ライフサイエンスコーパス: phenobarbital

1 clear expression is regulated in response to phenobarbital.

2 n after administration of ethanol, MK801, or phenobarbital.

3 to a wide range of CAR activators including phenobarbital.

4 in levels can be decreased by treatment with phenobarbital.

5 dose of opioid were treated with adjunctive phenobarbital.

6 mine, barbiturates, propofol, pentobarbital, phenobarbital.

7 cess in parental reports of side-effects for phenobarbital.

8 d not affect the EC50 of chlordiazepoxide or phenobarbital.

9 ent tumours generated by the tumour promoter phenobarbital.

10 7 bl/6 mice by either beta-naphthoflavone or phenobarbital.

11 in potentiating the anticonvulsant effect of phenobarbital.

12 idely used GABAergic anticonvulsants such as phenobarbital.

13 ime, but not by the indirect hCAR activator, phenobarbital.

14 he day they were given an overdose of sodium phenobarbital.

15 d 32 mg, respectively; 17% were treated with phenobarbital.

16 HNF-4alpha mRNA is modestly up-regulated by phenobarbital.

17 N62 block nuclear induction of HNF-4alpha by phenobarbital.

18 ldren were randomly allocated treatment with phenobarbital (1.5 mg/kg daily for 2 weeks; maintenance

19 men were randomly assigned to receive either phenobarbital (10 mg per kilogram of body weight) or pla

20 kilogram), lorazepam (0.1 mg per kilogram), phenobarbital (15 mg per kilogram), and phenytoin (18 mg

21 using hepatocytes treated for 48 hours with phenobarbital (2 mmol/L), oltipraz (50 micromol/L), or 3

22 In children with cerebral malaria, phenobarbital 20 mg/kg provides highly effective seizure

23 omly assigned a single intramuscular dose of phenobarbital (20 mg/kg) or identical placebo.

24 of the synaptic-dependent antiepileptic drug phenobarbital (20-40 microM) failed to inhibit veratridi

25 in 13 of the 30 neonates assigned to receive phenobarbital (43 percent) and 13 of the 29 neonates ass

26 inducing AED (carbamazepine, phenytoin, and phenobarbital), a cP450 inhibiting AED (valproate), or a

27 When the T1/T2 mice were administered phenobarbital, ALA and PBG markedly accumulated in their

28 The results indicate that phenobarbital alleviates the malfunction of the mutated

29 We report that a barbiturate anticonvulsant, phenobarbital, alleviates the effect of this mutation.

30 In contrast, induction of MRP2 by phenobarbital, an activator of CAR, was comparable in wi

31 ogenesis were rescued with administration of phenobarbital, an enhancer of GABA(A) receptor activity.

32 e and treated the resulting animals with DEN/Phenobarbital, an established protocol for liver carcino

33 Of the remaining 340, 170 received phenobarbital and 170 placebo.

34 ncentrations of 25 microg per milliliter for phenobarbital and 3 microg per milliliter for phenytoin.

35 esponse to GABAergic anticonvulsants such as phenobarbital and benzodiazepines.

36 ress this issue, cirrhosis was induced using phenobarbital and carbon tetrachloride (CCL(4)) and anim

37 Liver cirrhosis was induced with phenobarbital and carbon tetrachloride.

38 In the flurothyl model, phenobarbital and diazepam increased latency to seizure

39 er of two commonly used antiepileptic drugs, phenobarbital and diazepam, in preventing and suppressin

40 rtine, a selective KCNQ channel opener, with phenobarbital and diazepam, two drugs in current use for

41 Here we show that phenobarbital and dizocilpine can block measures of METH

42 Phenobarbital and dizocilpine did not block depletions b

43 logical studies found an association between phenobarbital and hepatocellular carcinoma, and several

44 nal injury, we found that the GABAA agonists phenobarbital and midazolam significantly increased stat

45 Phenobarbital and MK-801 were superior to phenytoin in s

46 e allocated to receive an additional dose of phenobarbital and one of four bumetanide dose levels by

47 Phenobarbital and phenytoin are equally but incompletely

48 ain, there may also be risks associated with phenobarbital and phenytoin exposure.

49 les did not differ significantly between the phenobarbital and phenytoin groups (Conners 2.64 [SD 0.7

50 We undertook a randomised comparison of phenobarbital and phenytoin to assess the acceptability

51 methylammonium chloride (8) exceeded that of phenobarbital and phenytoin upon oral administration to

52 been seen unequivocally in rodent models for phenobarbital and phenytoin; phenobarbital promoted live

53 nes respond to prototypical inducers such as phenobarbital and rifampicin, yet little has been report

54 with the nonselective potentiating compounds phenobarbital and tracazolate.

55 with corn oil (CO) or inducers of CYP2B (PB; phenobarbital) and CYP3A enzymes (DX; dexamethasone), is

56 pression of CYP2B6 induced by both indirect (phenobarbital) and direct CITCO [6-(4-chlorophenyl)imida

57 naphthalic anhydride (NA), triasulfuron (T), phenobarbital, and bacterial pathogens (Erwinia stuartii

58 UGT1A transcriptional activation by dioxin, phenobarbital, and endotoxin was significantly reduced i

59 d-generation AEDs, carbamazepine, phenytoin, phenobarbital, and primidone are potent inducers of hepa

60 d generation AEDs, carbamazepine, phenytoin, phenobarbital, and primidone induce the activity of seve

61 prim, triamterene, carbamazepine, phenytoin, phenobarbital, and primidone, may increase the risk not

62 nts who required supplemental treatment with phenobarbital, and safety.

63 metabolism, the rodent liver tumor promoter phenobarbital, and the skin tumor promoters okadaic acid

64 traditional antiepileptic agents phenytoin, phenobarbital, and valproate.

65 zed ultrafiltration of affinity complexes of phenobarbital antibody and barbiturates, including the s

66 Benzodiazepines are a reasonable option; phenobarbital appears to confer some advantages in combi

67 , pentobarbital ( approximately 310 microM), phenobarbital ( approximately 1.54 mM)] similar to that

68 This evidence supports the acceptability of phenobarbital as a first-line drug for childhood epileps

69 to assess the acceptability and efficacy of phenobarbital as monotherapy for childhood epilepsy in r

70 ith the S9 fraction of liver homogenate from phenobarbital/beta-naphthoflavone-induced Sprague-Dawley

71 onal degeneration since co-administration of phenobarbital blocked cell death.

72 The anticonvulsant efficacy of phenobarbital, bumetanide, and the combination of these

73 binding to microsomes from rats treated with phenobarbital but had no effect on microsomes from untre

74 d CncC binding at these loci was enhanced by phenobarbital, but not by tert-butylhydroquinone (tBHQ)

75 s or longer with anticonvulsants (phenytoin, phenobarbital, carbamazepine, or a combination) at the s

76 in plasma concentrations of lamotrigine and phenobarbital caused by valproic acid.

77 Phenobarbital changes the channel-opening rate constant

78 lly interfering drugs such as metronidazole, phenobarbital, chlorpheniramine maleate, pyridoxine and

79 In conclusion, the phenobarbital/cocaine injury model is useful to study re

80 Plasma phenobarbital concentrations were measured.

81 atment of these mice with diethylnitrosamine/phenobarbital (DEN/PB), which induces formation of liver

82 demonstrated that the classic CAR activator phenobarbital dephosphorylates the corresponding threoni

83 f primary cultures of human hepatocytes with phenobarbital, dexamethasone, or rifampin elevated hepat

84 Antenatal administration of phenobarbital does not decrease the risk of intracranial

85 ings suggest that bumetanide as an add-on to phenobarbital does not improve seizure control in newbor

86 curred in Pbp(DeltaLiv) mice pretreated with phenobarbital due to lack of expression of xenobiotic me

87 ency of seizure-like events and reduction in phenobarbital efficacy.

88 levations that were approximately 25-100% of phenobarbital-elicited increases) of CYP2B mRNA and immu

89 ) receptors in complex with the anaesthetics phenobarbital, etomidate and propofol reveal both distin

90 ate, males and females neonatally exposed to phenobarbital exhibited a dramatic overinduction of mult

91 Phenobarbital-exposed rats were also assessed for revers

92 ess (TrxR1/Gsr-null livers, standard care or phenobarbital-exposed TrxR1-null livers).

93 Additionally, phenobarbital exposure impaired striatal-mediated behavi

94 bination of these drugs was studied RESULTS: Phenobarbital failed to abolish or depress recurrent sei

95 ponse to periportal liver injury, induced by phenobarbital feeding and cocaine injection, is used to

96 percent) of the neonates assigned to receive phenobarbital first and 18 (62 percent) of those assigne

97 The use of phenobarbital for childhood epilepsy is controversial be

98 ty of intravenous bumetanide as an add-on to phenobarbital for treatment of neonatal seizures.

99 seizures not responding to a loading-dose of phenobarbital from eight neonatal intensive care units a

100 Partition coefficients for phenobarbital (from aqueous solution to membrane) decrea

101 ge was diagnosed in 70 of 311 infants in the phenobarbital group (23 percent) and 64 of 279 in the pl

102 of the 344 infants born to the women in the phenobarbital group (24 percent) and in 74 of the 324 bo

103 A total of 247 women (80 percent) in the phenobarbital group and 235 (78 percent) in the placebo

104 There were 309 women in the phenobarbital group and 301 in the placebo group.

105 ure frequency was significantly lower in the phenobarbital group than in the placebo group (18 [11%]

106 ency of respiratory arrest was higher in the phenobarbital group than in the placebo group, and morta

107 3 percent; risk ratio for the infants in the phenobarbital group, 1.1; 95 percent confidence interval

108 ngly, a low concentration of the barbiturate phenobarbital had a similar exacerbating effect on statu

109 Phenobarbital had insignificant anticonvulsant responses

110 treated with human hepatocyte cell therapy, phenobarbital has been used for reducing the serum bilir

111 n vivo drug metabolism was more rapid in the phenobarbital-imprinted male and female animals.

112 4.9 percent of those assigned to receive it, phenobarbital in 58.2 percent, diazepam plus phenytoin i

113 . -susceptible strains and can be induced by phenobarbital in adult susceptible flies.

114 In contrast, phenobarbital in combination with bumetanide abolished s

115 etanide enables the anticonvulsant action of phenobarbital in immature brain.

116 The efficacy of phenobarbital in potentiating currents elicited by a sat

117 tudy to assess the efficacy of intramuscular phenobarbital in preventing seizures in childhood cerebr

118 Diffusion coefficients of the solute phenobarbital in receptor-free membranes were also deter

119 tanide enhances the anticonvulsant action of phenobarbital in the neonatal brain METHODS: Recurrent s

120 elevated 3 hours after the administration of phenobarbital in wild-type, CAR-/-, and CAR-/-/PXR-/- mi

121 signs (and their alleviation by diazepam and phenobarbital) in mice are similar to those of the class

122 ate formation constants of a target species, phenobarbital, in membranes with various polymer concent

123 characterized nongenotoxic hepatocarcinogen, phenobarbital, in rats.

124 Phenobarbital increases Cyp2B expression in liver via ac

125 ingle i.v. dose of Alas1-siRNA prevented the phenobarbital-induced biochemical acute attacks for appr

126 We showed previously that phenobarbital-induced CYP2B protein is down-regulated in

127 ssociated protein (GAP)-43/neuromodulin, and phenobarbital-induced cytochrome P450.

128 entiated hepatocytes, and in rifampicin- and phenobarbital-induced hepatocytes.

129 In vitro analysis revealed that phenobarbital-induced HNF-4alpha expression is both time

130 mg/kg/day that were approximately 32-87% of phenobarbital-induced increases.

131 DNA clone designated 2B2FF was obtained from phenobarbital-induced Lewis rats and, like some previous

132 zyme gave products similar to those from the phenobarbital-induced microsomes.

133 liver microsomal P450 cytochromes, including phenobarbital-induced P450 2B4, catalyze the analogous d

134 -H abstraction and/or a SET mechanism, using phenobarbital-induced rat liver microsomal P450 enzymes

135 n nuclear extracts prepared from control and phenobarbital-induced rat livers.

136 ranscripts in older seedling shoots, whereas phenobarbital induces CYP92A1 expression in older seedli

137 hyde dehydrogenase, but is distinct from rat phenobarbital-inducible aldehyde dehydrogenase (PIADH),

138 aracterized as a trans-acting factor for the phenobarbital-inducible Cyp2b10 gene.

139 tocytes: they secreted urea and albumin, had phenobarbital-inducible cytochrome p450, could take up L

140 a dose-dependent increase in UGT2B1 mRNA, a phenobarbital-inducible enzyme; mRNA levels reached 210

141 mechanisms of mitochondrial targeting of the phenobarbital-inducible hepatic mitochondrial P450MT4, w

142 ALDHs): a constitutive isozyme (ALDH1) and a phenobarbital-inducible isozyme (ALDH-PB).

143 The phenobarbital-inducible rat cytochrome P450 (CYP) 2B1 an

144 ion studies and consistent with mediation of phenobarbital induction by CAR.

145 reased by NF-1, analogous to NF-1 effects on phenobarbital induction in previous transient transfecti

146 Phenobarbital induction of CYP2B genes is mediated by a

147 an additional inhibitory signal antagonizing phenobarbital induction of CYP2B1 and CYP2B2.

148 Phenobarbital induction of transcription of CYP2B genes

149 To further delineate the mechanism of phenobarbital induction, protein binding in native chrom

150 Phenobarbital is a classical inducer of the drug metabol

151 Phenobarbital is a lipophilic molecule used as a sedativ

152 res, as early life exposure to drugs such as phenobarbital is associated with adverse neurological ou

153 ric acid (GABA) neurotransmitter receptor by phenobarbital is presented.

154 CPOBOP), the most potent known member of the phenobarbital-like class of CYP-inducing agents.

155 TSO is considered a phenobarbital-like compound because it induces Cyp2B mRN

156 city in wild-type mice previously exposed to phenobarbital-like inducers and this toxicity is also ab

157 oked by a class of xenobiotics known as the 'phenobarbital-like inducers'.

158 scued by mevalonate supplementation, whereas phenobarbital-mediated induction was unaffected by these

159 Phenobarbital, MK-801, and phenytoin were administered a

160 ifferences in expression and inducibility by phenobarbital of the aldehyde dehydrogenase activity.

161 romol/L) revealed UGT1A1-inducing effects of phenobarbital, oltipraz, and, in particular, 3-methylcho

162 We studied the effects of phenobarbital on HNF-4alpha expression in hepatocytes an

163 ed the effect of antenatal administration of phenobarbital on the frequency of neonatal intracranial

164 animals were pretreated with CAR activators, phenobarbital or 1,4-bis[2-(3,5-dichlorpyridyloxy)]benze

165 ctra using microsomes from rats treated with phenobarbital or dexamethasone but not from untreated ra

166 though lorazepam is no more efficacious than phenobarbital or diazepam plus phenytoin, it is easier t

167 Unlike phenobarbital or diazepam, flupirtine prevented animals

168 Phenobarbital or dizocilpine during METH exposure blocke

169 We found therapeutic intervention with phenobarbital or phenytoin ineffective, whereas interven

170 tes were randomly assigned to receive either phenobarbital or phenytoin intravenously, at doses suffi

171 The treatment is usually with either phenobarbital or phenytoin, but the efficacy of the two

172 Treatment of mice with phenobarbital or TCPOBOP resulted in decreased hepatic m

173 nsferase alpha), following pretreatment with phenobarbital or TCPOBOP.

174 id, and calcium ionophore A23187, but not by phenobarbital or the steroid PP dehydroepiandrosterone s

175 from mice treated with a reference chemical (phenobarbital) or vehicle control for 7 days.

176 Administration of diethylnitrosamine, phenobarbital, or 2-amino-3,8-diethylimidazo[4,5-f]quino

177 ong activation of Cyp2b10 gene expression by phenobarbital, or by the more potent TCPOBOP, is absent

178 on-cholinergic drugs, diazepam, haloperidol, phenobarbital, pargyline, D-amphetamine, imipramine, pir

179 Phenobarbital (PB) administration is known to trigger pl

180 nstitutive androstane receptor (CAR) ligands phenobarbital (PB) and 1,4-bis-[2-(3,5-dichloropyridylox

181 by therapeutic drugs and xenobiotics such as phenobarbital (PB) and 1,4-Bis[2-(3,5-dichloropyridyloxy

182 In response to phenobarbital (PB) and other PB-type inducers, the nucle

183 observed after pretreatment of animals with phenobarbital (PB) and pregnenolone-16alpha-carbonitrile

184 atomegaly induced by the xenobiotic mitogens phenobarbital (PB) and TCPOBOP (1, 4-bis [2-(3, 5-dichlo

185 samine (DEN) and continued administration of phenobarbital (PB) in drinking water.

186 ctor 4 alpha (HNF4alpha) to induce CYP2B6 by phenobarbital (PB) in human primary hepatocytes (HPHs).

187 DDE is similar to phenobarbital (PB) in that both compounds are inducers o

188 xtracts against diethylnitrosamine (DEN) and phenobarbital (PB) induced hepatic injury in rats.

189 Phenobarbital (PB) induces various gene encoding drug/st

190 The endogenous CYP2B6 gene becomes phenobarbital (PB) inducible in androstenol-treated HepG

191 Phenobarbital (PB) induction of CYP2B genes is mediated

192 specific receptors thought to be involved in phenobarbital (PB) induction, the constitutive androstan

193 tein synthesis is a critical requirement for phenobarbital (PB) induction.

194 Phenobarbital (PB) is a prototype for a class of agents

195 Phenobarbital (PB) is an archetypal representative for c

196 Phenobarbital (PB) is the prototype of nongenotoxic caci

197 CC in response to a Diethylnitrosamine (DEN)/Phenobarbital (PB) liver tumor-induction protocol.

198 ma C6 cells were treated with P-450 inducers phenobarbital (PB) or benzo[a]anthracene (BA).

199 For decades, phenobarbital (PB) treatment for hyperbilirubinemia has

200 Phenobarbital (PB) treatment impairs the biliary excreti

201 in the liver of adult mice, it is induced by phenobarbital (PB) treatment or spontaneously in diabeti

202 r (CAR) translocates into liver nuclei after phenobarbital (PB) treatment, and activates the conserve

203 Phenobarbital (PB), a broadly used antiseizure drug, was

204 , such as P4502B, are known to be induced by phenobarbital (PB), and these P450s share a consensus se

205 typical P450 inducers (beta-naphthoflavone, phenobarbital (PB), Aroclor 1254, isoniazid, pregnenolon

206 Induction of P450s by phenobarbital (PB), beta-naphthoflavone (betaNF), or clo

207 eceptor signals xenobiotic exposure, such as phenobarbital (PB), by translocating into the nucleus.

208 nal responses to three xenobiotic compounds: phenobarbital (PB), chlorpromazine, and caffeine.

209 rat brain capillaries to the CAR activator, phenobarbital (PB), increased the transport activity and

210 en for this study were microcystin-LR (MLR), phenobarbital (PB), lipopolysaccharide (LPS), carbon tet

211 gene displays a curious strain dependence in phenobarbital (PB)-induced hepatic expression: the respo

212 eritoneal [i.p.]) was administered to naive, phenobarbital (PB)-induced or beta-naphthoflavone (betaN

213 AR) is a key transcription factor regulating phenobarbital (PB)-inducible transcription of various he

214 global hepatic protein synthesis, including phenobarbital (PB)-mediated induction of CYP2B enzymes i

215 have identified key candidate regulators of phenobarbital (PB)-mediated mouse liver tumorigenesis, a

216 tion rate is increased using microsomes from phenobarbital (PB)-pretreated rats.

217 nd diethylnitrosamine (DEN)-initiated and/or phenobarbital (Pb)-promoted HCC development using HCV co

218 By extending previous studies of the phenobarbital (PB)-responsive 132-base pair (bp) enhance

219 transactivates a distal enhancer called the phenobarbital (PB)-responsive enhancer module (PBREM) fo

220 or the induction of cytochrome P450 genes by phenobarbital (PB).

221 sed by treatment with certain drugs, such as phenobarbital (PB).

222 o the rodent liver non-genotoxic carcinogen, phenobarbital (PB).

223 ntiepileptic drugs with proapoptotic action (phenobarbital, phenytoin, lamotrigine) and without proap

224 nt in rats exposed at P7 to a single dose of phenobarbital, phenytoin, or lamotrigine.

225 o exposure to FAAs (including carbamazepine, phenobarbital, phenytoin, primidone, sulfasalazine, tria

226 s greatly increased in children who received phenobarbital plus three or more doses of diazepam (odds

227 t study, we found that liver microsomes from phenobarbital pretreated rats (which contain CYP2B1 as t

228 Animals receiving phenobarbital prior to daily kindling failed to recover

229 Perinatal exposure to phenobarbital produces a range of permanent reproductive

230 dent models for phenobarbital and phenytoin; phenobarbital promoted liver tumours and phenytoin cause

231 nsgenic mice via adaptive recognition of the phenobarbital response element (PBRE).

232 100 RORalpha was both enriched in the distal phenobarbital response element module (PBREM) and the pr

233 NF-4alpha and CAR is an integral part of the phenobarbital response, aimed at coordinated regulation

234 resulted in identification of an ARE in the phenobarbital-response enhancer module region of the UGT

235 B genes is mediated by an enhancer, termed a phenobarbital responsive unit (PBRU), approximately 2000

236 tion of CYP2B genes is mediated by a complex phenobarbital-responsive enhancer (PBRU), which contains

237 pression of CYP2B6 reporter genes containing phenobarbital-responsive enhancer module (PBREM) or PBRE

238 XR was shown to be capable of activating the phenobarbital-responsive enhancer module (PBREM) region

239 tional regulation of CYP2B genes through the phenobarbital-responsive enhancer module (PBREM).

240 pyridyloxy)]benzene (TCPOBOP) via the distal phenobarbital-responsive enhancer module (PBREM, at -173

241 F-kappaB, CBLB502 strongly activated STAT3-, phenobarbital-responsive enhancer module (PREM), and act

242 PBREM, the phenobarbital-responsive enhancer module of the cytochro

243 6 promoter; and looping the PXR-bound distal phenobarbital-responsive enhancer module toward the prox

244 responsible for mediating induction of many phenobarbital-responsive genes.

245 region or containing a previously described phenobarbital-responsive region.

246 chromatin structure, protein binding to the phenobarbital-responsive unit assessed by in vitro DNase

247 Functional analyses have identified a phenobarbital-responsive unit in the rat CYP2B1/2 and mo

248 n or architecture of proteins binding to the phenobarbital-responsive unit region and indicate that c

249 oses of CCl(4) in the presence or absence of phenobarbital resulted in increased injury and fibrosis

250 Suppression of these seizures with phenobarbital reversed the change in the voltage depende

251 Phenobarbital significantly augmented the bilirubin-lowe

252 ructure of an intact monoclonal antibody for phenobarbital, subclass IgG1, has been determined to 3.2

253 Phenobarbital suppressed thalamic seizure activity.

254 e dose of bumetanide with the second dose of phenobarbital; three were withdrawn for reasons unrelate

255 administration of therapeutic-like doses of phenobarbital to male and female rat pups during the fir

256 The administration of phenobarbital to pregnant women before delivery has been

257 We tested bumetanide added to phenobarbital to treat neonatal seizures in the first tr

258 d, n = 14; 2) heterotopically placed grafts, phenobarbital-treated (80 mg/kg/day), n = 17; 3) orthoto

259 in binding between extracts from control and phenobarbital-treated animals.

260 Incubation of liver microsomes from phenobarbital-treated males with monospecific anti-CYP2B

261 In the phenobarbital-treated mice, the binding of both CAR and

262 exhibited a strong synergistic expression in phenobarbital-treated mice.

263 tor RXR from the hepatic nuclear extracts of phenobarbital-treated mice.

264 eceiving saline prior to kindling as well as phenobarbital-treated non-kindled animals recovered with

265 Microsomes from phenobarbital-treated rats or purified P450 2B1 catalyze

266 y liver microsomes isolated from control and phenobarbital-treated rats, and by purified cytochrome P

267 n = 5; and 4) orthotopically placed grafts, phenobarbital-treated, n = 7.

268 hese results provide the first evidence that phenobarbital treatment alters the composition or archit

269 The combination of phenobarbital treatment and orthotopic small bowel trans

270 In contrast, phenobarbital treatment dramatically altered the protect

271 Phenobarbital treatment increased hyper-sensitivity in l

272 ction with dimethyl sulfate was observed and phenobarbital treatment increased the hypersensitivity b

273 Phenobarbital treatment of Gunn recipients of jejunal tr

274 Inhibition of the gonadotropin surge by phenobarbital treatment on D4:1100 h attenuated ESR36 ex

275 These data indicate that in liver phenobarbital treatment substantially alters protein bin

276 In this study, we used diethylnitrosamine/phenobarbital treatment to induce hepatocellular carcino

277 However, after phenobarbital treatment, the protection of this core reg

278 and Pepck was detected in mouse liver after phenobarbital treatment, whereas association of HNF-4 an

279 -1 and flanking NR sites were occupied after phenobarbital treatment.

280 A level after BA (benzo(a)anthracene) or PB (phenobarbital) treatments was detected.

281 mice treated with a diethylnitrosamine (DEN)/phenobarbital tumor induction protocol.

282 Sixteen structurally unrelated phenobarbital-type inducers activated the 51-bp enhancer

283 of the cytochrome P450 2B6 (CYP2B6) gene by phenobarbital-type inducers, such as 1,4 bis[2-(3,5-dich

284 -plant allelochemicals (up to 11.5-fold) and phenobarbital (up to 49-fold) corroborates previous in v

285 of diazepam (248 vs. 562 mg; p = .001), and phenobarbital use (17 vs. 58%; p = .01).

286 prone to induction by xenobiotics, including phenobarbital via constitutive androstane receptor (CAR)

287 The odds ratio for behavioural problems (phenobarbital vs phenytoin) was 0.51 (95% CI 0.16-1.59).

288 Adjunctive phenobarbital was administered in 5 of 33 infants (15%)

289 To this end, phenobarbital was coupled with daily electrical kindling

290 like activity, while a high concentration of phenobarbital was effective at reducing or preventing ep

291 Phenobarbital was most effective in suppressing electrog

292 )-confirmed seizures after >=20 and <40mg/kg phenobarbital were randomized to receive additional phen

293 features similar to those of the barbiturate phenobarbital were synthesized; one DHPM used (monastrol

294 Other medications, e.g., rifampin and phenobarbital, which also induce p450 3A activity, have

295 Uncoupling increases after treatment with Phenobarbital, which enhances the GABA(A) receptor (GABA

296 Phenobarbital, which is not a CAR ligand, binds the EGF

297 maleate] or the GABA(A) receptor potentiator phenobarbital, which mimics components of the effects of

298 rbital were randomized to receive additional phenobarbital with either placebo (control) or 0.1, 0.2,

299 izure burden attributable to bumetanide over phenobarbital without increased serious adverse effects.

300 doses of benzodiazepines in combination with phenobarbital would improve outcomes.