ライフサイエンスコーパス: periostin

1 myofibroblast-specific ECM genes like Postn (periostin).

2 anced fibrosis (collagen, laminin, vimentin, periostin).

3 the actin cytoskeleton and is stimulated by periostin.

4 apped within Fasciclin (Fas) I domain 1-4 of Periostin.

5 as extracted tumor samples were stained for periostin.

6 and suppression of PPARalpha in response to periostin.

7 or (VEGF), type I collagen, fibronectin, and periostin.

8 oduction of type I collagen, HSP-47, FN, and periostin.

9 sue repair, such as type I collagen, FN, and periostin.

10 y density was increased in animals receiving periostin.

11 proteins, such as the matricellular protein periostin.

12 eased osteoblast apoptosis in the absence of periostin.

13 r matrix proteins: collagen I, tenascin, and periostin.

14 cing fibrotic molecules such as collagen and periostin.

15 aglandin-endoperoxide synthase 1, CCL26, and periostin.

16 migration of IL-5-stimulated eosinophils on periostin.

17 mulated eosinophils on a surface coated with periostin.

18 tor-beta-induced expression of CCN2/CTGF and periostin.

19 ed with PDGF receptor beta, procollagen, and periostin.

20 versus 9% (95% CI, -24 to 34; P = 0.54); and periostin, 30% (95% CI, -2 to 51; P = 0.07) versus 3% (9

21 Periostin, a matricellular adapter protein highly expres

22 Previously, we showed that periostin, a matricellular protein involved in tissue re

23 Periostin, a matricellular protein, has an important rol

24 De novo expression in the kidney of periostin, a protein involved in odontogenesis and osteo

25 Increased renal expression of periostin, a protein normally involved in embryonic and

26 Periostin, a secreted extracellular matrix protein, has

27 renal function and is a key intermediate for periostin activation of signaling pathways involved in c

28 Periostin also inhibited the expression of Gob5, a putat

29 Recombinant periostin also suppressed Sost expression, which was med

30 sults support a potential mechanism by which periostin alterations could act as a contributing factor

31 nhances eosinophil adhesion and migration on periostin, an extracellular matrix protein upregulated i

32 We investigated the role of periostin, an extracellular matrix protein, in the patho

33 Periostin, an extracellular matrix protein, plays key ro

34 hus, the combination of an autocrine loop of periostin and a paracrine loop composed of IL-1alpha and

35 -47 (HSP-47), fibronectin (FN), ED-A-FN, and periostin and activation of the Smad pathway were evalua

36 Conversely, both genetic ablation of periostin and administration of a periostin-neutralizing

37 There was no association between logarithm periostin and age or sex, although levels were low in cu

38 Periostin and betaIGH3 proteins were also detected and s

39 fluorescent-labeled antibody that recognizes periostin and binds specifically to ESCC xenograft tumor

40 Similarly, BALF concentrations of periostin and CCL26 were significantly increased in eosi

41 ro-fibrogenic factors, TGF-beta1, TGF-beta2, periostin and endothelin-1, by human airway epithelial c

42 rized a PET tracer that specifically targets periostin and evaluated the probe in preclinical models

43 In vitro kinase assay was performed using Periostin and FAM20C proteins to see whether FAM20C phos

44 bstance P(+) cells, and dermal deposition of periostin and hemosiderin.

45 PTH stimulated periostin and inhibited MEF2C and sclerostin (Sost) expr

46 Notably, periostin and integrin-beta3 were highly colocalized in

47 The distribution of periostin and logarithm-transformed periostin levels was

48 to mesenchymal transition, and more recently periostin and members of the lysyl oxidase family of enz

49 e results demonstrate that interplay between periostin and renal inflammation orchestrates inflammato

50 We demonstrate that STAT3/periostin and STAT6 signaling are critical mediators of

51 Periostin and TGF-beta inducible gene clone H3 (betaIGH3

52 rway smooth muscle (Asm) area with decreased periostin and transforming growth factor beta-positive c

53 Periostin and vascular cell adhesion protein 1 (VCAM-1),

54 hemical studies indicated that the source of periostin and VCAM-1 was the inflamed sheep liver tissue

55 d pancreatic stellate cells, lower levels of periostin, and alterations in collagen production and or

56 fractional exhaled nitric oxide, serum IgE, periostin, and blood and sputum eosinophils.

57 Expression of airway mucosal CCL26, periostin, and IL-13-IVS all facilitated segregation of

58 verity-related serum biomarkers (TARC, PARC, periostin, and IL-22), eotaxin-1, and eotaxin-3 signific

59 esophageal transcripts, including eotaxin-3, periostin, and markers of mast cells and barrier functio

60 thepsin-L1, vascular cell adhesion molecule, periostin, and neutrophil gelatinase-associated lipocali

61 ng growth factor (TGF)-beta1, lysyl oxidase, periostin, and osteopontin are elevated.

62 activator of unclear factor kappa-B ligand, periostin, and peroxidasin gene expressions in peri-impl

63 timulated with a combination of substance P, periostin, and red blood cell lysate (representing hemos

64 Furthermore, delayed administration of periostin antisense oligonucleotides in wild-type animal

65 For example, serum periostin appears to be a biomarker for responsiveness t

66 ntegrin and metalloprotease 33 (ADAM33), and periostin are hypothesized to be involved in subepitheli

67 to investigate the potential role of sputum periostin as a biomarker of severe asthma phenotypes.

68 These findings implicate periostin as a catabolic protein that promotes cartilage

69 Strategies to target the peptide portion of periostin as a diagnostic or therapeutic biomarker for c

70 RNA-Seq suggested periostin as a potential key factor for angiogenesis and

71 The clinical utility of serum periostin as a type 2 biomarker in asthma is limited by

72 long with the potential utility of DPP-4 and periostin as biomarkers of interleukin-13 pathway activa

73 We identified Periostin as one of FAM20C-binding proteins by MS analys

74 ion, peripheral blood eosinophils, and serum periostin as potential biomarkers of asthma in children.

75 tion to FE(NO), blood eosinophils, and serum periostin at baseline.

76 -ERD (for blood eosinophils, AUC = 0.72; for periostin, AUC = 0.75).

77 on (marked reduction in collagen 3), but not periostin, biglycan, or fibronectin accumulation, was im

78 tion, siRNA-mediated knockdown of endogenous periostin blocked constitutive MMP-13 expression.

79 h the integrin alphaVbeta3 receptor, whereas periostin-blocking antibody prevented inhibition of MEF2

80 ese are the blood eosinophil count and serum periostin, both of which have demonstrated utility in id

81 Gene expression levels of CLCA1 and periostin, but not SerpinB2, were significantly higher t

82 amin K-dependent, gamma-carboxylated form of periostin by macrophages and, to a lesser extent, MSCs o

83 The 3-gene signature of periostin, chloride channel accessory 1 (CLCA1), and Ser

84 ithelial cell signature of IL-13 activation (periostin, CLCA1, and SERPINB2), TH2 genes (IL4, IL5, an

85 ranscription factor 21 or TCF21) and mature (periostin, collagen type III) fibroblast gene signatures

86 differentially express TGF-beta2, VEGF, and periostin compared with cells from atopic nonasthmatic a

87 entially express TGF-beta2, VEGF, ADAM33, or periostin compared with cells from atopic nonasthmatic a

88 at differed in the number of eosinophils and periostin concentration in serum.

89 ma medications, geographic region, screening periostin concentration, and blood eosinophil counts as

90 domisation was stratified by screening serum periostin concentration, history of asthma exacerbations

91 FEV1, ACQ-6, and AQLQ(S), and, in those with periostin concentrations higher than the median, we note

92 cific glycosylation present on glycoforms of periostin containing bisecting N-glycans in ovarian canc

93 cularis were detected via increased fibrosal periostin content, which tracked the presence of the CD4

94 s of TGF-beta, suggesting that inhibition of periostin could represent a unique treatment approach.

95 The Periostin Cre (Postn-Cre) lineage includes endocardial a

96 , inflammation, and remodelling were made in periostin deficient mice and wild-type controls followin

97 chial hyperresponsiveness are exaggerated in periostin deficient mice challenged with inhaled aeroall

98 prisingly, compared with wild-type controls, periostin deficient mice developed increased AHR and ser

99 ssion of TGF-beta1 and Foxp3 in the lungs of periostin deficient mice.

100 Sensitization and challenge of periostin-deficient mice with OVA resulted in increased

101 Periostin-dependent activation of JNK resulted in activa

102 Together, these results identify a periostin-dependent pathway that mediates obesity-induce

103 Periostin detection levels were reduced over time in res

104 Periostin did not identify blood or sputum eosinophilia,

105 r treating such macrophages with recombinant periostin, directly induced macrophage proliferation and

106 Mice lacking expression of periostin displayed preserved renal function and structu

107 encodes for the extracellular matrix protein periostin dramatically reduced with age.

108 sis and the deposition of the matrix protein periostin during the late stages of tendon repair, sugge

109 epithelial cells showed strong production of periostin during the repair phase of ischemia reperfusio

110 of cancer cells; conversely, the addition of periostin enhanced cancer cell proliferation in vitro.

111 with extracellular regeneration factors like periostin enhances cardiac repair in rodents.

112 odosomes along with clearance of the Stiny-1 periostin epitope.

113 Migrating IL-5-activated eosinophils on periostin exhibit loss of nucleopodal features and appea

114 peripheral blood eosinophils, serum IgE, or periostin exhibited a greater reduction in LAR compared

115 Our results define the myofibroblast as a periostin-expressing cell type necessary for adaptive he

116 d in a genetically engineered mouse model of periostin-expressing distal esophageal/forestomach ESCC.

117 tional Cre-expressing mouse lines shows that periostin-expressing myofibroblasts in the heart derive

118 cts of cell-specific Smad3 loss in activated periostin-expressing myofibroblasts using a mouse model

119 activity in cardiomyocytes and reduction of periostin expression allowing for a more homeostatic ext

120 Lack of periostin expression also blunted the de novo renal expr

121 We examined periostin expression by immunohistochemical analysis of

122 (EndoMT)-related genes PAI-1, collagen, and periostin expression in endothelial cells.

123 rulence factors (P. gingivalis LPS) decrease periostin expression in human PDL fibroblasts.

124 HDM exposure increased periostin expression in the airway epithelium, subepithe

125 ession of periostin or knockout mice lacking periostin expression in the renal ischemia-reperfusion i

126 proinflammatory transcription factors induce periostin expression in vitro and that binding of these

127 Whether and how periostin expression influences bone anabolism, however,

128 ery of antisense oligonucleotides to inhibit periostin expression protected animals from L-NAME-induc

129 Periostin expression was 3.7-fold higher in bronchial ce

130 ADAM33 and periostin expression was assessed by using real-time PCR

131 l lines, TE-11 with high and TT with minimal periostin expression, were implanted in nu/nu mice to ge

132 genic mice had higher levels of fibrosis and periostin expression.

133 We generated a (64)Cu-DOTA-anti-periostin-F(ab')2 with a dissociation constant of 29.2 +

134 mor necrosis factor-alpha (TNF-alpha), RAGE, periostin, fibronectin, and type I collagen.

135 Depletion of periostin from the serum abrogated the proliferation of

136 These data suggest that periostin functions as a disease determinant in MD by pr

137 Periostin functions by interacting with extracellular ma

138 In contrast, mice lacking the periostin gene showed less injury-induced interstitial f

139 Here we generate Postn (periostin) gene-targeted mice containing a tamoxifen-ind

140 ns over 52 weeks in biomarker-high patients (periostin >/=50 ng/mL or blood eosinophils >/=300 cells

141 The matricellular protein periostin has been associated with CKD progression in an

142 Because periostin has been reported to induce cell differentiati

143 nhaled corticosteroid therapy, especially in periostin-high patients.

144 n in CKD, we discovered a protective role of periostin in AKI.

145 ndotypes: T2-like (with an elevated level of periostin in BALF) and non-T2/proinflammatory (with high

146 In contrast to the detrimental role of periostin in CKD, we discovered a protective role of per

147 hat specific imaging of extracellular matrix periostin in ESCC is feasible using a targeted PET trace

148 r are limited due to increased expression of periostin in non-cancerous inflammatory conditions.

149 flammatory cytokines alter the expression of periostin in PDL cells.

150 This study demonstrates the utility of periostin in phenotyping severe asthma.

151 he mechanism(s) of induction and the role of periostin in renal disease.

152 data, we identified elevated mRNA levels of periostin in the hearts of TAC-operated mice.

153 Notably, overexpression of periostin in the livers of WT mice promoted hepatic stea

154 increase in the expression and synthesis of periostin in the obstructed kidney that associated with

155 to the non-loaded controls (higher levels of periostin in the supernatant in the non-loaded group).

156 Detection of periostin in the tumor microenvironment may help with ea

157 nding partner and that FAM20C phosphorylates Periostin in vitro.

158 roteins to see whether FAM20C phosphorylates Periostin in vitro.

159 FAM20C WT, but not D478A, phosphorylated Periostin in vitro.

160 Periostin increased MMP-13 expression dose [1-10 microg/

161 Furthermore, treatment of these cells with periostin increased the expression of collagen I and sti

162 In vitro, recombinant periostin increased the expression of integrin-beta3 and

163 hibition or shRNA knockdown of ILK prevented periostin-induced Akt/mammalian target of rapamycin (mTO

164 Airway epithelial cell-derived periostin-induced conversion of CD4(+) CD25(-) cells int

165 Periostin induction of MMP-13 expression was inhibited b

166 C function via impairment of the BMM and the periostin/integrin beta3 axis, possibly associating with

167 Periostin interacted with FAM20C in a kinase-activity in

168 Periostin interacted with its receptor, integrin-beta1,

169 Periostin is a 90-kDa member of the fasciclin-containing

170 our data demonstrate for the first time that Periostin is a direct FAM20C-binding partner and that FA

171 Periostin is a glycoprotein with high expression in many

172 Periostin is a matricellular protein essential for tissu

173 Periostin is a matricellular protein with roles in tissu

174 Periostin is a systemic biomarker of airway eosinophilia

175 Periostin is an integrin-binding protein that is importa

176 Periostin is expressed in a variety of tissues and expre

177 ated that the secreted cell adhesion protein periostin is markedly upregulated in livers of obese rod

178 we show that up-regulation and secretion of periostin is pathological and enhances disease in the de

179 We hypothesized that periostin is required for airway inflammatory responses

180 In mice, periostin is required for maximal airways hyperresponsiv

181 Periostin is required for maximal HDM-induced T-cell res

182 This gene signature, which includes periostin, is present in approximately half of asthmatic

183 The periostin layer, detected with monoclonal antibody Stiny

184 sions of TNF-alpha and RAGE but elevated the periostin level in all three phases of periodontitis.

185 Age 2 year periostin level of 150 ng/mL or more predicted asthma at

186 hma showed that, of these indices, the serum periostin level was the single best predictor of airway

187 level and blood eosinophil count) and serum periostin level.

188 ion between postbronchodilator FEV1 /FVC and periostin levels (-0.276, P < 0.05).

189 ) and significantly elevated fibronectin and periostin levels (P <0.01).

190 Serum periostin levels are significantly higher in children th

191 Serum periostin levels are significantly increased in asthmati

192 ithelial fibrosis in asthmatic patients, and periostin levels have been linked to increases in IL-13.

193 Reference values for serum periostin levels in adults without asthma or COPD are pr

194 Serum periostin levels in adults without asthma or COPD are si

195 We found high periostin levels in human and rodent OA cartilage.

196 allergen-induced airway eotaxin-2/CCL24 and periostin levels in miR-155 KO mice.

197 Periostin levels in sputum are associated with persisten

198 ution of periostin and logarithm-transformed periostin levels was derived, and 90% confidence interva

199 Periostin levels were also found to be high in the serum

200 Serum periostin levels were approximately 2- to 3-fold higher

201 Periostin levels were higher in patients with fixed as c

202 ic IgE levels, blood eosionophil counts, and periostin levels were measured in 244 children.

203 Serum periostin levels were measured in 480 individuals, compr

204 agen content associated with upregulation of periostin levels within the PDL.

205 d eosinophil numbers, Feno levels, and serum periostin levels, in 59 patients with severe asthma show

206 f chondrocytes to knock down and up-regulate periostin levels, respectively, and analyzed its effect

207 on of exhaled nitric oxide levels, and serum periostin levels, to aid decision making in clinical tri

208 f patients, for example asthmatics with high periostin levels.

209 f chronic periodontal inflammation on tissue periostin levels.

210 In addition, periostin localization by immunofluorescence was perform

211 Our findings suggest periostin may be a novel and important mediator of mecha

212 Targeting periostin may be a novel therapeutic strategy for treati

213 se in response to TGF-beta and that blocking periostin may be a promising therapeutic strategy agains

214 Serum periostin measurements do not need to be adjusted to tak

215 These data strongly suggest that periostin mediates renal disease in response to TGF-beta

216 Periostin might be a biomarker of the esophageal tumor m

217 well as reduced IL-4, IL-25, CD68, Gob5, and periostin mRNA expression.

218 lpha-smooth muscle actin staining by 56% and periostin mRNA levels by 60% compared with control.

219 Deletion of periostin(+) myofibroblasts reduces collagen production

220 57BL/6 mice treated with either IgM or OC-20 periostin neutralizing antibody.

221 blation of periostin and administration of a periostin-neutralizing antibody dramatically improved he

222 ctors responsible for bone and PDL damage in periostin-null mice (a periodontitis animal model) using

223 periostin was right skewed with a mean (SD) periostin of 51.2 (11.9) ng/mL, median (IQR) 50.1 (43.1

224 These data elucidate the complex role of periostin on bone anabolism, through the regulation of S

225 es of the effects of epithelial cell-derived periostin on murine T cells were also performed.

226 igh concentrations of type 2 biomarkers (eg, periostin or blood eosinophils).

227 onditional tubule-specific overexpression of periostin or knockout mice lacking periostin expression

228 the most differentially expressed gene), (2) periostin, or (3) a multigene IL-13 in vitro signature (

229 type 2 status based on airway mucosal CCL26, periostin, or IL-13-IVS gene expression.

230 poxia-treated primary tubules overexpressing periostin, or treating such macrophages with recombinant

231 overlapped expression pattern of FAM20C and Periostin, our data demonstrate for the first time that

232 After ischemia-reperfusion injury, periostin-overexpressing mice exhibited diminished expre

233 Macrophages from periostin-overexpressing mice showed increased prolifera

234 Periostin overexpression protected mice from renal injur

235 associated with increased IL-5 (P < .05) and periostin (P < .05) tissue levels and colonization with

236 In conclusion, periostin PDL tissue levels significantly decrease under

237 Treatment with periostin peptide increased the EF from 31% to 41% and d

238 rolled release system to deliver recombinant periostin peptide into the pericardial space.

239 est the functional and structural effects of periostin peptide treatment in a large animal model of m

240 However, periostin peptide treatment increased myocardial fibrosi

241 Periostin peptide-treated animals had newly formed myoca

242 andomly assigned to receive either saline or periostin peptide.

243 Periostin (PN), a novel fasciclin-related matricellular

244 r) or in activated cardiac fibroblasts using periostin (Postn) (MerCreMer) .

245 d colleagues analyze messenger RNA levels of periostin (POSTN) in pulmonary fibroblasts, endothelial

246 Periostin (Postn) is a matricellular protein preferentia

247 The matrix-specific protein periostin (POSTN) is up-regulated in human cancers and a

248 Here, we demonstrate that Periostin (Postn) via interaction with Integrin-alphav (

249 Highly proliferative Periostin (Postn)+ lineage CFs were found from postnatal

250 Here, we identify periostin (POSTN), a secreted protein, as a key componen

251 Periostin (POSTN), a secretory matricellular matrix prot

252 expression of 70 genes, including IL13, IL5, periostin (POSTN), calcium-activated chloride channel re

253 ersion of quiescent cardiac fibroblasts into Periostin (Postn)-positive cells that express high level

254 The extracellular matrix molecule periostin (POSTN, encoded by POSTN), which is secreted b

255 les (desmoglein 1, DSG1), tissue remodeling (periostin, POSTN), and mast cells (carboxypeptidase A, C

256 tro and that binding of these factors on the periostin promoter is enriched in glomeruli during exper

257 Periostin promotes cell proliferation, cyst growth, inte

258 Analysis of periostin protein expression in TAC-myocardium, as well

259 al virulence factors significantly decreased periostin protein levels in the loaded cultures.

260 found that FTY-720 treatment or knockdown of periostin protein was able to inhibit transforming growt

261 In a mechanically challenged environment, periostin protein was more efficiently incorporated into

262 ts, while subtracting those that bind to the periostin protein with glycoforms found in non-malignant

263 Here we investigated how periostin regulates proliferation and differentiation of

264 nts for FE(NO), blood eosinophils, and serum periostin, respectively.

265 ther determined the binding region(s) within Periostin responsible for FAM20C-binding.

266 Overexpression of periostin resulted in reduced expression of peroxisome p

267 was inversely correlated with the levels of periostin (rho = -0.545; p < 0.001).

268 ore, that eosinophils remodel and migrate on periostin-rich extracellular matrix in the asthmatic air

269 The mechanism of periostin's effect as a brake on allergen-induced respon

270 Periostin secreted from fibroblasts was required for IL-

271 epithelial cells increased the expression of periostin several-fold, leading to subsequent loss of th

272 Distinct expression pattern of periostin splice variants in chondrocytes and ligament p

273 ng with the fibrillar fibronectin/tenascin-C/periostin structures that characteristically surround me

274 (P < .001), and results were similar by the periostin subgroup, with no apparent differences between

275 the dose groups and the placebo group by the periostin subgroup.

276 emilin-1), and other extracellular proteins (periostin, tenascin-X).

277 18, CCL26, thymic stromal lymphopoietin, and periostin), TH9/IL-9, IL-23 (p40 and p19), and IL-16 med

278 However, in the case of periostin the effects on cardiac fibrosis may limit its

279 Though one might expect periostin to play a deleterious role in asthma pathogene

280 porter mice, was inhibited in the absence of periostin (TOPGAL;Postn(-/-) mice).

281 Periostin-traced myofibroblasts also revert back to a le

282 netically engineered mouse models, ESCC high periostin tracer uptake anatomically correlated with the

283 the epithelial-mesenchymal interactions, and periostin tunes the magnitude of keratinocyte proliferat

284 roducts, vascular endothelial growth factor, periostin, Type I collagen, and fibronectin were also ev

285 ent (PDL) extracellular matrix where that of Periostin was also immunostained in murine periodontal t

286 microscopy, and migration of eosinophils on periostin was assayed.

287 Immunolocalization of FAM20C and Periostin was examined using mouse periodontium tissues

288 Periostin was found by the analysis and the binding betw

289 analysis and the binding between FAM20C and Periostin was investigated in cell cultures and in vitro

290 Periostin was measured in sputum supernatants.

291 a group of matricellular proteins, of which periostin was prominent.

292 The distribution of serum periostin was right skewed with a mean (SD) periostin of

293 The 90% confidence limits for periostin were 35.0 and 71.1 ng/mL.

294 ges in eotaxin, epidermal growth factor, and periostin were also decreased in the lungs of house dust

295 Blood eosinophils adhering to adsorbed periostin were imaged at different time points by fluore

296 Fibroblast lineages expressing Tcf21 or Periostin were traced in transgenic GFP reporter mice, a

297 ription factors and also TGFbeta1, MMP16 and periostin, which are involved in oncogenic progression.

298 r identified the binding domain of FAM20C in Periostin, which was mapped within Fasciclin (Fas) I dom

299 96.2% of adenocarcinoma stained positive for periostin, with most stained strongly (67.3% and 69.3%,

300 c oxide (Feno), peripheral blood eosinophil, periostin, YKL-40, and IgE levels and compared these bio