ライフサイエンスコーパス: permeant

1 dy, thus underscoring its role as a vascular permeant.

2 ontaneously to MTA, which is stable and cell-permeant.

3 onium and N-methyl-D-glucamine are much less permeant.

4 ch that no ion possessing a methyl group was permeant.

5 tly determined by the size and charge of the permeant.

6 Using LC-MS, we demonstrate that 6c is CNS-permeant.

7 effective barriers for both liquid and vapor permeants.

8 simply on the basis of size or charge of the permeants.

9 insulin secretion in response to a membrane-permeant 2OG analog, dimethyl-2OG.

10 Permeant (300 microM nicotine) and impermeant (5 mM carb

11 by pre-exposure of the cone to the membrane-permeant acetoxymethyl ester of the Ca2+ chelator BAPTA.

12 ion of small molecules, translocation of the permeant across the biological membrane is traditionally

13 tivation of Gbetagamma using a specific cell-permeant activating peptide (myristoylated-SIRKALNILGYPD

14 ) up-regulated the current, whereas membrane-permeant activators of protein kinase A (PKA) were witho

15 We describe the synthesis and use of a cell-permeant active site-directed probe, which allows profil

16 with Cys and tested for reactivity with the permeant alkylating agent N-ethylmaleimide in right-side

17 ing Cys replacements react with the membrane-permeant alkylating agent NEM.

18 s is significantly increased by the membrane-permeant allosteric agonist NPS R-568, which acts as a c

19 oxic to certain neuronal cells that carry Ca-permeant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropi

20 rge movements were expressed by the non-Ca2+ permeant alpha1S(E1014K) variant, the alpha1C(E736K)/alp

21 uctural determinants that make pentamidine a permeant although most other diamidine drugs are exclude

22 family might control the protonated state of permeant ammonium to allow for its selective passage acr

23 ic-oxide donor, and 8-bromo-cGMP, a membrane-permeant analog of cGMP, mimic the effects of NECA on 5-

24 Treatment of astrocytes with a membrane permeant analog of IP3 also protected astrocytes against

25 mami transduction is not known, but membrane-permeant analogs of cAMP antagonize electrophysiologic r

26 Ins(1,4,5)P(3)/AM (6-Ins(1,4,5)P(3)), a cell-permeant analogue of Ins(1,4,5)P(3), at 10 microm increa

27 These cell-permeant analogues of cAMP activate both Epac1 and Epac2

28 mbrane integrity, as observed using membrane-permeant and -impermeant fluorescent DNA dyes.

29 ining a HaloTag in combination with membrane-permeant and -impermeant Halo dyes allows imaging of int

30 Ai and CAe) are distinguished using membrane-permeant and -impermeant pharmacological CA inhibitors,

31 tions Ba2+, Ca2+ and Zn2+ are not detectably permeant and block the gating pore at millimolar concent

32 engineered cysteines react with both channel-permeant and channel-impermeant probes occupy the outerm

33 screened for reactivity toward both channel-permeant and channel-impermeant thiol-directed reagents,

34 The use of mass spectrometry with permeant and impermeant thioimidates promises insights i

35 ntroduced cysteines was probed with membrane-permeant and membrane-impermeant sulfhydryl reagents und

36 TRPM7 is a Ca(2)(+)-permeant and Mg(2)(+)-permeant ion channel in possession

37 selective binding and selective exclusion of permeant and nonpermeant cations, respectively, are impo

38 reversible binding and activation of a cell-permeant and nontoxic fluorogenic ligand (a so-called fl

39 esent the synthesis of two enantiomeric cell-permeant and photocaged (PP)(2)-InsP(4) derivatives and

40 cells is produced by the opening of a Na(+) permeant and yet largely TTX insensitive ion channel.

41 ic acid (small, hydrophilic, and ER membrane-permeant), and N-phenylmaleimide (small, hydrophobic, an

42 exhibits a high photostability, is live-cell permeant, and does not require RNase treatment.

43 rhodamine B (SRB), a fluorescent hydrophilic permeant, and of rhodamine B hexyl ester (RBHE), a fluor

44 istributed along the pore that interact with permeant anions and affect anion selectivity, as well as

45 T1-Fab complexes, at 2.85 A resolution, with permeant anions and Ca(2+).

46 e-dependent calcium binding and regulated by permeant anions and intracellular protons.

47 insic property of the CLC-5 protein and that permeant anions, particularly Cl(-), modulate a voltage-

48 um concentrations ([Ca(2+) ]i ) and external permeant anions.

49 We used the cell-permeant antennapedia (AP)-conjugated CSD peptide, which

50 rated with liposomes containing the non-cell-permeant antibiotic gentamicin and a fluorescent marker.

51 rescent dye permeants, indicating that these permeants are distinctly gated.

52 rossover between small-scale rattling of the permeant around its present position in the membrane and

53 yl]methanethiosulfonate (MTSES) molecule and permeant Au(CN)(2)(-) ions, were applied to either side

54 Membrane-permeant biarsenical dyes such as FlAsH and ReAsH fluore

55 A cell-permeant, bioactivatable Ins(3,4,5,6)P4 analog elevated

56 mined by whole cell labeling with a membrane-permeant biotin maleimide and a membrane-impermeant 2-((

57 cysteines, 8 were labeled with both membrane permeant (biotin maleimide (BM)) and impermeant (2-((5(6

58 Ca(2+) permeability and its affinity for the permeant blocker dihydrostreptomycin.

59 Barium (Ba(2+)) is a classic permeant blocker of potassium (K(+)) channels.

60 ple kinetic model in which polyamines act as permeant blockers of Kir3.1/Kir3.4, but as relatively im

61 Polyamines and Mg(2+) are permeant blockers, as judged by relief of block at stron

62 llent potency, is highly blood-brain barrier-permeant, but suffers from rapid first-pass metabolism.

63 not BPH FPs) can incorporate a more membrane-permeant BV analog, making smURFP fluorescence comparabl

64 For the quickly membrane-permeant C(12)EO(8) and OG, leakage proceeds at a rather

65 Third, blocking Rac1 function by cell permeant C-terminal "Trojan" peptides corresponding to R

66 Here, membrane permeant C2-ceramide is shown to attenuate the basal and

67 tracellular CAs were inhibited by the poorly permeant CA blocker, benzolamide, or by inhibitory antib

68 lying 5% CO2 (Day 4), exposed oocytes to the permeant CA inhibitor ethoxzolamide (EZA), and measured

69 different pH and PCO2 with or without a cell-permeant CA inhibitor methazolamide (MTZ) or impermeant

70 s showed that endothelin-1, CPA and the cell-permeant Ca(2+) chelator BAPTA-AM activated the same 2.6

71 A cell-permeant Ca(2+) chelator reduced the CDDO-induced increa

72 ratio of fluorescence signals from membrane permeant (calcein) and membrane impermeant (propidium io

73 (PKA) inhibitor, inhibits the ability of the permeant cAMP analog cpt-cAMP [8-(4-chlorophenylthio)-cA

74 Injection of a cell-permeant cAMP analog, 8-bromo cAMP, into the dorsal root

75 n vitro or induction of capacitation by cell-permeant cAMP analogs decreased the depolarizing respons

76 In voltage-clamp studies, cell permeant cAMP analogs shifted the activation curve for I

77 8- fold in RAW cells treated with a membrane-permeant cAMP analogue (8-bromo-cyclic AMP; 8-Br-cAMP),

78 It is reproduced by cell-permeant cAMP analogues that activate PKA (6-Bnz-cAMP) o

79 amitochondrial cAMP, but along with membrane-permeant cAMP analogues, failed to induce measureable ma

80 The permeant carbonic anhydrase (CA) inhibitor methazolamide

81 alysis using the ionotropic receptor channel-permeant cation agmatine indicated that ONH axon segment

82 idney disease where it regulates the calcium-permeant cation channel polycystin-2.

83 with molecular characteristics of a calcium-permeant cation channel.

84 wardly rectifying, proton-impermeant, Ca(2+)-permeant cation channels.

85 Using the dimensions of the largest permeant cation, the minimum pore diameter of the PC2 ch

86 een dipolar carbonyl ligands, water, and the permeant cation, which allow for selective flow of K+ ov

87 etation of signals from fluorescent membrane-permeant cations (usually termed "mitochondrial membrane

88 , we identified a diverse group of minimally permeant cations for wildtype NaChBac, ranging in sizes

89 ls when Ca(2+) and Ba(2+) ions are the major permeant cations.

90 ernal pH sensitivity varies depending on the permeant cations.

91 e indenes completely lacked, while the brain-permeant CB1R agonist HU-210 (1) exhibited strong CNS si

92 ion of (ii) an NO donor (SNAP) or (iii) cell-permeant cGMP.

93 TRPM7 is a divalent-permeant channel and kinase of unknown function, recentl

94 block and by identifying methylene blue as a permeant channel blocker.

95 Here, we showed that the ER cation-permeant channel polycystin 2 (PC2) functions to reduce

96 r Potential Melastatin 7 (TRPM7), a divalent-permeant channel-kinase of unknown function, is highly e

97 peptide of Alzheimer's disease forms calcium permeant channels in artificial membranes, we have propo

98 t receptor potential canonical (TRPC) Ca(2+)-permeant channels, especially TRPC3, are increasingly im

99 nt receptor potential (TRP) family of Ca(2+)-permeant channels, forms a signaling complex with TGF-al

100 hanism, which appears to be triggered by the permeant Cl(-) anion.

101 A brain-permeant compound completely suppressed the up-regulatio

102 ble in-pore environment, which would elevate permeant concentration within the pore and hence the flu

103 s, with no effect on basal secretion; a cell-permeant control peptide (Kal-C-helixKKED-Arg9) did not

104 cally oligomerized upon addition of the cell-permeant cross-linker FK1012-A.

105 Cell-permeant cryptochrome proteins appear to be functional o

106 By using cell-permeant cryptochrome proteins, we demonstrate that cycl

107 phils, as disrupting the complex with a cell permeant CXCR2-specific peptide (containing the PDZ moti

108 nase-G system with nitroprusside or membrane-permeant cyclic GMP analogs mimicked the proexocytotic e

109 In response to externally added cell-permeant cyclic nucleotides (cpt-cAMP and cpt-cGMP), MEF

110 s relatively nontoxic prodrugs into membrane-permeant cytotoxic compounds with high bystander activit

111 ermal flux experiments, which showed greater permeant delivery both into and through the dual-frequen

112 When AtT-20 cells were treated with a cell-permeant derivative of the Kal-C-helix (Kal-C-helix-Arg9

113 Administration of a lipid-permeant dimerizing ligand (AP1903) induced oligomerizat

114 t and permeabilized glands, we used the cell-permeant, divalent cation chelator, tetrakis-(2-pyridylm

115 ing of live infected cells by a non-membrane-permeant DNA fluorescent dye.

116 terminus in AMPH-evoked DA efflux using cell-permeant dominant-negative peptides.

117 The addition of the synthetic membrane-permeant drug AP20187 induces rapid dimerization of the

118 nd reversibly controlled by Shield-1, a cell-permeant drug.

119 reversibly controlled with Shield-1, a cell-permeant drug.

120 owever, it is unknown whether such ionizable permeants dynamically neutralize at the membrane surface

121 iabetic fatty rats by addition of a membrane permeant ester of a pyruvate cycling intermediate (dimet

122 en bonding and entropic factors arising from permeant flexibility substantially contribute to the ene

123 ng of the mTORC1 component RAPTOR and a cell permeant fluorescent analogue of di-leucine methyl ester

124 recording and with accumulation of a channel-permeant fluorescent dye.

125 The membrane-permeant fluorogenic biarsenicals FlAsH-EDT(2) and ReAsH

126 tance and are highly coupled via neurobiotin-permeant gap junctions, while midline cells are signific

127 Osmotic loading with membrane-permeant glycerol (92 Da) and urea (60 Da) are observed

128 rt the first total synthesis of the membrane permeant, hydrolytically stable, cADPR receptor agonist

129 that mitochondrial accumulation of membrane permeant, hydrophilic cations can be used to maximize lo

130 nts on the physicochemical properties of the permeants imposed by these channels must be better under

131 criterion for establishing that a blocker is permeant in a channel that has a complex permeation cycl

132 trast, changes in selectivity made gluconate permeant in L46P EAAT2, and nonstationary noise analysis

133 almost full agonist in SUH and was membrane-permeant in whole eggs.

134 The subsequent residence time of model permeants in tissue after ultrasound-mediated delivery w

135 rasound treatments enabled delivery of large permeants, including microparticles, deep into colonic t

136 (269) was found to strongly bind the lactose permeant, indicating that proton transfer from water or

137 ll atomic ions (current) and fluorescent dye permeants, indicating that these permeants are distinctl

138 because of its ability to act as a membrane-permeant inhibitor of inositol 1,4,5-trisphosphate (IP3)

139 Two sets of stable Permeant Inhibitor of Phosphatase (PIP) peptides were ra

140 erichia coli beta-galactosidase and the cell-permeant inhibitor phenylethyl beta-D-thiogalactopyranos

141 This new class of cell-permeant inhibitors provides tools to investigate the ph

142 the Nernst equilibrium potential of the most permeant inorganic ion.

143 sponses to both anti-CD3 antibody and a cell-permeant InsP3 ester were decreased.

144 Occupation of an internal permeant ion binding site prevents Mg2+(o) permeation an

145 n which occupation of either of two external permeant ion binding sites prevents Mg2+(o) entry into t

146 that differed in the locations and number of permeant ion bound; blocker dissociation occurs exclusiv

147 TRPM7 is a Ca(2)(+)-permeant and Mg(2)(+)-permeant ion channel in possession of its own kinase dom

148 (A) receptors (GABA(A)R), which are chloride-permeant ion channels, and GABA(B) receptors (GABA(B)R),

149 alinization was prevented by blocking proton-permeant ion channels, suggesting that distinct mechanis

150 e hyperpolarizing direction from high to low permeant ion concentrations consistent with charge scree

151 mM), unlike KcsA, whose SF collapses at low permeant ion concentrations.

152 ellular pH, is dependent on an effect of the permeant ion on the channel pH(o) sensors.

153 We conclude that variations in permeant ion site properties shape the NR2 subunit depen

154 In contrast, other permeant ion species, such as Rb(+), NH(4) (+), and Cs(+

155 This regulation depends on the ability of a permeant ion to enter the selectivity filter (K(+) = Rb(

156 at the direction of the driving force on the permeant ion, as well as P(o), must be considered togeth

157 f C-type inactivation is a dependence on the permeant ion, but the mechanism by which permeant ions m

158 ge-dependent nor influenced by the nature of permeant ion.

159 mode-shift of gating when having K(+) as the permeant ion; (ii) that Cs(+) or Rb(+), known to halt C-

160 unique in that its members display opposite permeant-ion charge selectivities despite sharing the sa

161 In the absence of other permeant ions (Ca(2)(+) and Na(+) replaced by N-methyl-d

162 Whether permeant ions affect Mg2+(o) inhibition of NR1/2C or NR1

163 ive conformations defined by the presence of permeant ions along the conduction pathway.

164 Electrostatic interactions between permeant ions and channel pore helix dipoles have been p

165 ted to gating and contains binding sites for permeant ions and pore-blocking molecules including quat

166 cking toxins show specific interactions with permeant ions and strong dependence on the ionic strengt

167 nd our understanding of the coupling between permeant ions and TEA blockade.

168 er stability depends on interactions between permeant ions and the channel pore.

169 er a physiological electrochemical gradient, permeant ions are initially stabilized within the extrac

170 lter transport properties of hClC-4, varying permeant ions as well as mutating the "gating glutamate"

171 rturbed when positive charges occur near the permeant ions at a location that should counteract pore

172 This modulation prolongs the occupancy of permeant ions at the gate.

173 ion channels have "charge rings" that focus permeant ions at the mouth of the pore and increase chan

174 with a tight binding, we show that external permeant ions enhance CTX-dissociation, implying a path

175 ly-Tyr-Gly signature filter sequence and the permeant ions generate four equidistant K(+) binding sit

176 Previous work showed that permeant ions have profound effects on Mg2+(o) block of

177 riving force is coupled with the movement of permeant ions in the filter, maximizing the efficiency o

178 nd Rb+ ions; occupancy of this site by these permeant ions increases the TBSb off-rate.

179 g and electrostatic repulsive forces between permeant ions is needed to achieve efficient conduction.

180 the permeant ion, but the mechanism by which permeant ions modulate C-type inactivation is not known.

181 We investigated the effects of permeant ions on Mg2+(o) block of NR1/2D receptors by in

182 CLC channels are also known to couple to the permeant ions via their binding sites in the ion-permeat

183 rse a long (>70 A) pore, displacing multiple permeant ions, en route to a high affinity binding site

184 d to activation and is modulated by voltage, permeant ions, pore-blocking drugs, and membrane cholest

185 block, DPA antagonism did not interact with permeant ions.

186 nce that increased with the concentration of permeant ions.

187 ributions to the observed preference for the permeant ions.

188 itical role by acting as a driving force for permeant ions.

189 f ion conductance near the point of entry of permeant ions.

190 hannels in response to low concentrations of permeant ions.

191 the KcsA structure at high concentrations of permeant ions.

192 it orients TTX optimally and interacts with permeant ions.

193 channels open and close, and select between permeant ions.

194 tricted, leading to a loss of both water and permeant ions.

195 ase-C and accordingly were not stimulated by permeant IP3.

196 nditions, should strengthen selection of the permeant K(+) by the channel.

197 rmeation mechanism, driven by a reduction in permeant [K(+)](o) following pore block (which would ret

198 NMDA receptors (NMDARs) are Ca(2+)-permeant, ligand-gated ion channels activated by the exc

199 for microsecond simulations for even simple permeants like water and oxygen.

200 ed nuclei were also loaded with the membrane-permeant low-affinity Ca(2+) probe fluo-5N AM which comp

201 ion; disruption of this complex using a cell-permeant LPA2-specific peptide reversed LPA2-mediated in

202 e were resolved and transport of hemichannel-permeant LY dye was visualized when the hemichannel was

203 ese channels are modulated by NO, a membrane-permeant messenger in various physiological and patholog

204 The permeant MET channel blocker dihydrostreptomycin is two

205 HCs were also less sensitive to block by the permeant MET channel blocker dihydrostreptomycin, whethe

206 we show that systemic injection of the brain-permeant mGlu2/3 receptor agonist (-)-2-oxa-4-aminobicyc

207 Recently, we discovered a class of cell-permeant miniature proteins (CPMPs) containing a precise

208 he basis of this model, we engineered a cell-permeant minipeptide to destabilize the fusion-constrain

209 sibility of cytoplasmic residues to membrane-permeant modifying reagents supports the idea that this

210 s framework for describing the motion of the permeant molecule on the pico- to nanosecond timescale.

211 ate (ITPP) is a recently identified membrane-permeant molecule that causes allosteric regulation of H

212 Diffusion constant values of the permeant molecules were calculated from a statistical av

213 Because HIDE probes are small, cell-permeant molecules, they can visualize dual organelle dy

214 Analysis of permeant motion within the lipid bilayer reveals that, i

215 Because HSL-C12 is membrane permeant, multiple cell types in P. aeruginosa-infected

216 Application of membrane-permeant NAADP acetoxymethyl ester to PASMCs elicited a

217 NAADP acetoxymethyl ester (NAADP-AM), a cell-permeant NAADP analog, increases cytosolic Ca(2+) concen

218 -19, and reciprocally both are stimulated by permeant NAADP.

219 ported the potential of compound 37 as a BBB-permeant neuroprotective agent against H2O2-induced oxid

220 reover, 5b behaves as a water-soluble, brain-permeant neuroprotective agent against oxidative insults

221 derivative that has been described as a low-permeant neutral CB1 antagonist, though its pharmacology

222 l 3 (TRPC3) is a receptor-activated, calcium permeant, non-selective cation channel.

223 in primary murine B cells reveal that Ca(2+)-permeant nonselective cation channels (NSCCs) operate in

224 al steps in the activation of novel (calcium-permeant) nonselective cation channels (NSCCs) and calci

225 Thus, CRAC and distinct Ca(2+) permeant NSCCs are differentially activated by the BCR a

226 However, the potent cell-permeant O2*- trap manganese tetrakis (N-ethylpyridinium

227 s crossed, intracellular toxic IAPP membrane permeant oligomers (cylindrins) may form, compromising b

228 is potentially toxic, especially as membrane-permeant oligomers, which have been observed to accumula

229 proteins is not amyloid but smaller membrane-permeant oligomers.

230 nce, translocation, and exit of these simple permeants (one hydrophilic and one hydrophobic) can be s

231 n cells can be achieved by choosing membrane permeant or impermeant fluorogens.

232 rtitioning may occur even for small membrane-permeant osmolytes.

233 icating that the increased tortuosity of the permeant path was effective on barrier properties of the

234 Visualization of transdermal permeant pathways is necessary to substantiate model-bas

235 ing in regulating expression of the vascular permeant PDGF-B was confirmed in vitro using cell permea

236 urther demonstrate the efficacy of the brain-permeant PEGylated version of the anti-solTNF peptide, X

237 A cell permeant peptide derived from this sequence displaces cy

238 ably transduced with lenti-SUMO-1 and a cell-permeant peptide harboring SUMO-binding motif to interfe

239 pitating events that are sensitive to a cell-permeant peptide inhibitor of SRTF nuclear import (cSN50

240 A cell-permeant peptide that blocks binding of PAK to PIX inhib

241 We designed small membrane-permeant peptides that encode key functional residues wi

242 e tag can be reduced acutely with a membrane-permeant phosphine, labeled with ReAsH, monitored in the

243 A cell permeant phosphopeptide mimetic of Niban (NiPp) was gene

244 We developed a membrane-permeant, photoactivatable PI(4,5)P2, which is loaded in

245 g GABAergic postsynapses by using a membrane-permeant PI3P derivative, time-lapse confocal imaging, e

246 The only known CNS-permeant PKC inhibitor is the selective estrogen recepto

247 Here, using a channel-permeant probe, [Au(CN)2](-), we provide evidence that C

248 age apoptosis in vivo with a small, membrane-permeant probe, TcapQ(647) was synthesized comprising a

249 re cysteine reactivity is limited to channel-permeant probes occupy more cytoplasmic locations.

250 We provide a novel cell-permeant protein approach for manipulating cryptochrome

251 Cell-permeant proteins (CPPs) could overcome this limitation.

252 We report here that the permeant, pseudohalide anion [Au(CN)2]- can also react w

253 The membrane-permeant, radioactive thiol reagent N-[ethyl-1-14C]ethyl

254 ine residues to modification by the membrane permeant reagent N-ethylmaleimide (NEM) and the membrane

255 30 unique cysteine residues to the membrane-permeant reagent N-ethylmaleimide and the membrane-imper

256 We designed cell-permeant red-emitting fluorescent dye labels with >140 n

257 zed that methylene blue (MB), a mitochondria-permeant redox-active compound that can act as an altern

258 tants only showed activity with the membrane-permeant reductant.

259 li CNT family member NupC resembles hCNT1 in permeant selectivity but is H(+)-coupled.

260 The dependence of clearance time on permeant size was further confirmed in vivo in mice usin

261 Here we investigated the effect of permeant size, charge, and the presence of chemical pene

262 bsorption and retention patterns of membrane-permeant small molecules in a cellular context could fac

263 not volume expansion by isoosmotic medium by permeant solutes (ethylene glycol, diethyl urea, or ammo

264 t the intracellular partitioning of membrane-permeant solutes manifests itself as a partial volume re

265 that intracellular partitioning of membrane-permeant solutes manifests itself as a partial volume re

266 ular environment, it is likely that membrane-permeant solutes may be excluded from a fraction of the

267 by treatment of Swiss 3T3 cells with the non-permeant solutes sucrose or sorbitol, rapidly and robust

268 Adding sorbitol or alanine, permeant solutes that do not exhibit residual uptake, co

269 following osmotic lysis of infected cells in permeant solutes, these experiments have been limited to

270 n to the selective binding of K(+) and other permeant species over Na(+), there is a selective exclus

271 ory transmission from that of a postsynaptic permeant species to a presynaptic regulatory element.

272 rmeability of hemichannels is regulated in a permeant-specific manner and underscores that hemichanne

273 The six esters render the probe membrane permeant, such that it can be loaded into intact living

274 llular side of TM3, was affected by membrane-permeant sulfhydryl reagents.

275 xidants and HOCl, is a relatively weak, cell-permeant, sulfhydryl (SH)-reactive oxidant.

276 of a Nox2 inhibitor and quenched by the cell-permeant superoxide scavenger.

277 The highly sodium-permeant T-type channel expresses in the brain and is th

278 Membrane-permeant Tat-peptides encoding the unique C-terminal res

279 hiP to be approximately 200-300 Da for small permeants that pass through by general diffusion while a

280 While both complexes are live cells permeant, their intracellular localizations are signific

281 pH suggested that H(+) is not significantly permeant through OsHKT2;4 in most physiological ionic co

282 hylamine, ethylamine, and trimethylamine are permeant through the RyR but with reduced current amplit

283 rocytes took up fluorescent tracer molecules permeant to gap junction channels.

284 Because PSAC is permeant to small metabolic precursors essential for par

285 otic cells, but not those of live cells, are permeant to the DNA-intercalant dye YO-PRO-1.

286 vestigated delivery of fluorescently labeled permeants to colon tissues of Yorkshire pigs ex vivo and

287 eneration, human IAPP (hIAPP) forms membrane permeant toxic oligomers implicated in misfolded protein

288 the present study, we used the gap junction-permeant tracer Neurobiotin to compare the coupling patt

289 Here, we use the gap junction-permeant tracer Neurobiotin to determine the architectur

290 (PC2 or TRPP1, formerly TRPP2) is a calcium-permeant Transient Receptor Potential (TRP) cation chann

291 ng due to abnormal activation of the calcium permeant TRPC (Transient Receptor Potential Canonical) c

292 aused by depletion of the Ca(2+)- and Mg(2+)-permeant TRPM7 is suppressed by expression of a dominant

293 tive stimulus for acid taste is the membrane-permeant, uncharged acetic acid moiety (CH(3)COOH), not

294 y more strongly than did their more membrane-permeant unconjugated counterparts, suggesting that bile

295 exyl ester (RBHE), a fluorescent hydrophobic permeant, using dual-channel two-photon microscopy (TPM)

296 A cell-permeant version of the peptide encompassing amino acids

297 , an extracellular concentration gradient of permeant weak acid readily induces pH(i) nonuniformity.

298 by superfusion of acetate (salt of membrane-permeant weak acid), evoked a [Ca(2+)]i rise, independen

299 leimide (small, hydrophobic, and ER membrane-permeant), were monitored by Western blot analysis.

300 Extracellular application of a membrane-permeant Zn2+ chelator generated an inward current.