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1 paraoxonase-1 (PON1) was investigated, using peroxidized 1-palmitoyl-2-oleoyl phosphatidylcholine (PC
3 re obtained from reaction of DNA with either peroxidizing arachidonic acid (20:4omega6) or peroxyl ra
4 resent study we have examined the ability of peroxidizing arachidonic acid (AA, 20:4omega6) to induce
7 addition of a polar oxygen atom on numerous peroxidized fatty acids reorients the acyl chain, whereb
9 in which approximately 4% of the Ch had been peroxidized, giving mainly 5alpha-OOH, transferred total
14 ron-binding and iron-oxidizing protection of peroxidizing lipid membranes, were both significantly de
15 damage, generation of reactive oxidants that peroxidize lipids and damage other cellular components,
16 n also leads to preferential accumulation of peroxidized lipids and 4-hydroxynonenal (4-HNE) adducts
17 ize of LDs is a combination of enrichment in peroxidized lipids and a defect in their catabolism.
19 onstrated increased lipid droplets (LDs) and peroxidized lipids in both neurons and astrocytes, consi
20 very low abundance (20 pmol umol(-1) lipid) peroxidized lipids in subcellular compartments and their
21 found that iPLA2B-mediated detoxification of peroxidized lipids is sufficient to suppress p53-driven
22 direct antioxidant, prevents the increase of peroxidized lipids that alter both metabolic pathways an
24 mation of damaged membrane components (i.e., peroxidized lipids) as well as a terminating condensatio
26 ipid vesicles containing a small fraction of peroxidized lipids, the N-terminal Met residues in alpha
32 rols of various fatty acid compositions were peroxidized over time at 60 degrees C and the kinetic cu
33 reported for 12 selected in vivo native and peroxidized phosphatidylcholines and phosphatidylethanol
34 We found a severalfold increase in plasma peroxidized phosphatidylcholines, inflammatory and pro-a
37 However, its molecular targets, identity of peroxidized phospholipid species, and their signaling ro
38 detect and quantify intactin vivo ROS-driven peroxidized phospholipids (LPOx-PLs) in bovine retina ex
40 or PNPLA9 gene) can preferentially hydrolyze peroxidized phospholipids, it may eliminate the ferropto
41 esulting from the unrestrained occurrence of peroxidized phospholipids, which are subject to iron-med
43 ion (IDA) spectra confirmed the structure of peroxidized PLs, revealing that peroxidized species (+O-
44 structure of peroxidized PLs, revealing that peroxidized species (+O-OH) dominated over single O-adde