ライフサイエンスコーパス: perirhinal cortex

1 cies in inferior temporal visual area TE and perirhinal cortex).

2 uated the responses of neurons in high-level perirhinal cortex.

3 s in the contribution of the hippocampus and perirhinal cortex.

4 in basal ganglia and parietal, temporal, and perirhinal cortex.

5 er brain regions such as the hippocampus and perirhinal cortex.

6 presented configural stimuli depends on the perirhinal cortex.

7 d with a reduction in neural activity in the perirhinal cortex.

8 l of HD to assess synaptic plasticity in the perirhinal cortex.

9 amine receptors visualized in layer I of the perirhinal cortex.

10 s, anterior and posterior dentate gyrus, and perirhinal cortex.

11 h require glutamate receptor activity within perirhinal cortex.

12 ct structures, including the hippocampus and perirhinal cortex.

13 only modest connections with the rest of the perirhinal cortex.

14 ed in the hippocampus, entorhinal, or caudal perirhinal cortex.

15 merous in the rostral (polar) portion of the perirhinal cortex.

16 ortex has the strongest connections with the perirhinal cortex.

17 edial temporal lobe structure, including the perirhinal cortex.

18 cognitive tasks requiring the prefrontal and perirhinal cortex.

19 IL-1beta in the basolateral amygdala or the perirhinal cortex.

20 l topography at a fine-grained level in left perirhinal cortex.

21 arity effect for words was localized to left perirhinal cortex.

22 rade signalling mechanisms in LTD and LTP in perirhinal cortex.

23 model the projection from rat postrhinal to perirhinal cortex.

24 s been suggested between parahippocampal and perirhinal cortex.

25 ciation with large MTL lesions that included perirhinal cortex.

26 in basal ganglia and parietal, temporal, and perirhinal cortex.

27 In perirhinal cortex, a lasting decrement in neuronal respo

28 and facilitates long-term depression in the perirhinal cortex, a neural correlate of object recognit

29 Perirhinal cortex ablation has previously been shown onl

30 Subjects with perirhinal cortex ablation were severely impaired in new

31 The remaining 3 monkeys received bilateral perirhinal cortex ablation.

32 monkeys (Macaca fascicularis) with bilateral perirhinal cortex ablations were impaired relative to 3

33 Macaques with bilateral perirhinal cortex ablations were selectively impaired re

34 ne details; for example, in the locus of the perirhinal cortex activation.

35 Significantly, only perirhinal cortex activity is modulated by meaning varia

36 tions implemented across the hippocampus and perirhinal cortex, allowing formal rejection of a single

37 re given lesions of the rhinal cortex or the perirhinal cortex alone, and were then retested.

38 complement of VGF-expressing neurons in the perirhinal cortex, although endogenous neurotrophin-3 (N

39 n contrast, medial temporal lobe structures (perirhinal cortex, amygdala, hippocampus) and anterior i

40 iggered a switch in mechanisms of LTD in rat perirhinal cortex, an area critical for visual recogniti

41 projecting subiculum neurons also target the perirhinal cortex, an area strongly implicated in object

42 ern separation-related signals in DG/CA3 and perirhinal cortex and (2) source memory signals in poste

43 ory strength is nonlinear in hippocampus and perirhinal cortex and also distinctly different in those

44 h taste and olfactory cortical areas and the perirhinal cortex and appears to be involved in assessme

45 es, we recognize areas 35 and area 36 of the perirhinal cortex and area 36 contains five subdivisions

46 secondary somatosensory, retrosplenial, and perirhinal cortex and contralateral S1.

47 ial memory are typically associated with the perirhinal cortex and hippocampal formation, respectivel

48 The results suggest that, although the perirhinal cortex and hippocampus can be functionally di

49 In particular, the effects in entorhinal and perirhinal cortex and hippocampus might be important for

50 We conclude that perirhinal cortex and hippocampus participate in success

51 by greater across-item pattern similarity in perirhinal cortex and in parahippocampal cortex, but gre

52 hese findings reach beyond simple notions of perirhinal cortex and lateral entorhinal cortex neurons

53 Specifically, perirhinal cortex and lateral entorhinal cortex represen

54 gardless of subsequent memory, we found that perirhinal cortex and parahippocampal cortex exhibited d

55 e left entorhinal cortex, beginning with the perirhinal cortex and shifting through hippocampal subfi

56 vel had higher c-fos activity in the rostral perirhinal cortex and the lateral entorhinal cortex.

57 Outside the frontal cortex, the perirhinal cortex and the orbital prefrontal network are

58 anatomically conserved locations within the perirhinal cortex and the temporal pole.

59 ee MTL areas (hippocampus and entorhinal and perirhinal cortex) and visual area TE as monkeys perform

60 cortex, which shares features of the monkey perirhinal cortex, and a caudal region, the postrhinal c

61 levels of the ventral temporal neocortex or perirhinal cortex, and electron microscopic observations

62 Brain activity in the hippocampal region, perirhinal cortex, and parahippocampal cortex was associ

63 as for visual object representation, such as perirhinal cortex, and reward-guided learning, such as t

64 the entorhinal cortex, the hippocampus, the perirhinal cortex, and rostral parahippocampal cortex.

65 Thus, perirhinal cortex appeared to integrate timing informati

66 neuronal responses to associated stimuli in perirhinal cortex are altered over the course of learnin

67 e data indicate that behaviors requiring the perirhinal cortex are disrupted in advanced age, and sug

68 ding the hippocampus, entorhinal cortex, and perirhinal cortex are thought to be part of a unitary sy

69 (viz., ectorhinal cortex=Brodmann's area 36, perirhinal cortex=area 35, lateral entorhinal=area 28, a

70 In contrast, the connections of the perirhinal cortex (areas 35 and 36) indicated that the b

71 ort that bilateral, excitoxic lesions of the perirhinal cortex attenuate rats' familiarity-based stim

72 ents in the parahippocampal gyrus (BA27) and perirhinal cortex (BA36).

73 tion and establish a functional homology for perirhinal cortex between species, although we propose t

74 ced GAbeta accumulation in the subiculum and perirhinal cortex, both of which are brain regions requi

75 dial temporal lobe, especially involving the perirhinal cortex Brodmann area 36 and entorhinal cortex

76 eciprocally connected to parahippocampal and perirhinal cortex, but evidence for functional subregion

77 study: Patients with lesions, including the perirhinal cortex, but not patients with damage restrict

78 found that many neurons in both area TE and perirhinal cortex came to elicit more similar neuronal r

79 examined whether excitotoxic lesions of the perirhinal cortex can affect acquisition of a place-obje

80 The discovery that bilateral lesions of the perirhinal cortex can leave configural (structural) lear

81 ures other than the hippocampus, perhaps the perirhinal cortex, can support face recognition memory i

82 re is significantly more BDNF present in the perirhinal cortex compared with the occipital cortex in

83 AD-67 immunohistochemistry, we show that the perirhinal cortex contains GABAergic neurons with long-r

84 ancy by demonstrating that both pSTS and the perirhinal cortex contribute to crossmodal binding in hu

85 It has been suggested that the primate perirhinal cortex contributes exclusively to memory.

86 al (especially spatial) information, whereas perirhinal cortex contributes to and is necessary for fa

87 ch as at the level of an object and that the perirhinal cortex contributes to both memory and percept

88 t findings provide new insights into how the perirhinal cortex contributes to each: first, it contrib

89 perirhinal cortex, only damage to the caudal perirhinal cortex correlated significantly with recognit

90 Finally, activation in the perirhinal cortex correlated with successful associative

91 Reports that the extent of atrophy in perirhinal cortex correlated with the severity of impair

92 human lesion studies have demonstrated that perirhinal cortex damage impairs complex object discrimi

93 of the sensitivity of object recognition to perirhinal cortex damage is not the result of standard h

94 on of medial temporal lobe damage, including perirhinal cortex damage, to impaired semantic knowledge

95 The second factor was extent of perirhinal cortex damage.

96 te the object-recognition deficit seen after perirhinal cortex damage.

97 al atrophy, whereas SD patients have greater perirhinal cortex damage.

98 ections, the density of PHAL(+) axons in the perirhinal cortex decreased steeply with rostrocaudal di

99 not eCB-dependent signalling is important in perirhinal cortex-dependent visual recognition memory.

100 ceptor-mediated synaptic transmission within perirhinal cortex disrupted encoding for short- and long

101 There was no evidence that lesions of the perirhinal cortex disrupted the ability to learn the con

102 To investigate whether the perirhinal cortex does contribute to perception, we devi

103 sive to memory and conclude that the macaque perirhinal cortex does contribute to perception.

104 perception of places and paths, whereas the perirhinal cortex does so for objects and the contents o

105 obtained directly from human hippocampus and perirhinal cortex during a recognition paradigm and appl

106 receptor antagonist scopolamine into the rat perirhinal cortex during different stages (encoding, sto

107 cillations in the amygdala, hippocampus, and perirhinal cortex during this next-day memory test indic

108 tions of this region also suggested that the perirhinal cortex extends rostrodorsally to include the

109 esults further demonstrate the importance of perirhinal cortex for object recognition memory and sugg

110 the left posterior inferior frontal and left perirhinal cortex for words and objects, respectively, a

111 Tracing studies have revealed that the perirhinal cortex forms strong reciprocal connections wi

112 Bilateral lesions of the perirhinal cortex fully spared the capacity to make feat

113 d points to a need to refine those models of perirhinal cortex function that emphasize its role in re

114 ological study of age-related impairments in perirhinal cortex function.

115 ITI, ITR, and more ventral cortex, including perirhinal cortex (group ITR+), with visual learning in

116 efore, we reject the notion that the macaque perirhinal cortex has a role exclusive to memory and con

117 Because the rhinal (i.e., entorhinal and perirhinal) cortex has prominent reciprocal connections

118 Recent findings from the perirhinal cortex have shed new light on the ways in whi

119 ludes signals that are largely unique to the perirhinal cortex (i.e., object familiarity), consistent

120 Aspiration lesions of perirhinal cortex impaired performance with type (b) onl

121 ories and add more weight to the role of the perirhinal cortex in associative encoding of objects.

122 The role of the perirhinal cortex in discriminative eyeblink conditionin

123 providing novel evidence for the role of the perirhinal cortex in episodic intra-item encoding.

124 is study does not support a critical role of perirhinal cortex in learning for visual secondary reinf

125 anterograde amnesia, whereas the role of the perirhinal cortex in learning is dependent on the percep

126 Recent lesion studies have implicated the perirhinal cortex in learning that two objects are assoc

127 Perirhinal cortex in monkeys has been thought to be invo

128 These findings suggest a key role for the perirhinal cortex in representing and processing object-

129 n (including the entorhinal cortex), and the perirhinal cortex in two species of macaque monkey.

130 These results indicate an important role for perirhinal cortex in visual learning, memory, or both, a

131 results demonstrate a specific role for the perirhinal cortex in visual perception and establish a f

132 ractions between GluR2 and AP2 blocks LTD in perirhinal cortex in vitro.

133 s induced during whole-cell recording in rat perirhinal cortex in vitro.

134 100 Hz theta burst)-dependent LTP in the rat perirhinal cortex in vitro.

135 e identified regions in both hippocampus and perirhinal cortex in which activity varied as a function

136 A signal in the anterior MTL, including perirhinal cortex, indicated the successful retrieval of

137 gion for crossmodal perceptual features, and perirhinal cortex integrating these features into higher

138 e disease, and that the extent of atrophy in perirhinal cortex is a proxy for the overall severity of

139 by providing converging evidence that human perirhinal cortex is also critically involved in process

140 These findings suggest that the perirhinal cortex is at a higher level than the parahipp

141 The perirhinal cortex is critical for novelty detection, and

142 in monkeys and rats has established that the perirhinal cortex is critically involved in object- or s

143 The perirhinal cortex is directly connected to this system,

144 Synaptic plasticity in perirhinal cortex is essential for recognition memory.

145 The rat perirhinal cortex is heterogeneous in its efferent conne

146 The findings suggest that the perirhinal cortex is important for memory and not for pe

147 esults, the authors suggest that the role of perirhinal cortex is in "within-object" associations and

148 We argue that the perirhinal cortex is neither specialized for perception

149 and show that under a variety of conditions, perirhinal cortex is not critical for the identification

150 Previously it has been suggested that the perirhinal cortex is part of a pathway processing object

151 The perirhinal cortex is reciprocally connected with orbital

152 Our findings suggest that the perirhinal cortex is required for rats to encode familia

153 e fundus suggests that only this part of the perirhinal cortex is similar to area 35 of the primate b

154 Area 36c of the perirhinal cortex is the main interface between the peri

155 sked whether rhinal (that is, entorhinal and perirhinal) cortex is necessary to associate the visual

156 ated synaptic transmission (EPSC(KA) LTD) in perirhinal cortex layer II/III neurons that is distinct

157 Perirhinal cortex lesions also had no apparent effect on

158 In contrast, rats with perirhinal cortex lesions failed to benefit from increas

159 Perirhinal cortex lesions impaired encoding of objects a

160 The effects of perirhinal cortex lesions in rats on spatial memory migh

161 ir differential exploration times, rats with perirhinal cortex lesions showed very poor discriminatio

162 choose Object B, not Object A (A- vs. B+)." Perirhinal cortex lesions significantly impaired acquisi

163 The same rats with perirhinal cortex lesions were also unimpaired on a test

164 Rats with perirhinal cortex lesions were sequentially trained in a

165 Following bilateral perirhinal cortex lesions, rats continued to learn visua

166 ehavior has been observed in young rats with perirhinal cortex lesions.

167 is known to be sensitive to hippocampal and perirhinal cortex lesions.

168 Rats' perirhinal cortex, like monkeys', subserves object ident

169 nificant correlation was found between total perirhinal cortex loss and degree of recognition impairm

170 ies in macaque monkeys have implied that the perirhinal cortex may also contribute to object percepti

171 n supports the idea that the hippocampus and perirhinal cortex may be critical for the processing of

172 riments thus suggest that alterations in the perirhinal cortex may be responsible for reducing aged a

173 Rather, the cholinergic input to the perirhinal cortex may facilitate acquisition by enhancin

174 evidence to suggest that the hippocampus and perirhinal cortex may mediate processes beyond long-term

175 ocampal lesion studies and evidence that the perirhinal cortex may support object memory.

176 s important for learning and memory, such as perirhinal cortex, may be modifiable in adults.

177 studies suggest that at least one component-perirhinal cortex-might also contribute to perceptual pr

178 imental changes in the prefrontal cortex and perirhinal cortex occurred before metabolic syndrome or

179 thesis, we recorded from pairs of neurons in perirhinal cortex of macaques while they viewed multiple

180 We found that neurons in the perirhinal cortex of rats generate sustained firing patt

181 Local administration into perirhinal cortex of the nitric oxide synthase inhibitor

182 lity or interneuron loss was observed in the perirhinal cortex of these aged, memory-impaired monkeys

183 The perirhinal cortex, olfactory tubercle, and most subdivis

184 we tested the effects of DPFE infusions into perirhinal cortex on meth-seeking under two different te

185 Within the perirhinal cortex, only damage to the caudal perirhinal

186 eolus vulgaris-leucoagglutinin (PHAL) in the perirhinal cortex or adjacent temporal neocortex.

187 e on this task depends on area TE and not on perirhinal cortex or other medial temporal lobe structur

188 ion of short- and long-range inputs from the perirhinal cortex or temporal neocortex with perirhinal

189 ation of neurons and gliosis occurred in the perirhinal cortex or the hippocampus, with consequent sp

190 hen either received bilateral removal of the perirhinal cortex or were retained as unoperated control

191 anterior hippocampus, entorhinal cortex, and perirhinal cortex over the 30 s retention interval, with

192 t, activity in a different group of regions (perirhinal cortex, parahippocampal cortex, and inferior

193 fore and after this exposure, and found that perirhinal cortex, parahippocampal cortex, subiculum, CA

194 s share common features, suggesting that the perirhinal cortex participates in perceptual discriminat

195 Perirhinal cortex (PER) has a well established role in t

196 Perirhinal cortex (PER) has a well established role in t

197 role of the postrhinal cortex (POR) and the perirhinal cortex (PER) in processing relational or cont

198 The perirhinal cortex (PER) is known to process object infor

199 position that is comparable with that of the perirhinal cortex (PER) with regard to the lateral entor

200 The perirhinal cortex (PER), which is critical for associati

201 nation of the object recognition system (the perirhinal cortex) performs this critical function.

202 The perirhinal cortex plays a critical role in memory format

203 The perirhinal cortex plays a critical role in recognition a

204 The perirhinal cortex plays a key role in acquiring knowledg

205 ngs do not rule out the possibility that the perirhinal cortex plays a more general role in memory.

206 The results suggest that the perirhinal cortex plays a role in discriminative eyeblin

207 Whereas the perirhinal cortex plays an essential role in familiarity

208 n contrast, activity in both hippocampus and perirhinal cortex positively correlated with the subsequ

209 e studied in rat brain slices containing the perirhinal cortex (PR) and immediately adjacent lateral

210 The hippocampus and the perirhinal cortex (PR) are reciprocally connected both d

211 Recent work demonstrated the importance of perirhinal cortex (PR) in a variety of behavioral tasks

212 The polymodal input from the perirhinal cortex (PR) is a major informational gateway

213 Pretraining lesions of rat perirhinal cortex (PR) severely impair pavlovian fear co

214 Golgi-impregnated neurons from rat perirhinal cortex (PR) were classified into one of 15 di

215 la-fugal cortical areas: area TE2 and dorsal perirhinal cortex (PR), and moderate labeling in the lat

216 s activity in "persistent-firing" neurons of perirhinal cortex (PR).

217 the major white matter tracts converging on perirhinal cortex (PrC) and hippocampus (HC) would be di

218 edial temporal lobe (MTL), in particular the perirhinal cortex (PrC) and hippocampus (HC), are best c

219 l clusters evoked by acoustic stimuli in the perirhinal cortex (PRC) and in AC of freely behaving mal

220 merous studies support the importance of the perirhinal cortex (PRC) and parahippocampal cortex (PHC)

221 pal region are functionally divided into the perirhinal cortex (PRC) and the lateral entorhinal corte

222 emporal lobe cortex (MTLC), most notably the perirhinal cortex (PrC) and the parahippocampal cortex (

223 The perirhinal cortex (PRC) composed of areas 35 and 36 form

224 is well established that the hippocampus and perirhinal cortex (PrC) encode associative and item repr

225 with the aim of elucidating the role of the perirhinal cortex (PRC) in recognition memory.

226 The perirhinal cortex (PRc) is essential for visual recognit

227 The perirhinal cortex (PRC) is proposed to both represent hi

228 Although it is well established that the perirhinal cortex (PRC) makes an important contribution

229 s from each sensory stream are integrated in perirhinal cortex (PRc) of the anteromedial temporal lob

230 basis of episodic recollection, whereas the perirhinal cortex (PRc) supports familiarity for individ

231 Specifically, it remains unclear whether perirhinal cortex (PrC) supports item-based familiarity

232 subregions that connect differentially with perirhinal cortex (PRC) vs parahippocampal cortex (PHC)

233 elated fMRI to address the role of the human perirhinal cortex (PRC), and its interactions with the h

234 For instance, it has been proposed that perirhinal cortex (PRC), parahippocampal cortex (PHC), a

235 MTL), in particular the hippocampus (HC) and perirhinal cortex (PrC), play domain-sensitive roles in

236 TEd projects primarily to perirhinal cortex (PRC), which in turn projects to later

237 Here, we demonstrate that the perirhinal cortex (PRc), within the MTL, plays a role in

238 nds the contributions of the hippocampus and perirhinal cortex (PrC).

239 In contrast, encoding activation in perirhinal cortex predicted later item recognition, but

240 induced pattern effects in orbitofrontal and perirhinal cortex predicted the magnitude of categorical

241 ns of the left hippocampus, and in bilateral perirhinal cortex, predicted subsequent accuracy on the

242 demonstrate that the level of engagement of perirhinal cortex predicts later memory for individual i

243 The perirhinal cortex (PRh) and basolateral amygdala (BLA) a

244 responses in inferotemporal cortex (IT) and perirhinal cortex (PRH) as macaque monkeys performed a d

245 responses in inferotemporal cortex (IT) and perirhinal cortex (PRH) as macaque monkeys performed a t

246 Damage to perirhinal cortex (PRh) impairs object recognition memor

247 Perirhinal cortex (PRh) is strongly implicated in neuron

248 The perirhinal cortex (PRh) is widely accepted as having an

249 egions of AAC, such as temporal areas TE3 or perirhinal cortex (PRh), and quantitative analyses were

250 Microinjections into AMG and perirhinal cortex (PRh), which are not implicated in AGS

251 Projections to the perirhinal cortex primarily targeted the superficial lay

252 The perirhinal cortex processes aspects of recognition memor

253 Importantly, lesions of the perirhinal cortex produce similar deficits and also lead

254 Viral transduction of this peptide in perirhinal cortex produced striking deficits in visual r

255 Area 36 of the perirhinal cortex projects preferentially to areas TE an

256 The rostral portion of the perirhinal cortex receives strong projections from the m

257 Perirhinal cortex removal reduced the contribution of on

258 The reduced inhibition in the perirhinal cortex reported here could contribute to this

259 nhuman primates, and humans suggest that the perirhinal cortex represents information about objects f

260 Long-term depression (LTD) in perirhinal cortex requires group I, group II and NMDA re

261 Infusion of DPFE into perirhinal cortex restored novel object recognition in l

262 s been implicated in spatial memory, whereas perirhinal cortex seems critical for object memory.

263 structures: subiculum, entorhinal cortex and perirhinal cortex, septum, and olfactory system in the i

264 Lesions of the perirhinal cortex severely impaired acquisition of simul

265 Parahippocampal and perirhinal cortex showed different pattern information p

266 m one item presentation to the next, whereas perirhinal cortex signaled the conjunction of items and

267 Anatomically, the perirhinal cortex sits at the boundary between the media

268 Furthermore, there was a deficit of LTD in perirhinal cortex slices from virally transduced, recogn

269 In support of this, we demonstrate in perirhinal cortex slices that blocking mechanisms underl

270 chniques to provide strong evidence that the perirhinal cortex subserves perception and suggests that

271 e medial temporal lobe (MTL)--in particular, perirhinal cortex--support not just memory but certain k

272 the alERC as an extension of the neighboring perirhinal cortex, supporting object memory.

273 supports recollection and that the adjacent perirhinal cortex supports familiarity.

274 Specifically, it has been suggested that the perirhinal cortex supports the perceptual abilities need

275 these two retrograde signalling cascades in perirhinal cortex synaptic plasticity and in visual reco

276 a form of long-term depression (LTD) in the perirhinal cortex that relies on interaction between dif

277 ng neurons were also observed in the insular/perirhinal cortex, the ventromedial/ventrolateral thalam

278 The precise contribution of perirhinal cortex to human episodic memory is uncertain.

279 ll have to extend beyond the hippocampus and perirhinal cortex to incorporate a wider network of cort

280 n damage have revealed the importance of the perirhinal cortex to object recognition memory.

281 s in prefrontal, amygdaloid, entorhinal, and perirhinal cortex, to which there are few projections fr

282 uman memory: whether the hippocampus and the perirhinal cortex, two key components of the medial temp

283 rocess critical for the expression of LTD in perirhinal cortex, underlies visual recognition memory.

284 ne transfer to these postsynaptic neurons in perirhinal cortex used a His tag antibody, as the peptid

285 activation of amygdaloid nuclei, the ventral perirhinal cortex (vPRh), and several other brain areas

286 ccelerated function and that activity in the perirhinal cortex was associated with a statistically di

287 on that consolidated the sound-light memory (perirhinal cortex) was inhibited during formation of the

288 In synapses in the perirhinal cortex, we have directly compared the Ca(2+)

289 iments, rats with excitotoxic lesions of the perirhinal cortex were found to be indistinguishable fro

290 The differential efferent projections of the perirhinal cortex were traced by using anterograde and r

291 ns bilaterally in hippocampus, as well as in perirhinal cortex, where activity during learning increa

292 These forms of LTD occur in the perirhinal cortex, where long-term decreases in neuronal

293 ted match and mismatch signals in the monkey perirhinal cortex, where match signals were selective fo

294 ject location memory, but was reduced in the perirhinal cortex, which corresponds to impaired long-te

295 ted intrinsic functional connectivity of the perirhinal cortex, which is typically the first brain re

296 nterior medial temporal lobes, including the perirhinal cortex, which serve to integrate complex obje

297 at can be divided into a rostral region, the perirhinal cortex, which shares features of the monkey p

298 c information is uniquely represented in the perirhinal cortex, which was also increasingly engaged f

299 dy highlights the critical importance of the perirhinal cortex within the temporal lobe for recogniti

300 t addressed whether selective lesions of the perirhinal cortex would result in a delay-dependent defi