ライフサイエンスコーパス: phenotyping

1 sttransplant (including 5 with pretransplant phenotyping).

2 njury, C4d positivity, and inflammatory cell phenotyping.

3 ic acid droplet assays to include functional phenotyping.

4 ging and compared with results from standard phenotyping.

5 erent age groups and could be used in asthma phenotyping.

6 for technologies amenable to high-throughput phenotyping.

7 ardiac magnetic resonance imaging and immune phenotyping.

8 integrate whole-genome sequencing with deep phenotyping.

9 kout mice (DKO) were generated for metabolic phenotyping.

10 ity suggests a route to neuropathologic deep phenotyping.

11 a ConvNet, capable of cellular morphological phenotyping.

12 n, and enable high-throughput plant chemical phenotyping.

13 genetic perturbations following image-based phenotyping.

14 role of non-invasive biomarkers in clinical phenotyping.

15 graphy as well as histological and molecular phenotyping.

16 whole genome sequencing and high resolution phenotyping.

17 analysis of renal function and biomolecular phenotyping.

18 man scattering (SRS) microscopy for cellular phenotyping.

19 nd complicate the automation of cell surface phenotyping.

20 fluorescence as well as electron microscopic phenotyping.

21 s an important functional add-on whole-blood phenotyping.

22 orms a core element of systems biology-based phenotyping.

23 Phenotyping A2/S(269) (+)CD8(+) T cells from COVID-19 co

24 ly size and number of selfing generations on phenotyping accuracy and genomic selection.

25 However, blood phenotyping across these subsets is not yet available in

26 of probe substrates may support their use as phenotyping agents for the activity of the respective en

27 Expert-labeled data are essential to train phenotyping algorithms for cohort identification.

28 ature of RA, there are few reports of T-cell phenotyping along the IA-continuum.

29 null mutant mice using behavioural and motor phenotyping alongside molecular modelling and analysis o

30 and inform stage categorization and disease phenotyping among hospitalized COVID-19 patients.

31 ly rely on fluorescent labeling for cellular phenotyping, an indirect measure of the molecular landsc

32 a diagnostic workflow combining basic ocular phenotyping and a clinically available targeted NGS pane

33 this intermediate scale, using quantitative phenotyping and agent-based modeling to identify behavio

34 imited clinical relevance, it may impact ARD phenotyping and assessment of contribution of atopy to A

35 tegrated system for multi-parametric optical phenotyping and characterization of bacterial colonies,

36 High-throughput phenotyping and data mining can capture dozens or hundre

37 obacterial whole-genome sequencing, dormancy phenotyping and drug-susceptibility analyses on M. tuber

38 s permits much improved flow cytometry-based phenotyping and enumeration of murine iNKT and T(RM) fro

39 e an upgraded version of Single Cell Optical Phenotyping and Expression (SCOPE-seq2) for combining si

40 impeded by the need for laborious, repeated phenotyping and gaps in knowledge regarding the relation

41 ethods rely heavily on very large amounts of phenotyping and genotyping data, presenting new challeng

42 Additional phenotyping and in vitro studies enabled reclassificatio

43 man spectroscopy enables reliable neutrophil phenotyping and infection diagnosis in a label-free mann

44 Prospective deep phenotyping and longitudinal follow-up of a large sequen

45 etric approaches used to perform whole-plant phenotyping and quantitative approaches in capture proce

46 m microbiome has a potential role in disease phenotyping and risk stratification in chronic obstructi

47 el gene-disease associations, and additional phenotyping and RNA analysis.

48 Phenotyping and RNAseq analyses reveal no other signific

49 three independent cohorts with more specific phenotyping and specific study characteristics support m

50 ecture between depression defined by minimal phenotyping and strictly defined major depressive disord

51 o be personalized and some data suggest that phenotyping and subsequent individual management of GI p

52 ould have wide utilities in large-scale seed phenotyping and testing, for both research and routine s

53 neglected it, mainly because of the costs of phenotyping and the complexity of disentangling the role

54 to guide future applications of multivariate phenotyping and their analyses to understanding psychosi

55 Overall, this work demonstrates that digital phenotyping and unstructured phenotype data can be combi

56 to more distal features derived from digital phenotyping and wearable technologies, and how new disco

57 l of characterization (abnormality detection/phenotyping) and data fidelity (single-lead ECG/22-chann

58 ied new patients, performed extensive animal phenotyping, and explored new signaling pathways.

59 genome-wide association study-based disease phenotyping, and genetic lineage reconstruction to show

60 traction from the imaging report, electronic phenotyping, and prospective structured image reporting;

61 Identifying such epitopes enables tracking, phenotyping, and stimulating T cells involved in immune

62 T cells of interest for single cell cloning, phenotyping, and transcriptomics.

63 nt architectures remain challenging for many phenotyping applications.

64 Taken together, this integrative phenotyping approach of platelet-fibrin thrombus formati

65 Such a latent phenotyping approach provides insights into common neuro

66 We used a novel digital phenotyping approach that included 11 152 infected leave

67 We expect this multiparametric and rapid phenotyping approach to accelerate development of therap

68 Here, using a reverse phenotyping approach, we report heterozygous coding vari

69 High-content phenotyping approaches such as Perturb-seq (single-cell

70 l, we demonstrate the value in complementary phenotyping approaches to complex dietary datasets, and

71 th population-level and well-controlled deep phenotyping approaches.

72 The unPAK project - undergraduates phenotyping Arabidopsis knockouts - has generated phenot

73 Massively parallel phenotyping assays have provided unprecedented insight i

74 For this, we used a combination of root phenotyping assays, live-imaging and auxin quantificatio

75 with severe asthma heralded the beginning of phenotyping asthmatic subjects based on airways inflamma

76 MC) with 3D cell culture enabled single-cell phenotyping at 1 mum spatial resolution.

77 analysis of renal function and biomolecular phenotyping at 24 h, 48 h and 4 weeks after injury.

78 -hour biospecimen collection and cardiorenal phenotyping at baseline and again after 14 days of study

79 Cellular phenotyping at the RNA and protein level was performed u

80 ized due to limitations in the throughput of phenotyping at these stages.

81 Concomitantly, molecular phenotyping based on a transcriptomic analysis of bronch

82 offers a promising tool for engineering and phenotyping bees for diverse applications.

83 of Rhbdf2 in extreme-phenotype mice, and by phenotyping bones of Rhbdf2 knockout mice.

84 idity through large cohort studies with deep phenotyping, build a harmonized global sepsis registry t

85 lood cell surface and intracellular cytokine phenotyping by flow cytometry along with serum antibody

86 Recent advances in phenotyping can now functionally or genetically link cel

87 The rapid improvement of phenotyping capability, accuracy and throughput have gre

88 Vs and could form the basis of a system with phenotyping capability.

89 ee-dimensional (3D), dynamic, and multiscale phenotyping challenge they pose.

90 tial impact on metabolism studies, metabolic phenotyping, chemical reaction monitoring, and many othe

91 ed through detailed clinical and biochemical phenotyping, combined with whole-genome sequencing.

92 Digital phenotyping combines the excitement of fast-paced techno

93 cussing the new disciplines working with the phenotyping community: data science, to address the chal

94 and at the library scale, by systematically phenotyping conditionally essential genes involved in am

95 itability for survival (SUR) under all three phenotyping conditions.

96 The International Mouse Phenotyping Consortium (IMPC) aims to knock out every ge

97 The International Mouse Phenotyping Consortium (IMPC) database (data release 10.

98 phenotype data from the International Mouse Phenotyping Consortium (IMPC), adaptive windows were app

99 on knockout mice by the International Mouse Phenotyping Consortium and essentiality screens carried

100 Dnaaf2 obtained from the International Mouse Phenotyping Consortium.

101 e models produced by the International Mouse Phenotyping Consortium.

102 nome, limited genetic diversity and in-field phenotyping constraints.

103 In addition to ABCC4 genotyping, PEL phenotyping could open a new way toward drug dose adjust

104 to explore advanced methods for large-scale phenotyping data acquisition and processing in the comin

105 ry of synthetic peptides and root and nodule phenotyping data from synthetic peptide screens in plant

106 .1 marks a major step towards enabling plant phenotyping data reusability, thanks to its extended cov

107 integration of high-throughput fluorescence phenotyping data, resulting in gained parameters of high

108 spects of collection and analysis of digital phenotyping data, which takes us on a brief tour of seve

109 rocessing, QC and visualization of metabolic phenotyping datasets, either interactively, or in automa

110 GWAS based on minimal phenotyping definitions preferentially identifies loci t

111 , and reusable) data, and robotics, to apply phenotyping directly on farms.

112 his is particularly challenging in the plant phenotyping domain, due to its complexity and heterogene

113 ulness in vascular biology research, patient phenotyping, drug testing, and tissue engineering.

114 Plant phenotyping enables noninvasive quantification of plant

115 und the world and represent a broad scope of phenotyping endpoints and disease-related traits in naiv

116 by using it to express several heterogeneous phenotyping experiments in a range of different formats,

117 ng phenomena from large-scale temporal plant phenotyping experiments.

118 limited growth conditions, a high-throughput phenotyping facility was used to measure WUE(plant) in a

119 at combine genetic data and high-dimensional phenotyping for a large number of participants provide a

120 egration of whole-genome sequencing and deep phenotyping for clinical assessments in adults.

121 research in controlled-environment and field phenotyping for seed, shoot, and root traits.

122 robic germination, which will lead to better phenotyping for this trait in future studies.

123 lysis with extensive clinical and histologic phenotyping from 224 kidney transplant recipients betwee

124 ighly relevant to the goal of automated cell phenotyping from microscopy image data is rotation invar

125 nloadable via the internet) enables vascular phenotyping from multicontrast in vivo optical imaging d

126 Surface phenotyping, gene expression profiling and parallel anal

127 , marker-assisted selection, high-throughput phenotyping, genome editing, genomic selection and de no

128 r tasks are critical for numerous downstream phenotyping goals, such as quantifying plant biomass, pe

129 disease-associated genes in adults with deep phenotyping has not been reported.

130 e, challenging, and valuable applications of phenotyping have originated among scientists, prebreeder

131 ts for crop improvement from high-throughput phenotyping (HTP) observations remains challenging.

132 High-throughput phenotyping (HTP) technologies can produce data on thous

133 We provide a detail analysis of patient phenotyping, i.e., the automatic prediction of ten patie

134 We performed peripheral leukocyte phenotyping in 25 children with MIS-C, in the acute (n =

135 cent developments encompass improved sensory phenotyping in animal models and patients, brain imaging

136 review the major progress on high-throughput phenotyping in controlled environments and field conditi

137 ology, with applications for functional root phenotyping in nonsaline, temperature-controlled conditi

138 body titres, plasma cytokines and blood-cell phenotyping in patients with moderate COVID-19 who had n

139 e of this Supplement is to leverage the rich phenotyping in REPRIEVE, to provide data on detailed pat

140 des highlighting the potential for metabolic phenotyping in stratified medicine, this study reveals a

141 have made HPO the de facto standard for deep phenotyping in the field of rare disease.

142 rd resource allocation (e.g., genotyping and phenotyping) in order to maximize prediction accuracy.

143 Phenotyping included functional testing, immunostaining,

144 supplementation, followed by broad metabolic phenotyping, including hyperinsulinemic-euglycemic clamp

145 o four sub-cohorts according to the level of phenotyping information gained and their findings.

146 Plant phenotyping is mostly image based and therefore requires

147 Phenotyping is the current bottleneck in plant breeding,

148 physiological state of an individual ('deep phenotyping') is key to understanding the prevention, in

149 growth, six of them were further studied by phenotyping knock-out mutant plants.

150 to tackle three primary challenges in plant phenotyping: lamina/stem classification, lamina counting

151 and various proxies for diagnoses ('minimal phenotyping'), many of them also provide non-clinical ph

152 present a method, termed metabolic activity phenotyping (MAP), to probe metabolic fluxes by utilizin

153 OPD exacerbations, and indicate that NK cell phenotyping may be a useful and biologically relevant ma

154 s show that reliance on results from minimal phenotyping may bias views of the genetic architecture o

155 Liver perfusate cytofluorimetric phenotyping may contribute as a targeted preoperative to

156 As a result, the computational phenotyping method found four phenotypes with different

157 The study helped us understand the effect of phenotyping method on anaerobic germination, which will

158 assessments to develop a novel computational phenotyping method that groups brain regions from MRI an

159 laboratories, a reliable MS-based glycolipid phenotyping method that identifies colistin resistance i

160 E(plant) is a complex trait and an efficient phenotyping method that reports on components of WUE(pla

161 The phenotyping method was built based on coupled nonnegativ

162 ocular phenotyping using commonly available phenotyping methods and were grouped into four sub-cohor

163 phenotypes and that combining together both phenotyping methods improves power to detect genetic ass

164 hnologies have been described, including new phenotyping methods, digital imaging and genomic approac

165 Now that this latent phenotyping model has been validated in a general popula

166 ew knowledge of WUE arising from advances in phenotyping, modeling, physiology, genetics, and molecul

167 ng genome-wide association studies with deep phenotyping (multiple correlated phenotypes) is determin

168 Therefore, the cost of phenotyping needs to be optimized within a breeding prog

169 portance of detailed placental analysis when phenotyping new individual gene knockouts.

170 We next performed rapid-throughput skeletal phenotyping of 126 knockout mice with disruptions in pre

171 Genotyping and phenotyping of 186 apple accessions from a diverse genet

172 Comprehensive phenotyping of 25 patients from 22 families carrying lik

173 olbox for reproducible high-throughput dense phenotyping of 3D images, specifically geared towards bi

174 Specifically, high-throughput phenotyping of 530 unique mouse gene knockouts identifie

175 esource would facilitate comprehensive, deep phenotyping of a multicenter HFpEF patient cohort with s

176 ize, extensive specimen collection, and deep phenotyping of AD and ED glaucoma patients and control p

177 Mechanical phenotyping of adherent cells has become a serious tool

178 The deep molecular phenotyping of airway samples along with noninvasive bio

179 Refined phenotyping of allergic diseases may unravel novel pheno

180 e variation and heterodimer structure-guided phenotyping of AtEDS1 variants and AtPAD4-AtSAG101 chime

181 cal probes as a generalizable method for the phenotyping of bacterial cells at the population and sin

182 y, to propose a label-free route for optical phenotyping of cancer cells at single-cell resolution.

183 NA capture and to clonotype-aware multimodal phenotyping of cancer samples.

184 hese results illustrate the use of automated phenotyping of cardiac imaging data from the general pop

185 Advanced phenotyping of cardiovascular diseases has evolved with

186 Phenotyping of CD103(+) dendritic cells (DCs) from the o

187 We performed deep phenotyping of CMV-specific T cells to predict CMV outco

188 -breeding programme requires high-throughput phenotyping of component traits of WUE(plant) such as in

189 Using immunohistochemistry, we performed tau phenotyping of CTE neuropathologies and compared this to

190 kes it particularly powerful at quantitative phenotyping of different developmental stages, mutants w

191 fluorescent NTA, for the quantification and phenotyping of EVs.

192 be used for non-destructive high throughput phenotyping of grain chalk and potentially other grain q

193 e value of large-scale genomic databases and phenotyping of human loss-of-function carriers for targe

194 essively delineated, comprehensive molecular phenotyping of ichthyotic skin could suggest much-needed

195 ted from different anatomical districts; the phenotyping of immune cells circulating between parenchy

196 For correct identification and phenotyping of individuals at increased risk for metabol

197 , fully customizable technique for molecular phenotyping of intact tissue volumes.

198 may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as h

199 try as a new approach for in situ mechanical phenotyping of macrophages and for targeted macrophage c

200 DKO mice relative to other conditions, deep phenotyping of mitochondrial function revealed a surpris

201 Phenotyping of Mtb hadD deletion mutant revealed the inf

202 have performed in-depth in vitro and in vivo phenotyping of mutant parasites including targeted metab

203 sment of autopsy cases, surface marker-based phenotyping of neutrophils and platelets, and functional

204 The phenotyping of our novel mouse lines, together with anal

205 ons employing standardized methods, accurate phenotyping of outcomes and evaluation of the effect of

206 Rapid detection and phenotyping of pathogenic microbes is critical for admin

207 Comprehensive phenotyping of patients with suspected heart failure hig

208 Phenotyping of peripheral lymphocytes was done by flow c

209 field-based tents allowing for simultaneous phenotyping of popular winter wheat varieties from US Mi

210 The mechanical phenotyping of single cells therefore offers many potent

211 after death, detailed cellular and molecular phenotyping of the human type 1 diabetes pancreas is lac

212 iven ADAMTS17 involvement, we performed deep phenotyping of the patients' hands.

213 Phenotyping of the RNAi nematodes indicated that all tes

214 We present a detailed phenotyping of the TRPA1 KO rat in models of pain, itch,

215 Mechanical and electrical phenotyping of untreated, Cytochalasin B treated and N-E

216 Latent phenotyping offers a promising approach to elucidate com

217 orescent metabolic probes, we show metabolic phenotyping on the rare disseminated tumor cells in pleu

218 ate lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) f

219 alysis was used as an objective approach for phenotyping participants based on their OAB characterist

220 strains were evaluated using a multifaceted phenotyping pipeline to define their unique disease prof

221 ed PheCAP, a high-throughput semi-supervised phenotyping pipeline.

222 Using the INVertebrate Automated Phenotyping Platform (INVAPP) and the algorithm Paragon,

223 rtCube, a high-throughput unbiased automated phenotyping platform that collects >2000 behavioral feat

224 ped a modeling workflow named "Digital Plant Phenotyping Platform" (D3P), to access crop architectura

225 stigated using a custom-made high-throughput phenotyping platform, enzymatic assays, and gas chromato

226 phenology calibrated for each genotype on a phenotyping platform.

227 study to date using comprehensive metabolic phenotyping platforms (NMR spectroscopy and UHPLC-MS) to

228 ent of genomic resources and high-throughput phenotyping platforms, the 21st century is primed for ma

229 al instrumentation, smartphone-based digital phenotyping presents us with several opportunities and c

230 0.7 kg/m2) underwent comprehensive metabolic phenotyping prior to and 8 wk following a high-fructose

231 med to evaluate the feasibility of the image phenotyping protocol and assess GWAS and genomic predict

232 A quantitative phenotyping protocol using an image-based color trait an

233 A comprehensive immune phenotyping protocol was conducted using validated multi

234 veloped concurrent electrical and mechanical phenotyping provide great potential for high-throughput

235 report, neurocognitive, physiologic, digital phenotyping, psychophysical, neuroimaging, and genomic a

236 High-capacity phenotyping reaches hitherto inaccessible phenotypic cha

237 Minimal phenotyping refers to the reliance on the use of a small

238 source acquisition from soils; however, root phenotyping remains challenging because of the opacity o

239 ith severe CKD (stage >=4) from the Clinical Phenotyping Resource and Biobank Core.

240 le in these macrophages, and immunometabolic phenotyping revealed impaired mitochondrial function and

241 Phenotyping revealed that CPET-derived measures were imp

242 Finally, auditory phenotyping revealed that JAGGED1's function in supporti

243 porting life, as inferred from viability and phenotyping screens performed on knockout mice by the In

244 Our results support the value of deep phenotyping seemingly healthy individuals in prospective

245 Immune phenotyping showed that the donor MDSCs administration s

246 Heart failure sub-phenotyping shows that a new locus in chromosome 1 is as

247 approaches has become a focal point for deep phenotyping strategies.

248 a collected manually and via high-throughput phenotyping strategies.

249 As large-scale metabolic phenotyping studies become increasingly common, the need

250 Moreover, metabolic phenotyping studies revealed alterations in locomotor ac

251 resonance (NMR) spectroscopy-based metabolic phenotyping studies, with detailed information on sample

252 -generated biomarkers arising from metabolic phenotyping studies.

253 tream biological interpretation of metabolic phenotyping studies.

254 T) has become a powerful tool for biomedical phenotyping studies.

255 We sought to undertake a deep phenotyping study of asthmatic patients with upregulated

256 model supports the use of oral digoxin as a phenotyping substrate of intestinal P-gp, but not to ass

257 Current dynamic phenotyping system introduces time as an extra dimension

258 e, we describe a tool that tackles four core phenotyping tasks: classification of cloud points into s

259 cell mixture using the presented biophysical phenotyping technique with the trained neural network, w

260 Advancements in phenotyping techniques capable of rapidly and nondestruc

261 Advances in genotyping and phenotyping techniques have enabled the acquisition of a

262 Modern phenotyping techniques yield vast amounts of data that a

263 Select field phenotyping technologies have become state of the art an

264 ges in cardiovascular disease genotyping and phenotyping that can be addressed by the integration of

265 Novel variants were evaluated by recombinant phenotyping to assess their potential to confer resistan

266 xpression analysis with detailed physiologic phenotyping to capture the functional evolution of these

267 TJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil

268 luencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide ass

269 demonstrate the effectiveness of image-based phenotyping to quantify disease progression.

270 ll level, which brings accurate cell surface phenotyping to single-cell transcriptomics.

271 on, functional brain imaging, and behavioral phenotyping to uncover AT's molecular substrates.

272 and the costs remain prohibitive for scaling phenotyping to wider use-cases.

273 The participants also underwent extensive phenotyping together with measuring different biomarkers

274 Cell surface phenotyping, transcriptome analysis and developmental st

275 after surgery and subjected to comprehensive phenotyping, transcriptome profiling, molecular pathway

276 C57BL/6 recipients were harvested for immune phenotyping, transcriptomic profiling and functional ass

277 Phenotyping Tregs from CLL patients treated with idelali

278 rst large-scale study of automatic adipocyte phenotyping using both histological and genetic data, we

279 ents with nystagmus underwent routine ocular phenotyping using commonly available phenotyping methods

280 ibe a method that leverages high-dimensional phenotyping using CyTOF to trace latently infected cells

281 In addition, phenotyping using hierarchical Ward clustering was perfo

282 inic hours, requiring more detailed clinical phenotyping using home tonometry, the results of which m

283 iction schemes through comprehensive digital phenotyping using structured and unstructured data abstr

284 of 9,914 subjects we performed deep computed phenotyping using unsupervised clustering and derived tw

285 Phenotyping was done in growth chambers and in two Oklah

286 ive MSM and 72 HIV-negative MSW T-lymphocyte phenotyping was performed 3 times biennially.

287 to the health of the population, additional phenotyping was performed in 88 p.T224M carriers and 54

288 Gene expression and high throughput cellular phenotyping was used to characterize iPSCs at different

289 Using detailed clinical phenotyping, we find novel associations between autoanti

290 ession profiling, genetics and comprehensive phenotyping, we found that, paradoxically, sterol synthe

291 mages suitable for quantitative histological phenotyping, we scanned whole zebrafish, a small vertebr

292 , there is the potential for a revolution in phenotyping, which incorporates old and new in structure

293 ction accuracy and (2) to reduce the cost of phenotyping while improving precision.

294 It is no doubt that accurate high-throughput phenotyping will accelerate plant genetic improvements a

295 refinement, this label-free method of T cell phenotyping will lead to a rapid and cost-effective plat

296 grated metatranscriptomics, metabolomics and phenotyping with computational modelling to reveal condi

297 Challenges to phenotyping with EMR data include variation in the accur

298 lti-omics research combining high-throughput phenotyping with genetic studies.

299 combined large-scale biological sampling and phenotyping with restriction site associated DNA sequenc

300 ssing heritability in PAH we integrated deep phenotyping with whole-genome sequencing data using Baye