ライフサイエンスコーパス: phenotypic variation

1 ic-dependent selection in shaping functional phenotypic variation.

2 estigating proximate and ultimate factors of phenotypic variation.

3 uantify the role of stochasticity in shaping phenotypic variation.

4 leles explaining a substantial proportion of phenotypic variation.

5 ing how genomic changes translate to natural phenotypic variation.

6 her explained a total of 12 and 44% of total phenotypic variation.

7 ltiple genetic regions underlying this broad phenotypic variation.

8 connect the relationship between genetic and phenotypic variation.

9 igmentation, due to their high genotypic and phenotypic variation.

10 ion of all alleles, including singletons, to phenotypic variation.

11 Many common diseases show wide phenotypic variation.

12 e formation of circRNAs and further modulate phenotypic variation.

13 gene-expression levels are a major source of phenotypic variation.

14 auses of global patterns of biodiversity and phenotypic variation.

15 enriched among loci that are associated with phenotypic variation.

16 ghts into the evolutionary forces that shape phenotypic variation.

17 ation may underlie a large fraction of human phenotypic variation.

18 the genetic and molecular basis of heritable phenotypic variation.

19 abbage, turnip and oilseed, display enormous phenotypic variation.

20 re also found to be strongly associated with phenotypic variation.

21 role in translating genotypic variation into phenotypic variation.

22 LRD on chromosome C9 explaining ~18% of the phenotypic variation.

23 portant mediator of inter- and intra-species phenotypic variation.

24 utant cells that harbour a broad spectrum of phenotypic variation.

25 ually explained between 4.6 and 12.3% of the phenotypic variation.

26 binding activities, which may contribute to phenotypic variation.

27 associated with altered gene expression and phenotypic variation.

28 or identifying all genetic associations with phenotypic variation.

29 ions, totally accounting for 55.4-82% of the phenotypic variation.

30 formation within UTRs may also contribute to phenotypic variation.

31 s is also one of the essential indicators of phenotypic variation.

32 etion within 22q13, demonstrates significant phenotypic variation.

33 l conditions, range changes, and patterns of phenotypic variation.

34 werful tool for mapping loci responsible for phenotypic variation.

35 g in a net increase or decrease in heritable phenotypic variation.

36 decipher the causal link between genetic and phenotypic variation.

37 can be targeted for reactivation leading to phenotypic variation.

38 control of gene expression and its links to phenotypic variation.

39 n-restricted bacterium that exhibits limited phenotypic variation.

40 scaling with size is a fundamental aspect of phenotypic variation.

41 ng collectively between 9.8 and 14.8% of the phenotypic variation.

42 lobally produced crop with broad genetic and phenotypic variation.

43 linkage group 5, which explained 51% of the phenotypic variation.

44 s an important and understudied reservoir of phenotypic variation.

45 rter incubation times tended to show greater phenotypic variation.

46 late the exploration of the genetic basis of phenotypic variation.

47 e enriched for genes independently linked to phenotypic variation.

48 mammalian molars is fundamental to studying phenotypic variation.

49 g of the links between genetic diversity and phenotypic variation.

50 ontinuous distributions of environmental and phenotypic variation.

51 Ps accounts for 7% (se = 0.02, p = 0.015) of phenotypic variation.

52 d environment are fixed, also contributes to phenotypic variation.

53 of individually small effect contributing to phenotypic variation.

54 f both systems would elicit a wider range of phenotypic variation.

55 e genome sequencing, and their genotypic and phenotypic variation.

56 in the state of an organelle in single cell phenotypic variation.

57 e relevance of low-frequency variants on the phenotypic variation.

58 r transposons to modulate transcriptomic and phenotypic variations.

59 e in drug discovery to evaluate drug-induced phenotypic variations.

60 nding protein Piwi and mediates silencing of phenotypic variations.

61 ted traits, and explained 5.00 11.89% of the phenotypic variations.

62 uding physiological, physical, genotypic and phenotypic variations.

63 except epidermolytic ichthyosis, suggesting phenotypic variations.

64 ents and explained the highest proportion of phenotypic variation (9.3% to 11.5%) in CT.

65 The proportion of phenotypic variation accounted for by all genotyped comm

66 caused substantial shifts and reductions in phenotypic variation across diverse taxa, but the underl

67 ness and manipulate them to generate greater phenotypic variation across groups, thereby fueling cult

68 ss-based models, experimental evolution, and phenotypic variation, across a range of distinct spatial

69 genomic variation in the organelle to alter phenotypic variation alone and in epistatic interaction

70 issues that are associated with reproductive phenotypic variation, although the cause-effect relation

71 uption of certain genes alters the heritable phenotypic variation among individuals.

72 afish Danio rerio, we show that selection on phenotypic variation among intact fertile sperm within a

73 Heightened phenotypic variation among mutant animals is a well-know

74 ntial gene expression, epigenetic state, and phenotypic variation among people with A-T, we performed

75 for locating candidate mutations underlying phenotypic variations among these F. vesca accessions an

76 age at maturity in humans, explained 39% of phenotypic variation, an unexpectedly large proportion f

77 iRNAs and target genes contribute to natural phenotypic variation and annotated roles and interaction

78 ens is a Gammaproteobacterium that undergoes phenotypic variation and can have both pathogenic and mu

79 importance for host survival and involved in phenotypic variation and differences in disease risk.

80 Thus, local DNA dynamics contributes to phenotypic variation and disease in the human population

81 ctions, and systems properties that underlie phenotypic variation and disease risk in humans, model o

82 human genomes and play a significant role in phenotypic variation and disease susceptibility.

83 ng the molecular mechanisms underlying human phenotypic variation and disease susceptibility.

84 regions are one of the major causes of human phenotypic variation and diseases.

85 QTL had the largest effect of 36.51% to the phenotypic variation and encompassed 89.5 Kb genomic reg

86 Such modifications can bias phenotypic variation and enhance organism-environment fi

87 ially expressible phenotypes so as to retain phenotypic variation and expression.

88 sion variation is a key component underlying phenotypic variation and heterosis.

89 o vary ligands used for invasion, leading to phenotypic variation and immune evasion.

90 have led to a greater understanding of plant phenotypic variation and plant responses to the environm

91 Predation can affect both phenotypic variation and population productivity in the

92 sight into the generation and maintenance of phenotypic variation and provide potential targets for t

93 ariability in mammals, with implications for phenotypic variation and putative paradigms of mammalian

94 orkflow automatically handles assay-specific phenotypic variations and generalizes to different HT im

95 cts on the evolution of living organisms, on phenotypic variations and on disease processes.

96 ntially drive downstream expression changes, phenotypic variation, and even disease.

97 show that many loci of small effect underlie phenotypic variation, and identify five genomic regions

98 pontin were discovered, explaining 22-59% of phenotypic variation, and indicating a regulation of phe

99 luence the transmission and the upholding of phenotypic variation, and population dynamics.

100 heir target genes that contribute to natural phenotypic variation, and the underlying regulatory netw

101 cers, but the molecular mechanisms governing phenotypic variation are less well understood.

102 ." It is also poorly understood whether such phenotypic variations are shaped by early specification

103 -term consequences (e.g., ability to recover phenotypic variation) are unclear.

104 effects, which are pervasive in quantitative phenotypic variation, are difficult to detect in genome-

105 However, it remains largely unclear how phenotypic variation arises in the first place and thus

106 ied are unlikely to contribute to functional phenotypic variation, as there is a significant depletio

107 elucidating disease mechanism and causes of phenotypic variation, as well as in the development of t

108 iversity to harness genetic, mechanistic and phenotypic variation associated with oil yield in a glob

109 ociated with components of environmental and phenotypic variation at an intercontinental scale across

110 Heritability, defined as the proportion of phenotypic variation attributable to genetic variation,

111 n of novel modifiers of Min, we assessed the phenotypic variation between 27 F1 crosses between diffe

112 While the phenotypic variation between breeds is high, within-bree

113 The findings, which raise the possibility of phenotypic variation between bvFTD and FTD-ALS, have cli

114 Xenorhabdus nematophila exhibits phenotypic variation between insect virulence (V) and th

115 enetically modified mouse models has exposed phenotypic variation between investigators and instituti

116 berry skins were analysed in order to assess phenotypic variation between six grapevines belonging to

117 of large effect have been shown to underlie phenotypic variation between species.

118 We found significant (p < 0.05) phenotypic variation between the 27 F1 Collaborative cro

119 However, approaches to characterize phenotypic variations between clones are not established

120 subspecies and harbor extensive genetic and phenotypic variation both within and between these subsp

121 ught to be an important determinant of human phenotypic variation, but its inherent cell type specifi

122 usands of genomic regions that contribute to phenotypic variation, but narrowing these regions to the

123 ants (SVs) are a major source of genetic and phenotypic variation, but remain challenging to accurate

124 Genetic epilepsy is a common disorder with phenotypic variation, but the basis for the variation is

125 iated intergenic SNPs that may contribute to phenotypic variation by influencing target gene expressi

126 e likely to be involved in the modulation of phenotypic variation by LLERCPs.

127 conclude that a mechanistic understanding of phenotypic variation can accelerate development of strat

128 The resulting phenotypic variation can be triggered during development

129 This illustrates how phenotypic variation can be used to infer underlying dev

130 Nongenetic phenotypic variation can either speed up or slow down ad

131 Intraspecific phenotypic variation can strongly impact community and e

132 olites, which encompasses both genotypic and phenotypic variations, can enable early prediction of pe

133 t the system distribution exhibits increased phenotypic variation compared to individual component di

134 The phenotypic variation could be prevented by altering the

135 e the contribution of variability to overall phenotypic variation, current methods may miss important

136 erges via self-organising mechanisms and how phenotypic variation drives the behaviour and functionin

137 noise is likely underestimated in studies of phenotypic variation due to intrinsic mechanisms within

138 of migration timing, suggestive of a loss of phenotypic variation due to natural selection.

139 beginning to appreciate the extent to which phenotypic variation due to stochasticity is potentially

140 ontrol of cell specification lead to natural phenotypic variation during megasporogenesis.

141 ltimately gross limb morphology, to generate phenotypic variation during prenatal development.

142 unities to investigate their contribution to phenotypic variation, especially in meiosis and mitosis,

143 d 0.434 and 0.550 (both at p < 0.001) of the phenotypic variation for Fv/Fm and field survival respec

144 studies demonstrate among- and within-hypha phenotypic variation for growth in response to gallic ac

145 ommon SNPs explains only a small fraction of phenotypic variation for human complex traits and contri

146 We examined the phenotypic variation for mature grain size (length and w

147 e admixture proportions explains most of the phenotypic variation for quantitative phenotypes.

148 ogether, the QTLs explained 39 to 55% of the phenotypic variation for survival under anaerobic condit

149 biological shapes to better understand their phenotypic variation, genetic and developmental underpin

150 ation with the single largest contributor to phenotypic variation-genetic liability-has led to the ro

151 ay give rise to the overwhelming majority of phenotypic variation, greatly narrowing the scope of the

152 Although phenotypic variation has been noted in the context of an

153 bution of X-chromosome inactivation (XCI) to phenotypic variation has been postulated but not demonst

154 Exploiting this genetic and phenotypic variation has the potential to greatly advanc

155 Genetic sources of phenotypic variation have been a focus of plant studies

156 should have an important role in determining phenotypic variation; however, this hypothesis has not b

157 s of this model, we surveyed the genomic and phenotypic variation in 161 natural isolates.

158 variants in yeast explain a large amount of phenotypic variation in a complex trait like growth.

159 ovide new insights into potential sources of phenotypic variation in a free-living female bird and ad

160 processes are influencing the generation of phenotypic variation in a way that shapes evolution.

161 detectable associations of genetic loci with phenotypic variation in addition to highly polygenic her

162 nuclear genetic ancestry could contribute to phenotypic variation in admixed populations.

163 erlie natural, domesticated and experimental phenotypic variation in all Eukaryotes-mostly animals, p

164 ce behavior) consistently accounted for some phenotypic variation in all outcome measures, while cage

165 ed the molecular mechanisms of graft-induced phenotypic variation in anatomy, morphology and producti

166 eoffs might be a general mechanism promoting phenotypic variation in any pathogen for which hosts var

167 eir relative timing along development shapes phenotypic variation in body size and development time.

168 ty estimates suggest that roughly 60% of the phenotypic variation in BPH is accounted for by genetic

169 We show that DASC is a sensitive detector of phenotypic variation in CCP dynamics that is uncorrelate

170 Genetic association analyses of phenotypic variation in circulating white blood cell (WB

171 k a mechanistic understanding of the role of phenotypic variation in collective animal behaviour.

172 the LALI-type to generate the full range of phenotypic variation in color pattern seen on the heads

173 ariation within CREs plays a central role in phenotypic variation in complex traits including the ris

174 QTLs for different components contribute to phenotypic variation in composite traits.

175 ur findings provide structural insights into phenotypic variation in EI due to KRT10 mutations.

176 aptation with the potential to influence the phenotypic variation in extant Native American populatio

177 resented a relatively small component of the phenotypic variation in flowering time, but were suffici

178 We examined intraspecific phenotypic variation in freeze resistance of Populus bal

179 of viral DNA and reveals naturally occurring phenotypic variation in HIV-1 capsid stability.IMPORTANC

180 In this article, I argue that phenotypic variation in hosts arising from environmental

181 into environmental and genetic influences on phenotypic variation in humans.

182 By identifying loci underlying phenotypic variation in intra- and interspecific crosses

183 dy outlines the major sources of genetic and phenotypic variation in iPS cells and establishes their

184 The molecular mechanisms underlying phenotypic variation in isogenic bacterial populations r

185 on can provide unique information to explain phenotypic variation in maize.

186 context-social dominance-accounted for more phenotypic variation in mice than cage-identity.

187 ed a pervasive role in shaping genotypic and phenotypic variation in modern humans.

188 we report molecular changes associated with phenotypic variation in Paenibacillus polymyxa, a PGPR w

189 Cardiovascular disease (CVD) influences phenotypic variation in Parkinson's disease (PD), and is

190 This paper identifies and quantifies the phenotypic variation in photosynthetic, stomatal, and mo

191 complex I and IV activity, may explain some phenotypic variation in PMS individuals.

192 l complex activity abnormalities may explain phenotypic variation in PMS symptoms.

193 ecombinant inbred lines, we reveal extensive phenotypic variation in response to ambient temperature

194 Elucidating the genetic basis of phenotypic variation in response to different environmen

195 Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries) may facilitat

196 measures, while cage-identity accounted for phenotypic variation in some measures but virtually no v

197 n climate on the organization of genetic and phenotypic variation in the dominant coastal tree Avicen

198 ste receptor TAS2R38 explain the majority of phenotypic variation in the PROP phenotype.

199 This phenomenon is the result of phenotypic variation in the propensity of individual spo

200 om these pathways positively correlated with phenotypic variation in the S. arcanum accessions indica

201 loci together can explain as much as 20% of phenotypic variation in the surveyed population and incl

202 ifferent commercial vendors exhibited marked phenotypic variation in their susceptibility to Salmonel

203 ne craniosynostosis explained nearly all the phenotypic variation in these kindreds, with highly sign

204 e is known about the genetic architecture of phenotypic variation in these populations.

205 ty, despite strong evidence for considerable phenotypic variation in this trait.

206 riation, thus reducing the attention paid to phenotypic variation in those same diverging lineages.

207 l redundancy has 'locked up' a wide range of phenotypic variation in wheat.

208 ver, it remains unknown whether they display phenotypic variations in different cortical regions.

209 t genetic backgrounds that may contribute to phenotypic variations in immune responses.

210 se variants constitute candidates underlying phenotypic variation, including tandem duplications and

211 We show that larger phenotypic variation increases connectivity among predat

212 We provide new tools to understand how phenotypic variation influences population dynamics and

213 Understanding the regulatory architecture of phenotypic variation is a fundamental goal in biology, b

214 g causal relationships between genotypic and phenotypic variation is a key focus of evolutionary biol

215 Non-genetic phenotypic variation is common in biological organisms.

216 Phenotypic variation is common in most pathogens, yet th

217 Phenotypic variation is critical for the long-term persi

218 human genetic association studies, in which phenotypic variation is often driven by numerous variant

219 Determining the processes responsible for phenotypic variation is one of the central tasks of evol

220 ponses are possible if selectable or plastic phenotypic variation is produced by epigenetic differenc

221 hypothetical mechanism accounting for mutant phenotypic variation is progenitor cells variably choosi

222 egulation, one of the two primary sources of phenotypic variation, is challenging on a genome-wide sc

223 uced some of the most extreme within-species phenotypic variation known.

224 dditional wave 3 isolates revealed that this phenotypic variation likely evolved over time rather tha

225 Constraints on phenotypic variation limit the capacity of organisms to

226 only a few species (i.e., specialists), low phenotypic variation maximizes intake rates, while the o

227 ue habitat characteristics and intraspecific phenotypic variation may allow pikas to exist in areas o

228 eation/self-harm and explained up to 0.6% of phenotypic variation (minimum p = 3.9 x 10(-6)).

229 , the contribution of developmental noise to phenotypic variation must be separated and measured to f

230 re of spiders, but also shaped the amount of phenotypic variation observed among individuals.

231 The phenotypic variation observed in PCOS is suggestive of a

232 ay contribute to the resulting generation of phenotypic variations observed in complex congenital bra

233 ests that DNA methylation is associated with phenotypic variation of 156 traits.

234 The phenotypic variation of a given trait explained by each

235 Phenotypic plasticity describes the phenotypic variation of a trait when a genotype is expos

236 e local environments, landscape genomics and phenotypic variation of Arabidopsis, and illustrates how

237 ocused on comprehensively characterizing the phenotypic variation of CD8(+) T cells in psoriatic lesi

238 ts on gene expression are a major factor for phenotypic variation of complex traits and disease susce

239 The phenotypic variation of living organisms is shaped by ge

240 Spontaneous phenotypic variation of PGPR, which causes the loss of t

241 Phenotypic variation of quantitative traits is orchestra

242 in STF target sequences, suggesting that the phenotypic variation of RBC traits could stem from alter

243 rch on Pleurothallidinae orchids because the phenotypic variation of some characters evaluated here a

244 detected as significant contributors to the phenotypic variation of the first three traits, explaini

245 Phenotypic variation often does not reflect the cumulati

246 de no understanding of the influence of this phenotypic variation on population dynamics.

247 eritance, and then quantify the influence of phenotypic variation on population dynamics.

248 w cellular traits is environmentally induced phenotypic variation, or phenotypic plasticity.

249 ive contribution of genes and environment to phenotypic variation, our understanding of the role of d

250 8 expression has a nonlinear relationship to phenotypic variation, predicting levels of robustness am

251 therefore critical to quantify the degree of phenotypic variation present within populations, individ

252 to probe the genetic basis of metabolic and phenotypic variation, providing insight into the difficu

253 plotypes under selection are associated with phenotypic variations related to cardiovascular health.

254 ity and which region is more responsible for phenotypic variation remains opaque.

255 However, its phenotypic variation remains unexplained.

256 nal changes also contribute to the heritable phenotypic variation required for evolution.

257 veral complex traits, obscuring the specific phenotypic variation responsible for community-level eff

258 ata support the hypothesis that A. fumigatus phenotypic variation significantly contributes to diseas

259 specific and that genetic effects can exceed phenotypic variation stemming from fine-scale location-b

260 netic variation that directly contributes to phenotypic variation such as resistance to infectious di

261 an gut microbes can lead to inter-individual phenotypic variations such as digestive capacity.

262 n frequently assume that mutation introduces phenotypic variation symmetrically around the population

263 role for 3D chromatin conformation in human phenotypic variation than previously recognized.

264 ionary constraint is a bias or limitation in phenotypic variation that a biological system produces.

265 phometricity is defined as the proportion of phenotypic variation that can be explained by macroscopi

266 e, some modifiers are an important source of phenotypic variation that can elucidate how genes functi

267 a diversifying lineage and the evolution of phenotypic variation that facilitates the use of new env

268 ulation designs that will identify causes of phenotypic variation that have been hidden to date.

269 sal processes can potentially generate novel phenotypic variation that may facilitate persistence in

270 of individual components, thereby increasing phenotypic variation that selection could act on and fac

271 copies of a gene (homoeologs), and to expose phenotypic variation that was previously hidden by funct

272 ons result in ephemeral, but also heritable, phenotypic variations that are important for infection s

273 of a clonally aged population and uncovered phenotypic variations that subject the cells to natural

274 ve improved our ability to document cellular phenotypic variation, the fundamental mechanisms that ge

275 nt cooperators to elevate their potential of phenotypic variation, thereby increasing their opportuni

276 general stochastic model, that the degree of phenotypic variation, thus evolvability, escalates with

277 We found most phenotypic variation to be quantitative and identified p

278 ed the patterns of genomic relationships and phenotypic variation to establish training samples based

279 evolution is how organisms exhibit suitable phenotypic variation to rapidly adapt in novel selective

280 he origins, architecture and consequences of phenotypic variation under normal and dysfunctional cond

281 t variation in susceptibility helps maintain phenotypic variation, using experiments conducted with a

282 ue culture technique that sometimes leads to phenotypic variation via genetic and/or epigenetic chang

283 Because genetic variants also influence phenotypic variation via heterogeneity, we conducted a v

284 Striking individual phenotypic variation was apparent from color maps of com

285 o increased understanding of the patterns of phenotypic variation we observe today.

286 this tradeoff can help explain the extensive phenotypic variation we observed in field-collected path

287 acquired immune responses may drive parasite phenotypic variation, we have previously shown that host

288 going Chlamydomonas research and explain the phenotypic variation, we mapped the genetic diversity wi

289 To identify the genes driving this extensive phenotypic variation, we performed a genome-wide associa

290 of neuroanatomical variation that related to phenotypic variation were identified.

291 iation in many of these genes contributes to phenotypic variation were obtained.

292 individuals can differ in their potential of phenotypic variation, which is characterized by the numb

293 n between recombination, gene expression and phenotypic variation, which may enhance crop genetic imp

294 e and of oak interspecific and intraspecific phenotypic variation will improve our ability to sustain

295 xplained by genotype, and the interaction of phenotypic variation with hepcidin is unknown.

296 cant QTLs explained 8.20-27.00% of the total phenotypic variation, with the LOD ranging from 3.85-12.

297 ly present genes contribute substantially to phenotypic variation within a eukaryote species, these g

298 Such phenotypic variation within disorders implies the existe

299 adaptive diversification between species and phenotypic variation within populations.

300 The existence of both genetic and phenotypic variation within vegetative hyphae suggests t