ライフサイエンスコーパス: pharmacologically

1 to manipulate alveologenesis genetically and pharmacologically.

2 d not have this effect when SD was prevented pharmacologically.

3 ypoxia, and when cardiac output is increased pharmacologically.

4 hich locomotor-related output can be induced pharmacologically.

5 t to discover mechanisms that increase GLP-1 pharmacologically.

6 on and ask whether they can be distinguished pharmacologically.

7 and cytochrome P450 that could be activated pharmacologically.

8 , of which PSMD1 and TMG2 could be confirmed pharmacologically.

9 ersed by GSK3beta inhibition genetically and pharmacologically.

10 Our results reveal Rev-erbalpha as a pharmacologically accessible link between the circadian

11 L6, a gene downstream of SMAD2/3, as a novel pharmacologically accessible target of our transformed H

12 atients harbor a unique somatic profile with pharmacologically actionable alterations, justifying the

13 work identifies the vitamin B6 pathway as a pharmacologically actionable dependency in AML.

14 Here we identify a pharmacologically actionable pathway that controls cellu

15 tracellular matrix remodeling and represents pharmacologically actionable target for the inhibition o

16 mplification of NAPRT is shown to generate a pharmacologically actionable tumour cell dependence for

17 d that the anti-HIV drug efavirenz (EFV) can pharmacologically activate CYP46A1 in mice.

18 he critical role played by ATF6 in mediating pharmacologically activated proteostasis-based protectio

19 e exhibit reduced bacterial clearance, while pharmacologically activating Mrgprb2 in vivo eliminates

20 , we explored the neuroprotective effects of pharmacologically activating PKM2 via ML-265, a small mo

21 lain how amphipathic signaling molecules and pharmacologically active agents influence the channel ac

22 Herein we compile information about pharmacologically active aldehydes that are being used i

23 ed the therapeutic effect of cryptolepine, a pharmacologically active alkaloid derived from the roots

24 not been designed as a prodrug, could prove pharmacologically active and control urine production.

25 effectively generate preliminary data before pharmacologically active candidate compounds are process

26 ) pharmaceutical collection (NPC), the NCATS Pharmacologically Active Chemical Toolbox (NPACT), and a

27 Two such exposures with pharmacologically active components are coffee and tea c

28 n annotated chemical library, the library of pharmacologically active compounds (LOPAC), was screened

29 ch systematic methods for the preparation of pharmacologically active compounds as discrete stereoiso

30 Screening a library of 1280 pharmacologically active compounds in 1536-well plates t

31 P binds an abundance of structurally diverse pharmacologically active compounds, causing drug resista

32 synthesis of several valuable precursors for pharmacologically active compounds, with ee's at least a

33 drug candidates in clinical trials and other pharmacologically active compounds-as inhibitors of M(pr

34 in nature and present in a broad variety of pharmacologically active compounds.

35 sm more rapidly than target cells convert to pharmacologically active drug.

36 feasible approach to develop gut-restricted, pharmacologically active molecules with a potential adva

37 ets for molecular farming (the generation of pharmacologically active or biotechnologically usable co

38 nnabis largely depends on the content of its pharmacologically active secondary metabolites, mainly p

39 ent of novel strategies that target multiple pharmacologically active sites using a combination of di

40 One approach to extending the half-life of pharmacologically active small molecules is conjugation

41 ich can then be phosphorylated to become the pharmacologically active triphosphate.

42 Key to the concept was the identification of pharmacologically active zwitterions designed to be reta

43 e, and as a source of numerous under-studied pharmacologically-active compounds, a precise understand

44 k feeding is facilitated by an assortment of pharmacologically-active factors in tick saliva that cre

45 tivity of covalent inhibitors, identify new, pharmacologically addressable cysteine-thiols, and infor

46 er-specific genetic dependency, matching the pharmacologically addressable protein fold to a function

47 RP did not mimic the changes associated with pharmacologically administered FAHFAs on extent of upreg

48 ated that reconsolidation can be manipulated pharmacologically and behaviorally to impair problematic

49 e assays; cells and tissues were manipulated pharmacologically and by RNA interference.

50 gic neurons within the VLPO nucleus, defined pharmacologically and by single-cell transcript analysis

51 xone (BUP-NX), a partial opioid agonist, are pharmacologically and conceptually distinct intervention

52 L12/CXCR4 axis, we inhibited CXCR4 signaling pharmacologically and found that plerixafor decreases fi

53 or other therapeutic interventions, are both pharmacologically and functionally distinct.

54 approaches to models of liver regeneration, pharmacologically and genetically activated cell prolife

55 Here we pharmacologically and genetically manipulated brassinost

56 ly, increasing mitochondrial proteostasis by pharmacologically and genetically targeting mitochondria

57 role for the metal transporter ZIP14 during pharmacologically and high-fat diet-induced ER stress us

58 s are most sensitive to exposure duration at pharmacologically and supra-pharmacologically relevant d

59 uterine sarcomas that are genomically and/or pharmacologically annotated and explore dynamic pharmaco

60 Pharmacologically antagonizing either the angiotensin-co

61 We pharmacologically assessed mAChR-A to monitor intracellu

62 rtunities for development of more potent and pharmacologically auspicious MIF-2 inhibitors to investi

63 expression was inhibited when melanopsin was pharmacologically blocked by AA92593 as well as when its

64 Significantly, we demonstrated that pharmacologically blocking and knocking down the endolys

65 Silencing amacrine cells or pharmacologically blocking inhibitory neurotransmission

66 hyperpolarization-activated current, Ih, as pharmacologically blocking it prevented the long- and mi

67 instead required for cell migration and that pharmacologically blocking this pathway with either ISRI

68 f tumor necrosis factor alpha (TNF-alpha) or pharmacologically blocking TNF-alpha expression prevente

69 ow that DDR activation and DNA repair can be pharmacologically boosted by acting on such non-coding R

70 Pharmacologically boosting dopamine enhanced motor vigou

71 Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase,

72 Furthermore, inhibition of Sp1 by IFI16 or pharmacologically by Mithramycin A suppresses reactivati

73 Their physiology can be further modulated pharmacologically by targeting receptors for neurotransm

74 duction in current could be also be reversed pharmacologically, by FFA.

75 e-induced neurogenesis either genetically or pharmacologically can impact the frequency of chronic se

76 smooth muscle differentiation genetically or pharmacologically causes abnormal domain branching.

77 inases [PPIP5Ks] that synthesize InsP(8)) or pharmacologically [cell treatment with 2.5 uM dietary fl

78 We sequenced the MC4R from 20 cetaceans, and pharmacologically characterized 17 of these protein prod

79 s as amine bioisosteres were synthesized and pharmacologically characterized at native and selected r

80 ening selectivity profiles, synthesized, and pharmacologically characterized at the mouse melanocorti

81 To support face validity of the model, we pharmacologically characterized mouse and zebrafish TRPA

82 Here, we designed, synthesized, and pharmacologically characterized new peptidomimetics base

83 ediated endocytosis of LGR5 could be used to pharmacologically control cell behavior.

84 iagnosis, may persist even when seizures are pharmacologically controlled and are aggravated by valpr

85 ion of KARs in vivo and may prove useful for pharmacologically controlling the activity of neuronal n

86 rt to the notion that such influences can be pharmacologically dampened to reduce the onset of cancer

87 py number potentiates Galpha coupling of the pharmacologically dark receptor GPR68.

88 of these findings pertained to understudied pharmacologically dark receptors GPR4, GPR65, GPR68, and

89 In contrast, pharmacologically decreasing the biosynthesis of glutath

90 that SIRT1 inhibition, both genetically and pharmacologically, delays the onset and progression of A

91 Blocking K(ATP) channels pharmacologically depolarizes the beta-cell plasma membr

92 Pharmacologically difficult targets, such as MYC transcr

93 ed from extrasubicular excitatory afferents, pharmacologically disinhibited subicular slices generate

94 its, isolated from extrasubicular inputs and pharmacologically disinhibited, are sufficient to initia

95 easured by 2 behavioral assays, and could be pharmacologically disrupted by either depleting microgli

96 impaired when the PPARgamma-p53 complex was pharmacologically disrupted or when BMPR2 was reduced in

97 s associated with resolving uncertainty, and pharmacologically disrupting this network reduces the mo

98 ive degradation of CDK4 and CDK6 as tools to pharmacologically dissect their distinct biological func

99 TFD-MPAB)], we identified two homologous but pharmacologically distinct classes of general anesthetic

100 Pharmacologically distinguishing alpha3beta2 nicotinic a

101 provides a foundation for understanding how pharmacologically diverse and clinically essential drugs

102 brain hemodynamics provide information about pharmacologically driven downstream CNS drug effects; th

103 n in vivo have made it difficult to identify pharmacologically effective small-molecule inhibitors.

104 up opportunities for rational engineering of pharmacologically enhanced sKlotho therapeutics for mana

105 Further, pharmacologically enhancing endogenous cannabinoids (eCB

106 Pharmacologically enhancing mitophagy and accelerating t

107 ide scaffold were designed, synthesized, and pharmacologically evaluated, leading to the discovery of

108 ies (general structure III) was prepared and pharmacologically evaluated.

109 enethylamines was designed, synthesized, and pharmacologically evaluated.

110 ase in beta-cells, and show that this can be pharmacologically exploited to boost insulin secretion.

111 eptors (GPCRs) comprise the largest and most pharmacologically important family of cell-surface recep

112 controlling the central branch point of this pharmacologically important group of compounds.

113 receptors (GPCRs) in mouse brains to unravel pharmacologically important pathways.

114 ic stress, as a tool for bio-enrichment with pharmacologically important phytochemicals.

115 TREM1 inhibition genetically or pharmacologically improved outcome via protective antiox

116 Blocking V-ATPase pharmacologically in beta-cells increased mTORC1 activit

117 roduction or action, genetically in mice and pharmacologically in humans, respectively, has not produ

118 Lowering H3K27 trimethylation genetically or pharmacologically in the offspring of HFD-fed parents pr

119 Targeting platelet function pharmacologically in tumor-bearing mice with aspirin and

120 e of (52)Mn(2+) was successfully manipulated pharmacologically in vitro and in vivo using glucose, ni

121 Chronically increasing neuronal activity pharmacologically in vivo led to a normalization of Kv2.

122 ical recurrent node in this system, here, we pharmacologically inactivated parts of vlPFC and simulta

123 Here, we directly tested this hypothesis by pharmacologically inactivating individual, millimeter-sc

124 eted therapies with immunotherapies that are pharmacologically incompatible; (ii) early monitoring of

125 Moreover, pharmacologically increasing aHipp glutamate reduced anx

126 Pharmacologically increasing endocannabinoid tone mimics

127 onist treatments revealed a putative mode of pharmacologically independent regulation of transcriptio

128 ding of the hierarchy of cellular systems to pharmacologically induce a shift toward terminal commitm

129 massive doses of corticosteroids and maximal pharmacologically induced bronchodilation is the main ca

130 ractices such as therapeutic hypothermia and pharmacologically induced coma for many indications asso

131 es endocytosis in SMA models and ameliorates pharmacologically induced endocytosis defects in zebrafi

132 tau(-/-) mice abolished the protection from pharmacologically induced excitotoxicity and middle cere

133 We pharmacologically induced focal seizures in primary visu

134 mpletely lacked rebound sleep following both pharmacologically induced neuronal activity and physical

135 rain shift the threshold for spontaneous and pharmacologically induced seizures alongside changes in

136 the connectivity remains suppressed despite pharmacologically induced wakefulness in the presence of

137 nvironment from two different models of deep pharmacologically-induced coma (PIC): isoflurane (1.25%-

138 of the IL-6 family cytokines in response to pharmacologically-induced ER stress in astrocytes and ma

139 eness of the sensor to exogenous H(2) O(2) , pharmacologically-induced H(2) O(2) release, and genetic

140 tates of consciousness, such as psychotic or pharmacologically-induced hallucinations, provide a uniq

141 ition in nucleus accumbens required for such pharmacologically-induced motivations?

142 In this study, we identified a pharmacologically inducible vasculoprotective mechanism

143 We proceeded to pharmacologically inhibit GATA2 in concert with AML chem

144 validated anticancer target, but efforts to pharmacologically inhibit MYC have failed.

145 es to disease and consider new approaches to pharmacologically inhibit RAD51.

146 ppressor pathway is silenced, but efforts to pharmacologically inhibit YAP1 have been unsuccessful.

147 Likewise, when BRAF(V600E) is pharmacologically inhibited by targeted therapies (e.g.

148 Here, we pharmacologically inhibited microglial function with sys

149 If Galpha(q) is pharmacologically inhibited or genetically ablated, Gbet

150 When migration is pharmacologically inhibited, the ATP:ADP ratio decreases

151 Importantly, when glycolysis is pharmacologically inhibited, the impaired formation of n

152 changes-or cells in which these changes are pharmacologically inhibited-remain sensitive to drug tre

153 y deleted in a population of cells or GK was pharmacologically inhibited.

154 ored by supplementing with sphingolipids and pharmacologically inhibiting ER stress-induced cell deat

155 Genetically or pharmacologically inhibiting expression of FLIP(L) using

156 (-/-) astroglial translocation phenotype by pharmacologically inhibiting FGF signaling shows that th

157 Using this information, we demonstrate that pharmacologically inhibiting necroptosis or interferon s

158 These data suggest that pharmacologically inhibiting polyamine biosynthesis may

159 agonist was used to determine the effects of pharmacologically inhibiting RAGE on type 2 cytokine-ind

160 asing intestinal serotonin by genetically or pharmacologically inhibiting SERT decreases LEE expressi

161 We also found that pharmacologically inhibiting STING activation partially

162 Pharmacologically inhibiting the erratic output of the c

163 sis is restored at kismet mutant synapses by pharmacologically inhibiting the function of histone dea

164 ha phosphorylation site, genetically(11) and pharmacologically inhibiting the ISR kinases(14-17), or

165 Furthermore, pharmacologically inhibiting the NPY2R in vivo significa

166 lly blocking Drosophila gypsy activation and pharmacologically inhibiting viral reverse transcriptase

167 Thus, identification of pharmacologically interesting phenols requires systemati

168 amount of the base, providing access to new, pharmacologically interesting ring systems with high yie

169 epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS(1-4).

170 resistance on delta receptors in mice, then pharmacologically isolated delta receptors in mouse dent

171 leptiform activity and then replayed them in pharmacologically isolated neurons under control conditi

172 cell eradication, presents an opportunity to pharmacologically limit disease progression by promoting

173 We developed strategies to pharmacologically manipulate the AP waveform with the go

174 ulates PXR transcriptional activity and that pharmacologically manipulated AMPK activation exhibits a

175 To test this hypothesis, we genetically and pharmacologically manipulated ASIC1A and assessed effect

176 ma-exposed individuals may involve more than pharmacologically manipulating dysregulated molecules an

177 Both CRISPR-based and pharmacologically mediated inhibition of IKKbeta blocked

178 isualisation of a Cdx2-GFP reporter line and pharmacologically mediated loss and gain of function exp

179 The effect of pharmacologically mediated weight loss on renal outcomes

180 This was pharmacologically mimicked by the BH3 mimetic navitoclax

181 ma1-selective small molecules can be used to pharmacologically modulate protein homeostasis pathways.

182 tment alone, we demonstrate the potential to pharmacologically modulate the proliferation of memory C

183 anner, opening up this pathway as a means to pharmacologically modulate the receptors.

184 lly, the gain-of-function mutations could be pharmacologically modulated in vitro using an existing F

185 s of long-lived memory CD4(+) T cells can be pharmacologically modulated in vivo, thus establishing a

186 ergic receptors and chloride regulators were pharmacologically modulated.

187 Genetically or pharmacologically modulating PD-L1 acetylation blocks it

188 Pharmacologically, modulating histone acetylation with a

189 To date, the pursuit of pharmacologically more favorable approaches using low-mo

190 We report the discovery of BTSA1, a pharmacologically optimized BAX activator that binds wit

191 how that administration of an engineered and pharmacologically optimized human cyst(e)inase enzyme me

192 Disrupting this activity either pharmacologically or by electrical stimulation alters th

193 Inhibiting THIK-1 function pharmacologically or by gene knockout depolarizes microg

194 Induction of ER stress pharmacologically or by suppression of other ER stress r

195 Restoration of cAMP levels pharmacologically or chemogenetically rescued the motor

196 box binding protein 1 (Xbp1) axis is blocked pharmacologically or deleted genetically have significan

197 Pharmacologically or genetically abrogating Pi transport

198 f the transient elevation of O-GlcNAcylation pharmacologically or genetically aggravates the ischemia

199 optogenetics promotes proliferation, whereas pharmacologically or genetically blocking electrochemica

200 in learning deficits that can be rescued by pharmacologically or genetically consolidating sleep.

201 en mGluR5, NO production, or MMP-2 and MMP-9 pharmacologically or genetically is sufficient to recapi

202 l of cellular debris by microglia is reduced pharmacologically or genetically.

203 were alleviated by suppressing PERK activity pharmacologically or genetically.

204 e release, but not when Epac2 is inactivated pharmacologically or in Epac2(-/-) (Rapgef4(-/-)) mice.

205 neuropsychiatric disorders commonly treated pharmacologically or invasively.

206 Elevating cAMP pharmacologically or optogenetically produced plasticity

207 Upon inhibiting the isolated N domain pharmacologically or removing the Pre-N terminal 57 resi

208 g the PD-1-PD-L1 axis, either genetically or pharmacologically, partially alleviates TMP-mediated inh

209 (3))-H bond adjacent to the pyridine ring of pharmacologically prevalent picolyl amides with an allen

210 er pressing behavior with nicotine vapor was pharmacologically prevented by the alpha4beta2 nicotinic

211 enous protein kinases, making it possible to pharmacologically prime the proteasome for treating dise

212 This is largely due to our inability to pharmacologically probe circuit level contributions of V

213 ch provide rich resources of molecularly and pharmacologically profiled cancer samples at different l

214 We hypothesized that pharmacologically promoting glutamate spillover in the N

215 METHODS AND To pharmacologically re-induce HbF by DNMT1 inhibition, thi

216 sERr was pharmacologically recapitulated by combining the HIV-pro

217 gies are in clinical development designed to pharmacologically reduce serum HBsAg, break immune toler

218 nticancer immunotherapy might be enhanced by pharmacologically reducing intratumor copper levels.

219 Thus, COXs are physiologically and pharmacologically regulated by the FA tone of the milieu

220 similar properties in pseudokinases could be pharmacologically regulated.

221 art of gating constitutes an entry point for pharmacologically regulating channel function.

222 used in this analysis illustrated that some pharmacologically related binding assays are highly corr

223 A straightforward protocol toward pharmacologically relevant (het)areno[x,y-b]pyrrolo[1,2-

224 able acyclic and cyclic compounds (including pharmacologically relevant carbazoles, delta-lactams, an

225 Nilotinib is safe and achieves pharmacologically relevant cerebrospinal fluid concentra

226 MA-positive cancer-associated fibroblasts at pharmacologically relevant compound concentrations.

227 persistent and resurgent sodium currents, at pharmacologically relevant concentrations.

228 well tolerated across preclinical species at pharmacologically relevant doses with good ADME properti

229 sure duration at pharmacologically and supra-pharmacologically relevant doxorubicin concentrations.

230 n Pd-catalyzed Matsuda-Heck arylation to the pharmacologically relevant E-configured 3-arylmethyliden

231 oform composition for individual cancer- and pharmacologically relevant genes, including HRAS, PTEN,

232 r the study of ligand binding to elusive yet pharmacologically relevant GPCR states.

233 ted as inhibitors of six physiologically and pharmacologically relevant human (h) carbonic anhydrase

234 were evaluated for inhibitory action against pharmacologically relevant human CA isoforms I, II, IV,

235 ics of more complex p38 inhibitors and other pharmacologically relevant inhibitors in general, demons

236 Eighteen pharmacologically relevant molecules with competing site

237 d to significantly accelerate the search for pharmacologically relevant molecules.

238 or inhibition of the NGF/TrkA interaction at pharmacologically relevant peptide concentrations.

239 in-binding proteins, and topoisomerases in a pharmacologically relevant phenotypic setting.

240 cotransporting polypeptide, at the site of a pharmacologically relevant polymorphism (S267F).

241 an eco-friendlier methodology on examples of pharmacologically relevant privileged structures 5,6-dih

242 functional studies of RNA viruses and other pharmacologically relevant RNA transcripts.

243 e unbinding mechanism of an inhibitor of the pharmacologically relevant target p38 MAP kinase.

244 lter-activated potassium channels, including pharmacologically relevant two-pore domain (K2P) and big

245 ts that the observed metabolic gradients are pharmacologically relevant.

246 In this case, we observed enhancement of pharmacologically rescued F508del-CFTR by arginine-depen

247 ore whether these hDAT mutants could also be pharmacologically rescued in an intact organism.

248 on of eIF2α-P activity, genetically or pharmacologically, restores memory and prevents neurodeg

249 Pharmacologically restoring MT stability rescues gross c

250 The prospect of pharmacologically restoring or potentiating this endogen

251 d demonstrating that synaptic defects can be pharmacologically reversed, these data open the possibil

252 c transformation, resulting in what may be a pharmacologically reversible epigenetic field defect in

253 Pharmacologically reversible mutations of TREK channels

254 Lengthening surface lifetimes by pharmacologically slowing endocytosis was sufficient to

255 n parallel when triglycerides were decreased pharmacologically, so that subtracting pre-treatment fro

256 Here, we demonstrate that, in neurons, pharmacologically stabilizing G4-DNA with G4 ligands str

257 Here, we tested the impact of pharmacologically stimulated D(1) receptors on sensitivi

258 ogenetic inhibition of excitatory neurons or pharmacologically strengthening GABAergic tempos rescued

259 Moreover, pharmacologically sustained elevation of zinc in WT eggs

260 report the first single-compound strategy to pharmacologically target melanocortin receptor allosteri

261 tosis in diseases and will foster efforts to pharmacologically target this unique yet pervasive form

262 he transcription factor Stat3 as a critical, pharmacologically targetable effector of CD109-driven lu

263 II-A calcium binding sites could be putative pharmacologically targetable regions.

264 t also different because ZAP70 is not easily pharmacologically targetable.

265 ntifies PI3K/Akt/mTOR signaling as the first pharmacologically-targetable pathogenic process in IL-6-

266 ocrine glutamatergic signaling, which can be pharmacologically targeted by decreasing glutamate bioav

267 ease-relevant phenotypes ex vivo that can be pharmacologically targeted for drug discovery.

268 eptors (GPCRs) comprise the largest and most pharmacologically targeted membrane protein family.

269 sion and that this system of proteins can be pharmacologically targeted to inhibit the metastatic pot

270 ed in CREBBP-mutant DLBCL cells and could be pharmacologically targeted with selective small molecule

271 palmitoylation sites that can potentially be pharmacologically targeted.

272 esults focused on defining the potential for pharmacologically targeting ATF6 to intervene in such di

273 Our findings suggest that pharmacologically targeting Cdr1 in combination with azo

274 tem may contribute to these disturbances and pharmacologically targeting the D3 dopamine receptor (DR

275 be how this knowledge suggests approaches to pharmacologically targeting these transporters.

276 Pharmacologically targeting this convergence could overc

277 Pharmacologically, targeting PDGFRbeta disrupts APC nich

278 eosome components were depleted or inhibited pharmacologically, the steady-state levels of circular R

279 cose transporter (SGLT2), a protein targeted pharmacologically to increase urinary glucose excretion

280 the central signaling axis to be suppressed pharmacologically to treat for neoplastic disorders with

281 therapeutic mechanisms that can be targeted pharmacologically to treat Leigh syndrome.

282 vely, the findings presented here indicate a pharmacologically tractable approach to drive MYC degrad

283 LDHA is a pharmacologically tractable EWS-FLI1 transcriptional tar

284 ulator of glucose transport that regulates a pharmacologically tractable pathway necessary for PDAC t

285 le longer Abeta forms induce sleep through a pharmacologically tractable Prion Protein (PrP) signalin

286 ways, and this signaling axis may serve as a pharmacologically tractable target during infection and

287 Of these, 1,372 pharmacologically treated patients with diabetes and 10,

288 s after surgery and 61% of patients were not pharmacologically treated up to 7 years after surgery.

289 ey regulator for gastric acid production, or pharmacologically treated with a proton pump inhibitor,

290 argest family of transporters, yet, they are pharmacologically underexploited relative to other prote

291 unning luminescence rhythms can be modulated pharmacologically using a CK1 epsilon/delta inhibitor, s

292 ike proteins, and explores how to exploit it pharmacologically using drugs.

293 ascular adrenergic sensitivity were assessed pharmacologically using intradermal microdialysis.

294 We electrochemically and pharmacologically verify the selectivity of the serotoni

295 However, reliable means for pharmacologically weakening MRMs in humans remain elusiv

296 hibition of autophagy, either genetically or pharmacologically with chloroquine, synergizes with dual

297 d the role of ERK signaling was interrogated pharmacologically with MEK1/2 inhibitor U0126 or genetic

298 we show that targeting MUC1-C genetically or pharmacologically with the GO-203 inhibitor, which block

299 Boosting autophagy, either pharmacologically (with temsirolimus) or by dietary inte

300 e that sustained S1P(1) activation can occur pharmacologically without compromising the immune respon