ライフサイエンスコーパス: peroxyl radical

1 formed after abstraction of H-9 or H-14 by a peroxyl radical.

2 results support formation of a transient SOD-peroxyl radical.

3 al (g = 2.034, 2.007) is characteristic of a peroxyl radical.

4 ed selectively by the 5S-diastereomer of the peroxyl radical.

5 ne results in the accumulation of the carbon peroxyl radical.

6 ibits apoptosis by scavenging cellular lipid peroxyl radicals.

7 des, we derive the heats of formation of the peroxyl radicals.

8 ts and their scavenging capacity on DPPH and peroxyl radicals.

9 he individual extract components to scavenge peroxyl radicals.

10 s free radicals, particularly oxygen-derived peroxyl radicals.

11 humans as they scavenge molecular oxygen and peroxyl radicals.

12 yl radicals transform into the corresponding peroxyl radicals.

13 and torularhodin were most effective against peroxyl radicals.

14 tects the bacterial cell envelope from lipid peroxyl radicals.

15 pyrylium was more effective inhibiting lipid peroxyl radicals.

16 radicals, and (4) unimolecular decay of nine peroxyl radicals.

17 tal dG's are also oxidatively damaged by the peroxyl radicals.

18 ence for electron transfer by the nucleobase peroxyl radicals.

19 quent trapping by O2 leads to the respective peroxyl radicals.

20 heir reactivity toward H-atom abstraction by peroxyl radicals.

21 e suspensions with hydrophilic or lipophilic peroxyl radicals.

22 presence of either hydrophilic or lipophilic peroxyl radicals.

23 The major reaction pathways for the peroxyl radical (1) derived from 5,6-dihydro-2'-deoxyuri

24 olecular hydrogen atom abstraction by the C6-peroxyl radical (14) and suggests that gamma-radiolysis

25 Under aerobic conditions, the peroxyl radical (2) derived from 1 reacts approximately

26 peroxidation induced by an azo-initiator of peroxyl radicals, 2, 2'-azobis(2,4-dimethylvaleronitrile

27 -TO. radical reacts with lipid to form lipid peroxyl radicals. (2) Phase transfer: alpha-TOH can tran

28 content (TPC), antioxidant capacity towards peroxyl radical (31.1%) as well as reducing power (39.5%

29 turated fatty acids such as oxygen addition, peroxyl radical 5-exo cyclization, and S(H)i carbon radi

30 cause of its far superior reactivity towards peroxyl radicals, 7-DHC effectively shields (phospho)lip

31 H2B-QH2 is shown to react with peroxyl radicals, a form of reactive oxygen species (ROS

32 at lycopene, alpha-tocopherol, selenium, and peroxyl radical absorption capacity are unlikely to be a

33 or lycopene, alpha-tocopherol, selenium, and peroxyl radical absorption capacity.

34 n, lycopene, alpha-tocopherol, selenium, and peroxyl radical absorption capacity.

35 Products that arise from peroxyl radical abstraction at each position of the vari

36 ensitive fluorescent probes shows that lipid peroxyl radicals accumulate at the bacterial cell poles

37 AT) from a donor to the peroxyl radical; (b) peroxyl radical addition (PRA) to a "C C" double bond.

38 AT) from a donor to the peroxyl radical; (b) peroxyl radical addition (PRA) to a "C=C" double bond.

39 use the radical "ate" complexes derived from peroxyl radical addition to boron are sufficiently persi

40 orting the products resulting from competing peroxyl radical addition to cholesterol, the stereoisome

41 Kinetic studies revealed that peroxyl radical addition to the 5'-thymine was favored b

42 al products and provided direct evidence for peroxyl radical addition to the adjacent thymine bases.

43 chemically activated population of the major peroxyl radical adduct (*)O2CH2CH(OH)2 is predicted to u

44 were detected, to which rapidly decomposing peroxyl radical adducts also contributed.

45 ins with a hydrogen atom transfer, forming a peroxyl radical and a Compound II-like species.

46 imolecular beta-fragmentation (k(beta)) of a peroxyl radical and its bimolecular reaction with a hydr

47 ed by H-bond formation between the attacking peroxyl radical and the 3beta-OH.

48 e results also support the proposal that the peroxyl radical and the sulfinyl radical are intermediat

49 Here, the reaction between linoleate peroxyl radicals and *NO was examined using 2, 2'-azobis

50 with more lipophilic compounds trapping two peroxyl radicals and more hydrophilic compounds trapping

51 own to undergo an irreversible reaction with peroxyl radicals and other radical oxidants to generate

52 romise between H-atom transfer reactivity to peroxyl radicals and stability to one-electron oxidation

53 romise between H-atom transfer reactivity to peroxyl radicals and stability to one-electron oxidation

54 he ability of NO to react with lipid-derived peroxyl radicals and terminate the propagation of lipid

55 trolled reactivity between the RTA and lipid-peroxyl radicals and/or the potential limitations on RTA

56 ienyl radicals; (3) disproportionation of 10 peroxyl radicals, and (4) unimolecular decay of nine per

57 iologically relevant reactions of ascorbate, peroxyl radicals, and alpha-tocopherol.

58 ent and cyclization of allyl and pentadienyl peroxyl radicals, and homolytic substitution of carbon r

59 e short-lived organic species are similar to peroxyl radicals appears most consistent with our experi

60 The reactions of peroxyl radicals are at the center of the oxidative degr

61 Gas phase peroxyl radicals are central to our chemical understandi

62 The reactions of organoboranes with peroxyl radicals are key to their use as radical initiat

63 (5) Lipophilic peroxyl radicals are scavenged with the same efficiency

64 Nucleobase peroxyl radicals are the major reactive intermediates fo

65 leads to accumulation of a substrate-derived peroxyl radical as a result of off-pathway trapping of t

66 r substitutes since they often do not employ peroxyl radicals as the oxidant and do not account for b

67 ls at tyrosine and tryptophan residues and a peroxyl radical at an unknown location have been reporte

68 the energetic cost required to reorient the peroxyl radical at the rate-determining step.

69 from the liposome oxidations that linoleate peroxyl radicals at different positions on the eighteen-

70 inary work, we showed that TEMPO reacts with peroxyl radicals at diffusion-controlled rates in the pr

71 ogen-atom transfer (HAT) from a donor to the peroxyl radical; (b) peroxyl radical addition (PRA) to a

72 ogen-atom transfer (HAT) from a donor to the peroxyl radical; (b) peroxyl radical addition (PRA) to a

73 der these conditions wastage reactions among peroxyl radicals become important, and this translates i

74 thanol were shown to be potent scavengers of peroxyl radical, being 5.94 to 26.08 times more potent a

75 We suggest that peroxyl radical beta-scission depends on solvent polarit

76 t of cells with scavengers of superoxide and peroxyl radicals blocked adriamycin-induced oxidation of

77 d superoxide anion, peroxynitrite anion, and peroxyl radicals, but with different efficiencies; furth

78 The quenching of peroxyl radicals by ortho-(alkyltelluro)phenols occurs b

79 The reaction of the allyl group with a peroxyl radical (C-H hydrogen abstraction) proceeds with

80 The peroxyl radical can serve as the seed for the production

81 By changing the [O2]/[I] ratio, we show that peroxyl radicals can be detected and quantified preferen

82 n: polyunsaturated fatty acid (PUFA)-derived peroxyl radicals can undergo an intramolecular H-atom tr

83 y reacting with them, the resulting protein (peroxyl) radicals can oxidize the bound DNA.

84 We review the thermochemistry of the peroxyl radicals, CH(3)OO and CH(3)CH(2)OO.

85 iterature data for reactions of phenols with peroxyl radicals clearly reveals that diarylamines have

86 This peroxyl radical clock methodology has been successfully

87 e analytical approach on the linoleate-based peroxyl radical clock to enable the simultaneous measure

88 yrylperacetate as a precursor to a versatile peroxyl radical clock with the present paper, wherein we

89 benzene, as determined by a newly developed peroxyl radical clock.

90 A series of peroxyl radical clocks has been developed and calibrated

91 Peroxyl radical clocks have been used to determine the r

92 Recently described peroxyl radical clocks offer a simple, convenient, and i

93 s in spinach extracts provided resistance to peroxyl radicals, components that did not bind to the HP

94 base modifications induced as a function of peroxyl radical concentration was determined by quantita

95 ased in a log linear fashion with respect to peroxyl radical concentration.

96 ition of DNA damage (induced by hydroxyl and peroxyl radicals), copper-induced LDL-cholesterol peroxi

97 xidation, and the carbon[bond]oxygen BDEs of peroxyl radicals correlate with rate constants for beta-

98 ng from C1'-hydrogen atom abstraction by the peroxyl radical, could not be detected.

99 mulgel showed that in addition to inhibiting peroxyl radicals, curcumin and curcumin esters were like

100 pproximately 10(6) s(-1)) of the bis-allylic peroxyl radical decreased on going from the cis,cis to t

101 measurements of the reactions of RSeOH with peroxyl radicals demonstrate that it readily undergoes H

102 e modifications at guanines and cytosines by peroxyl radicals depends on the exact specification of 5

103 ition of the adjacent 2'-deoxyuridine by the peroxyl radical derived from 1 (3) is observed under aer

104 andem lesions resulting from addition of the peroxyl radical derived from 1 to the 5'-adjacent nucleo

105 hydrogen atom abstraction by an intermediate peroxyl radical derived from linoleic acid that leads to

106 The in vitro antioxidant capacity against peroxyl radicals, DPPH, and sulfhydryl groups were analy

107 Subsequent HAT or combination with another peroxyl radical drives the reaction forward, such that a

108 -classical" RTA activity, where they trap >2 peroxyl radicals each, at ambient temperatures.

109 M) and is sensitive to the presence of lipid peroxyl radicals, effective chain carriers in the lipid

110 ing processes, including reaction with lipid peroxyl radicals, erythrocytes and superoxide ions, were

111 ation involving beta-fragmentation of the 15-peroxyl radical followed by re-addition of oxygen to for

112 emarkable oxygen-dependent chain process via peroxyl radical formation and evolution to give the Delt

113 Peroxyl radical formation was not prevented by site-dire

114 contrast, mutation of tryptophan 14 prevents peroxyl radical formation, implicating tryptophan 14 as

115 histidinyl radical consumed oxygen, implying peroxyl radical formation.

116 to different rates of beta-fragmentation of peroxyl radicals formed from oxygen addition at differen

117 e oxidation of organic amines by NH2Cl and N-peroxyl radicals from the reaction of aminyl radicals wi

118 ine flanks drastically reduced the extent of peroxyl radical G oxidation.

119 eroxidizing arachidonic acid (20:4omega6) or peroxyl radicals generated by thermolysis of ABIP in the

120 minary applications include the detection of peroxyl radicals generated thermally in soybean phosphat

121 xidation system (ascorbate/Fe(II)/H2O2) or a peroxyl radical generating system, 2,2'-azobis(2-amidino

122 zobis-2,4-dimethyl valeronitrile (AMVN) as a peroxyl radical generator, and 6-hydroxy-2, 5,7,8-tetram

123 s-2-amidinopropane hydrochloride (AAPH) as a peroxyl radical generator; 6-hydroxy-2,5,7, 8-tetramethy

124 e constants for H-atom transfer reactions to peroxyl radicals, greatly enabling the kinetic and mecha

125 from Ch occurs at C7, although HA from C4 by peroxyl radicals has recently been observed.

126 tions of linoleate in which the C-9 and C-13 peroxyl radicals have similar reactivities.

127 The minor peroxyl radical HOCH2C(OO(*))HOH is even less stable and

128 oxidant capacities of 2c, 2f, and 2p against peroxyl radicals, hydroxyl radicals, superoxide anion, s

129 Reorientation of the peroxyl radical in the active site, concomitant with the

130 activities of lipophilic antioxidants toward peroxyl radicals in a lipophilic medium (octane:butyroni

131 nic solutions of different polarity and with peroxyl radicals in a micellar system mimicking the amph

132 ne (kinh = 3.8 x 10(4) M(-1) s(-1)) and four peroxyl radicals in acetonitrile (kinh = 9.5 x 10(3) M(-

133 al and prevent macrophage lysis, implicating peroxyl radicals in both mitochondrial dysfunction and m

134 1) in acetonitrile, and honokiol trapped two peroxyl radicals in chlorobenzene (kinh = 3.8 x 10(4) M(

135 ndicate that the rate of production of lipid peroxyl radicals in HeLa cells under basal conditions is

136 ties of the pyridinols toward chain-carrying peroxyl radicals in homogeneous organic solution were ex

137 s a good scavenger of hydroxyl, alkoxyl, and peroxyl radicals in homogeneous systems.

138 and the polarity of the local environment of peroxyl radicals in liposomal oxidations depends on the

139 have mapped oxidative base damage induced by peroxyl radicals in the supF tRNA gene and correlated th

140 We find that the intermediate peroxyl radicals in these cases have negative C[bond]OO*

141 The sequence-specific distribution of peroxyl radical induced base damage was mapped for 803 n

142 Peroxyl radical induced tandem mutations were also obser

143 cells, fibroblasts and lymphocytes) against peroxyl radical-induced apoptosis, necrosis and mitotic

144 ay, which measures antioxidant inhibition of peroxyl radical-induced oxidations and is a measure of t

145 C-9 and C-11 of AA so that the incipient 11-peroxyl radical intermediate is able to add to C-9 to fo

146 [bond]oxygen bond dissociation enthalpies of peroxyl radical intermediates (R[bond]OO*) have been cal

147 differential evolution channels of isomeric peroxyl radical intermediates at the 2- versus 3-positio

148 cate that reactions of .NO with lipoxygenase peroxyl radical intermediates will result in modulation

149 t/KM(16,16O2)/kcat/KM(18,16O2) reveal that a peroxyl radical is formed in or before the first kinetic

150 The peroxyl radical is shown here to be localized on tryptop

151 the reduced catalytic tyrosine to a terminal peroxyl radical is the first irreversible step that cont

152 Detection of photochemically produced peroxyl radicals is achieved by employing 3-amino-2,2,5,

153 nce intensity enhancement upon reaction with peroxyl radicals is reported.

154 her than expected reactivity of RSeOH toward peroxyl radicals is the strongest experimental evidence

155 irreversible step, subsequent to forming the peroxyl radical, is also discussed in the context of the

156 established rate constants for reaction with peroxyl radicals (k(H-tocopherol) = 3.5 x 10(6) M(-1) s(

157 highly reactive toward phospholipid-derived peroxyl radicals (k(inh) = 2 x 10(5) M(-1) s(-1)), equal

158 .6, and the rate constants for reaction with peroxyl radicals, k(inh), are 1200 and 3300 M(-1) s(-1)

159 us micelles, with rate constant for trapping peroxyl radicals kinh=(3.8 +/- 0.7) x 10(4)M(-1)s(-1) at

160 chanism starts with a 4-exo cyclization of a peroxyl radical leading to an intermediate dioxetane, a

161 eaction between nitric oxide (*NO) and lipid peroxyl radicals (LOO*) has been proposed to account for

162 dical in the active enzyme and the resulting peroxyl radical may react further with the sulfhydryl gr

163 esis and carcinogenesis, the contribution of peroxyl radical mediated DNA base damage is less well un

164 ced by traditional assays, and inhibited the peroxyl radicals mediated oxidation of a tryptophan-cont

165 ompounds 9-11 quenched linoleic-acid-derived peroxyl radicals much more efficiently than alpha-tocoph

166 ngly suggests that H atom abstraction by the peroxyl radical occurs with substantial quantum mechanic

167 This new radical could be either a peroxyl radical of BH(4) or an amino acid radical was in

168 al oxidations depends on the position of the peroxyl radical on the 18-carbon chain.

169 We propose that cellular lipid peroxyl radicals or lipid hydroperoxides induce an apopt

170 a hydroperoxide activator and the incipient peroxyl radical oxidizes Tyr385, or (2) ferric enzyme re

171 bservation of steady concentrations of lipid peroxyl radicals produced in live cell imaging condition

172 Perflubron did not serve as a sink for peroxyl radicals produced in the aqueous phase during se

173 uminate the physiological relevance of lipid peroxyl radical production during cell homeostasis and d

174 Each molecule trapped a number n of peroxyl radicals ranging from 4 to 7.

175 due to reaction with the enzyme-bound lipid peroxyl radical, rather than impairment of (13S)-HPODE-d

176 luorescence assay for monitoring kinetics of peroxyl radical reactions in liposomes is subsequently d

177 cular oxygen addition, and a factor of 5 for peroxyl radical reactions.

178 )(TOH), is ~8 in the presence of hydrophilic peroxyl radicals, regardless of the nature of the lipid

179 Scavengers of peroxyl radicals restore mitochondrial membrane potentia

180 The respective peroxyl radicals, resulting from O2 trapping, add to 5'-

181 tom transfer from pzH to alkyl, alkoxyl, and peroxyl radicals reveals that BDEs are not a good predic

182 we have clearly identified the generation of peroxyl radical (ROO(*)) by the unmodified SWCNT and the

183 s an (*)OH scavenger generates the secondary peroxyl radical (ROO(*)), influencing the oxidation of t

184 spectrum that we assign to the alpha-carbon peroxyl radical (ROO*) of the active-site glycine, G734.

185 erates free radical intermediates (primarily peroxyl radicals, ROO(*)) and electrophilic aldehydes as

186 Reducing power (RP), DPPH and peroxyl radical scavenging (PRS) evaluated indirect anti

187 Employing this method, the relative peroxyl radical scavenging activities of Trolox, alpha-t

188 ts showed similar total phenolic content and peroxyl radical scavenging capacity, with hypochlorous a

189 tribution of epigallocatechin gallate in the peroxyl radical scavenging of green tea extracts.

190 eroxidation products to perflubron or by the peroxyl radical scavenging properties of perflubron.

191 ioxidants, is shown herein to exhibit potent peroxyl radical scavenging properties that are controlle

192 droxyl radical scavenging, 279.02 mug mL(-1) Peroxyl radical scavenging).

193 Furthermore, since the assay has a Q(10) for peroxyl radical-scavenging of about 3, elevation of the

194 umn fractions permitted the determination of peroxyl-radical-scavenging profiles, demonstrating the r

195 (4) Lipophilic peroxyl radicals show reduced discrimination between ant

196 PPH and ABTS), reactive oxygen species (ROS; peroxyl radical, superoxide radical, hypochlorous acid),

197 nglet oxygen leads to hydroperoxides then to peroxyl radicals, tetraoxides, and decomposition product

198 epoxyallylic radical, giving an epoxyallylic peroxyl radical that does not further react with Fe(III)

199 provides a steady source of free amphiphilic peroxyl radicals that efficiently initiates oxidation of

200 )): the reduced form, ubiquinol, traps lipid peroxyl radicals that mediate lipid peroxidation, wherea

201 pite their remarkably high reactivity toward peroxyl radicals, the phenoxazines were found to be comp

202 cs, scavenging activity against hydroxyl and peroxyl radicals, the reducing power and chelating capac

203 nt radicals, including the hydroxyl radical, peroxyl radicals, the trioxidocarbonate radical anion, n

204 the transformation, that only the 12- and 8-peroxyl radicals (those leading to 12-HPETE and 8-HPETE)

205 alkoxyamine that subsequently reacts with a peroxyl radical to eventually re-form the nitroxide.

206 substituents on the rearrangement of the C-3 peroxyl radical to give conjugated diene products.

207 ad suggest that the reversible addition of a peroxyl radical to the bis(thiosemicarbazone) ligand is

208 cid-catalyzed reaction of a nitroxide with a peroxyl radical to yield an oxoammonium ion followed by

209 explained by the addition of intermediate 5'-peroxyl radicals to the C8 position of the attached puri

210 l has more than an order of magnitude better peroxyl radical trapping activity than alpha-tocopherol

211 Plasma total peroxyl radical trapping potential values did not change

212 ycopene and vitamin concentrations and total peroxyl radical trapping potential, a measure of antioxi

213 of H(2)B-PMHC consistent with unprecedented peroxyl radical-trapping activity in lipid bilayers.

214 pids do not efficiently scavenge hydrophilic peroxyl radicals; under these conditions wastage reactio

215 In the first mechanism, a peroxyl radical undergoes successive 5-exo cyclizations

216 PFL was mixed with oxygenated solution, the peroxyl radical was also observed at 10 ms but in this c

217 gen incorporation on their reactivity toward peroxyl radicals was comparatively small (a decrease of

218 reactivity of DNA bases toward oxidation by peroxyl radicals was found to be G >> C > T.

219 f dialkylamino-substituted diarylamines with peroxyl radicals were found to be >10(7) M(-1) s(-1), wh

220 Peroxyl radicals were generated with 2,2'-azobis(2-methy

221 hydrogen peroxide, peroxynitrite anions, and peroxyl radicals) were measured with an amine-reactive g

222 lipid peroxidation is the propagation of the peroxyl radical, where generally two types of reactions

223 lipid peroxidation is the propagation of the peroxyl radical, where generally two types of reactions

224 xidative stress is the reactivity of RSSH to peroxyl radicals, where favorable thermodynamics are bol

225 l radical yields a strand break containing a peroxyl radical, which initiates opposite strand cleavag

226 gen atom and the internal oxygen atom of the peroxyl radical, which is nominally better for the more

227 gamma-Tocopherol scavenges lipid peroxyl radicals, while phenolics donate hydrogen atoms

228 ary orbital interactions in the reactions of peroxyl radicals with good H-atom donors.

229 mined the DNA damage produced by reaction of peroxyl radicals with human fibroblast DNA.

230 utoxidations, CuATSM reacts with THF-derived peroxyl radicals with k(inh) = 2.2 x 10(6) M(-1) s(-1) r

231 data for reactions of the diarylamines with peroxyl radicals with literature data for reactions of p

232 and styrene at 303 K, magnolol trapped four peroxyl radicals, with a kinh of 6.1 x 10(4) M(-1) s(-1)

233 one molecule of DA traps approximately four peroxyl radicals, with a rate constant k(inh) >10(3) M(-

234 dimethylisovaleronitrile) (AMVN) to generate peroxyl radicals within cellular membranes of HL-60 cell

235 group on the chromanol group can trap lipid peroxyl radicals within the interior and near the surfac