ライフサイエンスコーパス: perivascular cell

1 activity of fresh, adult CNS parenchymal and perivascular cells.

2 of microglia and has little or no effect on perivascular cells.

3 nditions, including an adipocytic skewing of perivascular cells.

4 rometastatic neural/glial antigen 2 (NG2)(+) perivascular cells.

5 ing the quiescence and activation of uterine perivascular cells.

6 culture, are themselves derived in part from perivascular cells.

7 ed from both endothelial and Lepr-expressing perivascular cells.

8 including lumen formation and recruitment of perivascular cells.

9 rise to interstitial cardiac fibroblasts and perivascular cells.

10 ies implicating osteoblasts, endothelial and perivascular cells.

11 ently due to the insufficient recruitment of perivascular cells.

12 ires a ready source of endothelial cells and perivascular cells.

13 adjacent to lumens, confirming their role as perivascular cells.

14 In the absence of Arf, perivascular cells accumulate within the HVS and prevent

15 We show that a Nestin-Cre transgene targets perivascular cells (adventitial cells and pericyte-like

16 malian cardiomyocytes, is sharply induced in perivascular cells after injury to the adult zebrafish h

17 e skeletal stromal lineages, endothelial and perivascular cells also expressed GNAS c.602G>A and c.60

18 Knockout of Oct4 in perivascular cells also impairs perfusion recovery and d

19 f the remaining vasculature by enhancing the perivascular cell and basement membrane coverage.

20 helium through co-seeding of endothelial and perivascular cells and a two-phase culture protocol.

21 how that CD146 is expressed in both PDGFRB + perivascular cells and CD31 + endothelial cells.

22 y produced by sphingosine kinase 2 in kidney perivascular cells and exported via spinster homolog 2 (

23 rain barrier and was found in brain vessels, perivascular cells and in brain parenchyma 30 min after

24 of HO-1 immunoreactivity in CD163-expressing perivascular cells and infiltrating monocytes/macrophage

25 Ang1 is constitutively produced by perivascular cells and is protective of the adult vascul

26 f gp41 and iNOS was present predominantly in perivascular cells and most often in the basal ganglia.

27 ion site, meninges surrounding the brain and perivascular cells and neuron-like cells throughout the

28 606,380 freshly isolated endothelial cells, perivascular cells and other tissue-derived cells from 1

29 ocyte survival or proliferation; a supply of perivascular cells and possibly other cell types such as

30 CTGF activated bone marrow-derived perivascular cells and promoted fibrovascular membrane f

31 sion of kidney fibrosis using primary kidney perivascular cells and several conditional mouse models.

32 nd differentiate tumor vessels from both the perivascular cells and the matrix.

33 The crosstalk between perivascular cells and tubular epithelial, immune and en

34 eport a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TA

35 fibroblasts in the three layers of meninges, perivascular cells, and ependymocytes and in a populatio

36 rupted co-localization of ECs with desmin(+) perivascular cells, and reduction of blood flow primaril

37 losa cells, immune cells, endothelial cells, perivascular cells, and stromal cells.

38 tional vessels, a reduced vessel coverage by perivascular cells, and were more necrotic.

39 ium and their cognate receptors expressed on perivascular cells are involved in blood vessel maturati

40 lete loss of mature osteoblastic cells while perivascular cells are maintained.

41 vo organ culture methods, we determined that perivascular cells are multipotent progenitors that cont

42 Moreover, perivascular cells are now recognized as major innate im

43 tracing assays in mice to identify Nestin(+) perivascular cells as active contributors to re-epitheli

44 These results identify perivascular cells as fibro/adipogenic progenitors in WA

45 COX-2 was induced in endothelial cells, perivascular cells as well as infiltrating leukocytes 1

46 ested the ability of purified human CD146(+) perivascular cells, as compared with unfractionated MSCs

47 Later, vascular and perivascular cells associated with smaller penetrating b

48 type I collagen and Dspp gene expression in perivascular cells associated with the pulp stones.

49 obust expression of COX2 mRNA was induced in perivascular cells between 45 min and 6 h after LPS inje

50 In perivascular cells, bone morphogenetic protein (BMP) is

51 g bone remodeling originate from bone marrow perivascular cells, bone remodeling compartment canopy c

52 ult tcf21(+) cells revealed contributions to perivascular cells, but not cardiomyocytes, during each

53 Cathepsin K was localized to some perivascular cells by in situ hybridization.

54 A subset of kidney perivascular cells can also produce and secrete erythrop

55 Activation of PDGFRalpha signaling in perivascular cells causes them to transition into ECM-sy

56 via NOTCH3, a known mediator of endothelial-perivascular cell communication.

57 adult organ at 3 mo of age, these NC-derived perivascular cells continue to be associated with the va

58 r to normal perivascular cells, hMSC-derived perivascular cells contracted in response to endothelin-

59 In the pathophysiological state, kidney perivascular cells contribute to the progression of kidn

60 niche, including its sinusoidal vessels and perivascular cells, contributing to delayed hematopoieti

61 traparenchymal cells that networked with the perivascular cells coursing in the sheaths of adjacent b

62 cediranib treatment induced normalization of perivascular cell coverage and thinning of the basement

63 not change the functional vessel density and perivascular cell coverage in both tumor variants.

64 gration of mural cells in vitro and improved perivascular cell coverage in vivo.

65 c vascular network likely via regulating the perivascular cell coverage of the vessels thus affecting

66 impaired lymphatic vessel function, enhanced perivascular cell coverage, and abnormal lymphatic vesse

67 decreased alpha-smooth muscle actin-positive perivascular cell coverage.

68 h infrequent vascular branches and increased perivascular cell coverage.

69 lesions CCR1+/CCR5+ monocytes were found in perivascular cell cuffs and at the demyelinating edges o

70 pairs perivascular cell migration, increases perivascular cell death, delays endothelial cell migrati

71 Genetic inactivation of Klf4 in perivascular cells decreased formation of a pre-metastat

72 companied by increased vascular diameter and perivascular cell density.

73 with human cells, including endothelial and perivascular cells derived from induced pluripotent stem

74 ols, whereas the frequency of CXCR4-positive perivascular cells did not correlate with disease severi

75 ular tissue engineering and for the study of perivascular cell differentiation.

76 with arteriovenous segmentation and expanded perivascular cell diversity.

77 The origin of these scars is thought to be perivascular cells entering lesions on ingrowing blood v

78 We conclude that perivascular cells exhibit the lower threshold to COX-2

79 Moreover, CD146(+) perivascular cells express, natively and in culture, mol

80 Perivascular cells expressing phosphorylated PDGFR-beta

81 atopoietic stem cells is present in CD146(+) perivascular cells extracted from the nonhematopoietic a

82 variants in driving arterial endothelium and perivascular cell fates during early vascular developmen

83 form for profiling human cerebrovascular and perivascular cells for paired transcriptomic and epigeno

84 discussion, and current consensus holds that perivascular cells form mesenchymal stem cells in most t

85 These perivascular cells have crucial roles in preserving kidn

86 Similar to normal perivascular cells, hMSC-derived perivascular cells cont

87 Perivascular cells, however, quickly resumed proliferati

88 To enhance the recruitment of perivascular cells, human umbilical vein endothelial cel

89 deletion from vascular endothelial, but not perivascular, cells impeded tumor growth, suggesting a v

90 Notch signaling maintains Nestin(+) perivascular cells in a quiescent state, but these cells

91 ere, we examine the multiple roles of kidney perivascular cells in health and disease, focusing on th

92 nce that Oct4 plays an essential role within perivascular cells in injury- and hypoxia-induced angiog

93 Oct4 in cultured SMCs, and in Oct4-deficient perivascular cells in ischemic hindlimb muscle.

94 Zyme is immunolocalized to perivascular cells in monkey cortex and the AD brain.

95 uted throughout the BM, and on pericytes and perivascular cells in multiple organs.

96 in capillary and artery numbers, but not of perivascular cells in pancreas, testis and thyroid gland

97 revealed a previously unidentified role for perivascular cells in pre-metastatic niche formation and

98 expressed at enhanced levels in vascular and perivascular cells in scleroderma skin samples.

99 arization of neural crest cell (NCC)-derived perivascular cells in the brain, autophagy in the retina

100 The role of prostaglandins produced by these perivascular cells in the cerebral components of the acu

101 ad activation of macrophages, microglia, and perivascular cells in the CNS are held in check.

102 ss is known about the origin and turnover of perivascular cells in the human central nervous system.

103 Cell, Kramann et al. (2016) show that Gli1+ perivascular cells in the outermost vessel layer are pro

104 lineage-tracing models to trace the fate of perivascular cells in the pre-metastatic and metastatic

105 ocumented the role of local S1P signaling in perivascular cells in the progression of kidney fibrosis

106 ass II (OX3) molecules was detected in a few perivascular cells in the retina of chimeric rats treate

107 utative glial cells in the soma clusters and perivascular cells in the walls of arterioles.

108 izations and interaction patterns of ECs and perivascular cells in these regions.

109 ammatory signaling in human and mouse kidney perivascular cells in vitro and amelioration of kidney f

110 we use a developmental model to investigate perivascular cells in white adipose tissue (WAT) and the

111 r differences in endothelial cells (ECs) and perivascular cells, including astrocytes, pericytes and

112 Perivascular cells, including vascular smooth muscle cel

113 lecular specializations in ECs and unique EC-perivascular cell interactions contribute to BBB functio

114 leaky blood vessels, disrupted endothelium - perivascular cell interactions, endothelial cell vacuoli

115 creased the recruitment and incorporation of perivascular cells into tumor blood vessels and increase

116 Pericytes, perivascular cells involved in microvascular function, e

117 analyses predict substantial endothelial-to-perivascular cell ligand-receptor cross-talk, including

118 identified candidate regionally enriched EC-perivascular cell ligand-receptor pairs.

119 Presumptive perivascular cells lining large blood vessels had extrem

120 Pericytes are perivascular cells localized to capillaries that promote

121 We show that perivascular cells lose the expression of traditional vS

122 us remodeling, arterial differentiation, and perivascular cell maturation.

123 In the HVS, Arf expression in perivascular cells may block their accumulation or repre

124 pericytes (also defined as mural, Rouget, or perivascular cells) may play during angiogenesis, vascul

125 ibrotic collagen to test the hypothesis that perivascular cells mediate the response of vascular capi

126 Our analysis also reveals that perivascular cells migrate into the gonad from the meson

127 (SMC-P) knockout of Oct4 that Oct4 regulates perivascular cell migration and recruitment during angio

128 in perivascular cells significantly impairs perivascular cell migration, increases perivascular cell

129 ues and protein delivery into nonendothelium perivascular cells, neurons, and astrocytes within 2 d o

130 of stromal fibroblasts (PDGFRa+) and stromal perivascular cells (NG2/CSPG4+).

131 Cells captured by DDX4 antibody are perivascular cells, not oogonial stem cells.

132 mice, CTGF was prominently expressed in the perivascular cells of arteries.

133 stry demonstrated increased TGF-beta1 in the perivascular cells of AVMs compared to normal controls,

134 ctivity and synthesis of prostaglandin E2 by perivascular cells of the cerebral vasculature.

135 emaphorin receptor Nrp-1 is expressed on the perivascular cells of the collecting lymphatic vessels.

136 pothalamus, cyclooxygenase-2 fluorescence in perivascular cells of the paraventricular nucleus of hyp

137 Importantly, PDGFRs were expressed only in perivascular cells of this tumor type, suggesting that P

138 Our results demonstrate that perivascular cells, particularly SMCs, are a susceptible

139 The contractile perivascular cells, pericytes (PC), are hijacked by glio

140 )CD90(+) mesenchymal cells, CD146(+)CD271(+) perivascular cells, podoplanin(+)CD36(+) stromal cells,

141 ent is the reduction of both endothelial and perivascular cell populations.

142 In conclusion, hMSCs are perivascular cell precursors and may serve as an attract

143 y gene Klf4 in these phenotypically switched perivascular cells promoted a less differentiated state,

144 of coronary veins, while HH signaling to the perivascular cell (PVC) is necessary for coronary arteri

145 A small population of cells with perivascular cell (PVC)-like properties was found.

146 GE(2)) synthesis by endothelial (ECs) and/or perivascular cells (PVCs) (a macrophage-derived vascular

147 r cell types, endothelial cells (ECs) versus perivascular cells (PVCs; a subset of brain-resident mac

148 fibrotic collagen had abnormal migration of perivascular cells, reduced pericyte differentiation, in

149 This study was conducted to determine the perivascular cell responses to increased endothelial cel

150 naling in cardiac myocytes, as compared with perivascular cells, resulting in excessive coronary arte

151 ndothelia and differential interactions with perivascular cells seeded in the collagen bulk; and we d

152 dent signals and prevent the accumulation of perivascular cells selectively in a vascular bed destine

153 In adult mouse bone marrow, perivascular cells shape a "niche" for HSPCs.

154 Knockout of Oct4 in perivascular cells significantly impairs perivascular ce

155 either with endothelial cells alone or with perivascular cells silenced for NOTCH3 expression showed

156 of perivascular cells, we hypothesized that perivascular cells similarly regulate tumor cell fate at

157 We used perivascular-cell-specific and pericyte-specific lineage

158 iverse array of mesenchymal cells, including perivascular cells, stromal progenitor cells and bona fi

159 Perivascular cells such as macrophages and mast cells th

160 These findings demonstrate that perivascular cells support re-epithelialization and reve

161 CD146(+) perivascular cells support the long-term persistence, th

162 dominantly present in stromal, vascular, and perivascular cells surrounding nests of tumor cells.

163 althy animals at homeostasis and to identify perivascular cells that could be unique to nonlymphoid o

164 e identify a subpopulation of NG2(+)Runx1(+) perivascular cells that display a sclerotome-derived vSM

165 However, extrinsic factors from these perivascular cells that regulate barrier integrity are l

166 Transducing the Shh signal is a perivascular cell-the pericyte-rather than the more inte

167 we found that Scf was primarily expressed by perivascular cells throughout the bone marrow.

168 hese results demonstrate that signaling from perivascular cells to endothelial cells via ligand-recep

169 It bound to S1P1 expressed in perivascular cells to enhance production of proinflammat

170 his study was to examine the contribution of perivascular cells to odontoblasts during the developmen

171 Sox10(+) stem cells could differentiate into perivascular cells to stabilize newly formed microvessel

172 ontribution of mesenchymal cells, especially perivascular cells, to ovarian development is poorly und

173 er, we suggest a functional role for SPP1 in perivascular cells-to-microglia crosstalk, whereby SPP1

174 ptoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capilla

175 he fetal ovary, which is a Nestin-expressing perivascular cell type.

176 (VINE-seq) to profile the major vascular and perivascular cell types of the human brain through 143,7

177 on, which have also been attributed to other perivascular cell types such as pericytes and vascular s

178 nowledge of the location and identity of CNS perivascular cell types, with a particular focus on CNS

179 owth factor) expression, particularly within perivascular cell types.

180 of smooth muscle cells, pericytes, and other perivascular cells warrant continued investigation.

181 me cases, colocalization of HDMEC with mouse perivascular cells was observed.

182 Given the well-described plasticity of perivascular cells, we hypothesized that perivascular ce

183 smooth muscle cells (HSVSMCs) as a source of perivascular cells, were combined in Matrigel and implan

184 differentiation antigen, identifying them as perivascular cells, whereas none coexpressed endothelial

185 lood barrier also includes a large number of perivascular cells with both macrophage and melanocyte c

186 ent a unique subtype of microvessel-residing perivascular cells with diverse angiogenic functions and

187 Lineage tracing of perivascular cells with inducible PDGFRB and NG2 Cre mou

188 in the kidney detected evident expression in perivascular cells, with negligible expression in the en

189 Pericytes are perivascular cells within the brain that are proposed as

190 liposomes accumulated in a subpopulation of perivascular cells within the brain.

191 representation of fibroblasts within LA and perivascular cells within the left heart relative to NF

192 Arf was selectively expressed in perivascular cells within the vitreous of the postnatal

193 f cells (endothelial cells, ablumenal cells, perivascular cells) within the inner retina; however, th