ライフサイエンスコーパス: phenylalanyl-tRNA synthetase

1 ion from fars-3, an essential subunit of the phenylalanyl tRNA synthetase.

2 from the active site of human mitochondrial phenylalanyl-tRNA synthetase.

3 lanyl-tRNA is formed by Thermus thermophilus phenylalanyl-tRNA synthetase.

4 lyclonal antibodies raised against mammalian phenylalanyl-tRNA synthetase.

5 ines that inhibit a new antimalarial target, phenylalanyl-tRNA synthetase.

6 erminal module that resembles the OB-fold of phenylalanyl-tRNA synthetases.

7 nthesized in nature (by Thermus thermophilus phenylalanyl-tRNA synthetase), and many disubstituted tR

8 and the aminoacyl-tRNA hydrolytic domain of phenylalanyl-tRNA synthetase are functionally and evolut

9 we have engineered a Caenorhabditis elegans phenylalanyl-tRNA synthetase capable of tagging proteins

10 e we report that wild-type E. coli EF-Tu and phenylalanyl-tRNA synthetase collaborate with these muta

11 c azetidines targeting Plasmodium falciparum phenylalanyl-tRNA synthetase comprise one promising new

12 The phenylalanyl-tRNA synthetase editing mechanism is also a

13 Inhibition of purified yeast phenylalanyl-tRNA synthetase (FRS) catalyzed aminoacylat

14 ug resistance was engineered using a mutated phenylalanyl tRNA synthetase gene and marking strains wi

15 ficity in AcKRS and in a PylRS variant [iodo-phenylalanyl-tRNA synthetase (IFRS)] that displays both

16 -acetyllysyl-tRNA synthetase [AcKRS], 3-iodo-phenylalanyl-tRNA synthetase [IFRS], a broad specific Py

17 crimination in vivo revealed that editing by phenylalanyl-tRNA synthetase is essential for faithful t

18 We show that phenylalanyl-tRNA synthetase misactivates tyrosine and t

19 Human mitochondrial phenylalanyl-tRNA synthetase (mtPheRS) has been identifi

20 computationally designed mutant form of the phenylalanyl-tRNA synthetase of the host.

21 ares 45% identity with the yeast cytoplasmic phenylalanyl tRNA synthetase (PheRS) regulatory alpha-su

22 the amino acid binding and recognition step, phenylalanyl-tRNA synthetase (PheRS) faces the challenge

23 Phenylalanyl-tRNA synthetase (PheRS) is a multidomain (a

24 Phenylalanyl-tRNA synthetase (PheRS) maintains specifici

25 Phenylalanyl-tRNA synthetase (PheRS) preferentially liga

26 For example phenylalanyl-tRNA synthetase (PheRS) proofreads the non-

27 olutionary divergence of tyrosine editing by phenylalanyl-tRNA synthetase (PheRS) was used as a model

28 n its acceptor stem that prevents editing by phenylalanyl-tRNA synthetase (PheRS), leading to the acc

29 translation by the proofreading activity of phenylalanyl-tRNA synthetase (PheRS).

30 that of the heterotetrameric (alphabeta)(2) phenylalanyl-tRNA synthetase (PheRS).

31 ies of binding of phenylalanine analogues to phenylalanyl-tRNA synthetase (PheRS).

32 molog of one subunit of prokaryote and yeast phenylalanyl-tRNA synthetase (PheRS).

33 ynthetase (PylRS) is structurally related to phenylalanyl-tRNA synthetase (PheRS).

34 a proofreading ("editing") activity, such as phenylalanyl-tRNA synthetases (PheRS) that hydrolyze mis

35 tivity of aminoacyl-tRNA synthetases such as phenylalanyl-tRNA synthetases (PheRS), which edit misact

36 In addition, seryl- and phenylalanyl-tRNA synthetases that are only marginally r

37 The phenylalanyl-tRNA synthetase variants S57C and N280S bot

38 To define the mechanism of editing, phenylalanyl-tRNA synthetase was used to investigate dif

39 n of the nucleus-encoded human mitochondrial phenylalanyl-tRNA synthetase, which aminoacylates hmt-tR

40 A designed yeast phenylalanyl-tRNA synthetase (yPheRS (T415G)) activates

41 or tRNA (ytRNA(Phe)(CUA)) and a mutant yeast phenylalanyl-tRNA synthetase (yPheRS (T415G)) into an Es