ライフサイエンスコーパス: phenethylamine

1 directly measured positions of alaninol and phenethylamine.

2 e slowly and bound 75-fold more tightly than phenethylamine.

3 ves, 3-arylpiperidines, or other substituted phenethylamines.

4 thesize N-methyl- or N-methyl-N-(cyanomethyl)phenethylamines.

5 iety affords pharmaceutically important beta-phenethylamines.

6 lass of 5-HT(2A) receptor agonists, N-benzyl phenethylamines.

7 rimethamine with substituted benzylamines or phenethylamines.

8 al harms, or potential pharmaceutical use of phenethylamines.

9 dual electrophiles for the synthesis of beta-phenethylamines.

10 y restricted analogues of the hallucinogenic phenethylamine 1 (2,5-dimethoxy-4-bromophenethylamine, 2

11 , and a series of substituted tryptamine and phenethylamine 5-HT(2A) receptor agonists, we found that

12 concentrations of 16 metabolites, including phenethylamine, agmatine, and glucosamine-6-phosphate (P

13 The phenethylamine alkaloid hordenine, present in germinated

14 g affinities of a series of para-substituted phenethylamine analogues to MAO A show an increase in af

15 nd isotopic characterization of alaninol and phenethylamine, analogues of alanine and phenylalanine,

16 ding site for the aryl ring is identical for phenethylamine and for benzylamine analogues and that st

17 etary phenylalanine and tryptophan generated phenethylamine and tryptamine that directly stimulated s

18 Phenethylamine and tyramine prepared from a mixture of 1

19 nd further allows the simulation analysis of phenethylamine and tyramine, which are major monoamine c

20 each catalyze conversion of phenylalanine to phenethylamine and tyrosine to tyramine.

21 a-selective C-H arylation of nosyl-protected phenethylamines and benzylamines is disclosed using a co

22 A common binding mode for phenethylamines and imidazoles with alpha 2-adrenoceptor

23 an with conformational analysis of classical phenethylamines and medetomidine analogs.

24 strated on amides derived from benzylamines, phenethylamines and phenylpropylamines; amine-containing

25 vide a general and modular synthesis of beta-phenethylamines and significantly expand the utility of

26 ected reaction products to the corresponding phenethylamines and the first total syntheses of the neo

27 rototypical hallucinogenic drug classes, the phenethylamines and the tryptamines/ergolines.

28 We investigated 110 phenethylamines and their interaction with microtubules.

29 benzyl analogs, whereas most N-unsubstituted phenethylamines and traditional agonists were only weakl

30 zamide, homologation of the benzylamine to a phenethylamine, and incorporation of a methyl group at t

31 classical psychedelics from the tryptamine, phenethylamine, and lysergamide chemical classes.

32 ic study of the nitrosation of ethylbenzene, phenethylamine, and tyramine was carried out, using UV-v

33 mides prepared from readily available chiral phenethylamines, and allows easy variation of the stereo

34 ctive substances, such as opioid analgesics, phenethylamines, and cathinone derivatives.

35 We show levels of R. gnavus, tryptamine, and phenethylamine are positively associated with insulin re

36 ctional assays confirmed that these N-benzyl phenethylamines are potent and highly efficacious agonis

37 Natural phenethylamines are trace amine neurotransmitters associ

38 beta-Phenethylamines are widely represented in biologically a

39 of piperidinone- and piperidine-constrained phenethylamines as novel DPP4 inhibitors.

40 P450 2D6 discriminated between the various phenethylamines, as evidenced by binding and steady-stat

41 RS signals for histamine, tyramine, and beta-phenethylamine at 2220, 2251, and 2150 cm(-1), respectiv

42 ple bioamines (histamine, tyramine, and beta-phenethylamine) based on aptamer-driven magnetic-induced

43 Phenethylamine-betaxanthin was the most potent in the in

44 t catalyzes the oxidation of methylamine and phenethylamine, but not that of benzylamine.

45 hrine, and epinephrine, as well as for other phenethylamines, but not for imidazolines, a class of st

46 phenylalanine were converted to tyramine and phenethylamine by tyrosine and phenylalanine decarboxyla

47 Evidence indicates phenethylamines can directly alter the microtubule cytos

48 Synthetic phenethylamines can have psychoactive and hallucinogenic

49 implies, therefore, that the hallucinogenic phenethylamines cannot be directly superimposed on LSD i

50 A wide variety of phenethylamines containing a potentially free primary am

51 Although fenethylline shares a common phenethylamine core with other amphetamine-type stimulan

52 eral approach for (13)C(2)- and (2)H-labeled phenethylamine derivatives has been developed, based on

53 ence, we prepared nearly two dozen different phenethylamine derivatives, attached them to the C termi

54 catalyst to access medicinally valuable beta-phenethylamine derivatives.

55 facile access to biologically relevant beta-phenethylamine derivatives.

56 be used to easily access biologically active phenethylamine derivatives.

57 flavonols and their glycosides), alkaloids (phenethylamines derived betalains), and triterpenoids.

58 The NBOMe derivatives are phenethylamines derived from the 2C class of hallucinoge

59 Tryptamine- and phenethylamine-derived imides were selectively monotrifl

60 R. gnavus-derived metabolites tryptamine and phenethylamine directly impair insulin signaling in majo

61 f ammonia, 4-aminopyridine, benzylamine, and phenethylamine dissolved in methanol or dichloromethane

62 tes, such as tyrosine, tryptamine, tyramine, phenethylamine, dopamine, 3-methoxytyramine, serotonin,

63 thousand for alaninol, 6.54 per thousand for phenethylamine) due to propagation of errors.

64 Mucilage, phenethylamines, flavonol glycosides, betalains and some

65 e a higher potency and intrinsic activity of phenethylamines for polyphosphoinositide turnover but no

66 Finally, the phenethylamine fragment incorporated into these molecule

67 id pathway for the synthesis of various beta-phenethylamines from aromatic aldehydes has been develop

68 Pyrolysis of phenethylamine generated benzene and toluene fragments.

69 Unexpectedly, the phenethylamine hallucinogen, DOI, a partial agonist at 5

70 phetamine (DOM; 0.6 mg/kg, i.p.), which is a phenethylamine hallucinogen, increased glutamate to 206%

71 pulation of 5-HT cells in the DRN induced by phenethylamine hallucinogens in vivo.

72 nt with the proposed mechanism of action for phenethylamine hallucinogens, that such compounds must b

73 terium exchange (HDX) in aqueous droplets of phenethylamine has been determined with submillisecond t

74 Benzyl cyanide was reduced to phenethylamine in 83% yield.

75 iodides in an undivided cell, affording beta-phenethylamines in good to excellent enantioselectivity

76 it enhanced inhibitory activity (relative to phenethylamine), including para-substituted sulfonamide

77 been demonstrated to be the key mediators of phenethylamine-induced hyperthermia (PIH).

78 development of a protocol to transform beta-phenethylamines into N-H aziridine derivatives.

79 c psychedelics (tryptamine, lysergamide, and phenethylamine) is associated with lower odds of current

80 We selected naphthylpropane-2-amines of the phenethylamine library (PAL) including the partial subst

81 ses concerning the bioactive conformation of phenethylamine ligands upon binding to the 5-HT(2A) rece

82 reproducibility of delta15N of tyramine and phenethylamine measured by GCC-IRMS averaged SD(delta15N

83 e concentrations of 9 metabolites, including phenethylamine, N-methyl-glutamate, and agmatine (P < 0.

84 sitized, and internalized on exposure to the phenethylamines norepinephrine (NE), epinephrine, or phe

85 ng cells, such as by generating the alkaloid phenethylamine or calcium-reducing drug cinacalcet to el

86 e is key in favoring formation of the target phenethylamines over competing olefin polymerization pro

87 Phenethylamine oxidation by MAO A can be described as th

88 e-3-acetic acid (5-HIAA), tryptophane, and 2-phenethylamine (PEA) in rat brain using liquid chromatog

89 urthermore, Mg2(olz) was used to encapsulate phenethylamine (PEA), a model drug for a broad class of

90 m for the synthesis of the highly privileged phenethylamine pharmacophore is reported.

91 ynthetic cannabinoids, synthetic cathinones, phenethylamines, piperazines, ketamine and phencyclidine

92 m Ruminococcus gnavus-derived tryptamine and phenethylamine play a pathogenic role in gut dysbiosis-i

93 the blood-brain barrier and triggers lethal phenethylamine poisoning after monoamine oxidase inhibit

94 interacting with Phe339((6.51)), whereas the phenethylamine portion was likely to be interacting with

95 indings suggest a causal role for tryptamine/phenethylamine-producers in the development of insulin r

96 of medetomidine conformations with those of phenethylamines provided a tentative explanation for the

97 2,5-dimethoxy-4-iodoamphetamine (DOI) is a phenethylamine psychedelic with high affinity for 5-HT(2

98 rch into the efficacy of both tryptamine and phenethylamine psychedelics in promoting smoking cessati

99 ion of peptide-extended glycine residues and phenethylamines, respectively.

100 Examination of side chain analogues of phenethylamine show 3-phenylpropylamine to be oxidized 2

101 monoamine oxidase A (MAO A) with a series of phenethylamine substrate analogues has been investigated

102 is, we analyzed the binding and oxidation of phenethylamine substrates.

103 Hyperthermia induced by phenethylamines, such as 3,4-methylenedioxymethamphetami

104 A comparison of phenethylamine systems bearing different leaving groups

105 effects similar to DisA overexpression, and phenethylamine, the product of phenylalanine decarboxyla

106 exposed to the trace amines p-tyramine, beta-phenethylamine, tryptamine, and octopamine.

107 s of refrigerated storage, concentrations of phenethylamine, tryptamine, and tyramine in the sauerkra

108 ve binding conformation of the more flexible phenethylamine type hallucinogens.

109 this class of ligand binds differently than phenethylamine-type agonists and may be more antagonist-

110 hylurapidil, with no changes in affinity for phenethylamine-type agonists such as epinephrine, methox

111 In studies of the SAR of phenethylamine-type serotonin 5-HT(2A) receptor agonists

112 of sophorolipid ethyl ester in dry THF with phenethylamine, tyramine, p-methoxyphenethylamine, 2-(p-

113 analogues, such as ascorbic acid, catechol, phenethylamine, tyrosine, epinephrine, and norepinephrin

114 ffects for para-substituted benzylamines and phenethylamines, unlike native AADH for which a poor cor

115 Phenethylamine (varphiCH2CH2NH2) was chosen to study bec

116 is method delivers valuable beta-substituted phenethylamines via a challenging reductive elimination

117 incorporation of two carbon-13 isotopes into phenethylamines was accomplished using a palladium-catal

118 The putative product of DisA, phenethylamine, was able to inhibit disA expression, ind

119 The configurations of these chloro-phenethylamines were determined by 1D and 2D NMR analysi

120 The top 10% of phenethylamines were further screened based on pharmacok

121 In contrast to the 2,5-dimethoxy-substituted phenethylamines, where rigidification of the methoxy gro

122 Phe into the potent psychoactive trace amine phenethylamine, which crosses the blood-brain barrier an

123 Acylation of N-(benzoyloxy)phenethylamine with the acid chloride of N(alpha)-Fmoc-L

124 uence synaptic plasticity the interaction of phenethylamines with microtubules is important for under