ライフサイエンスコーパス: phenothiazine

1 -(benzo)oxa(or thia)zine and the antioxidant phenothiazine).

2 c acid) and the electron transfer donor PTZ (phenothiazine).

3 iolates terminally omega-functionalized with phenothiazine.

4 t by virtue of its binding properties toward phenothiazine.

5 dent binding of calmodulin (CaM) to the drug phenothiazine.

6 ium (DAC) substituent to the nitrogen of the phenothiazine.

7 ink directly to the two folded conformers of phenothiazine.

8 henol, S-propyl propane 1-thiosulfinate, and phenothiazine.

9 ipase-C inhibitor U73122, and anti-psychotic phenothiazines.

10 uncategorized mechanism, pyridoacridones and phenothiazines.

11 gen (0.18 angstrom(-1)) and hole transfer to phenothiazine (0.29 angstrom(-1)) from the same QD.

12 The computational studies on phenothiazines 1-18 reveal the LUMO is substantially sta

13 b(2)m)(2+)-Pro(6)-NH(2), where PTZ is 3-(10H-phenothiazine-10)propanoyl and (Ru(II)b'(2)m)(2+) is bis

14 The mono-TCBD-functionalized phenothiazine 2 shows higher thermal stability compared

15 2,5-diene-1,4-diylidene-expanded TCBD-linked phenothiazines 3-7 exhibit multiredox waves.

16 The computational studies on phenothiazines 3-7 exhibit substantial stabilization of

17 The single-photon absorption on phenothiazines 3-7 reveals that substitution of 1,1,4,4-

18 s of unsymmetrical and symmetrical push-pull phenothiazines (3-7) were designed and synthesized by th

19 is(methylene)diphosphonate with 10-hexyl-10H-phenothiazine-3-carbaldehyde.

20 nylenediamine) to form 3,7-Bis(dibutylamino)-phenothiazine-5'-ium chloride and the absorbance of this

21 r unit relative to phenothiazine-5-oxide and phenothiazine-5,5-dioxide, while the naphthalimide is a

22 s a stronger electron donor unit relative to phenothiazine-5-oxide and phenothiazine-5,5-dioxide, whi

23 with carbazole, diphenylamine, phenoxazine, phenothiazine, 9,9-dimethyl-9,10-dihydroacridine, and th

24 Remarkably, the reaction is catalyzed by phenothiazine, a simple organic photocatalyst with MW <

25 atform unexpectedly suggests a novel mode of phenothiazine action where chlorpromazine, a promising a

26 the crude cell lysates were loaded onto the phenothiazine affinity column in the presence of a Ca(2+

27 ic respiratory chains from Mtb and show that phenothiazine analogs specifically inhibit NADH:menaquin

28 Several phenothiazines analogs are highly tuberculocidal in vitr

29 Phenothiazine analogues, trifluoperazine, Compound 1, an

30 Use of a novel spin-labeled phenothiazine and detection of isotope-filtered nuclear

31 The phenothiazine and diaryl sulfide quaternary compounds we

32 (N,N-dimethylaminopentyl)-2-(trifluoromethyl)phenothiazine and exon 3- (exon 4 for FMO4) deleted FMOs

33 of strong ground-state interactions between phenothiazine and the electron-accepting groups results

34 y annihilation between the radical cation of phenothiazine and the radical anion of phenylquinoline s

35 Drug Administration-approved phenazines and phenothiazines and have identified that clofazimine (Lam

36 ive interference with the detergents and the phenothiazines and negative interference with dextran su

37 ce with the aminoglycosides, ampholytes, and phenothiazines and negative interference with SDS, citri

38 Related phenothiazines and pimozide also inhibited HCV infection

39 However, phenothiazines and pimozide exhibited improved genotype

40 the preparation and systematic variation of phenothiazines and their analogues containing a benzhydr

41 he ground state polarizabilities of cyanine, phenothiazine, and arylmethine derivatives calculated us

42 The dihydroacridine, phenothiazine, and carbazole analogues were also potent,

43 inohexyl)-5-chloro-1-naphthalenesulfonamide, phenothiazine, and chlorpromazine, resulted in rapid apo

44 hiophenol, S-propyl propane 1-thiosulfinate, phenothiazine, and thioformaldehyde, an elusive and high

45 s (SSRI), tricyclics, other antidepressants, phenothiazines, and antihistamines; results were very si

46 ogy, the effects of haloperidol, clotiapine, phenothiazines, and citalopram (including escitalopram)

47 e models, use of barbiturates, meprobamates, phenothiazines, and lithium was associated with an incre

48 nitrogen heterocycles, including carbazole, phenothiazines, and tetrahydroquinoline.

49 donating substituents, such as the S-atom in phenothiazines, another important class of RTA.

50 tive, homogeneous assay for the detection of phenothiazine antidepressants was employed.

51 henols (e.g., tannic acid and tea extracts), phenothiazines, antihistamines, statins, and antimalaria

52 f an antiparasitic agent, pentamidine, and a phenothiazine antipsychotic, chlorpromazine.

53 roughput screening, we previously identified phenothiazine antipsychotics as modulators of the human

54 tifungals, and, surprisingly, calcimimetics, phenothiazine antipsychotics, and polyaromatic antidepre

55 gic receptors that are the primary target of phenothiazine antipsychotics.

56 N-substituted phenothiazines are prominent and highly effective organi

57 Herein we describe the anion of benzo[b]phenothiazine as a super reductant species upon excitati

58 lanation for the recurring identification of phenothiazines as a class of drugs with anticancer effec

59 gs with the biosensor identified an array of phenothiazines as inhibitors of myosin-II associated S10

60 to previously reported dihydrophenazines and phenothiazines as photoredox catalysts to gain insight i

61 We herein report a phenothiazine-based Cu(II) fluorescent sensor that is hi

62 espectively which perhaps as a result of the phenothiazine-based donor group (MPT).

63 donor-bridge-acceptor system consisting of a phenothiazine-based donor linked to a naphthalene-monoim

64 Fluphenazine (Prolixin(R)) is a potent phenothiazine-based dopamine receptor antagonist, first

65 hetic strategy to tailor the photophysics of phenothiazine-based organic materials for different opto

66 o tune the reduction potential of metal-free phenothiazine-based photoredox catalysts and demonstrate

67 A series of new naphthalimide and phenothiazine-based push-pull systems (NPI-PTZ1-5), in w

68 The condensation of phenothiazine-based tripyrrane with bithiophene diol in

69 ridine)-1,3,5-triazine (Tri-TEMPO), N-propyl phenothiazine (C3-PTZ), and tris(dialkylamino)cycloprope

70 tramethylpiperdinyl oxy (TEMPO) and N-propyl phenothiazine (C3-PTZ), were used as catholytes.

71 conformation of calmodulin changes, and the phenothiazine--CaM complex dissociates.

72 z[b,f]azepine, dihydroacridine, phenoxazine, phenothiazine, carbazole, and diphenylamine analogues we

73 free heterocycles (acridone, phenoxazine and phenothiazine, carbazole, beta-carbolin triazoles, imida

74 is of greater importance for phenoxazine and phenothiazine catalysts.

75 ng of the MPC cores and the oxidation of the phenothiazine centers.

76 twisted approximately 77.5 degrees from the phenothiazine central ring.

77 This is unprecedented not only in phenothiazine chemistry but also in tetracyanobutadiene-

78 a diode (660-nm) laser in combination with a phenothiazine chloride dye is efficient in controlling i

79 Further computational optimization of phenothiazines, combined with in vitro screening, led to

80 ubstituted dihydrophenazine, phenoxazine and phenothiazine compounds with varying propensities for co

81 synthesis and characterization of five novel phenothiazine-containing cruciforms (5-9).

82 trate the suitability of the phenoxazine and phenothiazine core and also of the phenylpiperazine moie

83 cule gamma-carboline fragment of dimebon and phenothiazine core of methylene blue (MB) linked by 1-ox

84 ropenium (DAC) substituents to phenazine and phenothiazine cores.

85 erties of ZAC and efficiency in scavenging a phenothiazine derivative (methylene blue) from an aqueou

86 n (which occurs at 1.20 V vs Fc/Fc(+) in the phenothiazine derivative) reversible.

87 8 show red-shifted absorption as compared to phenothiazine derivatives 1, 4, 7, 10, 13, and 16 in the

88 trical and unsymmetrical donor-acceptor type phenothiazine derivatives 1-18 were designed and synthes

89 The electrochemical analysis of the phenothiazine derivatives 2, 3, 5, 6, 8, 9, 11, 12, 14,

90 The phenothiazine derivatives acetophenazine, fluphenazine,

91 methacrylate was investigated using several phenothiazine derivatives and other related compounds as

92 Here, a class of heteroaromatic phenothiazine derivatives is reported as promising posit

93 o papers in this issue of Cell show how some phenothiazine derivatives reactivate specific PP2A isozy

94 CBD) and dicyanoquinodimethane (DCNQ) in the phenothiazine derivatives resulted in systematic variati

95 The electronic absorption spectra of the phenothiazine derivatives with strong acceptors 2, 3, 5,

96 between cCSQ and tricyclic antidepressants, phenothiazine derivatives, anthracyclines, and many othe

97 d that several pharmaceutical drugs, such as phenothiazine derivatives, tricyclic antidepressants, an

98 ur results showed that several antipsychotic phenothiazine derivatives, tricyclic antidepressants, an

99 s higher thermal stability compared to other phenothiazine derivatives.

100 g P (partition coefficient) values among the phenothiazine derivatives.

101 Using a phenothiazine-dibenzothiophene-S,S-dioxide donor-accepto

102 support a unique mode of inhibition in which phenothiazines disrupt the S100A4/myosin-IIA interaction

103 ular electron transfer (ET) between the free phenothiazine donor (PH) and its cation radical (PH*+) p

104 In the presence of phenothiazine donors (or in the absence of an external d

105 ntaining CH(3)CN electrolytes with iodide or phenothiazine donors.

106 vity relationship within the carbendazim and phenothiazine drug clusters, providing valuable insights

107 Methylene blue (MB), a phenothiazine dye that crosses the blood-brain barrier,

108 ron oxidation relative to diphenylamines and phenothiazines (E degrees ranging from 0.59 to 1.38 V vs

109 goproline assembly bearing in linear array a phenothiazine electron donor, a tris(bipyridine)rutheniu

110 assembly formed a linear array containing a phenothiazine electron donor, a tris(bipyridine)rutheniu

111 chromophore (C2+) with one or more appended phenothiazine electron donors (D) and a diquat-type elec

112 rays of a Ru(II)-bipyridyl chromophore and a phenothiazine electron-transfer donor have been synthesi

113 cally more stable as opposed to the nonfused phenothiazine-embedded dithiasapphyrin.

114 lted in the formation of unique doubly fused phenothiazine-embedded dithiasapphyrins instead of the e

115 asapphyrins instead of the expected nonfused phenothiazine-embedded dithiasapphyrins.

116 e that tricyclic derivatives of acridine and phenothiazine exhibit half-maximal inhibition of PrP(Sc)

117 The phenothiazine family of compounds, as well as the flavon

118 Haloperidol, sertindole, clotiapine, phenothiazines, fluoxetine, citalopram (including escita

119 at incorporation of a nitrogen atom into the phenothiazine framework results in increased potency and

120 be immobilized on a solid support containing phenothiazine from the C-terminal domain of the fusion p

121 Self-assembly of a "phenothiazine"-functionalized ligand (L) with a cis-bloc

122 Consequently, since phenothiazines generally possess high bioavailability an

123 Substituted phenothiazines have low molecular weight, are not highly

124 escribes the design of diaminocyclopropenium-phenothiazine hybrid catholytes for non-aqueous redox fl

125 Four aromatic amine ring systems-phenothiazine, iminodibenzyl, iminostilbene, and dipheny

126 Here, we describe the synthesis of imidazo-phenothiazine (IPTZ), a sulfur-containing heterocycle wi

127 quantum mechanical calculations suggest that phenothiazine is a stronger electron donor unit relative

128 es of 9-fluoreneone, 9,10-anthraquinone, and phenothiazine is described.

129 the presence of Ca2+, a recognition site for phenothiazine is exposed on calmodulin, allowing the bin

130 rical validations, we repurposed an existing phenothiazine-like antipsychotic drug, trifluoperazine,

131 High scores were noted for several phenothiazine-like antipsychotic drugs, including triflu

132 that first-trimester exposure to low-potency phenothiazines, lithium, certain anticonvulsants, and be

133 was paired with N-(2-(2-methoxyethoxy)-ethyl)phenothiazine (MEEPT) to achieve a 2.3 V all-organic NAR

134 s of MPCs where alcohol, carboxylic acid, or phenothiazine moieties had been incorporated into the mo

135 light, leading to the sulfoxidation of the "phenothiazine" moieties in T and thereby generating an o

136 unctionalized with a peripheral redox-active phenothiazine moiety and explore its unique behavior wit

137 effects of acetopromazine suggests that the phenothiazine moiety has the closest contact to the bind

138 t compound, BPQ-PTZ, which contains a single phenothiazine moiety.

139 xed monolayer MPCs can contain as many as 10 phenothiazines/MPC; these electron donors are electroact

140 were selected for the HTS based on the known phenothiazine Ndh inhibitors, trifluoperazine and thiori

141 d hypothermia (33-35 degrees C for 1 h) with phenothiazine neuroleptics (chlorpromazine & promethazin

142 Furthermore, when phenothiazines, one of the most commonly identified NDH-

143 In contrary to N-substituted phenothiazines or benzophenothiazines, this molecule hol

144 ociation between the use of antidepressants, phenothiazines, or antihistamines and breast cancer.

145 Using phenothiazine (PHT) as a model, we demonstrate that ligh

146 ociation exists between the RuL3(2+) and the phenothiazine prior to photoexcitation.

147 Herein we report a stable N-phenyl-phenothiazine (PTH)-derived porous coordination cage (PC

148 Two backbones consisting of electron rich phenothiazine (PTZ) and electron deficient anthraquinone

149 photocatalyst was designed by cross-linking phenothiazine (PTZ) as a photoactive core in the presenc

150 ion of a model hydrocarbon (n-hexadecane) by phenothiazine (PTZ) at >=160 degrees C can be greatly en

151 donor-acceptor-donor (D-A-D) system, the two phenothiazine (PTZ) donor units were linked by three dif

152 idge-acceptor (D-B-A) molecules comprising a phenothiazine (PTZ) donor, an oligo(2,7-fluorene) (FL(n)

153 es of donor-bridge-acceptor molecules having phenothiazine (PTZ) donors, 2,7-oligofluorene (FL(n)) br

154 ve a redox-separated (RS) state containing a phenothiazine (PTZ) radical cation at the Pra(Ptzpn) sit

155 or-bridge-acceptor (D-B-A) system, where D = phenothiazine (PTZ), B = p-oligophenylene, and A = peryl

156 r-bridge-acceptor (D-B-A) systems, where D = phenothiazine (PTZ), B = p-phenylene (Ph(n)), n = 1-4, a

157 w electron shuttling mediator, unsubstituted phenothiazine (PTZ), was studied.

158 onductance through an acid oxidant triggered phenothiazine (PTZ-) based radical junction using the me

159 NX), and its less reactive chalcogen cousin (phenothiazine, PTZ), we explored structure-reactivity-po

160 re in donors tetraphenylethylene-TPE (D) and phenothiazine-PTZ (D') of contrasting donor abilities ar

161 either a dimethylamino-pyridine (DMAP) or a phenothiazine-pyridine ligand (PTZP) are simultaneously

162 nd [Mn(4)O(4)(O(2)PPh(2))(6)](+), 1(+), with phenothiazine (pzH).

163 53% efficiency an excited state containing a phenothiazine radical cation and an anthraquinone radica

164 neric representation: P(br)P*+, in which two phenothiazine redox centers are interlinked by p-phenyle

165 rom aminoglycosides, ampholytes, detergents, phenothiazines, reducing agents, and miscellaneous subst

166 End-capping with butterfly shaped phenothiazine restrained the formation of molecular aggr

167 ized structural features, which consist of a phenothiazine ring and a pyrrolidinyl group joined by a

168 Furthermore, new modulators with phenothiazine ring exhibited the best chemosensitizing a

169 tein-ligand interaction is pi-pi stacking of phenothiazine ring with indole group of Trp82.

170 However, the phenothiazine rings are twisted 46.5 degrees relative to

171 groups are twisted 82.5 degrees from the two phenothiazine rings, indicating a lack of electron deloc

172 stability to commonly used diphenylamine and phenothiazine RTAs had significantly greater reactivity

173 -microM 20S proteasome activators based on a phenothiazine scaffold.

174 egeneration by a donor, D, such as iodide or phenothiazine, sensitizers are present in an environment

175 eneration of the affinity column because the phenothiazine-silica support matrix is stable for long p

176 Y337 may sterically hinder the binding of phenothiazines such as ethopropazine, which contains a b

177 pite their wide utility, the closely related phenothiazine sulfoxides, which easily form upon oxidati

178 The phenothiazine system was identified as a favorable cap g

179 e TNA triphosphate analogue (1,3-diaza-2-oxo-phenothiazine, tCfTP) that maintains Watson-Crick base p

180 enyl)diketopyrrolopyrrole (TDPP) hosting two phenothiazine-tetracyanobutadiene (PTZ-TCBD) entities on

181 ne blue (MB, methylthioninium chloride) is a phenothiazine that crosses the blood brain barrier and a

182 Thioridazine is a member of the class of phenothiazines that act, in part, by inhibiting respirat

183 goes a conformational change upon binding to phenothiazines that alters the fluorescence properties o

184 Although we found no difference between phenothiazines, thioxanthenes, or other conventional ant

185 coated MPCs and to those functionalized with phenothiazine to analyze the coupling between the diffus

186 The process works using a phenothiazine-type photocatalyst, Hantzsch ester, and el

187 eterocycles, such as pyrazole, triazole, and phenothiazine, underwent the same via the N-center, sele

188 A shift to lower energy wavelengths of phenothiazine was observed upon the addition of the elec

189 nylene)bis(ethene-2,1-diyl)bis(10-hexyl-10H -phenothiazine) was reacted with several different aromat

190 new glucose oxidase mediator, unsubstituted phenothiazine, was discovered.

191 By combining hypothermia with phenothiazines, we significantly enhanced the neuroprote

192 ady-state kinetics and inhibitory actions of phenothiazines were characterized.

193 Phenothiazines were identified by virtual screening as p

194 Here, we show that derivatives of phenothiazines, which have widespread use in the fields

195 al RNA binding by six commercially available phenothiazines, while too few to establish a true struct

196 T derivatives surpass their parent congeners phenothiazines with lower oxidation potentials and prono

197 generate the light-emitting excited state of phenothiazine within a potential window not obtainable w

198 Phenothiazine XFs may have potential in array-type senso