ライフサイエンスコーパス: periportal

1 nt mice was predominantly hepatocellular and periportal.

2 Immunohistochemistry revealed the periportal accumulation of CCR6(+) mononuclear cells and

3 atosplenomegaly, retroperitoneal adenopathy, periportal adenopathy, mesenteric adenopathy, thickening

4 Although periportal and lobular necroinflammation vanished, porta

5 These alterations are enriched in periportal and mid-lobular hepatocytes but not in perice

6 Endogenous RRBP1 is enriched around periportal and mid-lobular regions of the liver.

7 dlobular region before proceeding toward the periportal and pericentral areas.

8 due to their spatial positioning across the periportal and pericentral axis.

9 e model, we identify key differences between periportal and pericentral cells accounting for higher s

10 livers from BDL rats, ET-1 was localized in periportal and pericentral hepatocytes and hepatic sinus

11 tivation of fatty acid beta-oxidation in the periportal and pericentral hepatocytes of AEG-1(DeltaMAC

12 establishing a method for the separation of periportal and pericentral hepatocytes that yields suffi

13 Gene expression in the liver varies between periportal and pericentral hepatocytes(1-3), and in the

14 MASH- and HCC-promoting pathways, mainly in periportal and pericentral hepatocytes, in AEG-1-C75S li

15 We find that periportal and pericentral mitochondria are morphologica

16 mTOR shifts mitochondrial phenotypes in the periportal and pericentral regions, linking nutrient gra

17 ibution of sepsis-associated changes between periportal and pericentral zones.

18 The zone-specific APR was evaluated in periportal and pericentral/centrilobular hepatocytes iso

19 in the livers of mice and the expression of periportal and perivenous hepatocyte markers was determi

20 erent cell populations, suggesting that both periportal and perivenous hepatocytes are induced.

21 to the perisinusoidal space surrounding the periportal and the pericentral regions.

22 developed progressively severe perivascular, periportal, and hepatic parenchymal lesions consisting o

23 ive hepatitis characterized by perivascular, periportal, and parenchymal infiltrates of mononuclear a

24 eage stage cells into bile, flow back to the periportal area and regulate the stem cells and other ea

25 th of hepatic progenitor cells (HPCs) at the periportal area and subsequent development of HCCs.

26 ing on the injury, DR is confined within the periportal area or invades the parenchyma.

27 marked extension of the gradient towards the periportal area was observed, indicating that the increa

28 sociated with neutrophil infiltration at the periportal area.

29 cally transplanted cells were distributed in periportal areas (zone 1) in mice, whereas in larger ani

30 ucleus of the vagus, and peripherally to the periportal areas in the liver.

31 (+)/C/EBP-alpha(-) were shown to extend from periportal areas into the SPHC clusters, differentiating

32 genesis, and biliary hyperplasia occurred in periportal areas of Prox1-deficient livers.

33 mpaired Kupffer cell function, especially in periportal areas, where transplanted cells were localize

34 6-phosphatase and lesser glycogen content in periportal areas.

35 ellular apoptosis but triggered autophagy in periportal areas.

36 , while there was no transgene expression in periportal areas.

37 eactions within regions of rapidly expanding periportal biliary fibrosis.

38 P=0.016), with most of the difference due to periportal/bridging necrosis (P=0.009) and lobular activ

39 crophage numbers with massive infiltrates of periportal CCR2(+) macrophages that display a proinflamm

40 greater in perivenous hepatocytes; however, periportal cells rapidly acquired this facility in cultu

41 ia manifested by a increased number of small periportal cells.

42 infected with the G133E virus had increased periportal cellular proliferation and numerous lysed apo

43 ut in which K19 staining revealed widespread periportal CoH loss, a finding we termed "minimal change

44 eactions (P = 0.0004) and significantly less periportal collagen deposition (P = 0.0001) compared wit

45 HOX fetuses had greater hepatic periportal collagen deposition.

46 ress-related metabolites in association with periportal collagen.

47 l cell response and AFP gene expression than periportal damage.

48 Periportal deposition of mainly collagen I and mature el

49 adual reduction in activity in a pericentral-periportal direction.

50 2(mut) mice had elevated hepatic iron with a periportal distribution and increased plasma iron, trans

51 itoneal injection resulted in a preferential periportal distribution of human hepatocytes that produc

52 t mice was predominantly in hepatocytes in a periportal distribution.

53 rom cells derived from either intraportal or periportal ductules.

54 In ALF the periportal ECM was normal in 2 cases, contained mainly c

55 o decreased density in NAFLD), hepatomegaly, periportal edema, and ascites.

56 calized periportally, consistent with a high periportal energy demand.

57 The intrahepatic periportal expansion of the PROM1(pos) cell population,

58 n(+)ICAM2(+)osteopontin(+)type I collagen(+) periportal fibroblast tracts, acting as cognate anchorin

59 ciation between current infection status and periportal fibrosis (OR 5.38, 95% CI 2.03-14.25) but thi

60 rices among patients with S. mansoni related periportal fibrosis (PPF).

61 udwig-Batts stage 0); 10 had early portal or periportal fibrosis (stages 1 and 2); and 6, advanced fi

62 le hepatic steatosis to steatohepatitis with periportal fibrosis and biliary hyperplasia.

63 unter among patients with S. mansoni related periportal fibrosis and it is independently associated w

64 curs in the absence of ultrasound-detectable periportal fibrosis and may be due to immunological infl

65 ng patients with Schistosoma mansoni related periportal fibrosis at Bugando Medical Centre, in Mwanza

66 ext of repeated mass drug administration and periportal fibrosis attributable to chronic intestinal s

67 r since birth, were examined for evidence of periportal fibrosis by ultrasound using the Niamey proto

68 s was associated with a higher likelihood of periportal fibrosis compared with no current infection (

69 The specific pathways leading to periportal fibrosis in HIV-infected men with newly acqui

70 f current infection status was observed with periportal fibrosis in studies that used the Niamey prot

71 alities, ductal plate remodeling defects and periportal fibrosis in the liver.

72 Periportal fibrosis is a severe morbidity caused by both

73 n-producing PROM1pos cells within regions of periportal fibrosis is associated with activated FGF and

74 These results demonstrate that periportal fibrosis is associated with cytokine producti

75 on is highly endemic in parts of Uganda, and periportal fibrosis is common in communities along the s

76 rices among patients with S. mansoni related periportal fibrosis is still inadequate including Aspart

77 Periportal fibrosis likelihood linearly increased with a

78 1% and less than 5% were not correlated with periportal fibrosis likelihood or village prevalence.

79 ssociated with more than two-times increased periportal fibrosis likelihood.

80 tic cholestasis of pregnancy was followed by periportal fibrosis or cirrhosis in 4 sisters.

81 score (P < 0.0001), specifically, the portal/periportal fibrosis or greater fibrosis) (P < 0.01).

82 icant fibrosis (ie, F>=F2, centrilobular and periportal fibrosis or more severe disease) were estimat

83 iliary abnormalities and rapidly progressing periportal fibrosis reminiscent of human CHF.

84 risk factors that could be investigated for periportal fibrosis surveillance and management.

85 Periportal fibrosis was diagnosed in 2834 individuals ag

86 Periportal fibrosis was heterogeneously defined with the

87 The outcome of periportal fibrosis was recorded as reported by study au

88 cific effects such as severe hepatosplenism, periportal fibrosis with portal hypertension, and urogen

89 ansoni or S. japonicum associated with liver periportal fibrosis, does not apparently lead to maligna

90 ment of regenerative nodules and concomitant periportal fibrosis, inflammatory infiltration, and acti

91 nduces liver injury in fa/fa rats leading to periportal fibrosis.

92 and intensity against author-defined current periportal fibrosis.

93 1%) of 2834 participants were diagnosed with periportal fibrosis.

94 d between infection intensity categories and periportal fibrosis.

95 ion status is only tenuously associated with periportal fibrosis.

96 comorbidities were examined as exposures for periportal fibrosis.

97 entifying probable cases or communities with periportal fibrosis.

98 osoma japonicum, or Schistosoma mekongi with periportal fibrosis.

99 cent to ductular reactions within regions of periportal fibrosis.

100 th progressive cyst formation and associated periportal fibrosis.

101 iltration of inflammatory macrophages to the periportal fibrotic tissue and ductal epithelium.

102 nantly CD8+ T lymphocyte infiltration in the periportal fields and sinusoids.

103 AIH, characterized by lymphoplasmacytic and periportal hepatic infiltrates, autoantibodies, elevated

104 splantation, specifically the development of periportal hepatic steatosis apparently induced by the l

105 s of chronic hepatitis, including portal and periportal hepatitis with lymphocytes and plasma cells,

106 cases of acute hepatitis E showed portal and periportal hepatitis, with polarization of neutrophils t

107 All 32 livers had varying degrees of diffuse periportal hepatocellular hyperplasia with multifocal at

108 glucose intermediates was less severe in the periportal hepatocyte compartments.

109 s fats being metabolised more rapidly in the periportal hepatocyte compartments.

110 Periportal hepatocyte injury triggers local repair as we

111 tal triads and periportal zone (zone 1) with periportal hepatocyte necrosis.

112 in cell composition, with increases in both periportal hepatocytes and cholangiocyte populations.

113 inantly expressed in the plasma membranes of periportal hepatocytes and in the basolateral membranes

114 t mice results in metabolic reprogramming of periportal hepatocytes and induces clonal expansion in a

115 toplasmic inclusions with a predilection for periportal hepatocytes but sometimes present throughout

116 Pericentral and periportal hepatocytes exhibited the most significant ch

117 ile salt uptake along the acinus and protect periportal hepatocytes from harmful bile salt concentrat

118 patients with PBC, PDC-E2 mRNA was found in periportal hepatocytes in 16 of 17 cases (94%).

119 AAV-LK03 preferentially transduced periportal hepatocytes in normal liver, whereas AAV5 tar

120 shifts hepatic bile salt uptake from mainly periportal hepatocytes toward pericentral hepatocytes, t

121 1/1A2 levels in centrilobular, midzonal, and periportal hepatocytes were increased by 82%, 159%, and

122 In control liver, periportal hepatocytes were positive in 15 of 17 cases (

123 We found that a pre-existing population of periportal hepatocytes, located in the portal triads of

124 Periportal hepatocytes, proliferating bile ductules and

125 YP1A1/1A2 as do centrilobular, midzonal, and periportal hepatocytes, respectively.

126 ring the last few hours of the daily fast in periportal hepatocytes, the oxygen-rich zone of the live

127 ated metabolic functions from pericentral to periportal hepatocytes, which is orchestrated with the d

128 chrome P450 activity, which was deficient in periportal hepatocytes.

129 ion was observed to localize strictly to the periportal hepatocytes.

130 le duct BEC, canals of Hering, and immediate periportal hepatocytes.

131 al hepatocytes) and glutamine catabolism in (periportal) hepatocytes represents the high-affinity amm

132 Higher portal/periportal Hh-ligand production was associated with male

133 nflammatory microenvironment that stimulates periportal HPC expansion but arrests differentiation, wh

134 l that activated the beta-catenin pathway in periportal HPCs and was responsible for their expansion

135 diated activation of beta-catenin pathway in periportal HPCs is a previously unrecognized mechanism f

136 Periportal immune complex deposition may play an importa

137 t in 16% in both biopsies, limited to portal/periportal in 73% in the first biopsy, and 64% in the fi

138 Because periportal infiltration is a common feature in both IMT

139 This is manifested by increased periportal infiltrations, bile duct damage, granulomas a

140 there is lymphocytic liver infiltration with periportal inflammation analogous to the histological pr

141 examination of the liver at 10 days revealed periportal inflammation and fibrosis.

142 ate biliary hyperplasia and hypertrophy with periportal inflammation and fibrosis.

143 ient with FLUX-induced liver injury revealed periportal inflammation and the infiltration of cytotoxi

144 hatase, atypical ductular proliferation, and periportal inflammation compared with wild-type animals,

145 Portal/periportal inflammation was the same in all groups; howe

146 individual features of portal inflammation, periportal inflammation/piecemeal necrosis, lobular infl

147 ccompanying histologic evidence of increased periportal inflammatory infiltration.

148 ibuted to regeneration after pericentral and periportal injuries.

149 It identified periportal injury and fibrosis with an early peak and sl

150 hin 1 to 2 days after carcinogen exposure or periportal injury in the rat, but both type II and type

151 icentral injury with carbon tetrachloride or periportal injury with 3,5-diethoxycarbonyl-1,4-dihydroc

152 ntrilobular injury) with allyl alcohol (AA) (periportal injury), as well as in a bile duct ligation (

153 ve periductular stem cell, which responds to periportal injury, such as induced by allyl alcohol and

154 f the liver lobule into three hepatic zones: periportal, intermediate or midzonal, and perivenous.

155 phate synthetase I (CPS I) is present in the periportal, intermediate, and the first few layers of th

156 ast differentiation trajectory that dictates periportal, interzonal and pericentral human hepatocytes

157 tes reversal in mice due to the emergence of periportal islet-like cell clusters.

158 P-101 and CX-1 colon cancer cells adhered to periportal Kupffer cells, the CX-1 cells resulted in Kup

159 ify the identity and roles of injury-induced periportal LGR5+ cells.

160 Liver damage induces periportal LGR5+ putative liver stem cells that can form

161 Periportal liver damage, mortality rate, and liver injur

162 of non-cirrhotic portal hypertension due to periportal liver fibrosis or nodular regenerative hyperp

163 es LPLC gene expression in several models of periportal liver injury and impairs liver regeneration,

164 tocarcinogenesis in rats; and in response to periportal liver injury induced by allyl alcohol in rats

165 The cellular response to periportal liver injury, induced by phenobarbital feedin

166 the contributions of injury-induced LPLCs to periportal liver regeneration.

167 M caused extended apoptosis predominantly in periportal liver regions, indicating that NF-kappaB acti

168 lows from portal triads that are situated in periportal lobular regions to the central vein via a pol

169 A predominantly periportal location is specifically found in oral contra

170 e placed in pancreas (n = 5), liver (n = 7), periportal lymph nodes (n = 1), and gallbladder bed (n =

171 nut oil, but not C(8)/C(10) feeding, induced periportal macrovesicular steatosis in Sirt5KO mice.

172 cyl-CoA dehydrogenase (LCAD), also developed periportal macrovesicular steatosis when fed coconut oil

173 nted with the 2-AA/AA model suggest that the periportal matrix may be as important as the cells that

174 we demonstrate that a subpopulation of mouse periportal mesenchymal cells exerts dual control on prol

175 The liver consists of three zones, periportal, mid-lobular, and pericentral, and zone-speci

176 By day 6, regression of periportal MIP-101 tumor growth correlated with ingrowth

177 s macrovesicular steatosis and predominantly periportal mononuclear cell infiltration.

178 rse of infection demonstrated hepatitis with periportal mononuclear infiltrates, hepatocellular micro

179 SNAT5 shows a more periportal mRNA distribution than SNAT3 in rat liver, in

180 orrelated independently with increasing age, periportal necroinflammation, and ALT elevations but not

181 se levels, and those with the most extensive periportal necrosis on initial liver biopsy.

182 s associated with elevated serum bile acids, periportal necrosis, and increased serum alanine aminotr

183 the histological activity index (P =.007 for periportal necrosis,.001 for lobular necrosis, and.013 f

184 I cells, but most of the cells that span the periportal necrotic zone are type III hepatocyte-like ce

185 +) vein phenotype, associated with a loss of periportal Nestin(+)NG2(+) cells and emigration of HSCs

186 cells (Kupffer cells, endothelial cells and periportal nondescript cells) became evident 12 hours af

187 wed diffuse microvesicular steatosis, marked periportal nuclear glycogen, and variable portal fibrosi

188 ing, bile duct dilation, EHBD stricture, and periportal oedema were observed in the IBD-PSC group.

189 No immunoreactivity was identified in periportal or midzonal hepatocytes.

190 In the 10-y biopsies, periportal or pericentral fibrosis was observed in 253 p

191 fferentiated HCCs display mutually exclusive periportal or perivenous zonation programs.

192 Acetaminophen injury was followed by periportal oval cell accumulation displaying a moderate

193 overexpressing TWEAK in hepatocytes exhibit periportal oval cell hyperplasia.

194 trictly compartmentalized in liver in a wide periportal pattern and the last downstream perivenous he

195 tion, hepatocyte ballooning degeneration and periportal/perisinusoidal fibrosis.

196 egree of bile duct injury in all 7 patients; periportal/perivenular hepatocyte necrosis was seen in 6

197 e in hepatocyte susceptibility occurs in the periportal (PP) and/or perivenous (PV) zones in response

198 The portal/periportal (progenitor) compartment of prepubescent male

199 nts with BA demonstrate similar expansion of periportal PROM1pos cells with activated Mothers Against

200 recapitulates the architecture of the liver periportal region and, when manipulated, models aspects

201 terogeneous population: those located in the periportal region do not coexpress desmin or alpha smoot

202 t emerge only under injury conditions in the periportal region of the liver.

203 4% of the glucose formed from lactate in the periportal region of the lobule was taken up by the most

204 -Cre-expressing cells are present within the periportal region shortly after injury.

205 NTPDase2 was expressed in the periportal region surrounding intrahepatic bile ducts, w

206 ammonia, normally detoxified to urea in the periportal region under homeostasis, is redirected for g

207 Oval cells are found in the periportal region under some circumstances and may repre

208 decreased distribution of fibronectin in the periportal region was found at 5 minutes after partial h

209 decreased distribution of fibrinogen in the periportal region was found by 15 minutes and continued

210 Glycogen levels were reduced in the periportal region when IQGAP2 was deleted.

211 ound associated with small bile ducts in the periportal region, indicating that the duct-like structu

212 to the perisinusoidal space surrounding the periportal region.

213 that mimic the cellular interactions of the periportal region.

214 lar regions (carbon tetrachloride [CCl4]) or periportal regions (allyl alcohol [AA]).

215 s, which is restricted to few liver cells in periportal regions in PPARalpha-/- AOX-/- mice, suggests

216 g of hepatocytes was diffuse and occurred in periportal regions of hepatic acinus, whereas perivenous

217 In some mice, hepatocytes in the periportal regions of liver lobules were also positive,

218 esized that peroxynitrite formed in normoxic periportal regions of the liver lobule has its reactivit

219 is and injury, oval cells proliferate in the periportal regions of the portal tracts and are suggeste

220 Under these conditions, periportal regions were well oxygenated but pericentral

221 he APAP challenge dose from centrilobular to periportal regions where CYP2E1 is not found, protective

222 ally distinct; beta-oxidation is elevated in periportal regions, while lipid synthesis is predominant

223 oid resident immune cells concentrate around periportal regions.

224 resulted in accumulation of nitrotyrosine in periportal regions.

225 e portal region and then progresses into the periportal regions.

226 In female liver, a strong periportal signal also was observed that decreased in Zo

227 s-like lesion in two patients and an area of periportal soft-tissue infiltration in three; one patien

228 eveloped prominent perivenous steatosis with periportal sparing.

229 and may shed light into the pathogenesis of periportal steatosis, a hallmark of human pediatric non-

230 there is low-level expression of HGF mRNA by periportal stellate cells, and HGF protein localizes to

231 m single founder clones unique to individual periportal structures and locally supporting somatic hyp

232 ), is associated with a 1.7 fold decrease in periportal sympathetic innervation, a 5 fold decrease in

233 ineage stages from the stem cells in zone 1 (periportal), through the midacinar region (zone 2), to t

234 me expression by splitting the sinusoid into periportal to pericentral compartments.

235 n 2 shows a lobular gradient increasing from periportal to pericentral hepatocytes, claudin 3 is unif

236 ition of transplanted cells was shifted from periportal to perivenous areas by targeted hepatic ablat

237 eversed when transplanted cells shifted from periportal to perivenous areas.

238 ing components, especially beta2SP, from the periportal to the pericentral zone as regeneration nears

239 ual hepatocytes use independently configured periportal-to-CV gradients to exhibit lobule-location de

240 protein is detectable on hepatocytes, with a periportal-to-perivenular gradient, but not on BEC.

241 ion in hepatocytes gradually spread from the periportal toward the central areas by 7 days after PHx,

242 binding, and CATCs bind and rotate all five periportal triplexes, but notably only about one peri-pe

243 ntiated, nonproliferation subclasses, namely periportal-type (wild-type beta-catenin) and perivenous-

244 Also, we identified an eight-gene periportal-type HCC signature, which was independently a

245 The new periportal-type subclass represented 29% of all HCCs; ex

246 Among all HCCs, periportal-type tumors have the lowest intrinsic potenti

247 a model in which HSCs are titrated against a periportal vascular niche with a fractal-like organizati

248 creased SOX9 expression, and thinning of the periportal vascular smooth muscle cell (VSMC) layer, whi

249 NG2-expressing cells are a population of periportal vascular stem/progenitors (MLpvNG2(+) cells)

250 cinar position of either pericentral vein or periportal vein.

251 nal patterns of Hh-ligand production, portal/periportal versus lobular, were observed.

252 Firstly, the periportal zonation of both glycogen synthase and the ox

253 Secondly, the periportal zonation of the enzymes mediating beta-oxidat

254 ocytic infiltration of the portal triads and periportal zone (zone 1) with periportal hepatocyte necr

255 During homeostasis, cells from both periportal zone 1 and pericentral zone 3 contracted in n

256 During repair of the periportal zone, oval cells acquire differentiation mark

257 s that were restricted to hepatocytes in the periportal zone.

258 l (SEC) porosities were compared between the periportal (zone 1) and pericentral (zone 3) regions of