ライフサイエンスコーパス: pharmaceutical

1 and industries including chemical, food, and pharmaceutical.

2 Bristol Myers Squibb and Ono Pharmaceutical.

3 ic molecule, flufenamic acid (FFA), a common pharmaceutical.

4 nufacturing and maximizing the efficiency of pharmaceuticals.

5 be used in organic light-emitting diodes and pharmaceuticals.

6 e useful and important substructures in many pharmaceuticals.

7 the way for the practical photosynthesis of pharmaceuticals.

8 ications for SIMS imaging of metabolites and pharmaceuticals.

9 can be addressed with existing FDA-approved pharmaceuticals.

10 linear optics and spintronics to biology and pharmaceuticals.

11 d the production rates of fine chemicals and pharmaceuticals.

12 ial reprogramming, heterochronic parabiosis, pharmaceutical administration and senescent cell ablatio

13 nsidering the recent discovery of veterinary pharmaceutical aerial transport from industrial cattle f

14 benefits and minimize the adverse effects of pharmaceutical agents for NAFLD.

15 -coupled receptor (GPCR), yet relatively few pharmaceutical agents targeting this visual receptor hav

16 While studying pharmaceutical agents that can target beta-catenin in ca

17 Pharmaceutical agents, drugs of abuse, and toxic substan

18 They are key functional groups in many pharmaceuticals, agro chemicals, or materials.

19 tionalities are present in a large number of pharmaceuticals, agrochemicals and biomolecules, and pla

20 tries for the synthesis of amines as well as pharmaceuticals, agrochemicals and biomolecules.

21 ical sciences(1), with applications spanning pharmaceuticals, agrochemicals and functional materials.

22 nes are key building blocks for synthesizing pharmaceuticals, agrochemicals, and ligands for metal co

23 reactions could streamline the synthesis of pharmaceuticals, agrochemicals, and other complex organi

24 oromethyl derivatives of current interest to pharmaceutical, agrochemistry, and materials sciences.

25 -CD(2)H, -CD(3), and -(13)CH(3) groups into pharmaceutical amines thus has been demonstrated by tuni

26 The ubiquity of tertiary alkylamines in pharmaceutical and agrochemical agents, natural products

27 centers are highly sought-after moieties in pharmaceutical and agrochemical discovery.

28 of stereochemically complex molecules in the pharmaceutical and agrochemical industries requires prec

29 becoming increasingly desirable targets for pharmaceutical and analytical chemists.

30 d drug targets, opening up possibilities for pharmaceutical and biological applications.

31 ve will provide the necessary incentives for pharmaceutical and device companies to generate comparat

32 ve will provide the necessary incentives for pharmaceutical and device manufacturers to generate comp

33 lasses with nanocellulose materials in food, pharmaceutical and dye applications, using a conventiona

34 LA-rich oils, suitable to be marketed by the pharmaceutical and food industries.

35 er significant information for the growth of pharmaceutical and food industries.

36 only practiced C-N bond-forming reactions in pharmaceutical and laboratory syntheses.

37 invasive modification of bionanomaterials in pharmaceutical and medical applications.

38 ular inhibition, control of physicochemical, pharmaceutical and selectivity properties, and potent in

39 atalyst for the synthesis of fine chemicals, pharmaceuticals and agrochemicals is often overlooked du

40 ssential to the discovery and manufacture of pharmaceuticals and agrochemicals(1,2).

41 an important functional group found in both pharmaceuticals and agrochemicals.

42 Non-natural terpenoids offer potential as pharmaceuticals and agrochemicals.

43 f the most common building blocks in current pharmaceuticals and are common in medicinally important

44 riles and their derivatives are prevalent in pharmaceuticals and bioactive compounds.

45 Efforts to mitigate the side effects of pharmaceuticals and counteract the life threatening effe

46 ronment, the need to characterise nano-scale pharmaceuticals and living systems in replicated in vivo

47 g Administration (FDA), and ten by the Japan Pharmaceuticals and Medical Devices Agency (PMDA).

48 understand and explore crystal structure in pharmaceuticals and minimize the risk of unanticipated l

49 Pharmaceuticals and pesticides, among other compounds of

50 tritiated and 10 carbon-11-labelled complex pharmaceuticals and PET radioligands, including a one-st

51 Novartis Pharmaceuticals and Secura Bio.

52 es and end points in fields such as organic, pharmaceutical, and biological chemistry, the developmen

53 scientific fields, including biotechnology, pharmaceuticals, and clinical sciences.

54 for accessing a myriad of natural products, pharmaceuticals, and drug candidates.

55 ry amines are prevalent in natural products, pharmaceuticals, and functional materials.

56 National Basketball Association, Millennium Pharmaceuticals, and Octapharma USA Inc.

57 existing nanomaterials for the detection of pharmaceuticals; and (ii) to provide examples of the pot

58 hic primitives can play an important role in pharmaceutical anti-counterfeiting and other security ap

59 time and cost are important factors for any pharmaceutical API.

60 he development of helminth glycoproteins for pharmaceutical applications or novel anti-helminth vacci

61 ttention owing to their chemical properties, pharmaceutical applications, and low toxicity.

62 faceted molecular structures, especially for pharmaceutical applications.

63 Because CBZ and many other pharmaceuticals are not readily removed in conventional

64 is applicable to syntheses of targets in the pharmaceutical area.

65 sis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance in

66 paration and late-stage functionalization of pharmaceuticals, as highlighted by the syntheses of thio

67 metabolism and excretion of metabolites and pharmaceuticals, as well as biomarkers for disease progr

68 ompounds are ubiquitous in natural products, pharmaceuticals, as well as in functional materials.

69 aliana Linfomi, Allos Therapeutics, Spectrum Pharmaceuticals, Associazione Italiana per la Ricerca su

70 pentane (BCP) motifs have become valuable as pharmaceutical bioisosteres of benzene rings, and in par

71 o use cell viability tests are needed in the pharmaceutical, biomaterial, and environmental industrie

72 d higher sample loading) for purification of pharmaceuticals by selectively switching the elution ord

73 The late-stage modification of pharmaceuticals by this method was also demonstrated.

74 ad areas, such as cancer biomarker research, pharmaceuticals characterization, and antiglycan vaccine

75 With increasing use of the SF(5) moiety in pharmaceutical chemistry, this general method of functio

76 onal death registration, hospital admission, pharmaceutical claim, and socioeconomic status databases

77 ification of Diseases, Tenth Revision codes, pharmaceutical claims, and laboratory results.

78 therapeutics, are one of the fastest growing pharmaceutical classes.

79 e as bioinspired mineralization, templating, pharmaceuticals, colloidal crystallization, and geochemi

80 Clinicians, patients, and pharmaceutical companies can report adverse drug reactio

81 attracted intense interest by academics and pharmaceutical companies due to their potential to hit c

82 tudy describes financial penalties levied on pharmaceutical companies for illegal activities by type

83 ess, interest in natural products from major pharmaceutical companies has decreased even as genomics

84 Understanding the profitability of pharmaceutical companies is essential to formulating evi

85 a strategy widely used in both academia and pharmaceutical companies to generate small-molecule prot

86 These limitations make it difficult for pharmaceutical companies to obtain full dissolution prof

87 nificant differential profit margin favoring pharmaceutical companies was evidence of greater profita

88 rom 2000 to 2018, the profitability of large pharmaceutical companies was significantly greater than

89 tudy compared the annual profits of 35 large pharmaceutical companies with 357 companies in the S&P 5

90 development, and few are sponsored by large pharmaceutical companies.

91 lly from 2002 - 2009, primarily led by small pharmaceutical company involvement.

92 nsortium, comprising MIT and 13 chemical and pharmaceutical company members.

93 worth, NJ, USA), a large, globally operating pharmaceutical company that develops and markets both hu

94 t that inclusion of bioactive solvent NMP in pharmaceutical compositions to treat inflammatory disord

95 hile couplings by screening a diverse set of pharmaceutical compound library.

96 sensors and biosensors for the detection of pharmaceutical compounds has garnered immense attention

97 ese devices have for the advanced sensing of pharmaceutical compounds toward safeguarding human healt

98 Screening a collection of ~3500 pharmaceutical compounds with the HEK293 cell tau aggreg

99 Emerging contaminants, including pharmaceutical compounds, are receiving research attenti

100 quantification of six classes of significant pharmaceutical compounds, including anti-inflammatory, a

101 entially suitable for the development of new pharmaceutical compounds.

102 late-stage functionalization of a variety of pharmaceutical compounds.

103 e to study modulation of alveolar repair by (pharmaceutical) compounds.

104 fects of long-term exposure to the pervasive pharmaceutical contaminant fluoxetine (Prozac) and acute

105 ize nosocomial infection, food spoilage, and pharmaceutical contamination.

106 as sources of food, feed, fiber, fuels, and pharmaceuticals continues to increase.

107 nd widespread utility across a wide range of pharmaceutical, cosmetic, and personal care products, an

108 ries including construction, pottery making, pharmaceuticals, cosmetics and engineering.

109 plying it toward the diverse applications of pharmaceutical crystallization, microbatch chemical reac

110 e linked to Medicare and Medicaid claims and pharmaceutical data.

111 les were analyzed monthly for 1 year for 109 pharmaceuticals/degradates using a comprehensive U.S.

112 Seventy-four individual pharmaceuticals/degradates were detected, spanning 5 ord

113 weekly for 2 years focused on 14 most common pharmaceuticals/degradates.

114 nes, including several highly functionalized pharmaceutical derivatives.

115 egy that is amenable to broad application in pharmaceutical design.

116 transformation was a descriptive activity in pharmaceutical development, viewed simply as structural

117 r dissecting cell signaling pathways and for pharmaceutical development.

118 calculate outpatient, inpatient, emergency, pharmaceutical, dialysis, and total health care costs by

119 ed and evaluated by the Machine Learning for Pharmaceutical Discovery and Synthesis (MLPDS) consortiu

120 e glucagon receptor (GCGR) in disease and in pharmaceutical drug development, there is a lack of spec

121 logical processes and are a major target for pharmaceutical drug development.

122 a novel approach for the protection of space pharmaceutical drug molecules from the radiation-induced

123 Pharmaceutical drugs are an important part of the global

124 ormulation platform for preventing damage to pharmaceutical drugs in potential space mission applicat

125 Pharmaceutical drugs targeting dyslipidemia and cardiova

126 Rational design of pharmaceutical drugs targeting integral membrane G prote

127 will also discuss the emerging role of diet, pharmaceutical drugs, and pathogen-microbiota interactio

128 ional treatment for HSV-1 infection includes pharmaceutical drugs, such as acyclovir and docosonal, w

129 to other environmental toxicants as well as pharmaceutical drugs.

130 erforming drug toxicity-testing, and testing pharmaceutical efficacy/safety.

131 f novel chemical phenotypes (chemotypes) for pharmaceutical end-use.

132 also known as Hypromellose, is a traditional pharmaceutical excipient widely exploited in oral sustai

133 -stressor environments, interactions between pharmaceutical exposure and other stressors remain poorl

134 Here, we quantified spatiotemporal pharmaceutical exposure concentrations and composition m

135 e drugs and reduced participation from large pharmaceutical firms.

136 in many processes used by microelectronics, pharmaceutical, food and other industries(1-4).

137 c fine chemistry, basic materials chemistry, pharmaceuticals, food chemistry, chemical engineering, e

138 f Technical Requirements for Registration of Pharmaceuticals for Human Use E9(R1) addendum, we provid

139 f radiation contribute to the instability of pharmaceutical formulations in space compared to those o

140 y on this technique for characterizations of pharmaceutical formulations, biosimilars, injectables, n

141 r waterless urinal sealants fluids to remove pharmaceuticals from urine.

142 High-dose, pharmaceutical-grade biotin (MD1003) might enhance neuro

143 Here, we demonstrate that cells treated with pharmaceutical-grade rigosertib (>99.9% purity) or comme

144 irmed with reference standards (45) included pharmaceuticals, herbicides, vehicle-related compounds,

145 treatment plant (WWTP) outflow has detected pharmaceuticals, hormones, and estrogen-receptor (ER)-,

146 Differential attenuation of individual pharmaceuticals (i.e., high = citalopram; low = metformi

147 The increasing pharmaceutical importance of trifluoromethylarenes has s

148 are, dental care, and purchase of prescribed pharmaceuticals in a retail setting.

149 has been recognized as one of the most toxic pharmaceuticals in the aquatic environment.

150 Marc Sumerlin, Cassandra Hanley, and Nacuity Pharmaceuticals, Inc.

151 ndard skin test allergens (prepared by Torii pharmaceuticals) including shrimp, crab, and squid.

152 rominently in bioactive natural products and pharmaceuticals, including antiviral, antibacterial, ant

153 has revealed that a number of commonly used pharmaceuticals induce changes in cholesterol metabolism

154 ophiles, a feature that is exploited in many pharmaceutical, industrial and laboratory-based reaction

155 nts with a myriad of academic, agricultural, pharmaceutical, industrial, and social interests.

156 ceutical ingredients (APIs) from formulating pharmaceutical industries (FPIs) were investigated for t

157 ovation programme and European Federation of Pharmaceutical Industries and Associations (EFPIA).

158 on, which is critical in hospitals, food and pharmaceutical industries to help minimize nosocomial in

159 ave potential applications in food, feed and pharmaceutical industries, contributing to the valorizat

160 y have potential for applications in food or pharmaceutical industries.

161 device for applications in the clinical and pharmaceutical industries.

162 wing applicability to the food, cosmetic and pharmaceutical industries.

163 ned products for application in the food and pharmaceutical industries.

164 products development in food, cosmetic, and pharmaceutical industries.

165 t paradigm is now well established among the pharmaceutical industry and regulatory agencies.

166 mpounds have become of great interest to the pharmaceutical industry as they possess various biologic

167 It is extensively used across the pharmaceutical industry for the quantitative analysis of

168 pean Medicines Agency issued guidance to the pharmaceutical industry in 2008.

169 The surging growth of the pharmaceutical industry is a result of the rapidly incre

170 Pectin has several purposes in the food and pharmaceutical industry making its quantification import

171 ylates are important polymers widely used in pharmaceutical industry such as drug coatings due to the

172 ines has forced the scientific community and pharmaceutical industry to take actions in the quest for

173 A pharmaceutical industry viewpoint on how the fundamental

174 The studies funded by pharmaceutical industry were less likely to be stopped e

175 transplant community stakeholders, including pharmaceutical industry, academic researchers, clinician

176 to transform basic biological research, the pharmaceutical industry, and clinical medicine of the li

177 ensive efforts, within both academia and the pharmaceutical industry, to introduce new treatments to

178 nds of wide use in organic chemistry and the pharmaceutical industry.

179 ls has garnered significant attention by the pharmaceutical industry.

180 the broad adoption of these reactions by the pharmaceutical industry.

181 into production mode within academia and the pharmaceutical industry.

182 n animal studies and clinical trials for the pharmaceutical industry.

183 in a decrease of environmental impact in the pharmaceutical industry.

184 g structural motifs, highly desirable by the pharmaceutical industry.

185 these, 135 (59.5%) studies were supported by pharmaceutical industry.

186 uct development and quality assurance in the pharmaceutical industry.

187 have potential applications in the food and pharmaceutical industry.

188 t times with much greater involvement of the pharmaceutical industry.

189 ations and applications of kenaf in food and pharmaceuticals industry.

190 Our approach combines insights of multiscale pharmaceutical information by constructing a multirelati

191 35), Eudra (CT2016-004734-22), and the Japan Pharmaceutical Information Center (JapicCTI-173630), and

192 and distribution of a topical drug's active pharmaceutical ingredient (API) allows for evaluating dr

193 ith specially prepared mixtures of an active pharmaceutical ingredient and a number of excipients.

194 his method for the modification of an active pharmaceutical ingredient and for the synthesis of a key

195 eproducible coating of >30 mug of the active pharmaceutical ingredient on a stainless steel MN array

196 Colchicine is an active pharmaceutical ingredient widely used for treating gout,

197 are an important structural motif in active pharmaceutical ingredients (APIs) and intermediates ther

198 greener processes for oligonucleotide Active Pharmaceutical Ingredients (APIs) as a critical unmet ne

199 In this work, emissions of active pharmaceutical ingredients (APIs) from formulating pharm

200 The development of small-molecule active pharmaceutical ingredients (APIs) is a classic example.

201 st used materials in drug delivery of active pharmaceutical ingredients (APIs), such as antitumourals

202 cules, including natural products and active pharmaceutical ingredients of approved human therapeutic

203 Solid state chemical analysis of pharmaceutical inhalation aerosols at the individual par

204 er mediator of osteoclastogenesis, while its pharmaceutical inhibition by a monoclonal antibody has b

205 3 in all three epitypes, however genetic and pharmaceutical inhibition experiments show that H3K27me3

206 le of coupling diverse substrates, including pharmaceutical intermediates, to rapidly form complex ke

207 ced by CSS, suggesting potential targets for pharmaceutical intervention that may improve patient out

208 heir EVH1 domains, are promising targets for pharmaceutical intervention.

209 paigns to identify potential RNA binders for pharmaceutical intervention.

210 pandemic, governments introduced strict Non-Pharmaceutical Interventions (NPI) that restricted movem

211 V-2) rely on population-wide adoption of non-pharmaceutical interventions (NPIs).

212 ct reductions, but that a combination of non-pharmaceutical interventions achieved the strongest and

213 s in mobility to capture the impact that non-pharmaceutical interventions and other behaviour changes

214 s still needed to assess the efficacy of non-pharmaceutical interventions and their timings(3).

215 blic health systems worldwide, and major non-pharmaceutical interventions have been implemented to sl

216 CoV-2)- in Wuhan (China), where vigorous non-pharmaceutical interventions have suppressed the local o

217 ombination of cell-based, rehabilitation and pharmaceutical interventions is the most promising appro

218 rove our understanding of the effects of non-pharmaceutical interventions on COVID-19, and will infor

219 ta on 1,700 local, regional and national non-pharmaceutical interventions that were deployed in the o

220 The strategies based on non-pharmaceutical interventions that were used to contain t

221 many European countries have implemented non-pharmaceutical interventions, such as the closure of sch

222 een proposed to monitor effectiveness of non-pharmaceutical interventions, to assess potential driver

223 Without non-pharmaceutical interventions, we predict that the number

224 Our results show that major non-pharmaceutical interventions-and lockdowns in particular

225 ty in obtaining polymorphs of the well-known pharmaceutical isoniazid and show that CSP provides the

226 further development and future evaluation as pharmaceutical leads.

227 To date, Razumab (Intas Pharmaceuticals Ltd, Ahmedabad, GJ, India) is the only a

228 At the WWTP receiving wastewater from a pharmaceutical manufacturing site, (i) 10 times as many

229 polymers are of significant interest to the pharmaceutical, medical device, and cosmetic industries.

230 on in temperate regions and generate complex pharmaceutical mixture exposure conditions that may impa

231 cuses on mapping the separation landscape of pharmaceutical mixtures to quickly identify spaces of pe

232 al function and lifespan, establishing a new pharmaceutical modality for myelin disorders.

233 As a result, the pharmaceutical modulation of epigenetic regulators, incl

234 s by molecular imaging and to transfer small pharmaceutical molecules to modulate the biological acti

235 We simulated photolysis of the pharmaceuticals morphine, codeine, and methamphetamine a

236 ber of arylcyclopropanes, which are valuable pharmaceutical motifs.

237 e most common form of nanotechnology enabled pharmaceuticals (NEPs) submitted for market approval and

238 cipal wastewater concentrations; and (iii) a pharmaceutical not authorized in Switzerland was identif

239 We observed a strong chemical gradient with pharmaceuticals only sporadically detected upstream from

240 As with other drugs or pharmaceuticals, opioids differ in their rewarding or an

241 Some varieties are used for both, pharmaceutical opium alkaloid generation and poppy seed

242 c acid, is used in many fields such as food, pharmaceutical or cosmetic industry.

243 is of structured peptides/proteins targeting pharmaceutical or pharmacological utilizations.

244 functions such as the metabolic stability of pharmaceuticals or the volatility of perfumes.

245 tings, photonic materials, biomaterials, and pharmaceutical oral drug delivery.

246 ving purely domestic wastewater; (ii) for 11 pharmaceuticals peak concentrations, >10 mug/L and up to

247 valuable intermediates for the production of pharmaceuticals, perfumes, and flavorings.

248 that have been reported for the detection of pharmaceuticals, pesticides, heavy metals and other cont

249 herto have been challenging, and the current pharmaceutical pipeline is nearly empty.

250 onstrate that long-term exposure to a common pharmaceutical pollutant and acute temperature stress al

251 ures of increasing complexity and exhibiting pharmaceutical (poppy alkaloids), nutritional (rosemary

252 nto the desired compounds via methylation of pharmaceutical precursors bearing aryl and alkyl bromide

253 spective of producing dietary supplements or pharmaceutical preparations.

254 nthropogenic organic micropollutants such as pharmaceuticals, present in our water supplies in trace

255 chine learning methods to simulate a complex pharmaceutical problem: development of an agitation prot

256 nontarget approach to detect discharges from pharmaceutical production in municipal wastewater treatm

257 strategy could improve polyketide titers for pharmaceutical production.

258 al outbreaks of bacteremia from contaminated pharmaceutical products.

259 CO prodrugs demonstrate promising pharmaceutical properties in terms of oral CO delivery a

260 nt inhibitor of CoV-2 3CL(pro) with suitable pharmaceutical properties to warrant further development

261 eliver potent drug conjugates with favorable pharmaceutical properties.

262 tform for producing high-value proteins with pharmaceutical properties; however, the ability to accum

263 nes and an inspiration for those involved in pharmaceutical R&D.

264 Pharmaceutical Rab7a inhibition may provide a means to p

265 the inhibitory G protein (G(i)) is vital for pharmaceutical research aimed at finding treatments for

266 rovides significant opportunities to improve pharmaceutical research and development.

267 Risk Action Team framework developed by the Pharmaceutical Research and Manufacturers of America, an

268 cal databases are increasingly available for pharmaceutical research, allowing for deep characterizat

269 asis for its broad successful application in pharmaceutical research, development, and manufacturing.

270 eoselectively deuterated building blocks for pharmaceutical research.

271 he untargeted metabolomic approaches used in pharmaceutical research.

272 ructured data have opened a new paradigm for pharmaceutical research.

273 ical Society (ACS) Green Chemistry Institute Pharmaceutical Roundtable (GCIPR) identified the develop

274 Therefore, its determination in racemic and pharmaceutical samples becomes a challenge.

275 rest across areas of molecular cell biology, pharmaceutical sciences, and nanoengineering.

276 of individual particles can be critical for pharmaceutical scientists to evaluate drug and excipient

277 The pharmaceutical sector requires new protein characterizat

278 lications of relevance to the biomedical and pharmaceutical sectors.

279 For this reason, we also introduce a novel pharmaceutical strategy based on modifying the activity

280 ectives raised by the discovery of the first pharmaceutical strongly affecting 3D genome organization

281 t patients and improve the efficiency of the pharmaceutical system.

282 ity for PCM determination in real samples of pharmaceutical tablets.

283 As such, MALT1 has emerged as a potential pharmaceutical target.

284 tein-coupled receptors (GPCRs) are important pharmaceutical targets.

285 focuses on the application of HPMC in modern pharmaceutical technologies including spray drying, hot-

286 or untreated with 2-deoxy-d-glucose (2DG), a pharmaceutical that targets cell metabolism.

287 n is systemically or locally delivered using pharmaceuticals that either bind preferentially to cance

288 dvance the rational design of novel specific pharmaceuticals that target GPCRs, but such studies requ

289 Pharmaceutical therapies could be an important addition

290 Rs) represent a significant target class for pharmaceutical therapies in which homology modeling coul

291 first-in-class MEIS inhibitors as potential pharmaceuticals to be utilized in modulation of HSC acti

292 c synthesis, with applications spanning from pharmaceuticals to natural products.

293 s and escalating spending on health care and pharmaceuticals, transparency and communication are lack

294 antipsychotics are deemed equally effective pharmaceutical treatments for both conditions.

295 excitability, which are the main targets of pharmaceutical treatments for uterine contraction disord

296 half-lives (DT50s) of 31 substances (mainly pharmaceuticals) under different combinations of bacteri

297 was used to study the crystallization of the pharmaceuticals urea: barbituric acid (UBA) and carbamaz

298 method for the enantioseparation of selected pharmaceuticals was developed.

299 f Biscay (Southern France) and 4 of these 42 pharmaceuticals were detected at low ng/g levels, sugges

300 isoselenazol-3(2H)-one, is an organoselenium pharmaceutical with antioxidant and anti-inflammatory pr