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2 mice have functional defects, with decreased phagocytic ability and a decreased capacity to generate
3 l interfering RNA enhanced FcgammaR-mediated phagocytic ability but have little effect on cytokine pr
6 By assessing in vivo MRI of mononuclear cell phagocytic ability with (19)F nanoparticles, MRI with du
12 Macrophages from KO mice showed increased phagocytic activity and elevated expression of LDL recep
14 n of TNF-alpha and interleukin-10, inhibited phagocytic activity and stimulated production of ROS.
15 ults suggested that astrocytes may engage in phagocytic activity during extended wake, but direct evi
19 we investigated whether increased microglial phagocytic activity that clears amyloid can also cause p
22 hondrial superoxide dismutase), (2) enhanced phagocytic activity toward red blood cells (an in vitro
24 appears to occur as a result of an enhanced phagocytic activity within the lung and an associated al
25 as inflammatory cytokines, NOS 2, increased phagocytic activity, and a greater osteoclast differenti
26 on of a K(+) conductance, the UDP-stimulated phagocytic activity, and the ATP-dependent laser lesion-
27 etabolism under conditions of chronic myelin phagocytic activity, as TREM2 LOF causes pathogenic lipi
28 NK cells poorly and drove moderate monocyte phagocytic activity, both likely compromised because of
29 KO mice was associated with perturbations in phagocytic activity, defective transition of macrophages
30 exercise regimen displayed higher macrophage phagocytic activity, enhanced RvD1 levels, and earlier n
31 duction, phagocytic receptor expression, and phagocytic activity, enhancing parasite clearance by mac
32 y evoked membrane currents, stimulated basal phagocytic activity, evoked intracellular Ca(2+) transie
34 of myocytes to stimulated endothelial cells, phagocytic activity, uptake of oxidized low-density lipo
38 the aortic wall by enhanced proteolytic and phagocytic activity; however, the cells do not transdiff
42 showed transcriptional evidence of abnormal phagocytic and cell-survival programs.Conclusions: Our f
43 mplex class II that was coupled with reduced phagocytic and chemotactic activity compared to controls
46 he recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumours.
47 r TIM4(lo) and TIM4(-) cells, which were not phagocytic and were more abundant than Kupffer cells.
48 yed a TM cell-like genotypic profile, became phagocytic, and responded to dexamethasone stimulation,
49 ith primate microglia, including complement, phagocytic, and susceptibility genes to neurodegeneratio
50 to as SYNB1891, targets STING-activation to phagocytic antigen-presenting cells (APCs) in the tumor
52 method made it possible not only to perform phagocytic assays with functionalized droplets and beads
54 interactions resulting in microbial growth, phagocytic attack and secretion of host antimicrobial fa
59 ages to an active M1 phenotype, and superior phagocytic capabilities as compared to individual drug t
62 astrocytes are accompanied by alterations in phagocytic capacity and effects on neuronal calcium sign
63 eostatic to a functional state with enhanced phagocytic capacity but reduced motility and synapse eng
64 reased Iba1 and C1q expression with enhanced phagocytic capacity in Pten(m3m4/m3m4) microglia, indica
66 macrophage marker expression, and augmented phagocytic capacity of human MDMs stimulated with LPS or
67 n were not different between groups, and the phagocytic capacity of Kupffer cells was preserved follo
69 globulin levels and a modest decrease in the phagocytic capacity of pulmonary macrophage populations
70 of host-pathogen interactions, for instance phagocytic capacity or phenoloxidase activation, or at t
71 targeting lung macrophages to increase their phagocytic capacity, enhance their ability to make retin
72 ntrols, both AH monocyte subsets had greater phagocytic capacity, enhanced ability to drive memory T
79 d raises the fundamental question of how the phagocytic cell optimizes the acidification process to p
85 d light on the interactions between NETs and phagocytic cells and provide new insights regarding the
86 plicate in professional and non-professional phagocytic cells and subvert immune responses for chroni
87 hogens encounter numerous insults, including phagocytic cells designed to degrade bacteria, while est
88 suggesting that the pathogen may not target phagocytic cells for intracellular growth during natural
94 ssion analysis by RNA sequencing of F4/80(+) phagocytic cells revealed activation of the activating t
96 n also be used with other phagocytic and non-phagocytic cells to study the individual or collective r
98 Bacterial ascent and the cell dynamics of phagocytic cells were assessed by biophotonic imaging an
101 ractions of live B. bacteriovorus with human phagocytic cells, determining the uptake mechanisms, per
102 icroglia (MG), a heterogeneous population of phagocytic cells, play important roles in central nervou
103 ated kinetoplastid parasites that parasitize phagocytic cells, principally macrophages, of vertebrate
104 the capacity to concentrate drug delivery to phagocytic cells, significantly reducing off-target toxi
105 the clearance of cell debris and bacteria by phagocytic cells, the role of CRP in additional immunolo
107 and molecular functions and may be deadly to phagocytic cells, which may result in increased suscepti
108 ighly immunogenic C. albicans hyphae attract phagocytic cells, which rapidly engulf adherent S. aureu
118 cells evade the immune system by disrupting phagocytic clearance and the effect of phagocytosis chec
120 ction produces elongated hyphae resistant to phagocytic clearance compelling alternative neutrophil e
121 L expression in the adult brain promotes the phagocytic clearance of Abeta and ameliorates Abeta-depe
122 myloidogenesis is accelerated due to reduced phagocytic clearance of amyloid seeds despite reduced pl
123 re currently being explored to stimulate the phagocytic clearance of apoptotic cells; however, these
126 and the discovery of cellular immunity, the phagocytic clearance of cellular debris has been conside
128 During the progression of the disorder, phagocytic clearance of dead photoreceptor cell bodies h
130 ating parasite sequestration to host organs, phagocytic clearance of parasites, and regulation of imm
131 stasis in the central nervous system through phagocytic clearance of protein aggregates and cellular
136 over that EhActn2 plays an important role in phagocytic cup formation and might constitute a new drug
139 Cdc42-deficient macrophages exhibited rapid phagocytic cup kinetics, but reduced particle clearance,
140 Focal complex-like adhesions formed in the phagocytic cup that contained beta(2) integrins, focal a
142 ith RBCs EhRab35 is recruited to the site of phagocytic cups as well as to the nascent phagosomes tha
143 Microglia first extend processes that end in phagocytic cups at the motoneuron surface, then they clo
144 days after injury, characterized by frequent phagocytic cups, high phagosome content and CD68 upregul
147 release was not dramatically regulated, yet phagocytic defects hindered MPhi function in chronic dis
148 cells, as well as rescue the cells from the phagocytic dysfunction induced by cholesterol crystals a
152 ealing subcellular force patterns throughout phagocytic engulfment and force dynamics in the cytotoxi
153 om the recognition of dying cells through to phagocytic engulfment and homeostatic resolution, and hi
154 d a prorepair phenotype, and increase of the phagocytic engulfment of neutrophils by macrophages.
158 orne cholera disease, uses the T6SS to evade phagocytic eukaryotes, cause intestinal inflammation, an
159 Cytochrome c oxidase dysfunction enhances phagocytic function and osteoclast formation in macropha
161 proinflammatory cytokine production, reduced phagocytic function of alveolar macrophages, and consequ
162 rt that high dose atorvastatin increased the phagocytic function of ARPE-19 cells, as well as rescue
163 lease from hepatocytes and/or modulating the phagocytic function of macrophages represents a promisin
165 ower levels of serum cytokines, and improved phagocytic function relative to wild-type (WT) mice.
166 r macrophages with more pro-inflammatory and phagocytic function respectively, and large alveolar mac
170 -associated genes, but also showed decreased phagocytic gene expression and increased epithelial-asso
172 isit to the glial cytoplasm, indicating that phagocytic glia act as obligatory intermediates in aggre
173 These findings expand our understanding of phagocytic glia as double-edged players in neurodegenera
177 This process involves corralling, wherein phagocytic immune cells become confined to the necrotic
178 ole for Fmr1 in regulating the activation of phagocytic immune cells both in the body and the brain.
179 riments, we also define specific subtypes of phagocytic immune cells in An. gambiae, providing insigh
180 use of a chemical-based treatment to deplete phagocytic immune cells in Anopheles gambiae, demonstrat
182 order of magnitude larger than neutrophils, phagocytic immune cells that densely surround aggregates
183 s catabolize chitin released from hemocytes (phagocytic immune cells) that traffic into the light-org
184 M nanoemulsion was intrinsically taken up by phagocytic immune cells, particularly macrophages, with
186 tly regulate actin assembly to ensure proper phagocytic internalization, and translocate phagosomes o
189 easing complement-mediated attack, improving phagocytic killing activity of neutrophils, and preventi
191 We demonstrated decreased resistance to phagocytic killing of GAS lacking EndoS in vitro and dec
192 nutritional immunity, protects them against phagocytic killing, and activates immune evasion strateg
193 eumococcal nasopharyngeal carriage, reducing phagocytic killing, and resulting in increased inflammat
196 ecting the function of neutrophils and other phagocytic leukocytes are notable for an increased susce
199 ate that the majority of adult hemocytes are phagocytic macrophages (plasmatocytes) from the embryoni
201 holestasis, which stalled the recruitment of phagocytic macrophages and the removal of cellular corps
203 ulatory secondary necrosis by binding to the phagocytic marker phosphatidylserine on dying tumour cel
204 lia in the embryonic retina are enriched for phagocytic markers and observe engulfment of nonapoptoti
205 ate synapse elimination through a novel, non-phagocytic mechanism in the retinogeniculate pathway dur
206 ed after spinal cord injury (SCI), but their phagocytic mechanisms and link to neuroprotection remain
208 Finally, we discovered that the secretome of phagocytic microglia limits the production of new neuron
209 ed the extent of amyloid plaques, oligomers, phagocytic microglia, and infiltrated T cells by 23.7%,
210 ed predominantly of a novel subset of highly phagocytic MPhi resembling small peritoneal MPhi (SPM) t
211 onses via TNF-alpha, which are essential for phagocytic myelin debris clearance and for oligodendroge
212 show a pathway for direct activation of the phagocytic NOX2 in hepatocytes by p52Shc binding and act
213 examining human peptides and the unicellular phagocytic organism Dictyostelium discoideum reveal that
214 sphoinositide signaling is critical both for phagocytic particle engulfment and subsequent phagosomal
215 k identifies a conserved crucial step in the phagocytic pathway of immune cells and provides a potent
217 t macrophages, by mediating acquisition of a phagocytic phenotype and by contributing to anti-inflamm
219 satory nerve terminal sprouts and to adopt a phagocytic phenotype on denervated NMJs in SOD1(G37R) mi
221 molecular patterns that are engulfed during phagocytic process and danger-associated molecular patte
223 is depleted during septal thinning through a phagocytic process provides a mechanism for the clearanc
224 terized by inflammatory processes, including phagocytic processes as well as complement cascade activ
225 further highlight that Vamp7 also regulates phagocytic processing and locomotion but uses pathways d
226 ml is needed for both hemocyte migration and phagocytic processing at distinct subcellular localizati
227 tility at the cell rear, whereas its role in phagocytic processing lies near the phagocytic cup in a
228 may have emerged during evolution to couple phagocytic processing to cell migration and facilitate s
230 elimited cell surface domains may enable the phagocytic pruning of these 'locally dead' domains by ma
231 adenine dinucleotide phosphate/NADPH levels, phagocytic reactive oxygen species production, neutrophi
232 tion technique to directly probe the role of phagocytic receptor "colocalization" in innate immune re
233 iously identified Jedi-1 (PEAR1/MEGF12) as a phagocytic receptor expressed by satellite glia in the D
234 regulated B1 cell expansion, IgM production, phagocytic receptor expression, and phagocytic activity,
236 of cardiac macrophages or deficiency in the phagocytic receptor Mertk resulted in defective eliminat
238 ody antagonist of CD47 (CD47nb)(12), an anti-phagocytic receptor that is commonly overexpressed in se
241 ant GPCR/Gi signaling works independently of phagocytic receptor/tyrosine kinase signaling to promote
242 rasite clearance mediated by upregulation of phagocytic receptors and increased IgM production, and d
244 s and neutrophils expressed higher levels of phagocytic receptors and showed enhanced phagocytosis of
246 ase bacteria through chemotaxis and then use phagocytic receptors coupled with tyrosine kinases to de
247 ic receptors, which were the main astrocytic phagocytic receptors for cell debris in the above experi
249 components on the macrophage surface shrouds phagocytic receptors, curtailing their ability to engage
250 ic cells relies on homeostatic engagement of phagocytic receptors, in particular, receptors of the ty
251 ever, the contribution of precursor monocyte phagocytic receptors, which are the first to interact wi
252 ven in a healthy CNS, astrocytes express TAM phagocytic receptors, which were the main astrocytic pha
259 led by efferocytosis of dying hepatocytes by phagocytic resident liver macrophages and infiltrating G
263 globoid cells in nerves, suggesting that the phagocytic response of healthy macrophages, rather than
265 primary microglia cultures, DHA reduced the phagocytic response to myelin, which was associated with
266 tivation and robust apoptotic and microglial phagocytic responses that extensively eliminate cells wi
269 verse roles, with TPCs providing a universal phagocytic signal for a wide range of particles and TRPM
270 data reveal CD24 as a highly expressed, anti-phagocytic signal in several cancers and demonstrate the
273 at endo-lysosomes act as platforms for a new phagocytic signalling pathway in which FcgammaR activati
274 as the levels of PA found on phagosomes and phagocytic sites as shown with the PA probe Spo20p-GFP.
275 ession of cytokines which promote microglial phagocytic states, such as IL-6 and IL-4, and increased
276 crophages through the overexpression of anti-phagocytic surface proteins called 'don't eat me' signal
279 specific cell corpse/phagocyte interactions (phagocytic synapses) that impinge on host immunity, with
280 udies using engineered microenvironments and phagocytic targets have demonstrated how altering the ac
282 phagocytosis exist that utilize a variety of phagocytic targets with different combinations of recept
283 articles with spatially patterned ligands as phagocytic targets, we can decouple the receptor pair, D
285 tivated in vitro by the venom, becoming more phagocytic; these results confirm that this cell is a ta
287 microbial pathogens and dead cells and their phagocytic uptake by specialized immune cells are essent
288 ication of bacterial peptidoglycans restored phagocytic uptake in the lysosomal degradation-defective
289 cally activates the PIP(3)-pathway to induce phagocytic uptake into primary or immortalized murine ce
293 elled PFCs was able to outcompete the strong phagocytic uptake of PFCs by circulating monocytes.
294 ent inhibited mannosidase-II recruitment and phagocytic uptake of serum-coated or -uncoated latex bea
295 feedback inhibition in these cells requires phagocytic uptake of the bacteria, but cannot be explain
296 phage-mediated bacterial clearance relies on phagocytic uptake of the pathogen, subsequent phagolysos
297 ecruitment of mannosidase-II vesicles during phagocytic uptake required Ca(2+) from both extra- and i