ライフサイエンスコーパス: permanently

1 o halt or exit the cell cycle temporarily or permanently.

2 ogies that prevent content from being stored permanently.

3 thyroid function of neonates transiently or permanently.

4 ibers without affecting absolute sensitivity permanently.

5 maculopathies that can reduce central vision permanently.

6 s in which the investigated molecule changes permanently.

7 ional high-frequency DBS (cDBS) is delivered permanently.

8 ergoing intubation elected to keep the stent permanently; 34% (n = 22) had an eyelid-tightening proce

9 leaking gas several decades after they were permanently abandoned.

10 ovide evidence that premature birth leads to permanently aberrant gyrification patterns suggesting an

11 protein product of the gene, which is either permanently abrogated or depleted at a rate defined by t

12 The original data will be easily and permanently accessible via the University of Cambridge d

13 shape change, the CAN structure responds by permanently adjusting its structure through either rever

14 s immune function later in life, which could permanently affect brain function and have implications

15 Permanently affecting one in seven adults, tinnitus lack

16 t developmental chronic circadian disruption permanently affects somatic and behavioral development i

17 atwaves have the potential to temporarily or permanently alter community structure with effects on bi

18 n, and that a history of stress exposure can permanently alter gene expression patterns in the hippoc

19 g of estrogen signaling has the potential to permanently alter ovarian organization and function.

20 rgeted biochemical modifications that do not permanently alter the DNA sequence (epigenome editing) m

21 anthropogenic inputs to natural systems may permanently alter the natural signatures of REE, motivat

22 aintained, and the program structure will be permanently altered as a lasting effect of this pandemic

23 Permanently altered DAergic function as a consequence of

24 terrestrial chemical weathering flux may be permanently altered--contrasting with the conventional v

25 and degree of hepatocyte polyploidy without permanently altering levels of ANLN.

26 placement may occur after natural disasters, permanently altering the demographic composition of the

27 xpanding network of roads into the Amazon is permanently altering the world's largest tropical forest

28 exposure can disrupt developmental programs, permanently altering tissues with impacts lasting into a

29 ormation, and a single course of antibiotics permanently alters CCM susceptibility in mice.

30 Pregnancy permanently alters maternal anatomy, physiology and immu

31 ut primary amino groups [R-NH2 ] and becomes permanently anchored via a tetrahedral iminosulfur(VI) l

32 lunatalensis is able to keep several diatoms permanently and exhibits unique dynamics to maintain the

33 unity structure and functional properties in permanently and seasonally flooded areas are lacking.

34 used by the nitrogen differences between the permanently and seasonally flooded areas caused by intra

35 tructure and nitrogen metabolic processes in permanently and seasonally flooded areas caused by water

36 probe that exposes its cryptic docking site permanently and thus integrates force history over time,

37 her the selfie was shared temporarily versus permanently) and are instead driven by the disinhibition

38 organs such as the heart because DNA damage permanently arrests cardiomyocyte proliferation shortly

39 assembly, and a state in which the system is permanently assembled.

40 All 45 subjects lived permanently at 3200-4000 m.

41 5 and 8.5, but two leaks did not self-repair permanently at pH 11.0 suggesting that water chemistry m

42 aspartates in the C2A-domain localizes Doc2B permanently at the plasma membrane, and renders an upstr

43 Cells remain permanently attached following mitosis, giving rise to c

44 an overdamped membrane pinned by an elastic, permanently attached spring subject to thermal excitatio

45 pe specimens to which the name of a taxon is permanently attached.

46 there is evidence that MP can temporarily or permanently be inhibited from migrating downstream by re

47 the Oligocene (27 Mya), all parts of the JMM permanently became part of the Eurasian plate following

48 arctic clam Laternula elliptica lives almost permanently below 0 degrees C and therefore is a valuabl

49 Research in permanently blind individuals has revealed brain reorgan

50 ly to what has been observed in congenitally permanently blind individuals.

51 actions, the unpaired cysteine-34 of HSA was permanently blocked by iodoacetamide and the primary ami

52 promote killing; and 3) surfaces containing permanently bonded agents that generate antimicrobial su

53 f cement proteins (CPs) that organize into a permanently bonded layer displayed as nanoscale fibers.

54 e is typically a monolithic integration that permanently bonds acoustic transducers with microfluidic

55 antification is the separation of labile and permanently bound heme and its high aggregation potentia

56 it functions like a GIRK4 subunit with Na(+) permanently bound.

57 the host dinoflagellates retain the diatoms permanently by controlling diatom karyokinesis.

58 tions of metallic drug-eluting stents, which permanently cage the vessel wall, thereby preventing nor

59 als can temporarily be carried off course or permanently carried away from their preferred habitat by

60 Transient movements of these permanently charged arginines, caused by the change of t

61 We made a permanently charged cationic derivative of an N-type cal

62 g to secondary interactions of the analytes' permanently charged quaternary ammonium head or hydropho

63 Hofmeister effects in Ca2+/Na+ exchange on a permanently charged surface over a wide range of ionic s

64 DAD is not permanently charged, and the uncharged form enables the

65 Both trials were permanently closed.

66 Ladahk were among the last habitable places permanently colonized by prehistoric humans due to the c

67 GFP(+)) cells in the Tri-PyMT model were not permanently committed to the mesenchymal phenotype; they

68 Sensory deprivation during these periods permanently compromises an organism's ability to perceiv

69 ypothesise that this loss was due in part to permanently condensed chromosomes and repeat-rich sequen

70 he results show that K4Nb6O17 nanolamina can permanently confine the toxic cations within the interla

71 offs evolve, and whether they transiently or permanently constrain virus adaptation.

72 In contrast, EPCS permanently controlled bleeding in 97% and 100% of the p

73 f this technology is that genome editing can permanently correct disease-causing mutations and circum

74 Here we develop a genome editing approach to permanently correct these genetic defects, using a singl

75 y and community composition of fungi in five permanently covered lake basins located in the Taylor an

76 uses of IDA, 64% to 75% of such patients are permanently cured by H pylori eradication.

77 pect this patient's hypoparathyroidism to be permanently cured.

78 etching across its thickness, resulting in a permanently curved shape.

79 H) can lead to fibrosis and cirrhosis, which permanently damage the liver.

80 or T cell production can be dramatically and permanently damaged after a single relatively low TBI do

81 marrow stroma cells (BMSCs) are severely and permanently damaged by the pre-conditioning irradiation

82 orter than drought recovery time, leading to permanently damaged ecosystems and widespread degradatio

83 tress by locking damaged exocrine cells in a permanently de-differentiated state.

84 impurities cause these catalyst particles to permanently deactivate.

85 onal population or an individual neuron), is permanently dedicated to mediate only one affective func

86 We show that amorphous aluminum oxide can permanently deform without fracture at room temperature

87 le terrestrial locomotors often contend with permanently deformable substrates like sand, soil, and m

88 nesis suggest, respectively, that MM-MSC are permanently dependent of tumor cells, might contribute t

89 currently with peptide self-assembly without permanently destroying the hydrogel's architecture and r

90 Covalent capture of oxidized PTP1B could permanently disable the intracellular pool of enzyme inv

91 diac arrest (CA) coma are expected to remain permanently disabled.

92 s largely non-preventable and often kills or permanently disables its victims.

93 emble into large multi-mRNP assemblies or be permanently disassembled and degraded.

94 ts had temporary dose modifications, and 17% permanently discontinued all three study drugs due to TR

95 ts met this criterion, the trial product was permanently discontinued and patients were not withdrawn

96 0%) of 304 patients who initiated nintedanib permanently discontinued nintedanib because of diarrhoea

97 No patient permanently discontinued the active drug.

98 One patient permanently discontinued treatment because of an adverse

99 lated adverse event; of these patients, nine permanently discontinued treatment.

100 onRI complexes, such allergic effector cells permanently display allergen-specific IgE on their surfa

101 ntensity monopolar pulsed electric fields to permanently disrupt cell membranes within a well-defined

102 We permanently disrupted the below-ground transfer of recen

103 rbing axon projection beyond postnatal day 7 permanently disrupts targeting specificity of the sensor

104 oma cells deficient for TF remain viable but permanently dormant at the injection site for nearly a y

105 ant pairs who migrated out of the study area permanently during the trial period.

106 T cells in which the CCR5 gene was rendered permanently dysfunctional by a zinc-finger nuclease (ZFN

107 ntified multiple pathways which appear to be permanently dysregulated in UC patients at formerly acti

108 re, we demonstrate that PDA subtypes are not permanently encoded, and identify the GLI2 transcription

109 of triggering unrestrained proliferation of permanently engineered T cells raises safety concerns th

110 he retina after ocular injury in mice become permanently engrafted into the tissue, establishing a pr

111 ly-life pheromone exposure are sufficient to permanently enhance specific avoidance responses.

112 ing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues.

113 tion I: the initially formed wrinkles can be permanently erased and never reappear; and (3) irreversi

114 ting to 95 degrees C for 5 minutes, however, permanently erases the message.

115 d that sexual phenotypes formed in utero are permanently established and do not require maintenance.

116 The 2.25-m flood height is permanently exceeded by 2280-2300 for scenarios that inc

117 study has data for whether a child has been permanently excluded from school up to the age of 8 year

118 , after which the majority of cardiomyocytes permanently exit cell cycle.

119 ding site or a cytosolic tripeptide sequence permanently expose the alpha-arrestin-targeted region so

120 The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is

121 andomly integrate into plant chromosomes and permanently express encoded transgenes, a process known

122 r basal state, recognize transporter regions permanently facing the cytosol or unveiled during transp

123 of note was that executive boards may not be permanently fixed as either unsupportive or supportive a

124 hology collections I show that nematodes are permanently fixed in shells for hundreds of years and th

125 particles to disperse, crystallize or become permanently fixed on demand.

126 Two inclined optical fibers are permanently fixed to a common board, rendering a modular

127 nhancement, making PAiRFPs advantageous over permanently fluorescent probes for in vivo imaging condi

128 al and temporal sensitivity in comparison to permanently fluorescent small molecules, represent power

129 Globular proteins are not permanently folded but spontaneously unfold and refold o

130 most common type of DNA damage, as they are permanently formed in living cells due to erroneous inse

131 geographic ranges of arctic megafauna became permanently fragmented after stable, interglacial climat

132 cting more than a 10% chance of disappearing permanently from the NIH system.

133 The sensitivity of permanently frozen ground (permafrost) in the Northern H

134 cumulation of fructose 1,6-bisphosphate in a permanently frozen solution as followed over months.

135 eriods in which the overlying ground was not permanently frozen.

136 leads to an accumulation of DNA damage that permanently halts beta-cell proliferation and dramatical

137 ugs, which bind with protein targets but not permanently, have been gaining attention because of thei

138 ut (K(ATP)-KO) mice, in which beta-cells are permanently hyperexcited, [Ca(2+)](i,) is chronically el

139 ophile Chlamydomonas sp. UWO241 evolved in a permanently ice-covered lake whose aquatic environment i

140 y share an allele at only one locus, or fuse permanently if they share an allele at both genes [5, 9]

141 The presence of permanently immobilized ion centers in ICOFs enables the

142 rbances in this process would be expected to permanently impact lung structure and might predispose t

143 gen-specific antibody responses but does not permanently impair their development or induce tolerance

144 ntinuation of life-saving chemotherapy and a permanently impaired quality of life for patients.

145 s; however, the fertility of patients can be permanently impaired.

146 window, after which MAIT cell development is permanently impaired.

147 In conclusion, neonatal hyperoxia permanently impairs hippocampal mitochondrial function a

148 Here we describe a minimally invasive, permanently implantable window for high-resolution intra

149 e biosensor overcomes the time limitation of permanently implanted biosensors and that the biosensors

150 sor that can be periodically inserted into a permanently implanted cannula.

151 electromechanical system pressure sensor was permanently implanted in all participants during right h

152 To overcome the time limitation of permanently implanted microbiosensors, we created a micr

153 wel symptoms during the trial phase and were permanently implanted.

154 nstrate that the capacity to generate TRM is permanently imprinted at the clonal level, before skin e

155 other sexual dimorphisms, drug metabolism is permanently imprinted by perinatal hormones, resulting i

156 of an individual's early-life experiences is permanently imprinted; this area of research is related

157 or Ku expression, we found that cells arrest permanently in G2 phase when Ku expression is turned off

158 ssemble, assembled transiently, or assembled permanently in kinetically trapped clusters.

159 Transmural stents were left permanently in situ in DPDS patients from 2008 onwards.

160 xhibited by nonswitching proteins, which are permanently in the on-state; when these bind to DNA nons

161 ereafter (time 3: cardiogenic shock excluded permanently) in New York and compared with Michigan.

162 uorescent protein expression, transiently or permanently, in cells that survive caspase-3 activation

163 ecision medicine strategy to selectively and permanently inactivate only mutant, not normal allele, c

164 me period in wild-type (WT) is sufficient to permanently induce a seizure behavior.

165 Many animals permanently inhabit the marine interstitium, the space b

166 unct PV neurons in the generation of TLE, we permanently inhibited GABA release selectively from PV n

167 alently conjugates only to the specific IgE, permanently inhibiting it.

168 y form covalent bonds to only sIgEs, thereby permanently inhibiting them.

169 iting can potentially overcome this issue by permanently inserting the corrective gene.

170 Highly stable permanently interlocked aryleneethynylene molecular cage

171 In addition, a permanently interlocked rotaxane was prepared by capping

172 Photooxygenation of permanently interlocked squaraine rotaxanes with anthrac

173 d structures by external fields can be bound permanently into stiff chains through electrostatic or v

174 apable of activating a host-cell reporter to permanently label all infected cells.

175 In this study, we used a mouse model to permanently label CD8(+) T cells produced during distinc

176 ndent photoconversion of CaMPARI2 in vivo to permanently label neurons according to mean FR.

177 ently, transplantation experiments involving permanently labeled cells revealed multipotent neural st

178 re)R26R(eYFP) mice, the fluorescent reporter permanently labels cells that have switched on Il22 expr

179 Male mice permanently lacking 5-HT2B receptors, even restricted to

180 ties as the surface of QDs is intimately and permanently ligated by a layer of outer hydrophobic poly

181 itu formation of robust hairy perovskite QDs permanently ligated by outer hydrophobic blocks via copr

182 in is the crafting of Au NPs, intimately and permanently ligated by thermoresponsive poly(N-isopropyl

183 ay-old rat pups had the right carotid artery permanently ligated followed by 160min of hypoxia (8% ox

184 These metadata are then validated and permanently linked to archived genetic data stored in th

185 Women were eligible for inclusion if they permanently lived in clusters and were confirmed pregnan

186 Women were eligible for inclusion if they permanently lived in the trial clusters (ie, the catchme

187 a cure, where reactivity to the allergen is permanently lost enabling the individual to consume the

188 in, often leads to RGC axon degeneration and permanently lost visual function.

189 a afferent synapses and stretch reflexes are permanently lost, even after regeneration and reinnervat

190 nt hosts and that immunological tolerance is permanently lost.

191 eks, even when ~95% of the original input is permanently lost.

192 eta-cells are chronically underexcited, with permanently low [Ca(2+)](i) and lack of glucose-dependen

193 This study investigated the role of a permanently manned Australian Antarctic research station

194 However, not all PAs remain intact permanently; many PAs undergo downgrading, downsizing an

195 in mice and then bred with reporter lines to permanently mark cell lineage.

196 a single episode of voluntary exercise, and permanently marked activated mature hippocampal dentate

197 rowth of 97 199 individual trees within 1070 permanently marked inventory plots as a function of tree

198 facilitates the study of neural circuits by permanently marking cells active during user-specified t

199 facilitates the study of neural circuits by permanently marking cells active during user-specified t

200 itive moiety yields an "ion integrator" that permanently marks cells undergoing high Ca(2+) flux duri

201 We highlight the recent work with permanently microporous metal-organic polyhedra (MOPs).

202 that combine extended pai-conjugation with a permanently microporous skeleton.

203 glucocorticoid receptor and degradation of a permanently misfolded protein, two previously defined ro

204 pre-1950, most (74%) of the sea floor in the permanently mixed area off East Anglia was within the ph

205 ility of DMF is compromised when devices are permanently modified with embedded sensors.

206 ing a stage of development when activity can permanently modify circuit structure and function.

207 posons offer an efficient nonviral method of permanently modifying the genomes of mammalian cells.

208 of the COVID-19 pandemic reminds us that we permanently need high-value flexible solutions to urgent

209 Furthermore, compared with the wild type, a permanently negative phototactic mutant required higher

210 Therefore, the global SAT will not remain permanently neutral.

211 inding mutants of kinesin-1 as roadblocks to permanently obstruct individual microtubule binding site

212 of control compounds whose PET processes are permanently "on" or "off".

213 state, i.e. in the absence of DctA, DcuS is permanently "on", but its activity is C4-diC-dependent w

214 a drastic gain-of-function effect leading to permanently open channels.

215 to the formation of a channel that is quasi-permanently open.

216 lanted for hereditary HLH (2000-2013) and DC permanently or transiently <75% (overall, CD3(+), CD56(+

217 Aphids that are anholocyclic (permanently parthenogenetic) or are monoecious (non-host

218 with DNA repair to minimize DNA damage being permanently passed through cell division.

219 refrontal DISC1 knock-down was sufficient to permanently perturb the prefrontal-hippocampal communica

220 p-POP is the first member of a new class of permanently porous 3D organic semiconductors.

221 th large three-dimensional channels that are permanently porous and chemically stable offers new oppo

222 The permanently porous crystal architecture is sustained by

223 ctivity, as a building block to assemble the permanently porous supramolecular cage Co-PB-1(6) bearin

224 A permanently porous, three-dimensional metal-organic mate

225 t organic frameworks (COFs) are crystalline, permanently porous, two-dimensional or three-dimensional

226 Patch formation is reversible but can be permanently preserved using a photocrosslinking step.

227 s and then freeze them into solid particles, permanently preserving their shape.

228 additional mechanisms need to be targeted to permanently prevent epilepsy development.SIGNIFICANCE ST

229 on, cytosolic and transmembrane isoforms are permanently produced within endosymbiont-bearing organ,

230 g that mavacamten-bound myosin heads are not permanently protected in the SRX state but can be recrui

231 ere, we used DcxCreER(T2) transgenic mice to permanently pulse-label age-defined cohorts of granule c

232 y, these data show that chronic inflammation permanently reconfigures the tissue-resident TCRgammadel

233 the recombinases can be layered and used to permanently record the transient state of a transcriptio

234 Certain larval traits of reef fishes are permanently recorded in the rings in their otoliths.

235 te that apartment-level billing and metering permanently reduce EEC by about 25%.

236 ple doses of ivermectin may cumulatively and permanently reduce the fertility and shorten the lifespa

237 overy of interventional strategies that will permanently reduce the number of productively infected c

238 gue, and syncope because of a temporarily or permanently reduced heart rate.

239 Endocrinologically, mating also permanently reduced the concentration of circulating pro

240 least 2% of most populations and can lead to permanently reduced vision if not detected and treated w

241 uring pregnancy and lactation in mice, which permanently reduces endocannabinoid levels in the offspr

242 t after which the majority of females become permanently refractory to further mating.

243 of older people (aged >/=65 years) who were permanently registered with a general practice in three

244 proteins represents a promising approach to permanently remedy blood disorders, although its applica

245 The renewed effort to eliminate malaria and permanently remove its tremendous burden highlights ques

246 ed bacterial carbohydrates and phospholipids permanently reprograms the natural antibody repertoire d

247 g the caries prevalence in children born and permanently residing in Chernobyl fallout areas.

248 oper control of vital reactions, NAD must be permanently resynthesized.

249 The shape of uncured gels can be permanently retained by templated UV-curing of the solve

250 ns' normal anterior-posterior pattern can be permanently rewritten by a brief perturbation of endogen

251 ogy of biopsy specimens that are painful and permanently scar.

252 al structure to heal and, in many instances, permanently seal the damaged location.

253 cessfully launch polio endgame activities to permanently secure and sustain the enormous gains of pol

254 bind to a capture or competitor DNA strand, permanently separating it from the BHQ-modified reporter

255 ming ability of deep-sea larvae, before they permanently settle at the bottom, is one way larvae can

256 he importance of early sensory experience in permanently shaping brain function.

257 elopment when activity plays a large role in permanently shaping neural circuits, our data show how t

258 by chromatin remodeling of specific loci to permanently silence genes that are not essential for the

259 the number of productively infected cells or permanently silence the covalently closed circular DNA i

260 K4me3 mark prevents the region from becoming permanently silenced and prepares the domain for activat

261 perfect piRNA target site can be rapidly and permanently silenced via RNAe.

262 he previously intact side before UL remained permanently silent during natural vestibular stimulation

263 dipose expansion and during chronic obesity, permanently skewing the immune system to a proinflammato

264 We tested this prediction in a permanently social spider, Stegodyphus dumicola that app

265 Here, we permanently stabilize the temperature response of isolat

266 large minority of resilient cooperators can permanently stabilize unravelling among a majority of ra

267 ferroelastic domains can be effectively and permanently stabilized by dislocations at the substrate

268 mediated by a neural module need not remain permanently stable but rather can change dynamically acr

269 sruptions are initiated by perturbation of a permanently stable steady state beyond a threshold.

270 ion and transcription in the affected region permanently stall, so the failure of R-loop removal in R

271 Emergency portacaval shunt permanently stopped variceal bleeding, almost never beca

272 olution depends on the ability to safely and permanently store CO2 This study demonstrates for the fi

273 s are acquired from transferred plasmids and permanently stored in genomic CRISPR arrays.

274 e incremental oil from depleted fields while permanently storing large tonnages of injected CO2.

275 This major hydrothermal activity that permanently stratifies Lake Kivu today was initiated app

276 to long-lived lakes in preglacially formed, permanently subsiding geological basins.

277 anscriptionally silenced in the syncytium to permanently suppress its activity during all nematode pa

278 lation, demonstrating that CD8(+) dT are not permanently suppressed and retain the capacity to respon

279 .0%; PP 22.2%) had their device explanted or permanently switched off before 5 years.

280 Consequently, clusters are permanently switched on by neuronal spiking, switched of

281 disease-associated variant of human MDA5 is permanently switched on.

282 rter mice, active cells expressing cfos were permanently tagged with reporter protein tdTomato during

283 blocks, the PEDOT chains are intimately and permanently tethered on the PbTe nanoparticle surface, t

284 rse ferroelectric nanoparticles directly and permanently tethered with ferroelectric polymers by capi

285 e river water compartment without increasing permanently the pumping losses.

286 this study, we use a reporter mouse model to permanently "time stamp" NK cells and type 1 innate lymp

287 ycle: when the manipulated host fixes itself permanently to a substrate by its mandibles.

288 Polylysine bound permanently to RG-II, precluding electrophoretic analysi

289 al upward ice transport, which may therefore permanently trap them below the ice surface and explain

290 ation appears to occur through Ede1, because permanently ubiquitinated Ede1 phenocopies deletion of U

291 enotypes could be replicated by expressing a permanently ubiquitinated version of Ede1, the yeast Eps

292 of yield, where a material changes its shape permanently under external deformation, are not yet unde

293 atients who stopped dosing at week 12 either permanently under the original protocol, or temporarily

294 poptotic pathways in effector T cells and by permanently upregulating their IL-7 receptor expression,

295 Twenty patients (9%) became permanently visually impaired or blind in at least 1 eye

296 Below the lowest water table, permanently water-saturated bedrock remains reducing, pr

297 Rigidifying this contact permanently with a disulfide bridge disrupts ligand-indu

298 lar senescence is a mechanism by which cells permanently withdraw from the cell cycle in response to

299 Mammalian cardiomyocytes permanently withdraw from the cell cycle shortly after b

300 However, the influence of temperature was permanently written into tree-ring structure only for th