ライフサイエンスコーパス: phenoxyl radical

1 TBP to give [Cu(II)2(UN-O(-))(OH)](2+) and a phenoxyl radical.

2 ic cleavage of the alcohol OH group from the phenoxyl radical.

3 on of OR with NADP+ prior to the exposure to phenoxyl radicals.

4 rmed on dimerization of two tyrosine-derived phenoxyl radicals.

5 The phenoxyl radical 1 was generated in high yields by flash

6 Similarly, the phenoxyl radical 2,4,6-tBu3C6H2O* and excess TEMPO* each

7 full characterization of the 4-(nitrophenyl)phenoxyl radical, 2,6-di-(t)butyl-4-(4'-nitrophenyl) phe

8 h in competition with beta-scission to yield phenoxyl radical and acetophenone.

9 elding a 2-substituted (cyano- or isocyano-) phenoxyl radical and an H-atom, (ii) recombination of th

10 lable and crystallographically characterized phenoxyl radical and is the only example in which the pa

11 ltered in the presence of a highly oxidizing phenoxyl radical and O(2).

12 lving a sigma lone pair on the oxygen of the phenoxyl radical and the O-H bond of phenol.

13 s, and luminescence quenching data implicate phenoxyl radicals and Bronsted acid-activated oligo(phen

14 emarkably augmented EPR-detectable etoposide phenoxyl radicals and enhanced etoposide-induced topoiso

15 nce of H2O2 and GSH caused the generation of phenoxyl radicals and GS* radicals, of which only the la

16 dium azide, suggesting the potential role of phenoxyl radicals and/or their derivatives.

17 )), i.e., the first 1H(+)/1e(-) (catechol--> phenoxyl radical) and the second 1H(+)/1e(-) (phenoxyl r

18 The anisotropic coupling tensors of the phenoxyl radical are resolved in the photoinduced D-band

19 Phenoxyl radicals are intermediates of one-electron oxid

20 Phenoxyl radicals are readily reduced by thiols, ascorba

21 nisms involving the evolution of the primary phenoxyl radical ArO are proposed to rationalise these e

22 aq)) diffusing into the bulk and leaving the phenoxyl radical at the surface.

23 hypothesis that HRP can be inactivated by a phenoxyl radical attack.

24 (GSH) to eliminate EPR-detectable etoposide phenoxyl radicals, (b) the ability of etoposide phenoxyl

25 contrast, when ascorbic acid reduced the DCF phenoxyl radical back to its parent molecule, it formed

26 This results in the generation of bis(phenoxyl radical)bis(mu-OH)dicopper(II) intermediates, s

27 neration of reactive intermediates, possibly phenoxyl radicals but not H2O2, is responsible for the E

28 lving the reduction of the resorufin-derived phenoxyl radical by the drugs' hydroquinone moiety back

29 Reduction of the phenoxyl radical by the quencher radical was examined as

30 Phenoxyl radical (C(6)H(5)O) was prepared photochemicall

31 mpartments from which APEX2-generated biotin-phenoxyl radicals cannot escape.

32 Photocatalytic generation of phenoxyl radical cations also enabled a nucleophilic aro

33 ens up strategies for the stabilization of a phenoxyl radical cofactor, with its full oxidizing capab

34 d II with the obligate generation of the DCF phenoxyl radical (DCF(.)).

35 Birch) reduction/protonation/reoxidation (by phenoxyl radical)/deprotonation cycle.

36 chromane, a hindered phenolic compound whose phenoxyl radicals do not oxidize endogenous thiols, effe

37 We hypothesize that etoposide phenoxyl radicals (etoposide-O(.)) formed from etoposide

38 = CF(3), tBu) and a localized Cr(V) nitride phenoxyl radical for the more electron-donating NMe(2) s

39 essions were determined for beta-scission of phenoxyl radical from 1-phenyl-2-phenoxyethanol-1-yl, Ph

40 henoxyl radical) and the second 1H(+)/1e(-) (phenoxyl radical--> quinone) free radical scavenging mec

41 as increase of the quinoid character of the phenoxyl radical in polar media.

42 -tyrosine cross-link to the stability of the phenoxyl radical in the enzyme, while highlighting the i

43 ectrochemical oxidations in each case is the phenoxyl radical in which the phenolic proton has transf

44 nce for MPO-dependent formation of etoposide phenoxyl radicals in growth factor-mobilized CD34(+) cel

45 AT, a second molar equiv of 2 couples to the phenoxyl radical initially formed, giving a Cu(II)-OO-(A

46 by phenolic toxins following metabolism into phenoxyl radical intermediates.

47 lectron oxidation of etoposide by MPO to its phenoxyl radical is important for converting this antica

48 e-electron oxidation products of phenol, its phenoxyl radicals, is involved in the oxidative effects.

49 Subsequently, AOH(*) reduces the phenoxyl radical (kET = 5.5 x 10(9) M(-1) s(-1)), formin

50 y phenols that yield comparatively transient phenoxyl radicals, leading to cross-coupling between the

51 This value is higher than related isolated phenoxyl radicals, making this a useful reagent for hydr

52 lic compounds resulting in the generation of phenoxyl radicals may be an important contributor to the

53 uces Fe(IV) horizontal lineO, Cu(II)-OH, and phenoxyl radical moieties, analogous to the chemistry ca

54 This complex, containing an unusual iron(II)-phenoxyl radical motif, represents an elusive example of

55 MPO-catalyzed production of etoposide phenoxyl radicals observed directly in HL-60 cells by el

56 The results indicate that phenoxyl radical of 2,2,5,7,8-pentamethyl-6-hydroxychrom

57 NADPH quenched directly the EPR signal of phenoxyl radical of a phenolic antitumor drug, etoposide

58 OR catalyzed quenching of EPR signal of the phenoxyl radical of a vitamin E homolog, 2,2,5,7,8-penta

59 approximately 500 nm, which we assign to the phenoxyl radical of compound 1.

60 Previous studies demonstrated that the phenoxyl radical of etoposide can be produced by action

61 by EPR spectroscopy and equilibrated with a phenoxyl radical of known stability in order to determin

62 tes lead to generation of kinetically stable phenoxyl radical of the incarcerated 4-hydroxy-diphenyla

63 Phenoxyl radicals of etoposide did not inactivate the OR

64 radicals with higher redox potential, e.g., phenoxyl radicals of etoposide, oxidize NADPH directly.

65 Phenoxyl radicals of phenol can also inactivate OR likel

66 d with DTNB was protected from inhibition by phenoxyl radicals of phenol.

67 R was inhibited irreversibly when exposed to phenoxyl radicals of phenol.

68 ence for the combination of hydroperoxyl and phenoxyl radicals over H-atom transfer between them.

69 tion increases the midpoint potential of the phenoxyl radical/phenol couple so that proton translocat

70 ), for (i) benzyl radical plus toluene, (ii) phenoxyl radical plus phenol, and (iii) methoxyl radical

71 troxide and thiyl radicals generated through phenoxyl radical recycling by peroxidase.

72 ein-derived (tyrosyl) radicals and etoposide phenoxyl radicals, respectively, we established that car

73 e of the dimer, the first for a para-coupled phenoxyl radical, revealed a bond length of 1.6055(23) A

74 e consistent with the initial formation of a phenoxyl radical-spectroscopic studies indicated that th

75 radical, 2,6-di-(t)butyl-4-(4'-nitrophenyl) phenoxyl radical ((t)Bu2NPArO(*)) is described.

76 tin-phenol substrate, APEX2 generates biotin-phenoxyl radicals that covalently tag proximal endogenou

77 nd protonated products and the corresponding phenoxyl radicals to form.

78 noxyl radicals, (b) the ability of etoposide phenoxyl radicals to oxidize GSH and protein thiols (aft

79 ar redox reaction of the cyclohexadienyl and phenoxyl radicals to yield a carbocation/phenoxide pair,

80 adish peroxidase (HRP) can be inactivated by phenoxyl radicals upon reaction with H(2)O(2)/phenol, we

81 tion of halophenols, wherein generation of a phenoxyl radical via formal homolysis of the aryl O-H bo

82 d, detected significant perturbations of the phenoxyl radical vibrational bands.

83 LYP/cc-pVTZ) led to a detailed assignment of phenoxyl radical vibrations.

84 rO-C bond homolysis to give para-substituted phenoxyl radicals, which can be observed directly in las

85 lic moiety with reactive radicals yields its phenoxyl radical, whose reactivity may determine the pro

86 scheme that involves coupling of a liberated phenoxyl radical with a ligated 2-naphthoxyl radical.

87 utyl phenol is oxidized to the corresponding phenoxyl radical with a second-order rate constant of 0.

88 tributed to the coupling between a liberated phenoxyl radical with an iron-ligated phenolic coupling

89 adical scavenging and/or by MPO results in a phenoxyl radical with low reactivity toward lipids, its

90 Phenoxyl radicals with higher redox potential, e.g., phe

91 This report describes reactions of phenoxyl radicals with human NADPH-cytochrome P-450 oxid

92 lectron transfer (PCET) with phenols to form phenoxyl radicals, with dihydroanthracene to form anthra