ライフサイエンスコーパス: peroxynitrite

1 ation of dityrosine, suggesting formation of peroxynitrite.

2 s and in the extracellular space, generating peroxynitrite.

3 ysteines made the enzyme more susceptible to peroxynitrite.

4 dose-dependently nitrated and inactivated by peroxynitrite.

5 DA) increased the Fe-SODB sensitivity toward peroxynitrite.

6 ed probe, pnGFP, which can selectively sense peroxynitrite.

7 tyrosine nitration, indicating production of peroxynitrite.

8 y active protein that was not susceptible to peroxynitrite.

9 ed as a probe for the selective detection of peroxynitrite.

10 ing is due to increases in the production of peroxynitrite.

11 synthase mRNA and produced higher levels of peroxynitrite.

12 ) synthesis and scavenging of superoxide and peroxynitrite.

13 )O(2)), 3-morpholinosydnonimine (SIN-1), and peroxynitrite.

14 Prx substrates such as hydrogen peroxide and peroxynitrite.

15 known to be driven by the overproduction of peroxynitrite.

16 A exposed to ultraviolet (UV) irradiation or peroxynitrite.

17 and the generation of nitric oxide (NO) and peroxynitrite.

18 ger, prevented hyperoxia-induced increase in peroxynitrite.

19 of many other genes that are up-regulated by peroxynitrite.

20 vels were also elevated after treatment with peroxynitrite.

21 he hairpin is susceptible to modification by peroxynitrite.

22 reaction of PDI with the biological oxidant peroxynitrite.

23 ydrogen peroxide, organic hydroperoxide, and peroxynitrite.

24 a previously unrecognized source of NO(*)and peroxynitrite.

25 beta can be nitrated at tyrosine 10 (Y10) by peroxynitrite.

26 e nitrogenous intermediates (RNI), including peroxynitrite.

27 none intermediate (2OHCBZ) and nitration via peroxynitrite (2OHCBZ and 3OHCBZ) as well as formation o

28 Peroxynitrite, a key cytotoxic and oxidizing effector bi

29 Peroxynitrite, a reactive short-lived peroxide with a pK

30 Blocking the production of peroxynitrite abrogated the SDR-induced increase in micr

31 ely neutralized by the pro-death activity of peroxynitrite after UVB radiation.

32 al oxidants, including hydrogen peroxide and peroxynitrite, also produce only the corresponding sulfo

33 retinal neuro/vascular injury is mediated by peroxynitrite-altered Trx antioxidant defense, which in

34 tyrosine nitration of chlamydial protein by peroxynitrite, an NO metabolite.

35 We further determined the role of peroxynitrite, an oxidant molecule generated from the re

36 Thus, the cellular responses to peroxynitrite and hydrogen peroxide are distinct.

37 h the physiologically relevant electrophiles peroxynitrite and hydrogen peroxide, and with the probe

38 angiogenic function in BMECs is mediated by peroxynitrite and involves c-src and MT1-MMP activation.

39 uction of P450 compound I through the use of peroxynitrite and laser flash photolysis.

40 Peroxynitrite and products of the autooxidation of NO in

41 duction of reactive oxygen/nitrogen species (peroxynitrite and protein nitrosylation).

42 ad increased production rates of superoxide, peroxynitrite and total reactive oxygen species (ROS) in

43 e, which is formed from the reaction between peroxynitrite and tyrosine (Try).

44 SH levels (scavenging of reactive oxygen and peroxynitrite)-and by supporting the mitochondrial energ

45 itroxidative species), including superoxide, peroxynitrite, and hydrogen peroxide.

46 tion of hydrogen peroxide, superoxide anion, peroxynitrite, and nitric oxide.

47 By reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides, peroxiredoxin

48 he peculiar ability to neutralize peroxides, peroxynitrite, and phospholipid hydroperoxides.

49 with superoxide results in the generation of peroxynitrite, and this powerful oxidant has been sugges

50 alter the activity of LKB1(S), but abolished peroxynitrite- and metformin-induced activation of AMPK.

51 *)NO rapidly react to form a potent oxidant, peroxynitrite anion (ONOO(-)).

52 The activation of the peroxynitrite anion (PN) by hemoproteins, which leads to

53 l three extracts scavenged superoxide anion, peroxynitrite anion, and peroxyl radicals, but with diff

54 shes the NO bioavailability by forming toxic peroxynitrite anion.

55 itrogen species (ROS/RNS; hydrogen peroxide, peroxynitrite anions, and peroxyl radicals) were measure

56 ts survival, induces apoptosis, and promotes peroxynitrite as a novel therapeutic target for the impr

57 stently thiol-modified in cells treated with peroxynitrite as follows: AsnB, FrmA, MaeB, and RidA.

58 ue, our findings highlight oxLDL, LOX-1, and peroxynitrite as important therapeutic targets in EPE.

59 n of TRPA1 cysteine residues, most likely by peroxynitrite, as a novel mechanism of action of STZ.

60 hich led to the formation of highly reactive peroxynitrite, as shown by 3-nitrotyrosine formation in

61 effect of iNOS on TIMP-2 may be mediated by peroxynitrite, as the latter reversed TIMP-2 expression

62 lly introduced into mammalian cells to image peroxynitrite at physiologically relevant concentrations

63 , and Kupffer cell activation while blocking peroxynitrite-attenuated NASH symptoms.

64 nthetic molecule having high reactivity with peroxynitrite, attenuates inflammatory pathogenesis in N

65 Scavenging the peroxynitrite avoids the inactivation of cellular enzyme

66 likely due to the imbalance of nitric oxide/peroxynitrite because treating the cells with lower (50

67 hought to proceed through an iron(III)-bound peroxynitrite before homolytic cleavage of the O-O bond

68 ancements and the challenges in the field of peroxynitrite biosensors and probes for in vivo and in v

69 the levels of fatty acid hydroperoxides and peroxynitrite, both of which are involved in host-pathog

70 Homocysteine treatment elevated peroxynitrite by approximately 85% after 9 hours.

71 Reduction of peroxynitrite by Ohr was also determined to be in the or

72 Although peroxynitrite caused a fairly indiscriminate nitration o

73 eases the generation of hydroxyl radical and peroxynitrite close to the cell nucleus, inflicting DNA

74 erization of the long sought after ferriheme peroxynitrite complex has been accomplished.

75 ct fast product formation from the iron(III)-peroxynitrite complex.

76 sis for assigning them to the six-coordinate peroxynitrite complexes (NH(3))Co(Por)(OONO).

77 ntrast, at 313 nm we observe no formation of peroxynitrite, corresponding to Phi(ONOO(-)) < 0.26%.

78 -deficient mice and from mice treated with a peroxynitrite decomposition catalyst [iron(III) tetrakis

79 he CypD-regulated mPT, we coadministered the peroxynitrite decomposition catalyst Fe-TMPyP (10 mg/kg,

80 tate (NMDA) in rats, which also received the peroxynitrite decomposition catalyst FeTPPs.

81 ion of SP-D dodecamers or murine lavage with peroxynitrite decreased the SP-D-dependent aggregation o

82 d phenomenon was NADPH oxidase, p47phox, and peroxynitrite dependent, as liver from p47phox-deficient

83 ming of energy metabolism characterized by a peroxynitrite-dependent decrease of oxidative phosphoryl

84 Peroxynitrite-dependent impairment of endothelial TRPV4

85 tosis of motor neurons through a copper- and peroxynitrite-dependent mechanism.

86 intramolecular electron transfer, preventing peroxynitrite-dependent nitration and consequent inactiv

87 This is the first demonstration of a peroxynitrite-dependent reprogramming of energy metaboli

88 nd peroxynitrite (ONOO(-)/ONOOH), as well as peroxynitrite-derived hydroxyl (HO(*)) and carbonate ani

89 The reaction of purified PP2A with peroxynitrite dissociated the A subunit, and 3-nitro-Tyr

90 om rat primary cardiomyocytes treated with a peroxynitrite donor.

91 s compound is able to inhibit the effects of peroxynitrite-driven toxicity, including the formation o

92 strongly suggest that NADPH oxidase-mediated peroxynitrite drove TLR4 recruitment into hepatic lipid

93 ratiometric and calorimetric response toward peroxynitrite due to ONOO(-)-triggered oxidative reactio

94 The mechanisms by which peroxynitrite exerts its protective effect may include i

95 altered transcription factors in response to peroxynitrite exposure, including OxyR and ArgR.

96 ggest S-nitrosylation to be a consequence of peroxynitrite exposure.

97 tress was suppressed and malondiladehyde and peroxynitrite expressions were absent.

98 Malondiladehyde and peroxynitrite expressions were present.

99 g NO synthase (l-NAME, 100 um) or scavenging peroxynitrite (FeTPPS, 5 um) reduced SMC death along wit

100 Treatment of N2a cells with peroxynitrite for 5 min followed by recovery of cells fo

101 oxide radicals, resulting in increased local peroxynitrite formation and subsequent oxidation of the

102 NMDA-induced peroxynitrite formation caused RGC loss, which was assoc

103 nduce the increases in eNOS activity, NO and peroxynitrite formation in COS-7 cells transfected with

104 We hypothesized that excess peroxynitrite formation in diabetic ischemia/reperfusion

105 The increase in peroxynitrite formation is accompanied by increases in n

106 Furthermore, scavenging or inhibiting peroxynitrite formation significantly and selectively de

107 and attenuates eNOS-beta-actin association, peroxynitrite formation, endothelial apoptosis, and pulm

108 Despite NO toxicity via peroxynitrite formation, endothelial integrity protects

109 formation, mitochondrial oxidant stress and peroxynitrite formation, mitochondrial dysfunction (asse

110 5% O(2)) for 24 h resulted in an increase in peroxynitrite formation.

111 g motor neurons required copper and involved peroxynitrite formation.

112 econditioning, the protection is mediated by peroxynitrite formed by the reaction of NO with superoxi

113 ied LOX-1 activation by oxLDL and subsequent peroxynitrite generation as a novel mechanism by which d

114 on of Nox4 abolishes the increase in ROS and peroxynitrite generation as well as eNOS uncoupling trig

115 demonstrate that cytokines fail to stimulate peroxynitrite generation by rat islets and insulinoma ce

116 (*-) detection, aconitase inactivation, and peroxynitrite generation were lower in Fe-SODB than in W

117 on of Nox4 abrogates the increase in ROS and peroxynitrite generation, as well as the eNOS uncoupling

118 r blood pressure, but blocked superoxide and peroxynitrite generation, reversed the decline in RBF, c

119 s through blockade of Nox4-dependent ROS and peroxynitrite generation, with subsequent eNOS uncouplin

120 itric oxide-producing macrophages results in peroxynitrite generation.

121 The peroxynitrite generator 3-morpholinosydnonimine stimulat

122 Likewise, exposure to the peroxynitrite generator SIN-1 degraded the mechanical pr

123 rpholinosydnonimine hydrochloride (SIN-1 , a peroxynitrite generator).

124 c levels in neural stem cells treated with a peroxynitrite generator, Sin-1, revealed an immediate de

125 A fraction of peroxynitrite, however, decayed to radicals that hydroxy

126 , pyrophosphate, bicarbonate, hydrosulphide, peroxynitrite, hypochlorite and hypobromite) a comprehen

127 f oxidants including H2O2, hydroxyl radical, peroxynitrite, hypochlorous acid, hypobromous acid, and

128 trated the utility of 4-MB for intracellular peroxynitrite imaging.

129 In the present study, the role of peroxynitrite in altering the antioxidant and antiapopto

130 hyperoxia increases the formation of NO and peroxynitrite in lung endothelial cells via increased in

131 ce the hyperoxia-induced formation of NO and peroxynitrite in lung endothelial cells.

132 We have previously shown a causal role of peroxynitrite in mediating retinal ganglion cell (RGC) d

133 microglial release of soluble mediators (and peroxynitrite in particular), which induced neuronal exp

134 the effect of hyperoxia on the production of peroxynitrite in pulmonary artery endothelial cells (PAE

135 ployed to visualize exogenous and endogenous peroxynitrite in RAW264.7 macrophages, EAhy926 cells, ze

136 of cytokines, (ii) beta-cells do not produce peroxynitrite in response to cytokines, and (iii) when f

137 quently, many efforts are underway to detect peroxynitrite in the biomedical field.

138 lysis of 3-NT-containing proteins exposed to peroxynitrite in the total protein lysate of cultured C2

139 In MD-Schwann cells, scavenging of peroxynitrite increased mitochondrial oxygen consumption

140 In experimental settings, peroxynitrite incubation of serum samples and isolated p

141 sGC stimulation prevented peroxynitrite-induced apoptosis of alveolar and endothel

142 ne thiol oxidation may be operant in vivo in peroxynitrite-induced FeOxI activity inhibition.

143 Reduced glutathione prevented peroxynitrite-induced FeOxI drop, tyrosine nitration, an

144 ut not cysteine oxidation, partially impeded peroxynitrite-induced FeOxI drop.

145 present studies tested the mechanism for the peroxynitrite-induced inactivation and subsequent reacti

146 h, we identified specific target proteins of peroxynitrite-induced modifications in Escherichia coli.

147 (Y284F) expressed in cells was resistant to peroxynitrite-induced nitration and reduction of A subun

148 In this study, we identified peroxynitrite-induced post-translational modifications (

149 Mechanistically, peroxynitrite-induced TLR4 recruitment was linked to inc

150 ing mitochondrial dysfunction, generation of peroxynitrite, induction of apoptosis, and oxidative str

151 Peroxynitrite inhibited purified KGDHC activity in a dos

152 in obesity and assessed the effectiveness of peroxynitrite inhibition in rescuing endothelial AKAP150

153 ur results provide evidence that I/R-induced peroxynitrite inhibits survival, induces apoptosis, and

154 A peroxynitrite intermediate complex is implicated; if 2,4

155 rmation of both Fe(III)-superoxo and Fe(III)-peroxynitrite intermediates and takes into account the e

156 oxide, peroxymonocarbonate, hypochlorite, or peroxynitrite involves the incorporation of oxygen atoms

157 Peroxynitrite is a highly reactive chemical species with

158 Peroxynitrite is a highly reactive molecule involved in

159 Peroxynitrite is a short-lived oxidant species that is a

160 Peroxynitrite is an endogenous toxicant but is also a cy

161 Peroxynitrite is believed to contribute to pathogenesis

162 Peroxynitrite is formed in macrophages by the diffusion-

163 The biological chemistry of peroxynitrite is modulated by endogenous antioxidant mec

164 s reactive oxygen species, and the generated peroxynitrite is responsible for significant bacterial i

165 Among reactive nitrogen species, peroxynitrite is the most powerful oxidant produced by c

166 Peroxynitrite is the product of the diffusion-controlled

167 roduct of the oxidation of guanine in DNA by peroxynitrite, is an excellent substrate of BER only.

168 est that heme/O(2)/*NO chemistry may lead to peroxynitrite leakage and/or exogenous substrate oxidati

169 betic cells by AVE3085 resulted in increased peroxynitrite levels and, therefore, did not enhance NO-

170 Strategies that lowered peroxynitrite levels prevented cysteine 36 oxidation of

171 eased mitochondrial superoxide formation and peroxynitrite levels.

172 O2 species through O-O bond homolysis of the peroxynitrite ligand.

173 eory (DFT) calculations, reveal that M(III) -peroxynitrite (M=Fe and Mn) species, generated in the re

174 mitochondrial 3-nitrotyrosine adduct levels (peroxynitrite marker) were decreased.

175 ed that GIT-27NO but not Saq-NO acts through peroxynitrite-mediated cell destruction.

176 bition or genetic depletion of CypD and that peroxynitrite-mediated cell injury predominates in the a

177 ent of Tyr(350) with phenylalanine abolished peroxynitrite-mediated eNOS translocation to mitochondri

178 t mass spectrometry analysis indicating that peroxynitrite-mediated inactivation of T. cruzi Fe-SODs

179 A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1

180 resistant to both streptococcus/nitrite- and peroxynitrite-mediated killing.

181 Redox inhibition of PP2A results from peroxynitrite-mediated nitration of a conserved tyrosine

182 modulators of neuronal excitability, and (2) peroxynitrite-mediated posttranslational nitration and i

183 We recently showed that peroxynitrite-mediated tyrosine nitration down-regulates

184 se in NO bioavailability, demonstrating that peroxynitrite mediates the effects of Ang II on eNOS dys

185 Peroxynitrite mediates the effects of HG on eNOS dysfunc

186 ion and killing of E. coli demonstrates that peroxynitrite mediates the stressor-induced increase in

187 pt to acute oxidative stress (e.g. H(2)O(2), peroxynitrite, menadione, and paraquat) through transien

188 duced hypertension and imply that inhibiting peroxynitrite might represent a strategy for normalizing

189 Hydrogen peroxide and peroxynitrite mimicked the inhibitory effect of high glu

190 S) leads to the emergence of highly reactive peroxynitrite molecules with significantly enhanced bioc

191 Treating CD4+ T cells with peroxynitrite nitrated PKCdelta, preventing PKCdelta T(5

192 uring infection, there were higher levels of peroxynitrite (NO(3).(-)) in livers from mice lacking ec

193 Scavengers of reactive oxygen species and peroxynitrite normalized HTRA3 and POLG1 levels in CS ce

194 racetamol often causes hepatotoxicity due to peroxynitrite ONOO(-) .

195 peroxide (H2 O2 ), superoxide (O2(-) ), and peroxynitrite (ONOO(-) ).

196 ide (NO), reactive oxygen species (ROS), and peroxynitrite (ONOO(-)) (spleen).

197 creasing photoacoustic signal in response to peroxynitrite (ONOO(-)) and hydrogen peroxide (H(2)O(2))

198 is oxidatively and nitrosatively modified by peroxynitrite (ONOO(-)) and hypochlorous acid (HOCl) and

199 ed myocardial superoxide anion (O(2)(-)) and peroxynitrite (ONOO(-)) and their enzymatic sources in s

200 lla, presumably by limiting the formation of peroxynitrite (ONOO(-)) arising from the diffusion-limit

201 t physiological pH leads to the formation of peroxynitrite (ONOO(-)) as a major intermediate.

202 Peroxynitrite (ONOO(-)) contributes to coronary microvas

203 nhibited by 3-morpholinosydnonimine (SIN-1) [peroxynitrite (ONOO(-)) donor]; ONOO(-) can be produced

204 O2showed complex kinetic behavior and led to peroxynitrite (ONOO(-)) formation, which was detected us

205 sive epidermal oxidative stress via H2O2 and peroxynitrite (ONOO(-)) in affected individuals.

206 We also monitored the formation of peroxynitrite (ONOO(-)) in HEK293 cells fluorimetrically

207 stress via hydrogen peroxide (H(2)O(2)) and peroxynitrite (ONOO(-)) in the skin of affected individu

208 stress via hydrogen peroxide (H(2)O(2)) and peroxynitrite (ONOO(-)) in the skin of affected individu

209 Peroxynitrite (ONOO(-)) inactivates eNOS, but questions

210 We found that d-flow-mediated peroxynitrite (ONOO(-)) increased PKCzeta activation, wh

211 Preincubation with antioxidants and peroxynitrite (ONOO(-)) inhibitors improved endothelium-

212 Among these RNOS, peroxynitrite (ONOO(-)) is a well-known inflammatory med

213 Peroxynitrite (ONOO(-)) is an important species involved

214 over, we show the presence of high epidermal peroxynitrite (ONOO(-)) levels via nitrotyrosine togethe

215 n addition, we found that oxidation of TE by peroxynitrite (ONOO(-)) prevented binding of SMCs and WI

216 ng by Ang II, we evaluated the potential for peroxynitrite (ONOO(-)) to mediate CaMKII activation and

217 hat oxidation and release of the zinc ion by peroxynitrite (ONOO(-)), a potent oxidant generated by n

218 ive nitrogen oxide species (RNOx), including peroxynitrite (ONOO(-)), are powerful nitrating agents.

219 oxide (O2 ()), hydrogen peroxide (H2O2), and peroxynitrite (ONOO(-)), the number of false positives w

220 nic probe (KNP-1) was developed by targeting peroxynitrite (ONOO(-)), which is upregulated at the ear

221 We recently reported a genetically encoded peroxynitrite (ONOO(-))-specific fluorescent sensor, pnG

222 ere inert to nitric oxide (NO(*)) as well as peroxynitrite (ONOO(-)).

223 n increase seen with exposure to the oxidant peroxynitrite (ONOO(-)).

224 (NO2(-)) and oxygen atom (O((3)P)), and (3) peroxynitrite (ONOO(-)).

225 gen trioxide (N(2)O(3)), nitroxyl (HNO), and peroxynitrite (ONOO(-)/ONOOH), as well as peroxynitrite-

226 f reactive nitrogen species (RNS), including peroxynitrite (ONOO).

227 ous treatment with stable oxidants (H2O2 and peroxynitrite [ONOO(-)]) and dampened the intracellular

228 Peroxynitrite ((-)OON horizontal lineO, PN) is a reactiv

229 myocardium and are thought to be mediated by peroxynitrite (OONO(-)) in vivo.

230 Although there was no effect of peroxynitrite or tyrosine mutations on lectin activity,

231 esis is increased in a spatial manner and 2) peroxynitrite orchestrates vascular endothelial growth f

232 ved unusual chemoselectivity of pnGFP toward peroxynitrite over hydrogen peroxide by using site-direc

233 eceptor, LOX-1, and subsequent generation of peroxynitrite (P<0.001).

234 2 schwannomas but also other tumors in which peroxynitrite plays a regulatory role.

235 ct rapidly with nitric oxide (NO) to produce peroxynitrite (PN) at the heme site.

236 We report the formation of a new copper peroxynitrite (PN) complex [Cu(II) (TMG(3) tren)(kappa(1

237 min at -80 degrees C, 3 is converted to the peroxynitrite (PN) complex [Cu(II)2(UN-O(-))((-)OON hori

238 We report that formation of peroxynitrite (PN) in response to activation of nitric o

239 Peroxynitrite (PN, ONOO(-)) is a potent oxidant and nitr

240 such as acrolein (AC), hydroxyquinones (HQ), peroxynitrites (PN), and hydrogen peroxide, on their abi

241 lls (MDSCs) are a source of the free radical peroxynitrite (PNT).

242 simulations, and MS analyses confirmed that peroxynitrite preferentially oxidizes the redox-active C

243 t as a contaminant in commercially available peroxynitrite preparations.

244 ide or nitric oxide production inhibits both peroxynitrite production and killing of E. coli demonstr

245 Peroxynitrite production and tyrosine nitration are pres

246 that the increased microbicidal activity and peroxynitrite production was dependent upon IL-1 signali

247 eta-actin association, eNOS activity, NO and peroxynitrite production, and protein tyrosine nitration

248 a-actin association contributes to increased peroxynitrite production, eNOS-beta-actin interaction we

249 Disturbed flow induces peroxynitrite production, which activates protein kinase

250 Excess peroxynitrite promoted further PDI oxidation, nitration,

251 l other compounds present in food to prevent peroxynitrite reactions in three different test systems,

252 h for drugs and nutraceuticals able to limit peroxynitrite reactions is thus of interest.

253 Inhibiting NO synthase or scavenging peroxynitrite reduced SMC death; endothelial denudation

254 tment of disulfide-oxidized Prx2 with excess peroxynitrite renders mainly mononitrated and dinitrated

255 also appeared to play a central role in the peroxynitrite response, because the ohr mutant was more

256 xposed to exogenous or endogenous sources of peroxynitrite resulted in nitration and inactivation of

257 reactions with a reporter disulfide and with peroxynitrite revealed that persulfides are better nucle

258 ) tetrakis(p-sulfonatophenyl)porphyrin] or a peroxynitrite scavenger (phenylboronic acid) had markedl

259 onse and were restored by treatment with the peroxynitrite scavenger 5,10,15,20-tetrakis(4-sulfonatop

260 essed using the superoxide dismutase mimetic/peroxynitrite scavenger MnTMPyP [Mn(III)tetrakis(1-methy

261 inflammation, whereas the in vivo use of the peroxynitrite scavenger phenylboronic acid, a novel synt

262 In fact, cotreatment with an NO-peroxynitrite scavenger revealed that GIT-27NO but not S

263 ation of the superoxide scavenger Tiron, the peroxynitrite scavenger Urate, or the eNOS inhibitor L-N

264 Peroxynitrite scavenger uric acid did not affect the fir

265 An antioxidant/peroxynitrite scavenger, ebselen, prevented stress-induc

266 Uric acid, a peroxynitrite scavenger, prevented hyperoxia-induced inc

267 omethenes, 4a-c, as potent and orally active peroxynitrite scavengers.

268 and neutralized by synthetic compounds with peroxynitrite-scavenging capacity.

269 mmonia, and both protonated and deprotonated peroxynitrite (selectivity coefficients of -5.3, -4.2, -

270 andom mutagenesis, we identified a selective peroxynitrite sensor, which is essentially unresponsive

271 prior to NO to generate an active iron(III)-peroxynitrite species that is able to nitrate l-Trp effi

272 Mechanistically, NOX2 mediated peroxynitrite species were primary to inflammasome activ

273 In addition to the major phenolic products, peroxynitrite-specific minor products of oxidation of bo

274 VEGF-neutralizing antibody and inhibitors of peroxynitrite, src kinase, or MMP blocked the migration.

275 To determine whether APAP-induced peroxynitrite stress might directly activate mitochondri

276 All four were required for peroxynitrite stress tolerance in vivo.

277 However, whether peroxynitrite supports a metabolic shift that could be e

278 including superoxide, nitric oxide (NO), and peroxynitrite, than LGN neurons with an intact cortical

279 s suggest a mechanism involving an iron(III)-peroxynitrite that splits homolytically to form an iron(

280 Complexes 4a-c are shown to reduce peroxynitrite through a two-electron mechanism, thereby

281 Uric acid (UA) can scavenge the peroxynitrite to avoid the formation of nitrotyrosine, w

282 the ability of the body from preventing the peroxynitrite toxicity.

283 Increasing cellular GSH in peroxynitrite-treated cells rescued KGDHC activity to th

284 505) phosphorylation, similar to PKCdelta in peroxynitrite-treated cells.

285 nished the nitrotyrosine immunoreactivity of peroxynitrite-treated KGDHC, restored the activity and t

286 ation of LKB1(S) in response to metformin or peroxynitrite treatment.

287 ive analysis of transcriptional responses to peroxynitrite under tightly controlled chemostat growth

288 as follows: superoxide using hydroethidine, peroxynitrite using boronate-based probes, nitric oxide-

289 When beta-cells are forced to generate peroxynitrite using nitric oxide donors and superoxide-g

290 The reaction of these PDI residues with peroxynitrite was considerably faster (k = (6.9 +/- 0.2)

291 active species superoxide, nitric oxide, and peroxynitrite was measured by electron paramagnetic reso

292 Susceptibility of T. cruzi Fe-SODA toward peroxynitrite was similar to that reported previously fo

293 with superoxide results in the formation of peroxynitrite, we have shown that beta-cells do not have

294 icals, superoxide anion, singlet oxygen, and peroxynitrite were determined by using ORAC, HORAC, SORA

295 intracellular levels of NO, superoxide, and peroxynitrite were evaluated.

296 eroxia-induced increase in the production of peroxynitrite which may cause nitrosative stress in pulm

297 superoxide-dependent cytotoxicity resides on peroxynitrite, which affects mitochondrial function and

298 Peroxynitrite, whose production is increased in heart fa

299 eveloping novel fluorescent probes to detect peroxynitrite with relatively high sensitivity and speci

300 Whereas scavenging of superoxide and/or peroxynitrite with superoxide dismutase, tiron, Mn(III)t