ライフサイエンスコーパス: phenoxy

1 1, 4-naphthoquinones and 2,3-bis(substituted phenoxy)-1, 4-naphthoquinones may suggest an approach fo

2 1a, N2O2(red) = N,N'-bis(3,5-di-tert-butyl-2-phenoxy)-1,2-phenylenediamide, L = THF) was explored wit

3 ally triggered release and an adamantylidene-phenoxy-1,2-dioxetane chemiluminophore payload.

4 e chemiluminescent light-emission pathway of phenoxy-1,2-dioxetane luminophores attracts growing inte

5 strain cyclic olefin monomer, 1,3-dimethyl-2-phenoxy-1,3,4,7-tetrahydro-1,3,2-diazaphosphepine 2-oxid

6 ibrary of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives was initially deve

7 ure-activity relationships for a series of 3-phenoxy-1,4-diarylazetidin-2-ones were investigated, lea

8 A small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquino

9 luding trans-4-(3-hydroxy-4-methoxyphenyl)-3-phenoxy-1-(3,4,5-trimethoxyphenyl)azetidin- 2-one (78b)

10 78b) and trans-4-(3-amino-4-methoxyphenyl)-3-phenoxy-1-(3,4,5-trimethoxyphenyl)azetidin-2- one (90b).

11 For the simple 2-phenoxy-1-phenylethane or its alcohol congener, 2-phenox

12 he conversion of the lignin model compound 2-phenoxy-1-phenylethanol shifts from phenol and acetophen

13 xy-1-phenylethane or its alcohol congener, 2-phenoxy-1-phenylethanol, the benzylic site is activated

14 l and acetophenone on bare ZIS to H(2) and 2-phenoxy-1-phenylethanone on the ZIS|NiP system (5 sun).

15 The 15(R)-16-phenoxy-17,18, 19,20-tetranor-LXA4 methyl ester (15-epi-

16 aspirin triggered 15-epi-LXA4, and 15(S)-16-phenoxy-17,18,19,20-tetranor-LXA4 methyl ester (16-pheno

17 alpha(1E,3S*), 4alpha]-7-[3[(3-hydroxy-4-(4'-phenoxy)-1butenyl)-7-oxabicycl o-[2.2.1]heptan-2-yl]-5-h

18 fonyl) benzamide), 931126 (2; 4-oxo-4-{2-[(5-phenoxy-1H-indol-2-yl)carbonyl]hydrazino}-N-(4-phenylbut

19 oles to synthesize 2-phenoxy-3H-indole and 2-phenoxy-1H-indole derivatives in the presence of diaryl

20 arried out, leading to the preparation of (4-phenoxy)-(2-n-pentylcarbonyl)-phenoxyethyl selenocyanate

21 is, and structure-activity relationship of 1-phenoxy-2-aminoindanes as inhibitors of the Na(+)/H(+) e

22 Aligning 1-phenoxy-2-aminoindanes onto the X-ray structure of 13d t

23 , 4-(4-methylphenoxy)-2-butyn-1-amine, and 4-phenoxy-2-butyn-1-amine.

24 diphenoxy-2-lambda(5)-phosphaquinolines or 2-phenoxy-2-lambda(5)-phosphaquinolin-2-ones under transit

25 Two diastereomeric 5-bromo-4-phenyl-2-phenoxy-2-oxo-1,3,2-dioxophosphepanes have been synthesi

26 used to study the contraction of 4-phenyl-2-phenoxy-2-oxo-1,3,2-dioxophosphorinan-5-yl radicals.

27 nated aromatic species (phenoxyethanol and 1-phenoxy-2-propanol), two esters (butyl butyrate and buty

28 [(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13), du

29 en ([6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]b enzo[b]thiophene hydrochl

30 e ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]be nzo[b]thiophene) is a se

31 1-[4-[[(3, 5-dimethylanilino)carbonyl]methyl]phenoxy]-2-methylcyclopentane carbox ylic acid (11), exh

32 f 2,4-[[(3,5-dimethylanilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid (RSR13, efaproxiral) 100

33 2-[4-[[(3,5-dimethylanilino) carbonyl]methyl]phenoxy]-2-methylpropionic acid, a synthetic allosteric

34 (2-[4-[[3,5-dimethylanilino) carbonyl]methyl]phenoxy]-2-methylproprionic acid) intravenously before o

35 [4-(1-methyl-4-trifluoromethyl -2-imidazolyl)phenoxy]-2-propanol dihydrochloride (CGP-20712A) prevent

36 [4-(1-methyl-4-trifluoromethy l-2-imidazolyl)phenoxy]-2-propanol], which showed no agonistic activity

37 [4-(1-methyl-4-trifluormet hyl-2-imidazolyl)-phenoxy]-2-propanolmethanesulfonate (CGP20712A), betaxol

38 [4-(1-methyl-4-trifluormet hyl-2-imidazolyl)-phenoxy]-2-propanolmethanesulphonate (CGP 20712A) and at

39 methy l)phenyl]-1,3-thiazol-5-yl}methyl)thio]phenoxy}-2-methylpropanoic acid (1), a potent PPARpan ag

40 A series of 2-phenoxy-3-phenylpropanoic acids has been prepared which

41 8 (N-((2-(methoxy-(11)C)-phenyl)methyl)-N-(6-phenoxy-3-pyridinyl)acetamide) binds to the 18-kDa trans

42 8 (N-((2-(methoxy-(11)C)-phenyl)methyl)-N-(6-phenoxy-3-pyridinyl)acetamide) PET scans were acquired w

43 udies on the acyclic analog 8 provided the 2-phenoxy-3-pyridylurea analog 18 with improved antiischem

44 pulcherosine (5-[4"-(2-carboxy-2-aminoethyl)phenoxy]3, 3'-dityrosine) by high resolution NMR spectro

45 e O-arylation of 2-oxindoles to synthesize 2-phenoxy-3H-indole and 2-phenoxy-1H-indole derivatives in

46 covery of (R)-4-[2-cyano-5-(3-pyridylmethoxy)phenoxy]-4-(2-methylphenyl)b utanoi c acid (12m).

47 derivatives of 3, 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine (4) and 2-(2-(dimethylaminome

48 [methyl-(11)C]N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine) is a recently developed radiolig

49 [methyl-(11)C]N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine)) ( approximately 1.2).

50 ific structural modifications to the benzoyl-phenoxy-acetamide (BPA) structure present in a common li

51 carboxylic group readily splits off from the phenoxy-acetate radical anion to give carbon dioxide.

52 hylphenyl)-1,3-thiazol-5-yl)-methylsulfany l)phenoxy-acetic acid (GW501516)] and RA.

53 (3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy] acetic acid sodium hydrate) or SR 59,230 (3-(2-

54 hyl)phenyl]-1,3-thiazol-5-yl]methylsu lfanyl]phenoxy]acetic acid), significantly reduced ischemia-ind

55 methyl-thiazol-5-ylmethylsulfanyl]-2-m ethyl-phenoxy}-acetic acid (GW0742)-induced up-regulation of A

56 Phenoxy acid herbicides are important groundwater contam

57 als of environmental concern--including some phenoxy acid herbicides, organophosphorus insecticides,

58 ticides (i.e. organophosphorus insecticides, phenoxy-acid herbicides, and triazine herbicide) to inhi

59 segment) and 1,10-bis[p-(benzylammoniomethyl)phenoxy]alkane bis(hexafluorophosphate)s (AyA, y = numbe

60 ated Wang linker derivative ((4-bromomethyl)-phenoxy-allyl acetate) (6) to give after ester hydrolysi

61 noic acid (rac-9), is formed by closure of a phenoxy-allyloxy intermediate 17 collapsing to a cyclopr

62 mpound bearing a N,N-bis(3,5-di-tert-butyl-2-phenoxy)amide ligand is reported.

63 cysteines of peptides couple covalently with phenoxy amino squarate moieties presented on self-assemb

64 ch tautomerism, were equal in potency to the phenoxy analogues and demonstrated selectivity for the l

65 A series of amino and phenoxy analogues have been synthesized, and although th

66 and that a trans configuration between the 3-phenoxy and 4-phenyl rings is generally optimal.

67 supported by terphenyl ligands appended with phenoxy and imine donors were synthesized.

68 c) ketones within the HS to form initially a phenoxy and ketyl radical.

69 roduct consistent with the cross-reaction of phenoxy and naphthoxy radicals.

70 ubsequent SAR studies have revealed that the phenoxy and phenylsulfanyl analogues of 6c, 3-(1-carboxy

71 his system hydrogenates functionalized alpha-phenoxy and related amides at room temperature under 4 a

72 g., methyl, hydroxy, amino, methoxy, phenyl, phenoxy) and electron withdrawing (e.g., fluorine, chlor

73 results suggested the presence of methoxyl, phenoxy, and substituted phenoxy radicals as precursors

74 efficient regiospecific 7-mono- and 7,12-di-phenoxy bay substitution at the "imide-activated" 7- and

75 2-(3,5-dimethylphenyl)pyrrolidin-1-yl)methyl)phenoxy)benzami de], JSPA071B [(S)-3-fluoro-4-(4-((2-(3,

76 4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide], and naloxone.

77 ne ((+/-)-N-methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride; FLX) are frequ

78 -((2-hydroxyethoxy)methyl)-5-(3-(substituted-phenoxy)benzyl)uracils as inhibitors of murine liver uri

79 etains both fluorine atoms and provides beta-phenoxy-beta,beta-difluorobenzyl alcohols.

80 2-hydroxy-3-propyl-4-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl) ethanone (4).

81 tigated; homologues 4-[4-(3-(trifluoromethyl)phenoxy)butyl]-1H-imidazole and 4-[2-(3-(trifluoromethyl

82 4-[4-[[(1,1-Dimethylethyl)-oxidoimino]methyl]phenoxy]butyl]triphenylphosp honium bromide (MitoPBN) pr

83 tivation of a pyrone C-Br or C-Cl bond and a phenoxy C-H bond.

84 The most potent member of the series, the 7'-phenoxy compound 14, binds to the delta site with a Ki o

85 In addition, the phenoxy compounds, which were not inhibitors of NQO1 enz

86 methoxy, ethyl, ethoxy, isopropoxy, phenyl, phenoxy, cyclohexyl, and cyclohexoxy substituents.

87 [1-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]cyclopentanecarboxyli c acid] with different D-

88 ing sites in 1,10-bis[p-(benzylammoniomethyl)phenoxy]decane bis(hexafluorophosphate) (A10A) were show

89 Both inhibitors and the phenoxy derivative of 3 have activity against P. aerugin

90 All of the new phenoxy derivatives have potent in vitro antimalarial ac

91 Hence, benzyloxy, benzylamino, and phenoxy derivatives of 5-phenyl-3-isoxazolecarboxylic ac

92 A series of benzyloxy and phenoxy derivatives of the adenosine receptor agonists N

93 value of 1.1 for the unsubstituted adduct 8-phenoxy-dG (Ph-O-dG).

94 none trigger moiety covalently tethered to a phenoxy-dioxetane moiety through a para-aminobenzyl alco

95 A simple and regioselective synthesis of phenoxy esters and phenylthio esters is reported.

96 he ability of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl, an AEBS-specific ligand, to comp

97 with acetoxymethyl ester of 1,2-bis (2-amino-phenoxy) ethane N:, N:, N:, N:-tetra-acetic acid (BAPTA-

98 revented by calcium chelator 1,2-bis(2-amino phenoxy)ethane-N,N,N', N'-tetraacetic acid.

99 ne-permeant calcium chelator 1,2-bis(2-amino phenoxy)ethane-N,N,N',N'-tetraacetic acid-tetrakis (acet

100 ol (p262-NP), 2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethanol (OP1EO) and endosulfan.

101 reas the O isostere 4-[2-(3-(trifluoromethyl)phenoxy)ethyl]-1H-imidazole is an antagonist as is the S

102 rmamidine) and B-TPMF (N-{7-[1-(4-tert-butyl-phenoxy)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-N'-

103 thanol,alpha-[1-[2,6-dimethoxy-4-(2-propenyl)phenoxy]ethyl]- acetate, (5) licarin C; benzofuran,2,3-d

104 ol; alpha-[1-[2,6-dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-3,4-dimethoxy-1-acetate, (3) odoratisol A

105 N-[2-[5-methyl-3-(2-chlorophenylsulfonyloxy)phenoxy]ethyl]-N- methyl-4 -aminopyridine (1), has been

106 and CGP-20712 [1-[2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethy l-2-

107 ptor antagonist 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl -2-

108 compounds with carbonyl substitutions of the phenoxy group (ester, amide, or ketone moieties) demonst

109 stabilization mechanisms associated with its phenoxy group located in the membrane hydrocarbon core.

110 The para-position of the 4-phenoxy group of the thieno[2,3-c]pyridine lead is found

111 lubilizing group at the para-position of the phenoxy group to increase the aqueous solubility of this

112 assay clustered among compounds in which the phenoxy group was substituted at the 3, 4, or 5 position

113 of the 1,7 bromine atoms in the bay area by phenoxy groups, which is a generally applied reaction fo

114 eplacing all but one phenylseleno group with phenoxy groups.

115 formation is accompanied by the loss of both phenoxy groups.

116 l-5-[7-[4-[(4S)-4-methyl-1,3-oxazolidin-2-yl]phenoxy]heptyl]-1,2-oxazole (W84) and gallamine.

117 uminum phosphide and ethylene dibromide; the phenoxy herbicide (2,4,5-trichlorophenoxy)acetic acid (2

118 Likewise, phenoxy herbicides may have adverse metabolic effects in

119 -(mercaptoethyl)-6-(3-(2-(methylamino)propyl)phenoxy)hexanamide [3, (+)-METH HSMO9] and its use to pr

120 ride (6FDA) with bis[omega-[4-(4-cyanophenyl)phenoxy]hexyl] 4,4'-diamino-2,2'-biphenyldicarboxylate (

121 Azole phenoxy hydroxyureas are a new class of 5-lipoxygenase (

122 Ti(CH2SiMe3)2Me and (FI)Ti(CH2CMe3)2Me (FI = phenoxy-imine), have been synthesized and structurally c

123 same media lead to the conclusions that (1) phenoxy is less reactive overall than 1-naphthoxy toward

124 les and o-QM precursors tethered by a simple phenoxy linker and furnishes cycloadducts with a promine

125 examined the effects of 15-epi-16-(p-fluoro)-phenoxy-lipoxin A(4) methyl ester, an aspirin-triggered

126 table analog of ATL, 15-epi-16-(para-fluoro)-phenoxy-lipoxin A4 analog (ATLa), inhibits neutrophil re

127 15-epi-16-(p-fluoro)phenoxy-LXA(4) (ATLa(1)) blocked the secretion of TNF-al

128 15-epi-LXA(4), a new 15-epi-16-(p-trifluoro)phenoxy-LXA(4) analog (ATLa(2)), as well as LXB(4), and

129 tion of LXA(4) analog (15-epi-16-para-fluoro-phenoxy-LXA(4), 10 microg/day) significantly reduced the

130 y-LXA4 approximately 5(S)-methyl-LXB4 >/= 16-phenoxy-LXA4 > 5(R)-methyl-LXB4.

131 ] and the omega end [15-epi-16-(para-fluoro)-phenoxy-LXA4 (ATLa2)] were recoverable to approximately

132 Neither LXA4 nor 16-phenoxy-LXA4 affected monocyte-mediated cytotoxicity.

133 rder of 15(R/S)-methyl-LXA4 > 16-para-fluoro-phenoxy-LXA4 approximately 5(S)-methyl-LXB4 >/= 16-pheno

134 15R/S-methyl-LXA4 and 16-phenoxy-LXA4 each attenuated (IC50 approximately 10 nM)

135 d 15-epi-LXA4 were equal in activity, and 16-phenoxy-LXA4 was more potent than native LXA4.

136 Both 15(R/S)-methyl-LXA4 and 16-phenoxy-LXA4 were approximately 1 log molar more potent

137 y-17,18,19,20-tetranor-LXA4 methyl ester (16-phenoxy-LXA4) were each as potent as equimolar applicati

138 19,20-tetranor-LXA4 methyl ester (15-epi-16-phenoxy-LXA4), an analogue of aspirin triggered 15-epi-L

139 0.05) cells/100 micron length of venule (16-phenoxy-LXA4-Me, 15-cyclohexyl-LXA4-Me, and 15-R/S- meth

140 t stable lipoxin A4 (LXA4) analogs (i.e., 16-phenoxy-LXA4-Me, 15-cyclohexyl-LXA4-Me, and 15-R/S-methy

141 as (3S,4R)-3 contains a [3,4-(methylenedioxy)phenoxy]methyl group.

142 )-4-(4-Fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl] piperidine [(3S,9R)-3, paroxetine] is a

143 fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-3 ,5-dimethyl-pyridine) and studied test

144 f 3-(4-fluorophenyl)-2-[[3,4-(methylenedioxy)phenoxy]methyl]nortropane+ ++ (4).

145 ,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy)methylphosphonic acid (MB07344), which distribut

146 IPY dyes bearing alkoxy or nonfunctionalized phenoxy moieties are characterized by a highly efficient

147 hibitors and selected 2-(tetrahydroindazolyl)phenoxy-N-(thiadiazolyl)propanamide 2 (TIPTP, M.W. 437.4

148 3-(dimethylamino)propoxy)benzo[d]oxazol-2-yl)phenoxy]-N,N-dimethylpropa n-1-amine} and E6446 {6-[3-(p

149 agonist naltrindole (1) possessing a phenyl, phenoxy, or benzyloxy group at the 4'-, 5'-, 6'-, or - 7

150 ation of an alpha-chloroaldehyde or an alpha-phenoxy- or alpha-acetoxy ketone with a substituted benz

151 een an acetate methyl group deuteron and the phenoxy oxygen of YZ*.

152 Topical application with the 15-epi-16-phenoxy-para-fluoro-LXA(4) stable analog (ATLa) dramatic

153 ed of three covalently linked 1,6,7,12-tetra(phenoxy)perylene-3,4:9,10-bis(dicarboximide) (PDI) units

154 polycrystalline thin films of 1,6,7,12-tetra(phenoxy)perylene-3,4:9,10-bis(dicarboximide) having eith

155 gamma/delta agonist (R)-3-{4-[3-(4-chloro-2-phenoxy-phenoxy)-butoxy]-2-ethyl-phenyl}-propionic acid

156 5-(1H-Indol-5-yl)-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazole (antibiotic 75b) was ef

157 (HA 966, 15 mg/kg), 7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)-quinolinone) (L-701,324, 40 mg/kg),

158 methyl 2-(4-{4-[(2-thiiranylpropyl)sulfonyl]phenoxy}phenyl)acetate (3) and 2-(4-{4-[(2-thiiranylprop

159 (3) and 2-(4-{4-[(2-thiiranylpropyl)sulfonyl]phenoxy}phenyl)acetic acid (4), and show that compound 3

160 1,2,4]triazine (RTI-4229-707), 5-methyl-3-(4-phenoxy-phenylethynyl-[1,2,4]triazine (RTI-4229-766), an

161 paB ligand, and by 4-[4-(methanesulfonamido) phenoxy] phenylsulfonyl methylthiirane, an MT1-MMP inhib

162 metabolism identified 5'-methyl [(S)-hydroxy(phenoxy)phosphoryl]-l-alaninate in combination with 2',3

163 (4-methyl-2,6-bis((prop-2-yn-1-yloxy)methyl)phenoxy) phthalocyaninato zinc(II) (Pc) bearing sixteen

164 he structural modification of the tert-butyl phenoxy portion of lead compound 1 and the subsequent di

165 eners were a l-aspartic acid diisoamyl ester phenoxy prodrug and a l-phenylalanine propyl ester phosp

166 The ortho-alkylated derivatives of phenoxy products possessing the ester functionality unde

167 xo-4,5-dihydro-1H-1,2,4-triazol-3- yl]propyl}phenoxy)propanoic acid (LY518674).

168 ng amino acid, benzyl carboxylic acid, and 2-phenoxy propionic acid, undergo oxidative decarboxylatio

169 2-(4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469) is among the most highly

170 he 7-position of a 2-(4-[(2-quinoxalinyl)oxy]phenoxy)propionic acid, generated the most highly and br

171 sult, (2R)-7-(3-[2-chloro-4-(4-fluorophenoxy)phenoxy]propoxy)-2-ethylchromane-2- carboxylic acid (48)

172 -2-amine (R-like)] related to riluzole and a phenoxy-propranol-amine moiety [(RS)-1-(3,4-difluorophen

173 to the local anesthetic receptor through its phenoxy-propranol-amine moiety, with consequent use-depe

174 n of N-(3-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)propyl) 3-(5-hydroxy-1,4-dihydro-1,4-dioxonaphth

175 em seems optimal and an N(2)-(3-(substituted-phenoxy)propyl) moiety results in high affinity, (c) tha

176 = 0.54 mg/kg) and 4-[3-[4-(trifluoromethyl)-phenoxy]propyl]-1H-imidazole (10c, UCL 1409; Ki = 14 nM,

177 SC-57461A (8d, 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid) are described.

178 mor effect of a novel 30-compound library of phenoxy pyridine and phenyl sulfanyl pyridine derivative

179 -(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)-pyridine-2-carboxyllic acid methyamide-4-methyl

180 butyl-[1,4]diazepane-1-carbonyl)-4-(3-fluoro-phenoxy)-pyrrolidin-1-y l]-ethanone, a hydroxyproline-ba

181 ved transient (150 ns) that we assign to the phenoxy radical and a shorter-lived (3-20 ns) transient

182 o the characterization of both p-substituted phenoxy radical and substituted 2-benzoylcyclohexadienon

183 For almost 100 years, phenoxy radical coupling has been known to proceed in na

184 oxidant, effects stereoselective bimolecular phenoxy radical coupling in vitro.

185 irigent proteins impart stereoselectivity to phenoxy radical coupling reactions in plants and, thus,

186 regio- and stereospecificity of bimolecular phenoxy radical coupling reactions, of especial importan

187 These results suggest that bimolecular phenoxy radical couplings in nature can be catalyzed by

188 protein dimers, suggesting that the ROIs are phenoxy radical derivatives of the amino acid tyrosine (

189 5, while 5 reacts with 2,4,6-tri(tert-butyl)phenoxy radical in a reverse H atom transfer to generate

190 mechanism involving generation of a reactive phenoxy radical intermediate by an electron transfer pro

191 the escape of the one-electron product, the phenoxy radical leading to polymeric products.

192 selected geometry parameters, and charge on phenoxy radical oxygen q(O).

193 argeted PLPs, including the peroxidase-based phenoxy radical platform (269 +/- 41 nm) and the high-re

194 Evidence of phenoxy radical presence upon oxidation raises a human h

195 Because O2(-)/phenoxy radical reactions can lead to more highly oxidiz

196 le light, the flavin photocatalyst generates phenoxy radical tags for targeted labeling.

197 let photoelectron spectroscopy bands for the phenoxy radical to generate the phenyloxenium ion 1.

198 ereoselective and regiospecific control over phenoxy radical-radical coupling appears to have evolved

199 How stereoselective monolignol-derived phenoxy radical-radical coupling reactions are different

200 Control over phenoxy radical-radical coupling reactions in vivo in va

201 enido dinickel(II) adduct upon addition of a phenoxy radical.

202 s(-1) and the reaction rate constant of the phenoxy radicals (k(R)) in the order of 10(9)-10(10) M(-

203 vant since recent studies have revealed that phenoxy radicals and electrophilic quinones, specificall

204 esence of methoxyl, phenoxy, and substituted phenoxy radicals as precursors for formation of major pr

205 hemistry of CDOM, we suggest that coproduced phenoxy radicals could represent a viable oxidative sink

206 ve which leads to a wide labeling radius and phenoxy radicals generated by peroxide treatment may dis

207 ling approaches based on activated esters or phenoxy radicals have been widely used for mapping subce

208 also provides evidence for the importance of phenoxy radicals produced by one-electron transfer react

209 nd located between 390 and 460 nm, while the phenoxy radicals showed two characteristic bands centere

210 itically important for oxidative coupling of phenoxy radicals to form polymers.

211 The resulting phenoxy radicals undergo 1,5- and 1,6-hydrogen shifts in

212 The methoxy-substituted phenoxy radicals undergo a complex series of reactions,

213 or superoxide is reaction with photoproduced phenoxy radicals within CDOM.

214 ogenation and H-atom transfer reactions with phenoxy radicals.

215 phenol radical-cations and the corresponding phenoxy radicals.

216 nt of one of the two o-methoxy groups at the phenoxy residue of the potent, but not subtype-selective

217 ogy for the depolymerization of a commercial phenoxy resin and high molecular weight hydroxylated pol

218 Phenoxy resin particles from the can coatings were also

219 luoroalkyl substituents at position 2 of the phenoxy ring 1-4 were synthesized.

220 The impact of substitution on the phenoxy ring and on the nitrogen atom at the 4-position

221 Replacement of the phenoxy ring in 1 with either simple aliphatic or cycloa

222 introduction of a methoxy group in the meso-phenoxy substituent redirects the photosubstitution towa

223 ulations also highlight the ability of the 8-phenoxy substituent to lower N(7) basicity and predict a

224 d in novel PBIs (e.g., compound 14) with two phenoxy substituents specifically at the 7- and 12-bay p

225 to sixteen 4-((diethylmethylammonium)methyl)phenoxy substituents was synthesized.

226 However, those with hydroxy and phenoxy substituents were poor inhibitors of NQO1 enzyme

227 We report here the synthesis of 7-phenoxy-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazin

228 experimental corroboration suggest that the phenoxy-substituted fluorinated ketone's sp(3)-hybridize

229 hip (SAR) studies demonstrated that (i) meta-phenoxy substitution of the N-1-benzyl group is importan

230 Importantly, electron-poor phenoxy substrates also worked well.

231 icient Rh(III)-catalyzed ortho-alkylation of phenoxy substrates with diazo compounds has been achieve

232 the characteristic ortho heterodisubstituted phenoxy substructure of 1, the S enantiomer of the dihyd

233 Synthesis of such compounds with a phenoxy tether using the 4-hydroxybenzimidazole 11 was p

234 afforded N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfona mide (PF-

235 hlorophenyl)-4-(2-fluoro-6-(trifluoromethoxy)phenoxy)thieno[2,3-d]pyrimidine (BCFTP).

236 ed at the meta- and ortho-positions of the 4-phenoxy to retain a good in vitro potency.

237 isodityrosine (3-[4'-(2-carboxy-2-aminoethyl)phenoxy]tyrosine), a non-fluorescent product of L-tyrosi

238 e dimerization of this new congener to the P-phenoxy variant are also reported, showing retention of