ライフサイエンスコーパス: phenylglyoxal

1 ese altered enzymes were also insensitive to phenylglyoxal.

2 espectively, may explain their resistance to phenylglyoxal.

3 100, and sensitivity to N-ethylmaleimide and phenylglyoxal.

4 2 equiv of phenylglyoxal 10 gave a different reaction pathway, yiel

5 nophenyl)pyrimidin-2-amine (3) and 4-methoxy-phenylglyoxal (4), while eudistidine B (2) was synthesiz

6 Modification with [14C]phenylglyoxal allowed the identification of two nitrite

7 The arginine-specific reagents phenylglyoxal and butane-2,3-dione irreversibly inactiva

8 onding location (Arg187), was susceptible to phenylglyoxal and butane-2,3-dione.

9 ondrial GPAT with arginine-modifying agents, phenylglyoxal and cyclohexanedione, inactivated the enzy

10 odification of arginines and histidines with phenylglyoxal and diethyl pyrocarbonate, respectively, r

11 hly purified enzyme to N-ethylmaleimide, F-, phenylglyoxal, and diethylpyrocarbonate, both substrates

12 M; and 4) was sensitive to N-ethylmaleimide, phenylglyoxal, and diethylpyrocarbonate.

13 ATP and CTP), N-ethylmaleimide, propranolol, phenylglyoxal, and divalent cations (Ca(2+), Mn(2+), and

14 In this study, the characterization of phenylglyoxal-based covalent probe designed to target un

15 date, sodium fluoride, N-ethylmaleimide, and phenylglyoxal but was not significantly affected by lipi

16 ics in presence of alpha,beta-diones such as phenylglyoxal, cyclohaxanedione, and 2,3-butadione sugge

17 ous substitutions in both pyrazole amine and phenylglyoxal derivatives, enabling the synthesis of var

18 ey arginine residue within this pocket using phenylglyoxal disrupted ARG-1 oligomerization.

19 inactivation of the tritrichomonal enzyme by phenylglyoxal follows time-dependent and concentration-d

20 After incubation with 2 mM phenylglyoxal for 1 h, the modified enzyme had a 10-fold

21 astinal, iodoacetamide, iodoacetic acid, and phenylglyoxal gave substantial inhibition, and methyl bo

22 Although phenylglyoxal has limited potency, it effectively suppor

23 ted alpha-ketoesters and cyclic ketones with phenylglyoxal hydrates were realized with cinchona alkal

24 om the cyanobacterium Anabaena PCC 7120 with phenylglyoxal in 50 mM Hepes, pH 8.0, at 25 degrees C re

25 Phenylglyoxal inactivates the R336Q variant at over half

26 Phenylglyoxal inhibition and substrate protection experi

27 Phenylglyoxal is an arginine-specific reagent that inact

28 total homocitrulline, and biotin-conjugated phenylglyoxal labeling and Western blot to detect carbam

29 This may explain why phenylglyoxal labeling of Arg155 inactivates the enzyme

30 ctrometry (MS/MS) was used to identify three phenylglyoxal-modified Arg residues in monomeric rabbit

31 ospray ionizaton Fourier-transform MS of the phenylglyoxal-modified CK that had lost approximately 80

32 Digestion of [7-(14)C]phenylglyoxal-modified enzyme with trypsin and separatio

33 room temperature between pyrazole amine and phenylglyoxal monohydrate in the presence of Na(2)-eosin

34 synthetase by the arginine-specific reagents phenylglyoxal or p-hydroxyphenylglyoxal inactivates the

35 to 2,4,6-trinitrobenzenesulfonate (TNBS) and phenylglyoxal (PG).

36 was reductive cross-coupling with methyl- or phenylglyoxal promoted by SmI(2), resulting in either 5-

37 e pyrophosphorylase with the arginyl reagent phenylglyoxal resulted in complete desensitization to fr

38 itrulline-specific chemical probe, rhodamine-phenylglyoxal (Rh-PG), which we show can be used to inve

39 esC, and less susceptible to inactivation by phenylglyoxal, than RN.

40 rg155 as the target site of two molecules of phenylglyoxal that is protected by the substrates.

41 Phenylglyoxal treatment of the protein indicates that ar

42 inine-specific modifiers 2,3-butanedione and phenylglyoxal were found to be inactivators, and inactiv

43 e sulfite oxidase was rapidly inactivated by phenylglyoxal, yielding a modified protein with kinetic