized at the perinuclear ER and the other at the junctional SR.

104 ression in HEK293T cells localizes it to the perinuclear ER region and it trans-rescues the ankB muta

105 sociated with lipid droplet formation in the perinuclear ER, is responsible for the initial rapid exi

106 Although RILP localizes in a perinuclear fashion, cRILP moves to the cell periphery.

107 membranes and is internalized to hydrophobic perinuclear features, the nuclear membrane and inside th

108 2 is nuclear throughout development, forming perinuclear foci in a cell cycle-dependent manner.

109 n germline P granules and in cytoplasmic and perinuclear foci in somatic cells.

110 perinuclear myofibril loss), accumulation of perinuclear glycogen, interstitial fibrosis, and myocard

111 cation of Gbetagamma to the Golgi stimulated perinuclear Golgi PI4P depletion and nuclear PKD activat

112 a indicate that Gbetagamma regulation of the perinuclear Golgi PI4P pathway and a separate pathway at

113 hosphate (PI4P) and binds GABARAPs, from the perinuclear Golgi region to autophagosomes to generate P

114 , these cisternae are stitched together as a perinuclear Golgi ribbon, which is required for the esta

115 enin trafficking, leading to accumulation at perinuclear Golgi structures.

116 l vanilloid 4 (TRPV4), significantly reduced perinuclear (Golgi) VEGFR2 in human ECs with a concomita

117 wn facilitates the spatial relocalization of perinuclear H3K9me3-positive heterochromatin, thus promo

118 and transcriptional upregulation through the perinuclear hydrolysis of phosphatidylinositol 4,5-bipho

119 hosphorylated MG cells, with a predominantly perinuclear immunostaining pattern.

120 ia and/or macrophages by their ingestion and perinuclear import of myelin transcripts, confirmed by f

121 frequently concentrated to the aggresome, a perinuclear inclusion body, and subsequently removed by

122 As expected for an assembly defective NiV, perinuclear inclusions (IBperi) were formed, but inclusi

123 The progression of perinuclear inclusions being accompanied by cell-cycle a

124 Electron microscopy reveals that perinuclear inclusions disrupt the nuclear envelope.

125 , medium spiny neurons (MSNs) that exhibited perinuclear inclusions expressed cell-cycle markers typi

126 The perinuclear insulin-like growth factor 1 receptor pool c

127 ormation (PGL-1 and PGL-3) and promote their perinuclear localization (GLH-1 and GLH-4) [9] and inves

128 basal levels, Arl8b was primarily found in a perinuclear localization and co-localized with LC3-posit

129 cells, concomitant with a disruption in the perinuclear localization of LMP1.

130 w that starvation conditions cause increased perinuclear localization of mitochondria and decreased c

131 Furthermore, in primary mouse neurons, the perinuclear localization of mitochondria that follows in

132 Csm4 interacts with Mps2 and is required for perinuclear localization of Myo2, implicating Csm4 as a

133 To investigate the role of nesprin-3 in the perinuclear localization of plectin, we generated nespri

134 We associated perinuclear localization of the activated NOTCH4 intrace

135 ZDHHCs 3, 7, and 15, which showed a defined perinuclear localization pattern, suggesting that the lo

136 ocalization of XIST, depletion of Cot-1 RNA, perinuclear localization, and ubiquitination of H2A occu

137 assive accumulation in the lumen of enlarged perinuclear, lysosomal-associated membrane protein 1 (LA

138 ized with upregulated Rab7 in LampI-positive perinuclear lysosome compartments.

139 shown earlier to displace phagosomes toward perinuclear lysosomes.

140 riminate between stem cell types by coupling perinuclear mechanical properties to nuclear shape.

141 bilizes association of this complex with the perinuclear membrane.

142 receptors, translocating the complex to the perinuclear membrane.

143 sted of expanded endoplasmic reticulum (ER), perinuclear mitochondria, and a higher abundance of stre

144 FYN and NOX4 colocalized in perinuclear mitochondria, ER, and nuclear fractions in C

145 TCO1), complex I activity, and the number of perinuclear mitochondria.

146 ed by pathological erythroid precursors with perinuclear mitochondrial iron deposition in bone marrow

147 propose the hypothesis that ICP34.5 promotes perinuclear mitochondrial localization by modulating tra

148 lcium entry through L-type channels elevates perinuclear mitochondrial oxidant stress in SNc dopamine

149 nogen activator system (uPAS) to relocate to perinuclear mitochondrial regions.

150 orms ectopic MT organizing centers, disrupts perinuclear MT arrays, reduces muscle stiffness, and dec

151 Here we report a perinuclear MTOC in Drosophila fat body cells that is an

152 ites on the cell surface with respect to the perinuclear MTOC.

153 g, EGFR accumulates in a subset of LBPA-rich perinuclear multivesicular bodies (MVBs) distinct from t

154 oplasmic P granules at the nuclear pores and perinuclear Mutator foci contribute to target mRNA surve

155 logy, cardiomyocyte diameters, myocytolysis (perinuclear myofibril loss), accumulation of perinuclear

156 Together, this study identifies a perinuclear ncMTOC with unique architecture that regulat

157 4 is necessary for the formation of a stable perinuclear network of keratin filaments (with type II p

158 MSP300 (nesprin) and rigidity provided by a perinuclear network of microtubules stabilized by Shot (

159 horing device organizing and stabilizing the perinuclear network of vimentin filaments.

160 We now reveal that cAMP signaling within a perinuclear neuronal compartment organized by the large

161 Virus-induced Asyn localized to perinuclear, neuronal regions expressing viral envelope

162 Our previous work recognized perinuclear Nox-4 as a key contributor to EOMA growth.

163 gulated, resulting in an increased number of perinuclear nuage-like granules where Piwi proteins loca

164 ne (Aub) and Argonaute-3 (Ago3), localize to perinuclear "nuage" granules and use guide piRNAs to tar

165 The fraction of cells with diffuse, perinuclear or intranuclear mHTT changed in parallel wit

166 We did not observe the perinuclear or perinucleolar replicative labeling patter

167 and (v) localization of aggregates (cytosol, perinuclear, or nuclear).

168 olution of our approach are 1) conversion of perinuclear organelle clustering into a two-dimensional

169 ockdown using RNA interference disturbed the perinuclear organization of vimentin.

170 ts with the NF-kappaB ortholog Relish inside perinuclear particles and delivers active Relish to PARP

171 n pattern: Although beta-catenin exhibited a perinuclear pattern in undifferentiated wild-type cells,

172 regulatory protein 1 (CARP-1 or CCAR1) is a perinuclear phosphoprotein that regulates signaling indu

173 ted from cell surface GPCRs to activation of perinuclear PLCepsilon is not clear.

174 We conclude that perinuclear PLCepsilon, scaffolded to mAKAP in cardiac m

175 fter activation and endosomal transport to a perinuclear position.

176 investigates the biological significance of perinuclear positioning for heterochromatin maintenance

177 to uncovering conserved factors required for perinuclear positioning of heterochromatin, these analys

178 hery; (2) PM invagination and formation of a perinuclear pre-DMS; (3) expansion through membrane deli

179 om the normal dispersed pattern to a stacked perinuclear presence.

180 n homogenate, resulting in a coarse granular perinuclear PrP(TSE) staining pattern.

181 n, complex I specifically was sequestered in perinuclear PTEN-induced putative kinase 1 (PINK1) and P

182 the p65 subunit of NF-kappaB is rerouted to perinuclear puncta in the cytoplasm, which are synonymou

183 oMA relocalizes Ser5 from plasma membrane to perinuclear punctated compartments and the important rol

184 ly intersects the TfR and pIgR pathways at a perinuclear Rab11-negative compartment termed common rec

185 K-2beta interactions were also predominantly perinuclear rather than nuclear as indicated by mTOR and

186 ulin-stimulated mobilization of GLUT4 from a perinuclear recycling endosome/TGN compartment.

187 ral genome replication and recapitulated the perinuclear redistribution of NS5A seen in the S225A mut

188 and amiodarone-treated cells showed that the perinuclear region (i.e., cytoplasm) of amiodarone-treat

189 tion to the nuclear envelope, there exists a perinuclear region (PNR or perinucleus) with unknown com

190 ciency results in lysosome clustering in the perinuclear region and a decrease in lysosome exocytosis

191 Absence of sarcomeres in the perinuclear region and abnormal invaginations of nuclei

192 l-length virus, viral genomes clustered in a perinuclear region and associated with cellular traffick

193 y, pDox nanoparticles are transported to the perinuclear region and cleaved into Dox, thereby avoidin

194 MCECs), Borg5 associates with septins in the perinuclear region and colocalizes with actomyosin fiber

195 Osm extended CLN3 distribution away from the perinuclear region and enhanced the lysosomal localizati

196 ), leads to the collapse of lysosomes to the perinuclear region and inhibition of PMR.

197 BP-1 and CSNK-2beta interactions were in the perinuclear region and mTOR and CSNK-2beta interactions

198 d, the Rap1-GTPases confine lysosomes to the perinuclear region and reduce lysosome abundance, which

199 1 is localized in the nucleus, cytoplasm, or perinuclear region but is transiently redistributed to c

200 t KCNQ1 and KCNE1 are both translated in the perinuclear region but traffic by different routes, inde

201 ile population of endosomes moved toward the perinuclear region in directed bursts of microtubule-bas

202 lues within the nucleus in LoVo-R and in the perinuclear region in LoVo-S cells.

203 Herein, the concept of the perinuclear region is advanced as a formal, identifiable

204 that the majority of rAAV accumulates in the perinuclear region of cells, presumably unable to traffi

205 sn) does not inhibit ExoS trafficking to the perinuclear region of intoxicated cells.

206 based GSTs) are also over-represented in the perinuclear region of mammalian cells, possibly for nucl

207 aled redistribution of activated Pyk2 to the perinuclear region of stressed pyramidal neurons.

208 lted in dispersal of AP-4 and ATG9A from the perinuclear region of the cell, consistent with the prev

209 served rapid transport of peroxisomes to the perinuclear region of the cell.

210 ocalization from the posterior region to the perinuclear region of the cytoplasm, as is typically obs

211 1 hour by HepG2 cells and accumulated in the perinuclear region of the hepatocyte.

212 transcription is completed in the nucleus or perinuclear region of the infected cell, where it is dep

213 he cytoplasm and completed in the nucleus or perinuclear region of the infected cell.

214 ke all known MSUD proteins, localizes in the perinuclear region of the meiotic cell.

215 This interaction was colocalized in the perinuclear region that could be dissociated by CDDP in

216 the primary location of genomic RNA from the perinuclear region to the plasma membrane without improv

217 d induce transient actin accumulation in the perinuclear region within approximately 2 min.

218 eticulum to the Golgi compartment and to the perinuclear region, acting as an indispensable adaptor c

219 lysosomes appeared to be concentrated in the perinuclear region, and autophagy flux was impaired.

220 nal motion in the cortex with respect to the perinuclear region, and suggests that the tracking routi

221 cular and tubular membranes localized to the perinuclear region, collectively known as the endocytic

222 larged vesicles and respective cargos in the perinuclear region, considerably impairing the extent an

223 tion of vinculin from focal adhesions to the perinuclear region, formation of cortical actin-rich lar

224 creased organelle proximity primarily in the perinuclear region, rapamycin increased organelle contac

225 ed stimulation of ARP2/3 concentrated in the perinuclear region, resulting in defective cell adhesion

226 Additionally, they all localize in the perinuclear region, suggesting that it is a center of MS

227 -dependent movement of effector kinases to a perinuclear region, thereby creating connections to uniq

228 aberrant increase in ribosome-free ER in the perinuclear region, without inducing ER stress response.

229 with an apparent higher concentration in the perinuclear region.

230 alpha2B-AR and arrested the receptor in the perinuclear region.

231 redistribute from the cell periphery to the perinuclear region.

232 e), the mutation in NS5A was restricted to a perinuclear region.

233 calized in the cytoplasm and the cytoplasmic perinuclear region.

234 d GEF-H1 and microtubule accumulation in the perinuclear region.

235 ption occurred both within nuclei and in the perinuclear region.

236 were mislocalized to the inner segments and perinuclear region.

237 st their distribution between peripheral and perinuclear regions and modulate lysosome-nucleus signal

238 ivity by immunohistochemistry accumulated in perinuclear regions and rimmed vacuoles in IBM muscle, l

239 R nanospectra generated from the nuclear and perinuclear regions of untreated and amiodarone-treated

240 LK, immature melanosomes are not retained in perinuclear regions, and mature melanosome trafficking a

241 Ubiquitinated pAKT translocates to perinuclear regions, where it is released into the cytop

242 , we show that oncogenic RAS and BRAF induce perinuclear relocalization of several RAS pathway protei

243 in a 10-fold reduction in replication and a perinuclear restricted distribution of NS5A, whereas the

244 ks fuse laterally to form the characteristic perinuclear ribbon structure.

245 The assembly of this perinuclear ring is dependent upon a second actin isofor

246 ol myristate acetate and ionophore A23187, a perinuclear ring pattern was observed for 5LO.

247 Actin perinuclear shells form each cell cycle and polygonal te

248 Together, they form a flexible perinuclear shield that protects myonuclei from intrinsi

249 Notably, these perinuclear signaling complexes (PSC) are present in tum

250 silicacomes from the blood vessel lumen to a perinuclear site within cancer cells.

251 GFP)-MyoVa colocalizes with mCherry-Rab8A in perinuclear small puncta, whereas GFP-MyoVa-CT collapses

252 of GABA-A receptors were distributed in the perinuclear space and along the processes of GFAP(+) cel

253 torsinA, an AAA+ ATPase that resides in the perinuclear space and continuous main ER.

254 n at early stages, and focal swelling of the perinuclear space at late stages.

255 the C terminus of ORF67 that resides in the perinuclear space does not impair the functions of ORF67

256 he retention of progeny nucleocapsids in the perinuclear space during egress.

257 yntaxins localize to the plasma membrane and perinuclear space in both tobacco epidermal and soybean

258 imary enveloped particles accumulated in the perinuclear space in the presence of brefeldin A, while

259 Distortions of the perinuclear space observed in unc-84 mutant muscle nucle

260 and MKL2, respectively) are enriched in the perinuclear space of epicardial cells during development

261 ysis revealed vesicle-like structures in the perinuclear space of intestinal and germ cell nuclei, si

262 hat progeny nucleocapsids were retained in a perinuclear space surrounded by inner and outer nuclear

263 i were morphologically abnormal with a wider perinuclear space than normal myonuclei.

264 Capsids were observed in the nucleus, in the perinuclear space, and in the cytoplasm adjacent to Golg

265 imod causes accumulation of TLR4 and TLR9 in perinuclear space, consistent with endoplasmic reticulum

266 e nucleus can be modulated by Torsins in the perinuclear space, shedding new light on the LAP1-Torsin

267 ormation, nuclear export by budding into the perinuclear space, tegument formation, and envelopment t

268 rved N-terminal domain that extends into the perinuclear space.

269 2A (PP2A) to the sarcoplasmic reticulum and perinuclear space.

270 ced by cell death with numerous vacuoles and perinuclear spaces, and depleted intracellular membranes

271 Skeletal muscle GLUT4 was trapped at perinuclear spaces, most pronounced in patients with CIM

272 this method differentiates between singular perinuclear specks and false positives.

273 The wild-type LHbeta subunit exhibited a perinuclear staining corresponding to the ER/nuclear env

274 mal tissues and particularly strong dot-like perinuclear staining in the lining epithelial cells, sug

275 ltaT and LHbetaL119A displayed no detectable perinuclear staining; only peripheral ER puncta were obs

276 to show that VIFs regulate nuclear shape and perinuclear stiffness, cell motility in 3D, and the abil

277 se recruitment domain (ASC) micrometer-sized perinuclear structures (specks).

278 ositol 4-phosphate (PI4P) is identified as a perinuclear substrate in the Golgi apparatus for mAKAP-s

279 ng oocyte activation and being stored in the perinuclear theca, the sperm compartment whose content i

280 enome associates with dynein and induces its perinuclear trafficking has remained unclear.

281 d and punctate trafficking distinct from the perinuclear, trans-Golgi pattern observed in normal cell

282 c recycling compartment (ERC) is a series of perinuclear tubular and vesicular membranes that regulat

283 overexpression causes localization of APP in perinuclear tubular structures, an increase of lipid raf

284 mentous forms in the cytoplasm to aggregated perinuclear tubules that form a cage-like structure arou

285 tructures revealed aberrant formation of the perinuclear tubules.

286 ive fusion and membrane biogenesis to form a perinuclear tubuloreticular structure enabling mixing of

287 of mTOR from lysosomes and increases mTOR's perinuclear versus cytoplasmic localization, changes pre

288 C activation and accumulation in nuclear and perinuclear versus cytosolic regions at 5 days post-TAC.

289 s no consensus regarding the exact effect of perinuclear versus peripheral distribution.

290 ed in the cytoplasm with genomic RNA also in perinuclear vesicle-like structures near envelope glycop

291 These perinuclear vesicles displayed positivity for histone in

292 induces LC3B lipidation onto single-membrane perinuclear vesicles mediated by ATG16L1 via its WD40 do

293 lin-associated glycoprotein (MAG) in LAMP1(+)perinuclear vesicles that fail to migrate to the nascent

294 absence of the vitamin, TTP is localized to perinuclear vesicles that harbor CD71, transferrin, and

295 e in the densely packed nucleocapsids inside perinuclear viral inclusions and in the dispersed rod-li

296 port of ebolavirus (EBOV) nucleocapsids from perinuclear viral inclusions, where they are formed, to

297 ds bud at the inner nuclear membrane forming perinuclear viral particles that subsequently fuse with

298 ds bud at the inner nuclear membrane to form perinuclear virions that subsequently fuse with the oute

299 This redistribution from cytosolic to perinuclear was clearly compromised in both CLP- and FLA

300 a homolog of the human pathogen KSHV, led to perinuclear wrapping by acetylated MT bundles and identi