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1 rx1 in the intermediate region of the second pharyngeal arch.
2 are expanded at the detriment of the second pharyngeal arch.
3 layer of the stomodeal ectoderm in the first pharyngeal arch.
4 tribute to the cranial ganglia and the first pharyngeal arch.
5 reside in the mandibular region of the first pharyngeal arch.
6 gsc, of moz and hox2 signaling in the second pharyngeal arch.
7 antly to confer proper pattern to the second pharyngeal arch.
8 lar identity during development of the first pharyngeal arch.
9 tation on cells derived from mouse embryonic pharyngeal arch.
10 d in epithelial-mesenchymal signaling in the pharyngeal arch.
11 ins along the dorsoventral axis of zebrafish pharyngeal arches.
12 is understood of its role in patterning the pharyngeal arches.
13 e and in the development of the tail bud and pharyngeal arches.
14 ession in migratory cranial neural crest and pharyngeal arches.
15 neural tube to populate the forming face and pharyngeal arches.
16 ion in the cardiac outflow tract, but not in pharyngeal arches.
17 mental identity in the second through fourth pharyngeal arches.
18 ions as a barrier for these axons within the pharyngeal arches.
19 neural crest derivatives are affected in the pharyngeal arches.
20 g and migrating through the third and fourth pharyngeal arches.
21 dorsoventral (DV) patterning in the anterior pharyngeal arches.
22 transcription factors within the developing pharyngeal arches.
23 ed in cephalic neural crest cells within the pharyngeal arches.
24 atory cephalic neural crest cells within the pharyngeal arches.
25 ing cranial crest cells as they populate the pharyngeal arches.
26 housands of genes in distinct regions of the pharyngeal arches.
27 tract translocates caudally relative to the pharyngeal arches.
28 rebrain, cranial neural crest, placodes, and pharyngeal arches.
29 n the neural crest-derived mesenchyme of the pharyngeal arches.
30 ent with their overlapping expression in the pharyngeal arches.
31 y associated with blood vessels in anamniote pharyngeal arches.
32 tterns demonstrate dissociation in the chick pharyngeal arches.
33 the head as well as in the first and second pharyngeal arches.
34 ge and mesoderm-derived muscles in all seven pharyngeal arches.
35 cue some of the patterning defects of mutant pharyngeal arches.
36 Met is required for vagus innervation of the pharyngeal arches.
37 mature derivatives from the first and second pharyngeal arches.
38 cells also failed to condense correctly into pharyngeal arches.
39 l progenitors, which contribute to posterior pharyngeal arches.
40 ation and proliferation within the posterior pharyngeal arches.
41 of condensing neural crest cells within the pharyngeal arches.
42 expressed early in the developing kidney and pharyngeal arches.
43 rning of neural crest cells (NCC) within the pharyngeal arches.
44 with that of the cranial musculature and the pharyngeal arches.
45 that patterns the dorsal-ventral axis of the pharyngeal arches.
46 s in transient, reiterated structures termed pharyngeal arches.
47 g the neural crest derived mesenchyme of the pharyngeal arches.
48 pattern the dorsal-ventral (DV) axis of the pharyngeal arches.
49 ties along the dorsoventral (DV) axes of the pharyngeal arches.
50 level, increased cell death was observed in pharyngeal arches.
51 we analyzed transcription profiles of human pharyngeal arch 1 (PA1), a conserved embryonic structure
54 haryngeal endoderm and the posterior part of pharyngeal arch 1, and is a potential point of cross tal
55 arily sequestered in the mesodermal cores of pharyngeal arch 2 (PA2), where they downregulate nkx2.5
57 : (1) accumulation of SHF-derived ECs in the pharyngeal arches, (2) remodeling of the EC plexus in th
58 bined with mesenchymal cells from the second pharyngeal arch, a region devoid of tooth development.
59 onding segmentation of the hindbrain and the pharyngeal arches, a key step in the development of the
60 n results in increased cell death within the pharyngeal arches, aberrant endodermal pouch morphogenes
63 In this study, we focus on the defects in pharyngeal arch and cardiovascular patterning present in
64 in tissues of neural crest origin including pharyngeal arch and craniofacial mesoderm, supporting a
65 valentino and kreisler mutants have similar pharyngeal arch and inner ear defects, consistent with a
66 e within the mandibular portion of the first pharyngeal arch and is likely to be impacted by this sig
67 Cad and Umps to be strongly expressed in the pharyngeal arch and limb bud, supporting a site- and sta
71 typed pattern in the embryo, including seven pharyngeal arches and a basicranium underlying the brain
72 r beta1 integrin were able to migrate to the pharyngeal arches and associate with endothelial lined a
73 fish is characterized by defects in the ear, pharyngeal arches and associated structures such as the
74 eural crest-derived ectomesenchymal cells of pharyngeal arches and cardiac outflow tissues, whereas E
78 crest (CNC) cells migrate to form segmental pharyngeal arches and differentiate into segment-specifi
79 ET-specific converting enzyme, ECE-1, in the pharyngeal arches and great vessels of the developing ch
81 es of reiterated structures that segment the pharyngeal arches and help pattern the vertebrate face.
83 ing cranial crest cells as they populate the pharyngeal arches and in trunk neural crest cells, in a
84 e deleted genes, is expressed throughout the pharyngeal arches and is considered a key gene, when mut
85 onic hedgehog (Shh) is also expressed in the pharyngeal arches and is necessary for normal craniofaci
86 the ectoderm and endoderm of the developing pharyngeal arches and known to play an important role in
87 we show that morphogenetic movements of the pharyngeal arches and patterning of the neural crest req
88 quirement for Pbx1 in the development of the pharyngeal arches and pouches and their organ derivative
89 d that it is required for the development of pharyngeal arches and pouches, as predicted by the DGS c
92 ng with the developmental progression of the pharyngeal arches and show that experimentally altering
93 egions of the developing heart, vasculature, pharyngeal arches and somites, and the periodicity of th
94 ipts were also detected in precursors of the pharyngeal arches and subsequently in the pharyngeal cle
95 ession overlaps in regions of the developing pharyngeal arches and that they interact genetically dur
97 ls for proper morphogenetic movements of the pharyngeal arches and the neural crest require the recep
98 ived cells to control the remodelling of the pharyngeal arches and the septation of the heart and out
99 th the proper condensation of the CNCCs into pharyngeal arches and the subsequent patterning and morp
101 play a major role in the development of the pharyngeal arches, and defects in these cells are likely
102 these mapping studies uncover nodules in the pharyngeal arches, and identify Twist1(-/-) neural crest
104 lack cartilage elements of the neurocranium, pharyngeal arches, and pectoral girdle similar to humans
106 nt to rescue Dlx2 expression in Dicer mutant pharyngeal arches, and regulated non-cell-autonomous sig
107 ed genes in the development of the heart and pharyngeal arches, and reinforce the paradigm of gene du
108 enes in the forebrain, cranial neural crest, pharyngeal arches, and sensory placodes of lamprey embry
109 arch-associated NA cells and has defects in pharyngeal arches, and soulless lacks both arch-associat
110 on-truncal fashion; these cells populate the pharyngeal arches, and thus contribute to the developing
111 -/- embryos at E10.5-11.0 had well-developed pharyngeal arches, aortic arch arteries, and no signs of
113 ofacial malformations in vertebrate embryos: pharyngeal arches are fused or absent, and a rostrad exp
116 1 null mouse including loss of caudal pa and pharyngeal arch arteries (paa), small otic vesicles, los
118 airment of vascular smooth muscle in the 4th pharyngeal arch arteries (PAAs) during early embryogenes
119 During embryonic life, the initially paired pharyngeal arch arteries (PAAs) follow a precisely orche
120 to join the OFT, instead contributing to the pharyngeal arch arteries (PAAs), and second, a loss of f
122 the cell biology of tissues contributing to pharyngeal arch arteries and cardiac outflow tract are t
123 also displayed inappropriate remodelling of pharyngeal arch arteries and defective outflow tract sep
124 wever, it is essential for remodeling of the pharyngeal arch arteries and for the assembly of the ves
125 cells participate in both remodeling of the pharyngeal arch arteries and outflow tract septation dur
127 remodeling of the cardiac outflow tract and pharyngeal arch arteries during cardiovascular developme
128 art, neural-crest-derived cells surround the pharyngeal arch arteries from the time of their formatio
129 y, is required for normal development of the pharyngeal arch arteries in a gene dosage-dependent mann
130 ated with aberrant development of the fourth pharyngeal arch arteries including interrupted aortic ar
131 t derivatives of the third, fourth and sixth pharyngeal arch arteries retain a substantial contributi
133 least in part, to failure to form the fourth pharyngeal arch arteries, altered expression of Fgf10 in
134 iciency, i.e. early hypoplasia of the fourth pharyngeal arch arteries, consistent with the time and l
135 t - specifically formation and growth of the pharyngeal arch arteries, growth and septation of the ou
136 re excluded from the walls of the developing pharyngeal arch arteries, indicating that ET(A) signalin
137 f Tbx1 affects the development of the fourth pharyngeal arch arteries, whereas homozygous mutation se
144 ly interact in the development of the fourth pharyngeal arch artery (PAA) and Fgf10 was identified to
145 ing the gene regulatory networks that govern pharyngeal arch artery (PAA) development is an important
146 rant range of 22q11DS-like defects including pharyngeal arch artery (PAA), outflow tract, craniofacia
147 retinoic acid signaling causes a variety of pharyngeal arch artery and great vessel defects, as well
148 e-specific mutation approaches, we segregate pharyngeal arch artery and pharyngeal pouch defects in R
149 ly, reducing the gene dosage of Fgf8 rescued pharyngeal arch artery defects caused by loss of Ctnnb1.
151 y of mutant embryos to recover from a fourth pharyngeal arch artery growth abnormality that is fully
152 onsible for craniofacial skeleton formation, pharyngeal arch artery remodeling and cardiac outflow tr
153 h and great arteries specifically during the pharyngeal arch artery remodeling process and indicate t
156 rm causes failure of formation of the fourth pharyngeal arch artery that results in aortic arch and s
158 ial nerves (IX, X, XI, and XII) and postotic pharyngeal arches as well as the presence of ectopic oti
159 holaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model f
160 le of the Edn1 signal in patterning anterior pharyngeal arch bone development during the first week a
161 geal endoderm and the mesodermal core of the pharyngeal arches, but were not present in the neural cr
162 eth develop on the oral surface of the first pharyngeal arch by a series of reciprocal interactions b
163 patterning of the separate components of the pharyngeal arches can proceed independently of neural cr
164 PG2 genes results in major defects in second pharyngeal arch cartilages, involving replacement of ven
165 ts exhibit a non-cell-autonomous increase in pharyngeal arch cell death accompanied by alterations in
169 the lack of overt cartilage differentiation, pharyngeal arch condensations in jef (sox9a) mutants lac
170 including immobility, small eyes, diminished pharyngeal arches, curved body axis, edema, underdevelop
171 ort that unplugged larvae display a striking pharyngeal arch defect, consistent with a dual function
172 tterned cranial ganglia, dysmorphogenesis of pharyngeal arch derivatives and abnormal organization of
173 he cardiac outflow tract compared with other pharyngeal arch derivatives, including the palatal bones
174 nting with bi- or unilateral OME, the fourth pharyngeal arch-derived levator veli palatini muscles we
176 genes that are implicated in the control of pharyngeal arch development and in the etiology of DGS.
178 esent here an analysis of cardiovascular and pharyngeal arch development in mouse embryos hypomorphic
179 ence of Shh, there is general failure of the pharyngeal arch development leading to cardiac and crani
180 of these, no arches, is essential for normal pharyngeal arch development, and is homologous to the re
181 echanisms underlying evolutionary changes in pharyngeal arch development, here we investigate embryos
182 sion of Dlx2, a transcriptional regulator of pharyngeal arch development, in the first pharyngeal arc
183 cy of the transcription factor TBX1 disrupts pharyngeal arch development, resulting in the cardiac an
194 Fgf8 is expressed within the developing pharyngeal arch ectoderm and endoderm during NCC migrati
196 Remarkably, ablating FGF8 protein in the pharyngeal arch ectoderm causes failure of formation of
197 blated in its expression domain in the first pharyngeal arch ectoderm from the time of arch formation
200 se a model in which Sdf1b signaling from the pharyngeal arch endoderm and optic stalk to Cxcr4a expre
202 from disruption of local FGF8 signaling from pharyngeal arch epithelia to mesenchymal cells populatin
204 r, our data indicate that the extreme distal pharyngeal arch expression domain of Hand1 defines a nov
208 iprocally, miR-196 knockdown evoked an extra pharyngeal arch, extra ribs, and extra somites, confirmi
211 ss of crest migration and, furthermore, that pharyngeal arches form, are regionalized and have a sens
212 morpholino oligonucleotides disrupts jaw and pharyngeal arch formation and recapitulates ocular chara
216 process is initiated by the formation of the pharyngeal arches from ectoderm, endoderm and mesoderm.
217 f Jagged1-Notch2 signaling in patterning the pharyngeal arches from fish to mouse to man, despite the
219 e neural crest-derived ectomesenchyme of the pharyngeal arches, from which many craniofacial and grea
220 unaffected; however, specific domains in the pharyngeal arches have elevated levels of reporter activ
222 oral fin bud initiation, deletion of the 6th pharyngeal arch, homeotic aberration and loss of rostral
223 ion in the vertebrate dorsal neural tube and pharyngeal arches, implying co-option of AP-2 genes by n
224 hymal and endodermal components of the first pharyngeal arch in lampreys, providing molecular evidenc
225 l neural crest cells (NCCs) migrate into the pharyngeal arches in three primary streams separated by
226 r dorsoventral patterning of the gnathostome pharyngeal arches in which Et-1 in the environment of th
229 ypic abnormalities of the derivatives of the pharyngeal arches, including cardiac outflow tract defec
230 erns the skeleton derived from the first two pharyngeal arches into dorsal, intermediate and ventral
231 f cardiac neural crest cells from the caudal pharyngeal arches into the outflow tract and base of the
234 nhancer that directs dHAND expression to the pharyngeal arches is used to drive Cre recombinase expre
235 ventrally in the primordia of the zebrafish pharyngeal arches, is required for correct patterning of
236 causes hypoplasia of the right ventricle and pharyngeal arches leading to lethality by embryonic day
237 s expressed in many other tissues, including pharyngeal arches, limb buds, otic vesicles, photorecept
238 at in cultured explants of presumptive first pharyngeal arch, loss of Shh signalling results in loss
241 Our study suggests that loss of HAND2 in the pharyngeal arch mesenchyme leads to apoptosis in an Apaf
242 vealed that, while ET(A) is expressed in the pharyngeal arch mesenchyme, populated by cardiac neural
245 -expressing neural crest cells medial to the pharyngeal arch mesoderm appears to be a primitive featu
247 h is a major source of myocardium and of the pharyngeal arch mesoderm that gives rise to skeletal mus
248 liferation and subsequent differentiation of pharyngeal arch neural crest and mesoderm-derived mesenc
249 re 4, the major site of origin of the second pharyngeal arch neural crest, is reduced in size and has
250 ion pattern in the limb and first and second pharyngeal arches not only explains SHOX -related short
251 eHAND was specifically downregulated in the pharyngeal arches of Galpha(q)/Galpha(11)-deficient mice
255 uctures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believ
259 e performed gene profiling of microdissected pharyngeal arch one (PA1) from Tbx1(+/+) and Tbx1(-/-) e
261 d upstream of a number of genes required for pharyngeal arch, outflow tract, and/or atrial septal mor
262 -gestation with defects in facial primordia, pharyngeal arches, outflow tract and cardiac ventricles.
263 ral tube and later migrates to the heart and pharyngeal arch (PA), where they contribute to distinct
264 lossus muscles that are derived from the 4th pharyngeal arch (PA); however, the tensor veli palatini,
267 logue Numblike (Nbl) depletes CPCs in second pharyngeal arches (PA2s) and is associated with an atrop
268 (crNCCs) migrate from the neural tube to the pharyngeal arches (PAs) of the developing embryo and, su
269 the ectoderm and the role of the endoderm in pharyngeal arch patterning may thus be indirectly mediat
271 e requirement for FGF8 during development of pharyngeal arch, pharyngeal pouch and neural crest-deriv
274 in dlx1/2 and emx2 expression in the second pharyngeal arch, presaging the differentiation of the re
275 in the first (mandibular) and second (hyoid) pharyngeal arch primordia are located most ventrally and
276 on from the rhombomeric neuroectoderm to the pharyngeal arches, proliferation as the ectomesenchyme w
277 itial migration of neural crest cells to the pharyngeal arch region occurs normally in the mutant emb
279 s a candidate gene responsible for defective pharyngeal arch remodeling in DiGeorge/Velocardiofacial
280 n, these experiments revealed that different pharyngeal arches require Tbx1 in different tissues.
281 opulations in the posterior forelimb, caudal pharyngeal arches, secondary heart field and sensory vib
282 mportant role during patterning of the first pharyngeal arch, setting up the oral region of the head
283 inder surrounding a core of mesoderm in each pharyngeal arch, similar to that seen in zebrafish and a
284 In addition, these mutants have hypoplastic pharyngeal arches, small or absent thymus and abnormal c
285 Additional analysis of beta1 integrin in the pharyngeal arch smooth muscle progenitors was performed
287 xcluded from the caudoventral aspects of the pharyngeal arches, suggesting a cell-autonomous role for
288 f the neural crest-derived mesenchyme of the pharyngeal arches, suggesting that it plays a crucial ro
289 use LRF gene was expressed in the limb buds, pharyngeal arches, tail bud, placenta and neural tube.
290 sed in the rhombencephalic neural crest, the pharyngeal arches, the pectoral fin buds and the gut in
291 g dynamic contribution of SHF-derived ECs to pharyngeal arches, the remodeling of endothelial plexus
292 nes expressed in hematopoietic, vascular and pharyngeal arch tissue, consistent with the expression o
295 ally derived FGF8 has essential roles during pharyngeal arch vascular development distinct from those
297 Cardiac neural crest cells migrate into the pharyngeal arches where they support development of the
298 e from embryonic neural folds and migrate to pharyngeal arches, which give rise to most mid-facial st
299 form in the third, fourth, fifth, and sixth pharyngeal arches, while those of the first, second, and
300 CaV1.2 is expressed in the first and second pharyngeal arches within the subset of cells that give r