ライフサイエンスコーパス: phenylethanolamine

1 All variants had increased Km values for phenylethanolamine (10), but only D267A showed a notewor

2 sm, mechanisms underlying the recognition of phenylethanolamines and ATD-mediated allosteric inhibiti

3 s and reveals the molecular determinants for phenylethanolamine binding.

4 sites, and the architecture of the putative phenylethanolamine-binding site.

5 and GluN2B ATDs form a heterodimer and that phenylethanolamine binds at the interface between GluN1

6 Ifenprodil and related phenylethanolamine compounds, which specifically inhibit

7 Zinc, polyamines, and phenylethanolamines exert their respective modulatory ef

8 The phenylethanolamines, ifenprodil and CP-101,606, are NMDA

9 The expression of phenylethanolamine N-methyl transferase and chromogranin

10 injection of AAV2 into RVLM of TH-Cre rats, phenylethanolamine N-methyl transferase and VGLUT2 immun

11 ntrol of enzymes relevant to both synthesis (phenylethanolamine N-methyl transferase) and disposition

12 Phenylethanolamine N-methyl transferase-immunoreactive (

13 s was also found for the epinephrine marker, phenylethanolamine N-methyl transferase.

14 ng VLM neurons (75%) were immunoreactive for phenylethanolamine N-methyl transferease, thus were C1 c

15 amined in PC-12 cells transfected with a rat phenylethanolamine N-methyl-transferase (PNMT) promoter-

16 The X-ray structure of human phenylethanolamine N-methyltransferase (hPNMT) complexed

17 -fluoromethyl-THIQs) was proposed, and their phenylethanolamine N-methyltransferase (PNMT) and alpha(

18 s synthesized and evaluated as inhibitors of phenylethanolamine N-methyltransferase (PNMT) and as inh

19 abeling experiments using antibodies against phenylethanolamine N-methyltransferase (PNMT) and cholin

20 combinase under the chromaffin cell-specific phenylethanolamine N-methyltransferase (PNMT) gene promo

21 The rat phenylethanolamine N-methyltransferase (PNMT) gene promo

22 introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, whic

23 21) were synthesized and evaluated for their phenylethanolamine N-methyltransferase (PNMT) inhibitory

24 Phenylethanolamine N-methyltransferase (PNMT) is a criti

25 chain reaction, we detected a single form of phenylethanolamine N-methyltransferase (PNMT) mRNA in hy

26 Phenylethanolamine N-methyltransferase (PNMT) promoter-l

27 the most potent and selective inhibitors of phenylethanolamine N-methyltransferase (PNMT) reported t

28 mone epinephrine through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT) via PNMT g

29 es (3-methyl-THIQs) are potent inhibitors of phenylethanolamine N-methyltransferase (PNMT), but are n

30 We report for the first time that phenylethanolamine N-methyltransferase (PNMT), proteasom

31 tional inhibitory activity of finasteride on phenylethanolamine N-methyltransferase (PNMT), the limit

32 n of the genes Tyrosine Hydroxylase (Th) and Phenylethanolamine N-methyltransferase (Pnmt), which als

33 re highly potent and selective inhibitors of phenylethanolamine N-methyltransferase (PNMT).

34 The enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.2

35 -substituted-THIQs) are potent inhibitors of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.2

36 M, selectivity (alpha2 Ki/PNMT Ki) = 6.0) of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.2

37 9661, 1) is a potent inhibitor of the enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.2

38 -759 and -773 bp in the promoter of the rat phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.2

39 e synthesized and evaluated as inhibitors of phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.2

40 reactive for tyrosine hydroxylase [TH-ir] or phenylethanolamine N-methyltransferase [PNMT-ir]).

41 s labeled with biotinamide were examined for phenylethanolamine N-methyltransferase immunoreactivity

42 nes for nicotinamide N-methyltransferase and phenylethanolamine N-methyltransferase in several specie

43 nes for nicotinamide N-methyltransferase and phenylethanolamine N-methyltransferase in several specie

44 Interestingly, phenylethanolamine N-methyltransferase KO did not change

45 in which the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase was knocked out (

46 tent of the epinephrine synthesizing enzyme, phenylethanolamine N-methyltransferase, immunohistochemi

47 ne hydroxylase, dopamine ss-hydroxylase, and phenylethanolamine N-methyltransferase, we used coimmuno

48 e labeled using an antibody directed against phenylethanolamine-N-methyl transferase (PNMT) and the N

49 ) antibody, or adrenergic neurons labeled by phenylethanolamine-N-methyl transferase (PNMT) antibody.

50 against the epinephrine synthesizing enzyme phenylethanolamine-N-methyl transferase (PNMT), whereas

51 agonist) synthesis, tyrosine hydroxylase and phenylethanolamine-N-methyl transferase, both localized

52 NK) and the epinephrine synthesizing enzyme, phenylethanolamine-N-methyltransferase (PNMT) in the sam

53 In the VMM and RVLM, immunoreactive phenylethanolamine-N-methyltransferase (PNMT) neurons we

54 mber of dopamine-beta-hydroxylase (DBH)- and phenylethanolamine-N-methyltransferase (PNMT)-positive n

55 ownregulated B2AR, tyrosine hydroxylase, and phenylethanolamine-N-methyltransferase expression, but p

56 e synthetic enzymes tyrosine hydroxylase and phenylethanolamine-N-methyltransferase were assayed.

57 tained for c-Fos, dopamine beta-hydroxylase, phenylethanolamine-N-methyltransferase, and glucagon-lik

58 lase, and dopamine beta-hydroxylase, but not phenylethanolamine-N-methyltransferase, indicating inner

59 sine hydroxylase, dopamine beta-hydroxylase, phenylethanolamine-N-methyltransferase, neuronal nitric

60 pa decarboxylase, dopamine beta-hydroxylase, phenylethanolamine-N-methyltransferase, tryptophan hydro

61 gonist structurally unrelated to the classic phenylethanolamine pharmacophore, binds at the same GluN