ライフサイエンスコーパス: pharmacologic

1 ely predicted blood-to-brain permeability of pharmacologics.

2 H expression and activity and tested whether pharmacologic 15-PGDH inhibition (PGDHi) is protective i

3 course unless mice also underwent genetic or pharmacologic ablation of TGFbeta signaling.

4 Pharmacologic activation of AMPK with 5-aminoimidazole-4

5 Thus, pharmacologic activation of ATF6 represents a proteostas

6 Genetic or pharmacologic activation of Golgi complex fragmentation

7 Finally, enhancing APOE expression via pharmacologic activation of liver X receptors, previousl

8 cardial ischemia/reperfusion, that selective pharmacologic activation of the ATF6 arm of the unfolded

9 Pharmacologic activation of the LXR pathway reduced the

10 Based on our prior work indicating that pharmacologic activation of the PPARgamma pathway protec

11 loxazolidin-2-ones, by virtue of the diverse pharmacologic activities exhibited by them after subtle

12 ed into significantly enhanced and sustained pharmacologic activities.

13 for further investigating chrysin as a novel pharmacologic agent and contributes to the academic adva

14 A novel pharmacologic agent targeting this mechanism, suppressor

15 tructures were affected independent from the pharmacologic agent, drug concentration, and direction o

16 The intravitreal injection (IVI) of pharmacologic agents is the most commonly performed ocul

17 biology but also for the development of new pharmacologic agents that exploit or target TMPRSS6 to t

18 ffects, and possible mechanisms of action of pharmacologic agents used to treat patients with type 2

19 s mellitus and cardiovascular disease (CVD), pharmacologic agents used to treat type 2 diabetes melli

20 y reported with small-molecule HPA-targeting pharmacologic agents.

21 uroblastoma cell lines, followed by in-depth pharmacologic analysis in a sensitive and resistant pair

22 activation of HbF gene expression using both pharmacologic and cell-based therapeutic approaches.

23 tal FXIII-B deficiency, provides a potential pharmacologic and experimental tool to modulate FXIII-A2

24 Pharmacologic and genetic approaches lowering calpain ac

25 Here we use a combination of pharmacologic and genetic approaches to delete SIGN-R1(+

26 ated lipids through the use of complementary pharmacologic and genetic approaches to disrupt this enz

27 velopmental defects of Tsc2-RG mice, we used pharmacologic and genetic approaches to reduce ODC activ

28 is not required for hyperadhesion induced by pharmacologic and genetic approaches.

29 Accordingly, pharmacologic and genetic inhibition of eATP signaling i

30 Pharmacologic and genetic inhibition of Prkd1 in the Twi

31 Pharmacologic and genetic promotion of activated RhoA en

32 Pharmacologic and genetic reduction of activated RhoA pr

33 ATM was inhibited through pharmacologic and genetic strategies in human and murine

34 Using a combination of physiologic, pharmacologic and genetic strategies, we observe improve

35 Use of pharmacologic and genetic tools indicates that the optim

36 ation restores cell proliferation under both pharmacologic and genetic-mediated lysosomal dysfunction

37 eighted proportion of visits associated with pharmacologic and nonpharmacologic (stress/mental health

38 t and treatment recommendations address both pharmacologic and nonpharmacologic approaches for patien

39 Both pharmacologic and nonpharmacologic interventions are use

40 ) seeking behaviors using the combination of pharmacologic and optogenetic approaches.

41 Pharmacologic and probiotic approaches directed towards

42 nabis use disorder as well as evidence-based pharmacologic and psychosocial treatments.

43 re collected evidence regarding nutritional, pharmacologic, and other interventions, such as exercise

44 Plasmid overexpression of the MasR or pharmacologic angiotensin-(1-7)/MasR activation did not

45 Pharmacologic antagonism of NMDARs in patients with depr

46 Here we report a novel pharmacologic approach for selective inhibition of beta-

47 d animals slows osteogenesis, and suggests a pharmacologic approach that targets beta-catenin to impr

48 talase supplementation may represent a novel pharmacologic approach to be explored in human for preve

49 Utilizing a pharmacologic approach to reduce placental adenosine lev

50 Treatment involves pharmacologic approaches (typically with levodopa prepar

51 findings in PTSD and resilience, and also of pharmacologic approaches that have emerged from this wor

52 and factor XIa inhibition constitute 2 novel pharmacologic approaches that might provide future treat

53 Evaluating for non-pharmacologic approaches to managing symptoms and asthma

54 n colon cancer cell line, RNA silencing, and pharmacologic approaches were used to identify the molec

55 Using genetic and pharmacologic approaches, antitumor activity was seen wi

56 Using genetic and pharmacologic approaches, we show that the IgE/Fcepsilon

57 stimulating beta-cells with chemogenetic and pharmacologic approaches.

58 to target renal lymphatics using genetic and pharmacologic approaches.

59 Pharmacologic ascorbate treatment (P-AscH(-), high-dose,

60 Functional, histologic, molecular, and pharmacologic assays characterize the presentation of re

61 Pharmacologic Aurora B inhibition might be a potential e

62 Moreover, pharmacologic blockade of B-family DNA polymerases using

63 Pharmacologic blockade of Kcnn2 improves these learning

64 Like LIN9, genetic or pharmacologic blockade of NEK2 activity in the presence

65 Deficiency or pharmacologic blockade of PK renders mice less susceptib

66 Similarly, pharmacologic blockade of TGFbeta signaling in normal mi

67 Pharmacologic blockade of the leukotriene pathway holds

68 ics (BE) procedure, we previously found that pharmacologic blockade of the OxR1 decreased motivation

69 Pharmacologic CCR2 blockade and genetic deletion of Ccr2

70 ntify functional determinants of response to pharmacologic CDK4/6 inhibitors.

71 nesis, and NUP98-fusion AML was sensitive to pharmacologic CDK6 inhibition in vitro and in vivo.

72 dvances in the therapeutic implementation of pharmacologic CFTR modulators have renewed the field's f

73 PAX3-FOXO1 expression and identified a novel pharmacologic combination therapy that interferes with P

74 ponse to genetic (shRNA and CRISPR/Cas9) and pharmacologic (crizotinib) inhibition of c-MET.

75 Coupling pharmacologic data with genomic and transcriptomic infor

76 n analyses and intersection with genetic and pharmacologic data.

77 Thus, pharmacologic de-repression of the inflammasome by targe

78 Genetic and pharmacologic depletion of fibrinogen reduced astrocyte

79 gp inhibition and to mitigate the off-target pharmacologic effects that complicate their clinical use

80 with wild-type mice demonstrated significant pharmacologic effects.

81 -of-concept efforts concentrated on coupling pharmacologic efficacy with desirable safety profiles.

82 ytokines to their receptors, a number of new pharmacologic entities have been designed to target both

83 Genetic and pharmacologic experiments demonstrate that asymmetric ce

84 Pharmacologic FAK catalytic inhibition reduces Sost mRNA

85 Extensive pharmacologic, genetic, and epigenetic research has link

86 als, SCD patients, and patients treated with pharmacologic HbF inducers, HbF is present only in a sub

87 Pharmacologic HIF hydroxylase inhibitors (HIs) are effec

88 In studies into the effect of pharmacologic hydroxylase inhibition on TLR-induced infl

89 we tested the effects of treatment with the pharmacologic hydroxylase inhibitor DMOG, which mimics h

90 rial, these data support the hypothesis that pharmacologic IL-13 inhibition ameliorates both inflamma

91 Distinct from pharmacologic immune suppression, we have developed what

92 Pharmacologic inducers of ferroptosis and mechanical str

93 HT22 cells were subjected to pharmacologic induction of ferroptosis or mechanical str

94 Thus, genetic or pharmacologic induction of hypochlorhydria and decreased

95 Exogenous overexpression and pharmacologic induction of p27 via inhibition of SKP2 an

96 Genetic induction of active IL1beta or pharmacologic inflammasome stimulation increased HSPC nu

97 siRNA knockdown or pharmacologic inhibition [GKT137831 (Setanaxib)] of NOX4

98 Indeed, pharmacologic inhibition and genetic ablation of JNKs, a

99 Pharmacologic inhibition and genetic loss of CoREST in T

100 CRISPR-based CDK4 and CDK6 gene editing with pharmacologic inhibition approaches in orthotopic transp

101 erminants of HIV-1 latency and support their pharmacologic inhibition as tools to regulate PML stabil

102 EC dysfunction induced by CM, whereas PAFAH2 pharmacologic inhibition augmented deleterious effects o

103 P110alpha-selective pharmacologic inhibition blocks transformation in cells

104 eatic cancer progression, and its genetic or pharmacologic inhibition led to a striking defect in pan

105 Pharmacologic inhibition of ABCB1/ABCG2 may improve the

106 Importantly, knockdown as well as pharmacologic inhibition of ABL2 using allosteric inhibi

107 Pharmacologic inhibition of alpha5 subunit-containing ga

108 RG1-deficient lung cancers were sensitive to pharmacologic inhibition of ATR.

109 Mimics of miR-30c-2* or miR-497, as well as pharmacologic inhibition of AURKA, a miR-497 target, sup

110 TEMENT Here we show that genetic deletion or pharmacologic inhibition of diacylglycerol lipase-alpha

111 In tumor-bearing mice, pharmacologic inhibition of DNMT with the DNA methyltran

112 In agreement, ablation of p50 as well as pharmacologic inhibition of either the PGE2 receptor EP2

113 These findings show that pharmacologic inhibition of FEN1, which is predictive of

114 nits, shRNA-mediated knockdown of GATA-6, or pharmacologic inhibition of GATA-6 and NF-kappaB in BSM

115 ogenesis in these cells as well as localized pharmacologic inhibition of glucocorticoid biosynthesis

116 ucose starvation-induced cell death and that pharmacologic inhibition of glucose transporter 1 and PR

117 Pharmacologic inhibition of GRK2 by the clinically appro

118 Pharmacologic inhibition of H3K27-demethylases in human

119 Further, pharmacologic inhibition of HCV replication in vitro and

120 moted HPASMC proliferation in vitro, whereas pharmacologic inhibition of hyaluronidase activity preve

121 interleukin-18 (IL18) signaling pathway, and pharmacologic inhibition of IL18 has been shown to rever

122 Pharmacologic inhibition of Ly6c(Lo) non-classical monoc

123 MC deficiency in mice or pharmacologic inhibition of MCs reversed thrombocytopeni

124 In contrast, pharmacologic inhibition of monoacylglycerol lipase atte

125 bundance of PKM2, indicating genetic loss or pharmacologic inhibition of Mst1/2 directly modulates th

126 human lung adenocarcinoma cell line, we show pharmacologic inhibition of Mst1/2 increases the abundan

127 e rescue of neurogenesis normally induced by pharmacologic inhibition of myosin activity.

128 The genetic and pharmacologic inhibition of NLRP3 suppressed PMN-MDSC tu

129 Pharmacologic inhibition of NOX4 potentiates immunothera

130 ), was highly expressed in these tumors, and pharmacologic inhibition of Pi3kgamma blocked tumor cell

131 nhibition of RA production in tumor cells or pharmacologic inhibition of RA signaling within TME incr

132 We demonstrate that deletion or pharmacologic inhibition of RAGE prevents development of

133 ion of sEV secretion from primary tumors and pharmacologic inhibition of sEV uptake in secondary orga

134 Likewise, pharmacologic inhibition of Shh signaling with cyclopami

135 Genetic perturbation or pharmacologic inhibition of specific members of the BCL2

136 hibitor triclosan to determine the effect of pharmacologic inhibition of SULT1E1 on AKI.

137 Genetic knockout or pharmacologic inhibition of Sult1e1 protected mice of bo

138 ckdown of the SUMO-activating enzyme SAE2 or pharmacologic inhibition of SUMOylation resulted in decr

139 Pharmacologic inhibition of the ABL2 kinase using small

140 five human chordoma cell lines revealed that pharmacologic inhibition of the histone 3 lysine 27 deme

141 Pharmacologic inhibition of the mammalian target of rapa

142 letion of MEK5/ERK5 sensitized SCLC cells to pharmacologic inhibition of the mevalonate pathway by st

143 We found pharmacologic inhibition of the p38, CK2, CDK, AXL, and

144 of infectious disease studies indicate that pharmacologic inhibition of the PI3K pathway could poten

145 Pharmacologic inhibition of the principal thrombin recep

146 We investigated pharmacologic inhibition of the proinflammatory leukotri

147 we have demonstrated for the first time that pharmacologic inhibition of the SIX1/EYA2 complex and as

148 Pharmacologic inhibition of V2R with tolvaptan increases

149 Pharmacologic inhibition or cholangiocyte-selective dele

150 Consistently, pharmacologic inhibition or genetic downregulation of au

151 Pharmacologic inhibition or genetic silencing of either

152 Pharmacologic inhibition or knockdown of TGFB or JNK sig

153 Pharmacologic inhibition or myeloid-specific ablation of

154 -induced activation of Akt, whereas specific pharmacologic inhibition or short hairpin RNA knockdown

155 DNA methyltransferases DNMT1 and DNMT3B and pharmacologic inhibition with 5-Aza-2'-deoxycytidine (5-

156 down by short hairpin RNA or CRISPR/Cas9 and pharmacologic inhibition) synergistically impaired HCC p

157 hs of the zebrafish-genetic manipulation and pharmacologic inhibition-to interrogate the role of 12-L

158 Sortilin inhibition by siRNA and the pharmacologic inhibitor AF38469 strongly reduced the adh

159 al protein-based inhibitor alpha1-PDX or the pharmacologic inhibitor Decanoyl-Arg-Val-Lys-Arg-chlorom

160 Pharmacologic inhibitor of pyruvate dehydrogenase, which

161 ing antibody directed against CD36 or with a pharmacologic inhibitor of SRC kinases restored the anti

162 apeutic potential, targeting NF-kappaB using pharmacologic inhibitors has proven challenging.

163 Treatment with pharmacologic inhibitors of ERK1/2 or PKCbeta prevented

164 The effects of pharmacologic inhibitors of hypoxia-inducible factor (HI

165 f ABCB1 was mitigated by combined use of the pharmacologic inhibitors U0126 and ISRIB, which inhibit

166 acini cultures were incubated with IL22 and pharmacologic inhibitors, and protein levels were knocke

167 nvolving both immunofluorescent staining and pharmacologic inhibitors, we show that both PI3K/AKT and

168 tumor metabolic environments and collateral pharmacologic insults.

169 fortunately, adverse effects accompany every pharmacologic intervention and may affect overall outcom

170 atients with EoE and provide a rationale for pharmacologic intervention of ANO1 function in patients

171 randomized, double-blind, placebo-controlled pharmacologic intervention using oral vancomycin or matc

172 portunities for future clinical research and pharmacologic intervention, as well as the implications

173 sposition that might benefit from a targeted pharmacologic intervention.

174 tunities for prediction of GC resistance and pharmacologic intervention.

175 variants are high value oncology targets for pharmacologic intervention.

176 h placebo or usual care in inpatients, other pharmacologic interventions (aminophyllines, magnesium s

177 Pharmacologic interventions associated with improvements

178 Although data on pharmacologic interventions for CUD are scarce, evidence

179 ded: (5) overall and comparative efficacy of pharmacologic interventions for inpatients refractory to

180 rventions seemed to be more efficacious than pharmacologic interventions for reducing aggression and

181 Pharmacologic interventions generally were associated wi

182 sentation of renal disease and enable useful pharmacologic interventions in the humanized C3 (C3(hu/h

183 We hypothesize that these pharmacologic interventions may have transformative effe

184 /or improve weight gain, currently available pharmacologic interventions that may be used include pro

185 ve ligands, which should enable more precise pharmacologic interventions while limiting the effects o

186 We conducted pharmacologic investigations on isolated aortas and gene

187 Pharmacologic IRE1alpha kinase inhibition reverses ultra

188 Pharmacologic IRE1alpha kinase inhibition strongly atten

189 Finally, broad assessment of the pharmacologic landscape of drug-drug interactions downst

190 negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to dr

191 Both pharmacologic LIF blockade and genetic Lifr deletion mar

192 hat contribute to the antitumoral effects of pharmacologic LXR activation.

193 We tested a strategy of pharmacologic macrophage reprogramming to rescue HSPC mo

194 ical recommendations on nonpharmacologic and pharmacologic management of acute pain from non-low back

195 efficacy and safety of nonpharmacologic and pharmacologic management of acute pain from non-low back

196 including high-quality trials that addressed pharmacologic management of type 2 diabetes.

197 TFFs are not readily "druggable" in a direct pharmacologic manner and thus have proven difficult to t

198 Genetic and pharmacologic MAPK-ERK activation through DUSP6 inhibiti

199 Inhibition of TTK by both genetic and pharmacologic methods enhanced radiosensitivity in multi

200 n used either a chemical-genetic strategy or pharmacologic methods to disrupt signaling for 2 days fo

201 Collectively, these data demonstrate that pharmacologic mitochondrial uncoupling with BAM15 has po

202 Genetic and pharmacologic modulation of IRE1alpha and PERK in cultur

203 Moreover, pharmacologic modulation of TH activity rescues the chan

204 ding of the signaling process as well as how pharmacologic modulation of these pathways impacts on th

205 ally induced myotonia using both genetic and pharmacologic mouse models of myotonia congenita.

206 rol FAHFA levels in vivo in both genetic and pharmacologic mouse models.

207 re substantially enhanced when combined with pharmacologic mTOR inhibition.

208 Genetic and pharmacologic mTORC1 inhibition restores lysosomal prote

209 Lastly, pharmacologic NGFR inhibition restores tumor sensitivity

210 Therefore, pharmacologic Nrf2 activation is a promising strategy fo

211 on are provided to guide in the selection of pharmacologic options for intermittent and persistent AR

212 Currently available pharmacologic options for the treatment of sleepiness in

213 Several pharmacologic options for type 2 diabetes are available.

214 nt, selection of monotherapy and combination pharmacologic options, and allergen immunotherapy for AR

215 rgo immediate restoration of sinus rhythm by pharmacologic or electrical cardioversion.

216 g the turnover of these cells through either pharmacologic or genetic approaches can yield a neuropro

217 In macrophages, blockade of ERK signaling by pharmacologic or genetic approaches inhibited interleuki

218 Pharmacologic or genetic inhibition of calcineurin and N

219 In mice, tumour progression is delayed upon pharmacologic or genetic inhibition of MCL-1.

220 Moreover, pharmacologic or genetic manipulation of vitamin D signa

221 Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically res

222 f the ACE2/Ang-(1-7)/Mas receptor pathway by pharmacologic or molecular maneuvers, which stimulates m

223 No clinically established pharmacologic or perisurgical therapies currently addres

224 Estimates are presented for the effects of pharmacologic or strategy-driven glucose-lowering interv

225 ecretion by endothelial cells using genetic, pharmacologic, or immunologic approaches abolished intes

226 Administration of pharmacologic p300 inhibitor C646, but not PCAF/GCN5 inh

227 rature block assay combined with genetic and pharmacologic perturbation of luminal pH, we monitored t

228 on and to determine how inhibition of MK2 by pharmacologic (PF-3644022) and genetic (siRNA) methods i

229 further studies are required to investigate pharmacologic, pharmacodynamic and physical properties o

230 Our results suggest that pharmacologic PPAR-gamma activation, via its vasoactive

231 This pharmacologic profile is consistent with the observed an

232 hizophrenia in order to identify the in vivo pharmacologic profile that may be relevant to the antips

233 zomib, carfilzomib and ixazomib) with better pharmacologic profiles as well as compounds targeting re

234 ult to analyze high-throughput molecular and pharmacologic profiles of PDX.

235 Sc-would guarantee identical chemistries and pharmacologic profiles.

236 hese congeners, B2, demonstrated 1) improved pharmacologic properties, specifically increased maximum

237 Its distinct pharmacologic properties, which have recently been attri

238 ce of deep venous thrombosis among different pharmacologic prophylaxis regimens, although our analysi

239 Pharmacologic RAF or MAPK kinase (MEK) inhibitors decrea

240 Cardiovascular disease and pharmacologic RAS inhibition both increase ACE2 levels,

241 In animals, genetic and pharmacologic reduction of senescent cell burden results

242 nique patient-derived, molecularly annotated pharmacologic resource that is reflective of TNBC.

243 osis, patient stratification, and monitoring pharmacologic response.

244 pharmacological mouse model of SMA in which pharmacologic restoration of SMN has taken place either

245 Here, we report that pharmacologic restoration of the blood-brain barrier (BB

246 Pharmacologic reversal of DNA methylation enhanced gap-j

247 Employing genetic, pharmacologic, RNAscope assay, and cell-specific ablatio

248 cell lines (CCLs) and tumors, and systematic pharmacologic screens of CCLs.

249 o using a previously validated, now expanded pharmacologic sheep model of CF-like, inflammation-assoc

250 ocking effects in the presence or absence of pharmacologic sigma(1) receptor blockade with FTC146.

251 Here we show that genetic depletion or pharmacologic stabilization of the septin cytoskeleton s

252 The genomic and pharmacologic stimulation and inhibition of AR activity

253 Responses to chemogenetic and pharmacologic stimulation of beta-cells were blocked by

254 Pharmacologic strategies show limited efficacy and can p

255 led to significant interest in establishing pharmacologic strategies to selectively modulate IRE1, A

256 AAE rates varied significantly by pharmacologic stressor, GBCA molecular structure (macroc

257 Using transgenic mice and pharmacologic studies, we found that Wnt/beta-catenin wi

258 Additional pharmacologic support did not increase the risk of a new

259 rdial infarction (AMI), the optimal level of pharmacologic support is unknown.

260 us of rhabdomyosarcoma cells, and genetic or pharmacologic suppression of YES1 resulted in cytoplasmi

261 ess response in tumor growth and demonstrate pharmacologic susceptibility to inhibition of polycomb a

262 trol were associated with greater use of non-pharmacologic symptom management strategies (r = 0.645,

263 Using two distinct measures of pharmacologic synergy, we demonstrated that SOS1 inhibit

264 r (HRI), suggesting that HRI might present a pharmacologic target for raising fetal hemoglobin levels

265 a result, glutamine pathways are an emerging pharmacologic target.

266 R-MSC migration was abrogated by genetic and pharmacologic targeting of ATX and LPA1 receptor.

267 sEV-treated epithelial cells, and genetic or pharmacologic targeting of ILK reversed mitochondrial re

268 at is induced by heme-derived CO, suggesting pharmacologic targeting of macrophage metabolism as a no

269 Pharmacologic targeting of MCL1 in a mouse model of chro

270 ith lung adenocarcinoma, and that genetic or pharmacologic targeting of PRSS3/mesotrypsin reduces lun

271 Importantly, pharmacologic targeting of YAP reversed treatment-induce

272 CRISPR and pharmacologic targeting of ZEB1 with honokiol reversed t

273 There are no approved pharmacologic therapies to lower lipoprotein(a) levels.

274 Pharmacologic therapies were prescribed in 49.7% (95% CI

275 vances in mechanical circulatory devices and pharmacologic therapies, heart transplantation (HTx) is

276 form has important implications for targeted pharmacologic therapy of a wide range of cutaneous disea

277 ients who do not respond to antiosteoporosis pharmacologic therapy with an improvement in BMD, or who

278 lower incidence of deep-vein thrombosis than pharmacologic thromboprophylaxis alone is uncertain.

279 ression in critically ill patients receiving pharmacologic thromboprophylaxis would result in a lower

280 Randomized trials of BP pharmacologic treatment (more intensive BP goal or activ

281 ent tool (FRAX) to guide decisions regarding pharmacologic treatment for osteoporosis.

282 t least 50 y old with osteopenic BMD warrant pharmacologic treatment if they have a FRAX-calculated 1

283 h morbidity and mortality rate, for which no pharmacologic treatment is currently available.

284 synopsis focuses on guidance relating to the pharmacologic treatment of adults with type 2 diabetes.

285 nt provides clinical recommendations for the pharmacologic treatment of chronic obstructive pulmonary

286 ask force made recommendations regarding the pharmacologic treatment of COPD based on currently avail

287 et treatment goals, and nonpharmacologic and pharmacologic treatment of essential and resistant hyper

288 acid type A receptors are novel targets for pharmacologic treatment of traumatic brain injury-induce

289 Recently two new pharmacologic treatment options, solriamfetol and pitoli

290 is a crucial step in developing an effective pharmacologic treatment to prevent disease progression.

291 ogic interventions, and limited evidence for pharmacologic treatments and harms.

292 No disease-modifying pharmacologic treatments are available.

293 se of disability worldwide, yet no effective pharmacologic treatments exist to improve cognition.

294 owever, the clinical meaningfulness of these pharmacologic treatments has not been conclusively estab

295 ns is theoretically powerful and may lead to pharmacologic treatments more effective than those based

296 Pharmacologic treatments used for the components of the

297 views of randomized trials of behavioral and pharmacologic treatments.

298 habilitative therapy and exercise complement pharmacologic treatments.

299 ists for more research to identify effective pharmacologic treatments.

300 etry was modeled from experimentally derived pharmacologic variables.