ライフサイエンスコーパス: peripheral tissue

1 as to be balanced against excess exposure of peripheral tissue.

2 mechanism for controlling T cell function in peripheral tissue.

3 an suppress protein misfolding in C. elegans peripheral tissue.

4 h blocks the export of lymph node cells into peripheral tissue.

5 cells residing in distinct locations within peripheral tissue.

6 development of inflammatory hyperalgesia of peripheral tissue.

7 chizophrenia (SZ) is suggested by studies of peripheral tissue.

8 o basolateral membranes for copper efflux to peripheral tissues.

9 re neuronal receptors for Sides expressed on peripheral tissues.

10 both light entrainment and clock function in peripheral tissues.

11 s energy storage vs expenditure in liver and peripheral tissues.

12 r selectivity and preferential expression in peripheral tissues.

13 king and ability to take up residence within peripheral tissues.

14 tion of the HMGB1-mediated response in these peripheral tissues.

15 expressed in the hypothalamus compared with peripheral tissues.

16 e in regulating immunity and inflammation in peripheral tissues.

17 owever, Abeta is generated in both brain and peripheral tissues.

18 s, and not Tem cells, predominantly surveyed peripheral tissues.

19 ogeneity and in regulating their function in peripheral tissues.

20 te the immune system, peritoneal cavity, and peripheral tissues.

21 stem might also control energy metabolism in peripheral tissues.

22 ion of GluT4 in the hippocampus from that in peripheral tissues.

23 ack the migration of spleen-derived cells to peripheral tissues.

24 ring the initiation of allergic responses in peripheral tissues.

25 cretion and increasing insulin resistance in peripheral tissues.

26 self-ligands in the thymus, and finishes in peripheral tissues.

27 mmunicating external and internal signals to peripheral tissues.

28 , insulin regulates a variety of pathways in peripheral tissues.

29 ates metabolic and circadian rhythm genes in peripheral tissues.

30 onses necessary to control this infection in peripheral tissues.

31 ol leukocyte egress from lymphoid organs and peripheral tissues.

32 te T-cell activation and end-organ damage in peripheral tissues.

33 lymphoid organs and subsequent migration to peripheral tissues.

34 nscripts encoding proteins characteristic of peripheral tissues.

35 es metabolism and mitochondrial integrity in peripheral tissues.

36 hat the treatment also reduced viral load in peripheral tissues.

37 he only known hunger signal derived from the peripheral tissues.

38 ed us to enumerate metastatic cells in mouse peripheral tissues.

39 n the SCN is also expressed and functions in peripheral tissues.

40 r, in regulating effector T cell egress from peripheral tissues.

41 on in the hypothalamus and that occurring in peripheral tissues.

42 chiasmatic nucleus and subordinate clocks in peripheral tissues.

43 e in the regulation of glucose metabolism in peripheral tissues.

44 pture signatures of environmental insults in peripheral tissues.

45 ct capillary beds in the retina and in other peripheral tissues.

46 with a concomitant delay in distribution to peripheral tissues.

47 metabolic basis of vitamin A homeostasis in peripheral tissues.

48 hat elicit effects across insulin-responsive peripheral tissues.

49 ed ability to migrate into the parenchyma of peripheral tissues.

50 eptors CB1 and CB2 in the nervous system and peripheral tissues.

51 gestation, with abundant MECP2 mutations in peripheral tissues.

52 e central nervous system, but not in several peripheral tissues.

53 led neurons and synchronizes other clocks in peripheral tissues.

54 t is mediated by M2 activated macrophages in peripheral tissues.

55 rcadian oscillators in other brain sites and peripheral tissues.

56 n RagA loss, a myeloid population expands in peripheral tissues.

57 notype is accompanied by phase adjustment of peripheral tissues.

58 hrough its actions on the pancreas and other peripheral tissues.

59 rcumstances with little influence from or on peripheral tissues.

60 or excitability and attenuate nociception in peripheral tissues.

61 e SCN stays close to the periods of cells in peripheral tissues.

62 etabolism by signaling through the brain and peripheral tissues.

63 s, which measure removal of cholesterol from peripheral tissues.

64 cells and decrease in regulatory T cells in peripheral tissues.

65 gamma production in the thymus as well as in peripheral tissues.

66 icit full-length MeCP2 protein expression in peripheral tissues.

67 amounts of thyroid hormone for the needs of peripheral tissues.

68 hree precursors are highly expressed in some peripheral tissues.

69 T cell responses on neoantigen induction in peripheral tissues.

70 type, suggesting a potential to traffic into peripheral tissues.

71 d function, and determines iNKT pool size in peripheral tissues.

72 stinct antigen specificity for iNKT cells in peripheral tissues.

73 he iNKT2/17 subsets in the thymus but not in peripheral tissues.

74 ) and N-acyl taurines (NATs), in central and peripheral tissues.

75 bone marrow and mature basophils in multiple peripheral tissues.

76 park the disease process in the brain and/or peripheral tissues.

77 microns, and regulates their distribution to peripheral tissues.

78 sure to regulation of biological pathways in peripheral tissues.

79 ice display reduced PPi levels in plasma and peripheral tissues.

80 age potential upon progenitor recruitment to peripheral tissues.

81 ophages in the extracellular matrix (ECM) of peripheral tissues.

82 the induction of cytokines and chemokines in peripheral tissues.

83 thymus, circulate in the blood, and home to peripheral tissues.

84 cal barrier that monitors lymph drained from peripheral tissues.

85 for restricted dissemination of bacteria to peripheral tissues.

86 pression of CCR5, which keeps DC in inflamed peripheral tissues.

87 involved in a growing number of functions in peripheral tissues.

88 aneous proliferation of immature NK cells in peripheral tissues, a phenotype that is replicated under

89 to an equal extent enhances GSIS and acts as peripheral tissue activator of insulin-independent gluco

90 Peripheral tissue analysis revealed systemic IL-27 expre

91 n vaccine biology is that DCs migrating from peripheral tissue and classical lymphoid-resident DCs (c

92 macrophages result in poised macrophages in peripheral tissue and negatively impact wound repair.

93 They have functions in peripheral tissue and peripheral and central nervous sys

94 ppress dendritic cell maturation and present peripheral tissue and tumor Ags for autoreactive T cell

95 ensive viral sampling from several different peripheral tissues and cell types and from three distinc

96 mes that are differentially expressed in the peripheral tissues and central nervous systems.

97 CTRP4 is also produced by peripheral tissues and circulates in blood.

98 ars mutations, leading to sensory defects in peripheral tissues and correlating with overall disease

99 ggered by alloreactive T cells, which damage peripheral tissues and lymphoid organs.

100 ting memory CD4 T cells that traffic between peripheral tissues and lymphoid sites.

101 that regulate glucose and fat metabolism in peripheral tissues and modulate inflammation in adipose

102 Not only the myocardium, but also peripheral tissues and organs are affected by metabolic

103 mals failed to prevent systemic pathology in peripheral tissues and organs, indicating fundamental mo

104 on the endogenously expressed HTT protein in peripheral tissues and post-mortem HD brain tissue, as w

105 that alpha-Syn aggregation can originate in peripheral tissues and progress to the brain via autonom

106 ry cells, frequently neurons, that signal to peripheral tissues and promote survival during the prese

107 rst time define CRY expression in Drosophila peripheral tissues and reveal that CRY acts together wit

108 in (OT) regulates biologic functions in both peripheral tissues and the central nervous system.

109 in the brain, but its physiological role in peripheral tissues and the extent to which it intersects

110 associated with enhanced fluid drainage from peripheral tissues and thus with a hypotensive phenotype

111 olite of 11OHA4 (which is mostly produced in peripheral tissues), and its 5alpha-reduced product, 11-

112 scape from the bone marrow, differentiate in peripheral tissue, and undergo activation in response to

113 Th1 responses, to efficiently accumulate in peripheral tissues, and almost exclusively differentiate

114 ulation, transmigration to and activation in peripheral tissues, and clearance of senescent neutrophi

115 ledge of how Treg cells home to lymphoid and peripheral tissues, and control antibody production and

116 d lipolysis, increases lipid accumulation in peripheral tissues, and exacerbates tissue-specific and

117 al role in synchronizing circadian rhythm in peripheral tissues, and multiple mechanisms regulate tis

118 ctions by apoptosis or by dissemination into peripheral tissues, and those residing in nonlymphoid or

119 is partially controlled by the expression of peripheral tissue antigens (PTAs) in lymph node stromal

120 ic endothelial cells (LECs) directly express peripheral tissue antigens and induce CD8 T-cell deletio

121 which promote thymic display of thousands of peripheral tissue antigens in a process critical for est

122 not promote AIRE-dependent transcription of peripheral tissue antigens in vitro.

123 They contribute to tolerance by presenting peripheral tissue antigens to both CD4 and CD8 T cells.

124 not been shown whether lipid oscillations in peripheral tissues are driven by diurnal cycles of rest-

125 monstrate lower presence of monocytes inside peripheral tissues as compared to adults.

126 CNS function since they are found throughout peripheral tissues as well as being highly expressed in

127 ave identified altered metabolic profiles in peripheral tissues associated with MDD.

128 e memory subset that develops and remains in peripheral tissues at the site of infection, providing f

129 es, and the emerging literature on fluid and peripheral tissue biomarkers.

130 and glial cells or between neurons and other peripheral tissues, both in physiological and pathologic

131 hat these cells preferentially accumulate in peripheral tissues but not in the primary tumor.

132 ed from the liver was acquired mainly by the peripheral tissues but not retained efficiently, causing

133 mouse model that expresses ApoE normally in peripheral tissues, but has severely reduced ApoE in the

134 cine transiently activates mTORC1 in several peripheral tissues, but in contrast to leucine uniquely

135 one factor that sets the circadian clock in peripheral tissues, but relatively little is known about

136 Telomeres have been studied extensively in peripheral tissues, but their relevance in the nervous s

137 n the accumulation of lipid intermediates in peripheral tissues, but this was not associated with a w

138 accumulation was observed in their brains or peripheral tissues, but very low infectivity was detecte

139 unctions that determine efficient seeding of peripheral tissues by a limited number of cells.

140 the immature state are positioned throughout peripheral tissues by acting as sentinels, sensing the p

141 ting distribution from the injection site to peripheral tissues by reducing renal clearance.

142 Frataxin measurements from peripheral tissues can be used to identify FRDA patients

143 These mitochondrion-related disorders in peripheral tissues can impact on brain functions through

144 extent to which different brain regions, and peripheral tissues can sustain HSF1 activity and HS prot

145 Cholesterol from peripheral tissue, carried by HDL, is metabolized in the

146 ice to constant light disrupted the clock in peripheral tissues, causing loss of the nighttime repres

147 ously established role in retaining T(RM) in peripheral tissues, CD49a facilitates locomotion of viru

148 thalamic suprachiasmatic nucleus and various peripheral tissue clocks.

149 LC2 progenitors (ILC2Ps) and mature ILC2s in peripheral tissues compared with females.

150 Increasing SMN exclusively in peripheral tissues completely rescued necrosis in mild S

151 As neural innervation of the peripheral tissue continues to develop after birth, neur

152 phils are well characterized as mediators of peripheral tissue damage in lupus, but it remains unclea

153 To investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of U

154 Following antigen acquisition in peripheral tissues, DCs migrate to draining lymph nodes

155 complex class I-dependent interactions with peripheral tissue-derived migratory dendritic cells (DCs

156 Changes in peripheral tissues differed from those in the tumor micr

157 on of a dynamic role for oxygen sensing in a peripheral tissue directly modifying cardiovascular resp

158 akdown are harmful inflammatory responses in peripheral tissues driven by innate immunity and self an

159 permit monocytes to tailor miRNA profiles in peripheral tissues during differentiation to macrophages

160 ell migration is crucial to the formation of peripheral tissues during vertebrate development.

161 controls human female reproductive tract and peripheral tissue dynamics in single, dual and multiple

162 ddition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neur

163 o the maintenance of glucose homeostasis and peripheral tissue energy balance.

164 lasts and use to elucidate the CSF/brain and peripheral tissue expression of HTT in preclinical HD mo

165 The Lin28a/Let-7 axis has been studied in peripheral tissues for its role in metabolism regulation

166 However, they are also secreted de novo by peripheral tissues for local use.

167 glia and then to reactivate and move back to peripheral tissues for spread to other hosts.

168 otactic migration of effector T cells within peripheral tissue forms an important factor in the speed

169 or (Aire), is critical for the protection of peripheral tissues from autoimmune attack.

170 the action of these hormones on behavior and peripheral tissue functions.

171 In mammals, most cells in the brain and peripheral tissues generate circadian ( approximately 24

172 Locally produced peripheral tissue GH, in contrast to circulating pituita

173 cose-stimulated insulin secretion (GSIS) and peripheral tissue glucose uptake.

174 ta cells from oxidative stress and improving peripheral tissue glucose utilization.

175 believed to be a minor memory cell subset in peripheral tissues has been dramatically underestimated.

176 fore, communication between the CNS, BBB and peripheral tissues has many endocrine-like properties.

177 unity, the role of memory T cells present in peripheral tissues has not been explored.

178 nostic biopsies, particularly as biopsies of peripheral tissues has unsatisfactory sensitivity and sp

179 s the primary site of molecular pathology in peripheral tissues, has not been addressed.

180 s (LNs) and resident memory T (TRM) cells in peripheral tissues have distinct roles in protective imm

181 use of an overflow of lipids from the WAT to peripheral tissues; however, this did not occur when Ad-

182 e., neuromuscular junction) and infection of peripheral tissues (i.e., muscle cells).

183 The family of OT-like molecules affects both peripheral tissues implicated in reproduction, homeostas

184 ite evidence of TCF7L2 expression in various peripheral tissues important in glucose homeostasis.

185 icular benefits to a therapy that can target peripheral tissues in addition to brain.

186 t of mobilization of splenic immune cells to peripheral tissues in health and disease, however, remai

187 n in the central nervous system (CNS) versus peripheral tissues in mouse models using a therapeutic s

188 viors, and alters neurotransmitter levels in peripheral tissues in recipient mice.

189 or human CTRP6 impaired glucose disposal in peripheral tissues in response to glucose and insulin ch

190 nstrates potent efficacy in both the CNS and peripheral tissues in severe SMA mice following systemic

191 and demonstrate a role for BDNF produced by peripheral tissues in short-term controls of feeding, li

192 tely 150 brain pacemaker neurons and in many peripheral tissues in the head and body, but can also be

193 ndrial reactive oxygen species generation in peripheral tissues in the latter.

194 TRA project nonredundant representations of peripheral tissues in the thymus.

195 whether leptin has similar effects in human peripheral tissues in vivo, ex vivo, and in vitro and wh

196 or T cells exit the vasculature to enter the peripheral tissues in which an infection is ongoing.

197 litates insulin-stimulated glucose uptake in peripheral tissues including adipose, muscle, and heart.

198 growth, DR reduces parasite accumulation in peripheral tissues including the brain, and increases cl

199 at steady-state levels of ATP7A are lower in peripheral tissues (including the heart, spleen, and liv

200 was transiently expressed at high levels in peripheral tissues, including adrenal cortex (E16-E21) a

201 vehicle) within peripheral tissues, including blood, lungs, liver, and s

202 o facilitates the efflux of cholesterol from peripheral tissues, including macrophages, back to liver

203 early onset gene (BRCA1) influences numerous peripheral tissues, including skeletal muscle.

204 terized by impaired uptake of cholesterol in peripheral tissues, including the liver and the pancreas

205 ally delivers retinol from hepatic stores to peripheral tissues, including the placenta and fetal eye

206 Notably, T reg cells in peripheral tissues, including tumors, are more sensitive

207 embrane properties in a non-clock-containing peripheral tissue independent of light.

208 Analysis of peripheral tissues indicates that itk(-/-) innate PLZF(+

209 illumination, either of the thalamus or the peripheral tissues, induced JF-NP-26-mediated light-depe

210 nounced than the benefits of young, and that peripheral tissue injury compounds the negative effects.

211 Within peripheral tissues iNKT cell recent thymic emigrants exh

212 s by which inflammation is able to convert a peripheral tissue into one that resembles a secondary ly

213 chanism of prion transport in axons and into peripheral tissue is unresolved.

214 chanism of prion transport in axons and into peripheral tissue is unresolved.

215 Immune homeostasis in peripheral tissues is achieved by maintaining a balance

216 cally invade through surrounding stroma into peripheral tissues is an essential component of metastat

217 is of circadian signaling in single cells of peripheral tissues is as-yet uncharacterized.

218 Via RCT, excess cholesterol from peripheral tissues is carried back to the liver and henc

219 Metastatic invasion of tumors into peripheral tissues is known to rely upon protease-mediat

220 w HSPCs migrate between bone marrow (BM) and peripheral tissues is of great significance in the clini

221 pensate in response to insulin resistance in peripheral tissues is secondary to hyperplasia, as well

222 Immune homeostasis in peripheral tissues is, to a large degree, maintained by

223 Although skeletal muscle is a key peripheral tissue, it remains unknown whether muscle-sec

224 accumulation and leads to fat spillover into peripheral tissues, leading to the deleterious effects o

225 ould be detected in blood monocytes and some peripheral tissues (liver, spleen) up to 30 d after the

226 opallium, hippocampus, and hypothalamus) and peripheral tissues (liver, spleen, and fat) of zebra fin

227 ystemic alterations affecting both brain and peripheral tissues might underlie the disorders.

228 lock) mRNA expressions in various neural and peripheral tissues of buntings in different LHSs and dis

229 ta TCR are disproportionately represented in peripheral tissues of mice and humans, suggesting they t

230 ily acquired but not retained efficiently in peripheral tissues of neonatal rats, suggesting that a m

231 sue loss, and insulin activity is reduced in peripheral tissues of tumor-bearing hosts.

232 s significantly, and prions were detected in peripheral tissues only in NN animals.

233 s are made using alternative sources such as peripheral tissues or in vitro-derived neurons.

234 Lipids delivered to peripheral tissues originate mostly from the intestine a

235 N), modifying timing signals to contributing peripheral tissue oscillators, and are mediated by under

236 a hunger signalling peptide derived from the peripheral tissues, overcomes the satiety signals evoked

237 diabetes and obesity (insulin sensitivity in peripheral tissue, pancreatic islet and beta cell functi

238 Circadian rhythms in peripheral tissues persisted but became desynchronized a

239 ong lived, poly-functional CD8(+) T cells to peripheral tissues, phenotypically displaying hallmarks

240 ibition of glucose uptake by liver and other peripheral tissues, principally adipose and muscle and w

241 receptor components in the hypothalamus and peripheral tissues, promoting FGF21 resistance.

242 Foxp3(+) regulatory T cells in peripheral tissues (pT(regs)) are instrumental in limiti

243 In peripheral tissues, PTP1B regulates insulin signaling, b

244 However, P2Y(6)R's roles in peripheral tissues regulating energy and glucose homeost

245 However, the role of NAA in peripheral tissues remained elusive.

246 pithelial genes critical for their long-term peripheral tissue residency.

247 sessed the expression of AIRE and of several peripheral tissue-restricted Ag genes by quantitative PC

248 ells by impairing lymph node (LN) display of peripheral tissue-restricted antigens (PTAs).

249 on of tolerogenic stromal cells that display peripheral tissue-restricted antigens in lymph nodes, wh

250 by directly infecting nerves that innervate peripheral tissues, resulting in debilitating direct and

251 lar mechanisms that guide ILC migration into peripheral tissues, revealing common features among diff

252 esis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with inc

253 Additionally, we found that in peripheral tissues, SFB selectively expand dual T cell r

254 or populations circulating between blood and peripheral tissues shared a PRDM1-dominant landscape.

255 , vast numbers of T cells reside in multiple peripheral tissue sites including lungs, intestines, liv

256 moma samples for transcripts for AIRE and 16 peripheral tissue-specific autoantigens (TSAgs) by quant

257 ain at all ages and in all brain regions and peripheral tissues studied.

258 ed adipose tissue inflammation and decreased peripheral tissue substrate utilization after being rein

259 ASCT2 is highly expressed in peripheral tissues such as the lung and intestines where

260 ivate from latency and then cause disease in peripheral tissues, such as skin and mucosal epithelia.

261 cated in the blood from cells present within peripheral tissues, such as the lung.

262 n previously reported in patients' brain and peripheral tissue, suggesting their relevance in sporadi

263 gates were observed consistently in infected peripheral tissues, suggesting a new role for MCs as non

264 binding of (123)I-CLINDE to blood cells and peripheral tissues, SUV is not a sufficient surrogate of

265 colon cancer, but rarely expressed in normal peripheral tissues, targeting GRM3 with such agents woul

266 nal Ube3a but does not affect periodicity in peripheral tissues that are not imprinted for uniparenta

267 ched and fatty acid spillover occurs into to peripheral tissues that metabolic diseases develop.

268 In peripheral tissues, the intravascular processing of TRLs

269 importance as a relay hub between cortex and peripheral tissues, the investigation of three-dimension

270 nto the limelight due to their prevalence in peripheral tissues, their sentinel-like phenotypes, and

271 Sensory dendrites innervate peripheral tissues through cell-cell interactions that a

272 f ASD by determining molecular signatures in peripheral tissues through mass spectrometry methods (ul

273 ILCs maintain their presence in lymphoid and peripheral tissues thus far has been unclear.

274 strointestinal tract before disseminating to peripheral tissues to cause disease, but intestinal fact

275 er signals, and immune cells travelling from peripheral tissues to lymph nodes.

276 in glucose metabolism and communicates with peripheral tissues to maintain energy homeostasis.

277 edonic brain responses, altered responses of peripheral tissues to metabolic signals, and changes in

278 Dendritic cells (DCs) migrate from peripheral tissues to secondary lymphoid organs (SLOs) t

279 complexes (ICs) stimulates DC migration from peripheral tissues to the paracortex of draining lymph n

280 often evade immune surveillance by adopting peripheral tissue- tolerance mechanisms, such as the exp

281 in brain, whereas infectivity was present in peripheral tissues too.

282 rested in studying the communication between peripheral tissues under metabolic homeostasis perturbat

283 hloride (NaCl) was proposed to accumulate in peripheral tissues upon dietary intake and to promote au

284 clei (SCN) and the SCN in turn synchronizing peripheral tissues via endocrine mechanisms.

285 of the spinal cord that receives input from peripheral tissues via several types of primary afferent

286 l signs, and their brains as well as several peripheral tissues were analyzed for the accumulation of

287 emonstrated that a subset of host T cells in peripheral tissues were proliferating (Ki67+) and produc

288 ssential carrier of energy from the liver to peripheral tissues when the supply of glucose is too low

289 ipt in rat brain tissues, in contrast to rat peripheral tissues where there existed little overlappin

290 and specialized lymphocyte subsets colonize peripheral tissues, where they contribute to organogenes

291 ate directs virus access to nerve endings in peripheral tissue, whereas the second delivers virus par

292 f CCL2 and TNFalpha in FXYD5-expressing lung peripheral tissue, which suggests a possible role for FX

293 one protein, widely expressed in central and peripheral tissues, which can translocate to the plasma

294 itute circadian oscillators in the brain and peripheral tissues, which drive rhythms in physiology an

295 by encounter with self-antigen expressed on peripheral tissues, which is likely to be relevant to th

296 avior in response to local energy demands of peripheral tissues, which secrete orexigenic and anorexi

297 icellular CNS wound responses not present in peripheral tissues, which serve to isolate damaged neura

298 KISS1R is expressed in other brain areas and peripheral tissues, which suggests that kisspeptin has a

299 draining lymph nodes after administration in peripheral tissues with programmable degradable linkers.

300 e induces inflammatory cytokine reactions in peripheral tissues without adversely affecting the centr