ライフサイエンスコーパス: peroxy

1 es may proceed through the generation of a 6-peroxy-2,4-cyclohexadienone intermediate.

2 ctivated human phagocytes converted 17-hydro(peroxy)-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid to th

3 red formation of 5-H(p)ETE (5-hydroxy- and 5-peroxy-6-trans-8,11,14-cis-eicosatetraenoic acid) by the

4 ter plates with two species of oxidized A2E, peroxy-A2E, and furano-A2E, followed by incubation with

5 d in serum incubated in wells precoated with peroxy-A2E, the lipofuscin pigment all-trans-retinal dim

6 (OVOCs) in the atmosphere are precursors to peroxy acetyl nitrate (PAN), affect the tropospheric ozo

7 2O2 was observed for all investigated linear peroxy acids but not for carboxylic acids and could ther

8 the ionization and fragmentation behavior of peroxy acids in mass spectrometers.

9 step toward unambiguous characterization of peroxy acids in the atmosphere.

10 ds, the identification and quantification of peroxy acids is often highly uncertain.

11 Peroxy acids might play a significant role in particle t

12 oduced by the oxidation of Fe complexes with peroxy acids or H(2) O(2) : reactions that entail breaki

13 The MS/MS spectra of the peroxy acids showed fragmentation patterns clearly diffe

14 The peroxy acids were separated using liquid chromatography,

15 ir fragmentation patterns, we synthesized 12 peroxy acids with C8 to C10 carbon backbones and mono- o

16 lpha,beta-unsaturated acids, tertiary acids, peroxy acids, esters, ketones, and alpha,beta-unsaturate

17 ould therefore serve as a diagnostic ion for peroxy acids.

18 ntermediate compound P (P), presumed to be a peroxy adduct.

19 one of three degradation products of the PBN-peroxy-adduct.

20 mechanisms for flavin oxidation in which C4a-peroxy and -hydroperoxy flavin intermediates accumulate

21 ) = 790 cm(-1) transition (P-->F, where P is peroxy and F is ferryl) is triggered not only by electro

22 des unequivocal evidence for the presence of peroxy and ferryl species during dioxygen reduction by c

23 d observations of NO(3), N(2)O(5), nighttime peroxy and OH radicals, and related compounds.

24 oxidase and generate the well-characterized "peroxy" and "ferryl" forms.

25 ts, the subsequent reactions of alkyl, alkyl peroxy, and alkoxy radical intermediates, and the compos

26 tates that are tentatively assigned as C(4a)-peroxy- and C(4a)-hydroperoxyflavin intermediates and th

27 istidine during the initial formation of the peroxy anion/heme iron complex is not simply base cataly

28 owed by treatment with an aqueous mixture of peroxy anions buffered at pH 9.6.

29 s of phenol and bicyclic peroxy radical (BCP-peroxy) are experimentally constrained at 295 K to be 42

30 loped by taking advantage of X-ray-activated peroxy bond cleavage within TBHP to generate *OH, which

31 of water that has been proposed to assist in peroxy bond cleavage.

32 als, facilitating the destabilization of the peroxy bond for radical formation.

33 her intermediate followed by cleavage of the peroxy bond to form two ester molecules, releasing stoic

34 of enzymes with equivalent mu-eta(2):eta(2) peroxy bridged coupled binuclear copper active sites.

35 between PCA and O(2) in the formation of the peroxy-bridged ESO2 intermediate.

36 sign, synthesis, and in vivo applications of Peroxy Caged Luciferin-1 (PCL-1), a chemoselective biolu

37 o establish this approach, we have developed Peroxy Caged Luciferin-2 (PCL-2), a H(2)O(2)-responsive

38 Here we report Peroxy-Caged-[(18)F]Fluorodeoxy thymidine-1 (PC-FLT-1),

39 at pH >/= 6.0, spontaneous decomposition of peroxy carboxylic acids, generated from H(2)O(2) and org

40 dium, and (2) reacting with H(2)O(2) to form peroxy carboxylic acids, which are extremely strong oxid

41 Ultraviolet light (UV) combined with peroxy chemicals, such as H2O2 and peroxydisulfate (PDS)

42 f atmospheric reactions that proceed through peroxy complexes.

43 showed the in situ conversion of tert-butyl peroxy compounds into peresters with the aid of external

44 obtained, including alpha-heterosubstituted peroxy compounds, are amenable to useful synthetic elabo

45 Many peroxy-containing secondary metabolites have been isolat

46 Bimolecular peroxy decomposition is promoted by the red-light or nea

47 age 12-lipoxygenase (hm12-LOX) gave 14-hydro(peroxy)-docosahexaenoic acid (14-HpDHA), as well as seve

48 , and nuclear H2O2, as measured with nuclear peroxy emerald 1 (NucPE1).

49 Peroxy-fatty acids such as 13-hydroperoxydodecanoeic aci

50 ation of the previously characterized 1,2-mu peroxy Fe(III)Fe(III) (P) intermediate to a 1,1-mu hydro

51 3HB complex reacts with oxygen to form a C4a-peroxy flavin with a rate constant of 1.13 +/- 0.01 x 10

52 Tyr(71) , along with nearby Glu(70) and a peroxy flavin, facilitates a keto-enol transition of the

53 ated with the absence of any detectable C4a-(peroxy)flavin formation in stopped-flow kinetic studies.

54 Peroxy Green-1 Fluoromethyl (PG1-FM) is a diffusible sma

55 The resulting SNAP-Peroxy-Green (SNAP-PG) probes consist of appropriately d

56 ver, incorporating a fluorine atom and alkyl peroxy group at the C4 and C3 positions on pyrazolone an

57 The complete conversion of carbonyl into peroxy groups made the resulting polyperoxide ideal for

58 The simulation indicates a prevalence of peroxy groups, with hydroxyl and ether groups being the

59 rp] dioxygenase complexes generates a ferric peroxy heme species with very similar EPR and (1)H ENDOR

60 through a dynamic kinetic resolution of the peroxy hemiacetal intermediate.

61 e nighttime production and cycling of OH and peroxy (HO(2) + RO(2)) radicals.

62 Peroxy (HO2 and RO2) radicals are important intermediate

63 atom abstraction through a cyclic network of peroxy-hydroperoxide-mediated free-radical chain reactio

64 reaction with dioxygen to form the so-called peroxy intermediate (compound P).

65 sequential two-electron steps generating the peroxy intermediate (PI) and the native intermediate (NI

66 e premature O-O bond cleavage, such that the peroxy intermediate can perform a nucleophilic addition

67 ecause of the amidine methyl group, the heme peroxy intermediate cannot be protonated, thereby preven

68 laboratory have indicated that the putative peroxy intermediate formed during the reduction of dioxy

69 pound or it can rearrange to form a bicyclic peroxy intermediate that subsequently undergoes ring cle

70 acts with oxygen to form a flavin-C4a-(hydro)peroxy intermediate, which we show has a maximum absorba

71 th the proximal oxygen of the catalytic iron-peroxy intermediate, yielding efficient production of de

72 ical role in determining the fate of the key peroxy intermediate.

73 d created by rearrangement of the postulated peroxy intermediate.

74 The "peroxy" intermediate (P form) of bovine cytochrome c oxi

75 me oxidase have indicated that the putative "peroxy" intermediate in the catalytic cycle (P(R)) is a

76 absence of any external electron donor, the "peroxy" intermediate of cytochrome c oxidase (CcO-607) i

77 s also possible that breakdown of a putative peroxy-intermediate controlled TPQ formation.

78 ry study of the structures and energetics of peroxy intermediates arising from reaction of nitrosamin

79 only provides the first direct detection of peroxy intermediates in cofactor biogenesis but also ind

80 p, presumably arising from the reaction of a peroxy-iron species with the aldehyde to give a peroxyhe

81 Over 20 new, cyclic, peroxy ketals have been prepared via a two-step protocol

82 prior to DNA cleavage is a low spin Fe(III) peroxy level species, termed activated bleomycin (ABLM).

83 OR spectra in which protonation of the basic peroxy ligand does not occur at 77 K.

84 , properties, and biological applications of Peroxy Lucifer 1 (PL1), a new fluorescent probe for imag

85 rates support the radical formation of alpha-peroxy malononitrile species, which can cyclize to dioxi

86 iological and medicinal chemistry studies of peroxy natural products.

87 We investigate the formation of hydroxy peroxy nitrites (ROONO) and nitrates (RONO(2)) from the

88 ith a hydrogen peroxide (H2O2)-specific dye, peroxy orange 1 (PO1), and nuclear H2O2, as measured wit

89 ing one of the new H(2)O(2)-specific probes, Peroxy Orange 1 (PO1), in conjunction with the green-flu

90 tretching modes at 790 and 804 cm(-1) at the peroxy oxidation level (PM).

91 The redox states of the "peroxy" (P) and "ferryl" (F) intermediates formed during

92 In this scheme, the presence of the "peroxy" ("P") intermediate does not build up a sufficien

93 ase A2 activity, catalyzes the conversion of peroxy-phospholipids to lysophospholipids and oxidized f

94 h is believed to be formed directly from the peroxy precursor and not via elimination of superoxide.

95 irst step of the mechanism is formation of a peroxy-pterin species, which subsequently reacts with th

96 tive production rates of phenol and bicyclic peroxy radical (BCP-peroxy) are experimentally constrain

97 the second-generation dihydroxy hydroperoxy peroxy radical (C5H11O6.) must undergo an intramolecular

98 oducts have been shown to form via gas-phase peroxy radical (RO(2)) cross reactions.

99 for biogenic NPF, which are covalently bound peroxy radical (RO(2)) dimer association products.

100 terminating hydroperoxide formation from the peroxy radical (RO(2)) reaction with HO(2) and organonit

101 icture of a formation mechanism advancing by peroxy radical (RO2) isomerization through intramolecula

102 cations and strand break densities caused by peroxy radical (ROO*) oxidation were measured by glyoxal

103 nal oxygenated compounds formed through acyl peroxy radical + alkene reactions are potentially import

104 w synthetic methodology for the synthesis of peroxy radical addition-induced hydroperoxide formation.

105 ize the electronic excitations of the phenyl peroxy radical as well as other hydrocarbon substituted

106 In this work, the peroxy radical chemical amplification (PERCA) method was

107 Laboratory characterizations of the peroxy radical chemical ionization mass spectrometer (Pe

108 In this review, laboratory studies of this peroxy radical chemistry are detailed, as they pertain t

109 The peroxy radical concentration was obtained from the ampli

110 t of CAPS baseline offsets on the calculated peroxy radical concentrations.

111 experimental work has shown that the phenyl peroxy radical exhibits a transition in the visible regi

112 Gas-phase autoxidation-regenerative peroxy radical formation following intramolecular hydrog

113 , only one isomeric pathway via the bicyclic peroxy radical is accessible to lead to ring cleavage.

114 In this regime, beta hydroxy peroxy radical isomers comprise approximately 95% of the

115 H-shift isomerization of the Z-delta hydroxy peroxy radical isomers produced from OH addition to C4 i

116 In addition, the Z-delta hydroxy peroxy radical isomers undergo unimolecular 1,6 H-shift

117 difference in the relative stability of the peroxy radical isomers.

118 or beta to the OH group forming six distinct peroxy radical isomers.

119 The formed perester peroxy radical may either undergo further H-shift reacti

120 The peroxy radical mixing ratio is determined by the differe

121 8-oxo-dG by HPLC/electrochemical analysis of peroxy radical oxidation of dG, suggesting that the G --

122 ISOP(OOH)2(C5H12O6), a major product of the peroxy radical reacting with HO2.

123 tion of DNA exposed to micromolar amounts of peroxy radical resulted in a 30-fold increase in mutatio

124 of the carbenoid, with a rhodium peroxide or peroxy radical species generated upon the activation of

125 The peroxy radical substituent is also compared against isoe

126 TDDFT calculations of the phenyl peroxy radical support an excitation in the visible spec

127 d in Escherichia coli upon transfection with peroxy radical treated DNA carrying the lacZ alpha gene

128 Electrophoretic analysis of peroxy radical treated DNA exposed to NaOH, Nth, and Fpg

129 ation, ring-breaking reactions, and alpha-OH-peroxy radical unimolecular reactions.

130 Thus, acyl peroxy radical-initiated oxidation chemistry may need to

131 eover, saturation vapor pressures of benzoyl peroxy radical-initiated oxidation intermediates were es

132 + oxidizes a peroxide to yield an initiating peroxy radical.

133 limonene, and sabinene, initiated by benzoyl peroxy radical.

134 ntermediates (CI) produced from beta-hydroxy peroxy radicals (beta-OH-RO(2)*).

135 ical calculations, we show that the bicyclic peroxy radicals (BPRs) formed in OH-initiated aromatic o

136 ts, such as ozone (O3) and hydroxyl (OH) and peroxy radicals (HO2 + RO2), determines the lifetimes of

137 Peroxy radicals (HO2 and RO2) within this air are detect

138 rument for the quantification of atmospheric peroxy radicals (HO2, CH3O2, C2H5O2, etc.) using the che

139 OH) and molecular oxygen to produce isoprene peroxy radicals (ISOPOO).

140 Organic peroxy radicals (often abbreviated RO(2)) play a central

141 rce of reactive species such as hydroxyl and peroxy radicals (OH and HO2, "HOx") indoors.

142 H) formation from heterogeneous HO(2)(*) and peroxy radicals (RO(2)(*)) reactions for the first time.

143 , depending on numerous parameters affecting peroxy radicals (RO(2)) autoxidation.

144 onstrates that rapid autoxidation of organic peroxy radicals (RO(2)) formed during VOC oxidation resu

145 Direct gas-phase measurements of peroxy radicals (RO(2)) from flowtube ozonolysis experim

146 n between nitrogen monoxide (NO) and organic peroxy radicals (RO(2)) greatly impacts the formation of

147 icals, oxidized nitrogen species and organic peroxy radicals (RO(2)) in OFR.

148 an oxidation flow reactor, in which ~95% of peroxy radicals (RO(2)) react with NO.

149 re through the gas-phase reaction of organic peroxy radicals (RO(2)) with hydroxyl radicals (OH).

150 The reaction of hydroxy peroxy radicals (RO(2)) with NO represents one of the mo

151 t mimic the atmospheric chemistry of organic peroxy radicals (RO(2)), a key intermediate in VOC oxida

152 addition of a VOC that photolyzes to produce peroxy radicals (RO(2)), similar to pyruvic acid, into t

153 In HO2-dominant experiments, organic peroxy radicals (RO2) primarily react with HO2.

154 stigate the rate of autoxidation for organic peroxy radicals (RO2) produced in the oxidation of a pro

155 Hydroxy, alkoxy, and peroxy radicals all have the potential to react with DNA

156 by an increase in the level of intracellular peroxy radicals and lipid peroxidation products, two ind

157 ttachment/detachment density diagrams of the peroxy radicals and present a qualitative picture of the

158 between intramolecular hydrogen migration of peroxy radicals and their bimolecular termination reacti

159 ns are unaffected by formation of stabilized peroxy radicals and to estimate atmospheric pressure yie

160 ation and bimolecular reactions with organic peroxy radicals are also possible.

161 the case of reaction with oxygen, persistent peroxy radicals are formed in high yield.

162 Peroxy radicals are mixed with high concentrations of NO

163 calibration method: peroxyacetyl and methyl peroxy radicals are produced by the photolysis of aceton

164 Aromatic peroxy radicals arising from initial OH and subsequent O

165 Dimerization of the peroxy radicals by recombination and cross-combination r

166 venging of reactive oxygen species and lipid peroxy radicals by tocopherols can result in the formati

167 arbons such as isoprene and monoterpenes and peroxy radicals containing various functional groups.

168 find that the ratio of delta to beta hydroxy peroxy radicals depends on their bimolecular lifetime (t

169 The chemistry of peroxy radicals derived from limonene upon addition of o

170 Without this rearrangement, peroxy radicals derived from MTbuK and DTbuK cannot unde

171 d kinetic model results suggest that organic peroxy radicals formed by alpha-pinene reacting with sec

172 Nitrooxy-peroxy radicals formed from NO(3) chemistry suppress the

173 f the atmospheric fate of the entire pool of peroxy radicals formed via addition of OH at C4 for typi

174 idation mechanism mediated by particle-phase peroxy radicals greatly accelerates OA oxidation, with e

175 find that reactions between alkenes and acyl peroxy radicals have reaction rates high enough to be fe

176 ief discussion of methods used to detect the peroxy radicals in the laboratory is presented.

177 on between unsaturated hydrocarbons and acyl peroxy radicals leads to an alkyl radical, to which mole

178 ility of the allylic radical, however, these peroxy radicals lose O2 in competition with bimolecular

179 accurate evaluation of the concentration of peroxy radicals over a variety of atmospheric conditions

180 ith monoterpenes, and the resulting isoprene peroxy radicals scavenge highly oxygenated monoterpene p

181 measurements of the reaction products of the peroxy radicals to diagnose this complex chemistry.

182 In the amplification channel, the peroxy radicals were converted in an excess amount of NO

183 ation of 1-alkenylperoxy radicals, which are peroxy radicals where the OO moiety is bonded to an sp2-

184 > 10 s, the distribution of isoprene hydroxy peroxy radicals will be controlled primarily by the diff

185 e sensitivities of the instrument to organic peroxy radicals with different hydrocarbon groups.

186 u, and sensitive measurements of atmospheric peroxy radicals with fast time response.

187 ently inside the particle by the reaction of peroxy radicals with SO2.

188 In particular, the reaction of organic peroxy radicals with the HO2 radical and the H2 OHO2 rad

189 thereby constraining first-generation RO(2) (peroxy radicals) to react nearly exclusively with NO.

190 PerCIMS provides measurements of the sum of peroxy radicals, HO2 + RO2 (HOxROx mode), or the HO2 com

191 ng the formation of both carbon-centered and peroxy radicals.

192 er rates than O(2) addition to form bicyclic peroxy radicals.

193 ssignment of electronic transitions in alkyl peroxy radicals.

194 cal as well as other hydrocarbon substituted peroxy radicals.

195 ibiting the lateral propagation of the lipid peroxy radicals.

196 c compound (VOC) reactivity, and the fate of peroxy radicals.

197 (NOx) (NMOG:NOx), which affects the fate of peroxy radicals.

198 formed via decomposition of the beta hydroxy peroxy radicals.

199 l instrument for measurements of atmospheric peroxy radicals.

200 It decays to a 1:6 mixture of peroxy species (a3(3+)-O(-)-O-) in which cytochrome a is

201 favors protonation of a cryogenerated ferric peroxy species at 77 K.

202 The peroxy species decay to a ferryl intermediate, with a pe

203 nor in most hydroxylation reactions, an iron-peroxy species is apparently involved in the deformylati

204 presence of a uniquely stable Fe---O---O(H) peroxy species is not detected.

205 tificial oxidants, we conclude that the iron-peroxy species is the direct oxygen donor.

206 rk Ti sites to co-ordinate hydrogen peroxide/peroxy species.

207 lear center which is substantially in the P (peroxy) state, not the well-characterized F (oxyferryl)

208 The initially formed peroxy-type adduct (RO(2)) is found to evolve in a compl

209 y 53% yield for phenol and 47% yield for BCP-peroxy under atmospheric conditions.

210 Similarly, the reaction of BCP-peroxy with HO(2) largely recycles HO(x), producing the

211 The reaction of BCP-peroxy with NO produces bicyclic hydroxy nitrate with a

212 Mitochondria peroxy yellow 1 (MitoPY1) is a small-molecule fluorescen

213 and biological applications of mitochondria peroxy yellow 1 (MitoPY1), a new type of bifunctional fl

214 Molecular imaging with Peroxy Yellow 1 Methyl-Ester (PY1-ME), a new chemoselect

215 duction was assayed in arterioles using mito peroxy yellow 1.