ライフサイエンスコーパス: phenytoin

1 and vehicle, vehicle and phenytoin, CORT and phenytoin).

2 d with lamotrigine (but not carbamazepine or phenytoin).

3 o dose effects were seen for lamotrigine and phenytoin.

4 r deaths in control mice after withdrawal of phenytoin.

5 R) and selective permeability to sucrose and phenytoin.

6 R)-6 and (R)-7 in rats (po) exceeded that of phenytoin.

7 and rats that compared favorably to that of phenytoin.

8 the anticonvulsant drugs, carbamazepine and phenytoin.

9 current exhibited either of two responses to phenytoin.

10 henobarbital and 3 microg per milliliter for phenytoin.

11 pilepticus, lorazepam is more effective than phenytoin.

12 nventional antiepileptic drugs, diazepam and phenytoin.

13 : 152 allocated to levetiracetam, and 134 to phenytoin.

14 or clarithromycin; dronedarone; rifampin; or phenytoin.

15 rmine the total and ionized concentration of phenytoin.

16 cing/increasing the ionized concentration of phenytoin.

17 whether volumetric changes can be blocked by phenytoin.

18 nges can, as in animal models, be blocked by phenytoin.

19 ppocampal changes that can be prevented with phenytoin.

20 r for lamotrigine and levetiracetam than for phenytoin.

21 5), lamotrigine (108, 105-110; p=0.0003), or phenytoin (108, 104-112; p=0.0006).

22 For phenytoin (~ 13% free at t = 0), HD brings the patient t

23 mg per kilogram of body weight) followed by phenytoin (18 mg per kilogram), lorazepam (0.1 mg per ki

24 am), phenobarbital (15 mg per kilogram), and phenytoin (18 mg per kilogram).

25 ts), phenobarbitone/primidone (72 patients), phenytoin (184 patients) or valproate (228 patients) in

26 maintenance dose 3.0 mg/kg daily; n = 47) or phenytoin (2.5 mg/kg daily then 5.0 mg/kg daily; n = 47)

27 ceive levetiracetam (40 mg/kg over 5 min) or phenytoin (20 mg/kg over at least 20 min), stratified by

28 29 were assigned to phenytoin 4 mg/kg and 13 to phenytoin 6 mg/kg.

29 ml), and half were given daily injections of phenytoin (40 mg/kg), an antiepileptic drug that prevent

30 nd 13 of the 29 neonates assigned to receive phenytoin (45 percent; P=1.00).

31 Both diazepam (10 mg/kg i.v.) and phenytoin (50 mg/kg i.v.) prevented the establishment of

32 were assigned to phenytoin 4 mg/kg and 13 to phenytoin 6 mg/kg.

33 nts lower than the score of those exposed to phenytoin (95% CI, 0.2 to 14.0; P=0.04), and 6 points lo

34 osed to lamotrigine, 99 for those exposed to phenytoin, 98 for those exposed to carbamazepine, and 92

35 ently exposed to reduced oxygen levels or to phenytoin, a drug known to cause embryonic hypoxia.

36 We show that phenytoin, a Na channel blocker used clinically for trea

37 The model analyte was phenytoin, a typical small drug molecule.

38 al firing and behavior in GEPR-9s, following phenytoin administration.

39 is by 33% and 37% greater than the effect of phenytoin alone (n = 3; P < 0.01).

40 drostenedione when compared to the effect of phenytoin alone (n = 3; P < 0.01).

41 olled clinical trial: 20 patients were given phenytoin and 22 acted as controls.

42 sis included 81 participants (39 assigned to phenytoin and 42 to placebo).

43 eb 3, 2012, and May 22, 2014 (42 assigned to phenytoin and 44 to placebo).

44 between plasma and saliva concentrations of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPP

45 and therapeutic index comparable to those of phenytoin and carbamazepine and greater than those of so

46 The widely prescribed anticonvulsants phenytoin and carbamazepine are potent inducers of cytoc

47 a mechanistic model to assess the removal of phenytoin and carbamazepine during HD with or without bi

48 These findings suggest that phenytoin and carbamazepine may substantially increase t

49 causes loss of bone mass in women, and both phenytoin and carbamazepine produce increases in serum l

50 Both phenytoin and carbamazepine significantly improved the c

51 control serum concentration (P<.001 for both phenytoin and carbamazepine); free T4 fraction (by ultra

52 Because phenytoin and dantrolene belong to the hydantoin class o

53 Combinations of phenytoin and EGF stimulated DHT and 4-androstenedione s

54 Two sodium channel blockers, phenytoin and flecainide, have been reported to protect

55 quid chromatography for the determination of phenytoin and HPPH concentrations.

56 Both phenytoin and lamotrigine increased functional expressio

57 is trial compared the efficacy and safety of phenytoin and levetiracetam for second-line management o

58 with a prescription of antiepileptic drugs, phenytoin and levetiracetam were prescribed most often.

59 Phenytoin and lignocaine (membrane stabilizing drugs) ar

60 gher affinity blockade of T-type currents by phenytoin and MPS may require additional regulatory fact

61 IL-6 secretion, and this effect is shared by phenytoin and nifedipine.

62 These mice were given phenytoin and rifampicin for 3 days, after which monocro

63 with females, including greater induction by phenytoin and rifampicin of cytochrome P450 3A4 isoform

64 values and a selective permeability to [14C] phenytoin and the well-known paracellular marker [3H] su

65 crog/mL/h) of O(6)-BG for patients receiving phenytoin and those not treated with this drug.

66 only used drugs (carbamazepine, lamotrigine, phenytoin and valproate).

67 herapy, which was the case for barbiturates, phenytoin and valproate.

68 many important drugs including tolbutamide, phenytoin, and (S)-warfarin.

69 f the administration of cyclosporin A (CSA), phenytoin, and calcium blockers.

70 Mice were treated with rifampicin, phenytoin, and monocrotaline.

71 enzyme (cP450) inducing AED (carbamazepine, phenytoin, and phenobarbital), a cP450 inhibiting AED (v

72 ly less in subjects receiving carbamazepine, phenytoin, and valproate than in those receiving lamotri

73 ne-step CEDIA for three AEDs (carbamazepine, phenytoin, and valproic acid), in the presence of serum,

74 lower than the control concentration in both phenytoin- and carbamazepine-treated patients.

75 microcolumn containing a small layer of anti-phenytoin antibodies.

76 (IC50 = 68 microM), and the anti-convulsant phenytoin ( approximately 50% inhibition at 200 microM).

77 Phenobarbital and phenytoin are equally but incompletely effective as anti

78 hree known ligands (ibuprofen, warfarin, and phenytoin) are involved to demonstrate the concept and t

79 bout the speciation of ionizable drugs, with phenytoin as a model example.

80 nd clinically used serum levels, pointing to phenytoin as a more human-safe alternative to dantrolene

81 tive RyR2 channels in humans and pointing to phenytoin as a more human-safe alternative to dantrolene

82 study, we report the electrical detection of phenytoin as an antiepileptic medication with a narrow t

83 st it could be an appropriate alternative to phenytoin as the first-choice, second-line anticonvulsan

84 Phenytoin blocked the volume reduction associated with h

85 This approach is not limited to phenytoin but can be adapted for other analytes through

86 en exposed to carbamazepine, lamotrigine, or phenytoin but not among those exposed to valproate.

87 ment is usually with either phenobarbital or phenytoin, but the efficacy of the two drugs has not bee

88 bound phenytoin, the rate of capture of free phenytoin by immunoextraction microcolumns, the behavior

89 owth is caused by the antiseizure medication phenytoin, calcium channel blockers, and ciclosporin.

90 The tricyclic anticonvulsant drugs phenytoin, carbamazepine, and lamotrigine block neuronal

91 sy receiving antiepileptic drug monotherapy (phenytoin, carbamazepine, valproate, and lamotrigine).

92 in; phenobarbital promoted liver tumours and phenytoin caused lymphoid cell and liver tumours in rats

93 Specifically, phenytoin causes loss of bone mass in women, and both ph

94 ileptic drugs (AEDs; i.e., carbamazepine and phenytoin (CBZ, PHT)).

95 cases of hepatotoxicity caused by isoniazid, phenytoin, clavulanate/amoxicillin, or valproate occurri

96 0% reduction in the extent of RNFL loss with phenytoin compared with placebo.

97 se of amiodarone, fluconazole, rifampin, and phenytoin compared with the use of NOACs alone, was asso

98 significantly reduced in subjects receiving phenytoin compared with those receiving lamotrigine (p =

99 (only one, severe rash, was attributable to phenytoin) compared with two (5%) of 44 in the placebo g

100 glaucoma, a subset of animals was placed on phenytoin-containing chow; this treatment continued for

101 t observed (vehicle and vehicle, vehicle and phenytoin, CORT and phenytoin).

102 We conclude that phenytoin could effectively inhibit RyR2-mediated releas

103 d increased burstiness that was sensitive to phenytoin, currently a standard treatment for SCN8A-rela

104 s an iatrogenic disease caused by the use of phenytoin, cyclosporine, nifedipine, and other medicatio

105 Cyclic sulfate 2, like topiramate and phenytoin, did not interfere with seizures induced by pe

106 ipant who received levetiracetam followed by phenytoin died as a result of catastrophic cerebral oede

107 ; and 56.07 for NOAC use alone vs 108.52 for phenytoin (difference, 52.31 [99% CI, 32.18-72.44]; P <

108 ver biosensors showed a solid correlation of phenytoin drug detection with that in the clinically use

109 e/R-oxazepam hemisuccinate, and L-tryptophan/phenytoin during their binding to HSA.

110 (18, ED50 = 3.9 mg/kg; 19, ED50 = 19 mg/kg; phenytoin, ED50 = 23 mg/kg).

111 herapeutic hypothermia significantly reduces phenytoin elimination in children with severe traumatic

112 Phenytoin exhibits a different binding distribution owin

113 Hepatocytes isolated from the phenytoin-exposed donors exhibited marked declines in UG

114 o be risks associated with phenobarbital and phenytoin exposure.

115 ors with the highest levels had a history of phenytoin exposure.

116 18 (62 percent) of those assigned to receive phenytoin first (P=0.67).

117 g individuals treated with isoniazid (nine), phenytoin (five), clavulanate/amoxicillin (15), and valp

118 inding of diverse drugs including lidocaine, phenytoin, flecainide, and quinidine, suggesting that th

119 lt epileptic patients who had been receiving phenytoin for greater than 6 months without a recent cha

120 Higher CTGF staining in phenytoin gingival overgrowth tissues was accompanied by

121 Cellular and extracellular CTGF content in phenytoin gingival overgrowth tissues was significantly

122 at 6 months was 81.46 mum (SD 16.27) in the phenytoin group (a mean decrease of 16.69 mum [SD 13.73]

123 oup and 45 min (24 to not assessable) in the phenytoin group (hazard ratio 1.20, 95% CI 0.91-1.60; p=

124 tients having a serious adverse event in the phenytoin group (only one, severe rash, was attributable

125 e levetiracetam group and in 86 (64%) in the phenytoin group.

126 significantly between the phenobarbital and phenytoin groups (Conners 2.64 [SD 0.71] vs 2.65 [0.89],

127 level (p = 0.0004), whereas those taken off phenytoin had a decrease in homocysteine level (-1.7 mic

128 One participant who received phenytoin had serious adverse reactions related to study

129 Subjects receiving phenytoin had significantly greater levels of bone-speci

130 Phenytoin has been causally implicated in three human ca

131 Recently, (11)C-phenytoin has been evaluated preclinically as a tracer f

132 The anticonvulsant phenytoin has been reported to be an inducer of human CY

133 with a number of advantages over intravenous phenytoin, has been released.

134 , we test the hypothesis that dantrolene and phenytoin have similar inhibitory effects on RyR2 using

135 diazepam plus phenytoin in 55.8 percent, and phenytoin in 43.6 percent (P=0.02 for the overall compar

136 phenobarbital in 58.2 percent, diazepam plus phenytoin in 55.8 percent, and phenytoin in 43.6 percent

137 Lorazepam was significantly superior to phenytoin in a pairwise comparison (P=0.002).

138 Phenytoin in doses (mean, 6.3 mg/kg) that suppressed TE

139 al plasticity and fibrosis were regulated by phenytoin in gingival epithelial tissues and in connecti

140 nylhydantoin (HPPH), the major metabolite of phenytoin in man, and the prevalence and severity of gin

141 34 epilepsy patients taking carbamazepine or phenytoin in monotherapy whose physicians had elected to

142 e, mediated luciferase reporter induction by phenytoin in mouse livers in vivo and was activated by C

143 support the concept of neuroprotection with phenytoin in patients with acute optic neuritis at conce

144 This protocol was applied to measure phenytoin in pharmaceutical tables (100mg per tablet).

145 Moreover, the IC(50) of phenytoin in RyR2 is at least threefold lower than for o

146 y using it to determine the free fraction of phenytoin in serum or samples containing the binding pro

147 biosensor was approved for the detection of phenytoin in solutions of deionized water and 100% fetal

148 Phenobarbital and MK-801 were superior to phenytoin in suppressing SE and in preventing chronic ep

149 a signal proportional to the amount of free phenytoin in the sample.

150 We detected weak transport of phenytoin in two of the transport systems (MDCK and LLC-

151 Hepatic CYP2C29 mRNA was induced by phenytoin in wild-type but not in CAR-null mice, indicat

152 s with the concentration of a model analyte (phenytoin) in the sample stream.

153 Treatment of cells with phenytoin increased cell surface expression of WT-Na(V)1

154 Although phenytoin increased surface expression of G1674R, channe

155 Our previous investigations concerning phenytoin-induced effects on platelet-derived growth fac

156 the ability of a mouse model to mimic human phenytoin-induced gingival overgrowth and assess the abi

157 Data indicate that phenytoin-induced gingival overgrowth in mice mimics mol

158 y show significantly higher CTGF staining in phenytoin-induced gingival overgrowth tissues compared t

159 promoting development of fibrotic lesions in phenytoin-induced gingival overgrowth.

160 a or saliva and the extent, or prevalence of phenytoin-induced gingival overgrowth.

161 Data are consistent with characterization of phenytoin-induced human gingival overgrowth in vivo and

162 We found that phenytoin-induced human gingival overgrowth tissues, the

163 at statins may serve to prevent or attenuate phenytoin-induced human gingival overgrowth, although sp

164 little fibrosis, nifedipine- and especially phenytoin-induced lesions are highly fibrotic.

165 nflammatory exudate may have implications on phenytoin-induced overgrowth via the steroid metabolic p

166 ctive or androstane receptor (CAR) regulates phenytoin-induced transcription of the Cyp2c29 gene.

167 However, the molecular mechanism mediating phenytoin induction remains unclear.

168 erapeutic intervention with phenobarbital or phenytoin ineffective, whereas intervention with vigabat

169 Na(+) currents with tetrodotoxin, QX-314, or phenytoin inhibited bursting before inhibiting action po

170 Phenytoin inhibits RyR2 from failing human heart and not

171 Notably, phenytoin inhibits RyR2 from failing human heart but not

172 We simulated dialytic removal of (1) phenytoin, initial concentration 70 mg/L, using 2000 mg

173 assigned to receive either phenobarbital or phenytoin intravenously, at doses sufficient to achieve

174 Phenytoin is a commonly used anticonvulsant drug for the

175 Phenytoin is a hydantoin derivative that is used clinica

176 Our results demonstrate that phenytoin is associated with changes in bone metabolism

177 Phenytoin is ineffective in the management of seizures s

178 blish whether sodium-channel inhibition with phenytoin is neuroprotective in patient with acute optic

179 Phenytoin is the recommended second-line intravenous ant

180 Dilantin (phenytoin) is a commonly used antiepileptic agent that i

181 icacious than phenobarbital or diazepam plus phenytoin, it is easier to use.

182 sh between the assumed presence of Dilantin (phenytoin), Keppra (levetiracetam), or neither.

183 Our aim was to investigate transport of phenytoin, lamotrigine and carbamazepine by using seven

184 ugs with proapoptotic action (phenobarbital, phenytoin, lamotrigine) and without proapoptotic action

185 two commonly prescribed antiepileptic drugs (phenytoin, lamotrigine), as well as the cystic fibrosis

186 ate the impact of therapeutic hypothermia on phenytoin levels and pharmacokinetics in children with s

187 A trend toward elevated free phenytoin levels in the hypothermia group (p=0.051) to a

188 A sum of 121 total and 114 free phenytoin levels were evaluated retrospectively in 10 hy

189 minimisation via a web-based service to oral phenytoin (maintenance dose 4 mg/kg per day if randomise

190 and not from healthy heart, indicating that phenytoin may selectively target defective RyR2 channels

191 but not from healthy heart, indicating that phenytoin may selectively target defective RyR2 channels

192 Doses of phenytoin (mean, 8.3 mg/kg), which completely blocked AG

193 variant component of the maximum velocity of phenytoin metabolism (Vmax) 4.6-fold (11.6-2.53 mg/hr) a

194 tained from patients undergoing therapy with phenytoin (n = 9), nifedipine (n = 4), cyclosporin A (n

195 Treatment with intravenous phenytoin (n=32) as a second-line therapy was associated

196 Gingival overgrowth induced by drugs such as phenytoin, nifedipine, and cyclosporin develops due to a

197 Medication with phenytoin, nifedipine, and cyclosporine-A often causes g

198 sions occur principally as side-effects from phenytoin, nifedipine, or ciclosporin therapy in approxi

199 Experimental assay results for the drug phenytoin, obtained using surface plasmon resonance imag

200 xons was performed to examine the effects of phenytoin on glaucoma-induced adverse neurodegeneration.

201 The differential effects of phenytoin on structures requisite to the seizure network

202 Phenytoin, one of the most widely used antiepileptic dru

203 In the epilepsy patients, switch from either phenytoin or carbamazepine produced significant declines

204 edications, including an antiepileptic drug (phenytoin or carbamazepine), dexamethasone, and ranitidi

205 ed free T4 concentrations in patients taking phenytoin or carbamazepine, clinicians should rely on se

206 In patients taking phenytoin or carbamazepine, serum total T4 decreased sig

207 rocyte glycoprotein-induced EAE treated with phenytoin or carbamazepine.

208 found no evidence of a relationship between phenytoin or HPPH concentrations in plasma or saliva and

209 establish the relationship, if any, between phenytoin or HPPH levels and gingival overgrowth.

210 se family of enzymes have been documented in phenytoin or nifedipine lesions.

211 pacing to restore synchrony; 4) digoxin; 5) phenytoin or propranolol or verapamil; 6) procainamide o

212 levels through exposure to the antiepileptic phenytoin or the inhibitory transmitter GABA.

213 sed at P7 to a single dose of phenobarbital, phenytoin, or lamotrigine.

214 rug monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate) between October, 1999, and Febr

215 epileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational

216 monotherapy (ie, carbamazepine, lamotrigine, phenytoin, or valproate) were enrolled from October 14,

217 tologic samples support the concept that the phenytoin overgrowth tissues are fibrotic.

218 reased 65% and 44%, respectively (P<.001 for phenytoin, P<.01 for carbamazepine); and free T4 remaine

219 Dynamic (11)C-phenytoin PET scans of 6 healthy volunteers with arteria

220 ntitative parametric images of dynamic (11)C-phenytoin PET studies was evaluated.

221 Double-baseline 60-min dynamic (11)C-phenytoin PET studies, including online arterial samplin

222 ethods: Double-baseline 60-min dynamic (11)C-phenytoin PET studies, including online arterial samplin

223 erone (DHT) from testosterone in response to phenytoin (Ph), interleukin-1 (IL-1), and epidermal grow

224 Among old-generation AEDs, carbamazepine, phenytoin, phenobarbital, and primidone are potent induc

225 Among old generation AEDs, carbamazepine, phenytoin, phenobarbital, and primidone induce the activ

226 as trimethoprim, triamterene, carbamazepine, phenytoin, phenobarbital, and primidone, may increase th

227 ved for the traditional antiepileptic agents phenytoin, phenobarbital, and valproate.

228 for 30 days or longer with anticonvulsants (phenytoin, phenobarbital, carbamazepine, or a combinatio

229 cally in rodent models for phenobarbital and phenytoin; phenobarbital promoted liver tumours and phen

230 Phenytoin (pht) is an anticonvulsant drug commonly used

231 A common side effect of phenytoin (PHT) therapy is connective tissue hyperplasia

232 gical and patient outcomes following topical phenytoin (PHT) treatment of experimental palatal wounds

233 Phenytoin (PHY), a widely used antiepileptic drug, is a

234 try allows one to assess the ionized form of phenytoin (pKa~8.2) that corresponds to a negatively mon

235 eceived hydrocortisone (160 mg/day)/placebo, phenytoin/placebo, both medications together, or placebo

236 adout appears to be the diffusion of ionized phenytoin preceded by comparatively rapid deprotonation

237 AAs (including carbamazepine, phenobarbital, phenytoin, primidone, sulfasalazine, triamterene, and tr

238 In addition, fosphenytoin, a water-soluble phenytoin prodrug with a number of advantages over intra

239 In one subpopulation of cells, phenytoin produced a partial, higher affinity block (IC(

240 Phenytoin produced a reversible inhibition of RyR2 chann

241 In other cells, phenytoin produced complete, but lower affinity, blockad

242 tiepileptic drugs tested in this model, only phenytoin proved ineffective, while valproate, gabapenti

243 demonstrate here that oral administration of phenytoin provides long-term (up to 180 days) protection

244 These observations demonstrate that phenytoin provides long-term protection of CNS axons and

245 crofluidic device, we demonstrate assays for phenytoin ranging in concentration from 75 to 1000 nM in

246 In this study, prophylaxis with phenytoin reduced the frequency of such seizure activity

247 agents, including valproate, gabapentin and phenytoin, reduced the ability of astrocytes to transmit

248 ays of the Cyp2c29 promoter to delineate the phenytoin-response activity to a phenytoin-responsive mo

249 lineate the phenytoin-response activity to a phenytoin-responsive module located at -1371 kb upstream

250 The phenytoin-responsive module, consisting of two motifs of

251 Withdrawal of phenytoin resulted in acute exacerbation, accompanied by

252 However, these doses of phenytoin resulted in significant (51.6% of control) sup

253 (including samples from donors treated with phenytoin) revealed a general absence of CYP24A1 mRNA.

254 Together, phenytoin, rifampicin, and monocrotaline caused further

255 Phenytoin, rifampicin, and monocrotaline produced injury

256 Prior administration of BU and/or phenytoin significantly alters exposure to CY and HCY.

257 lar to that observed for the anticonvulsants phenytoin (slowly binds to the fast-inactivated state) a

258 ma kinetic model for quantification of (11)C-phenytoin studies in humans.

259 te model for quantification of dynamic (11)C-phenytoin studies.

260 icle and vehicle, CORT and vehicle, CORT and phenytoin), supporting the interpretations that CORT lev

261 ak for a NIR-fluorescent-labeled analogue of phenytoin that appeared within 2-3 min of sample injecti

262 included the dissociation rate of HSA-bound phenytoin, the rate of capture of free phenytoin by immu

263 etiracetam was not significantly superior to phenytoin, the results, together with previously reporte

264 er time (benzocaine, phenacetin, metribuzin, phenytoin, thiacloprid, valproic acid).

265 a randomised comparison of phenobarbital and phenytoin to assess the acceptability and efficacy of ph

266 ts from the enzyme-inducers carbamazepine or phenytoin to the noninducing drugs levetiracetam or lamo

267 loss in the optic nerve was also reduced in phenytoin-treated animals, compared to controls.

268 In phenytoin-treated animals, however, the loss of RGCs was

269 of CST axons are lost at 90 and 180 days in phenytoin-treated C57/BL6 mice with EAE.

270 90 days, and only 8% are lost at 180 days in phenytoin-treated C57/BL6 mice with EAE; only 21-29% of

271 (ICP) were also seen less frequently in the phenytoin-treated group compared with the controls (5 an

272 enuated epithelial gingival tissue growth in phenytoin-treated mice and altered the expressions of ma

273 erior gingival tissue overgrowth occurred in phenytoin-treated mice based on gross tissue observation

274 ation into the dorsal columns was reduced in phenytoin-treated mice with EAE compared with untreated

275 gns of cerebral edema in only 2 (22%) of the phenytoin-treated patients compared with 7 (70%) of the

276 status was also significantly enhanced with phenytoin treatment at 90 and 180 days in this model.

277 oride (8) exceeded that of phenobarbital and phenytoin upon oral administration to rats.

278 (adjusted OR = 1.15, 95% CI 1.03-1.29), and phenytoin use (adjusted OR = 2.93, 95% CI 1.04-8.30) wer

279 One had congenital abnormalities caused by phenytoin use by the mother.

280 nds on one randomly chosen side received 10% phenytoin USP and contralateral wounds received carrier

281 Phenytoin was effective in aborting SSSE when injected 1

282 Orally delivered phenytoin was effective in protecting neurons in an anim

283 the final UFIDA method, the free fraction of phenytoin was extracted in approximately 100 ms by a mic

284 Phenytoin was the most common antiepileptic drug prescri

285 o for behavioural problems (phenobarbital vs phenytoin) was 0.51 (95% CI 0.16-1.59).

286 The activity reduction by an anticonvulsant, phenytoin, was also localised to treated networks.

287 Phenobarbital, MK-801, and phenytoin were administered at 1, 2, and 4 hours after i

288 Nifedipine and phenytoin were also tested to further support findings w

289 sion and that the neuroprotective actions of phenytoin were not through CORT alterations.

290 o-salko-to); and decreased concentrations of phenytoin when combined with the Ayurvedic syrup shankha

291 We compare results obtained using phenytoin (which induces cleft lip) and 6-aminonicotinam

292 tiepileptic drugs, such as carbamazepine and phenytoin, which are sodium channel blockers.

293 For lidocaine and phenytoin, which bind preferentially to inactivated Na+

294 in contrast to drugs like carbamazepine and phenytoin, which bind tightly to fast-inactivated states

295 The anticonvulsant, phenytoin, which partially blocks DRG T current, blocked

296 on of PAG and PRF neuronal firing induced by phenytoin with complete seizure blockade is consistent w

297 se of amiodarone, fluconazole, rifampin, and phenytoin with NOACs had a significant increase in adjus

298 "green" synthesis of the antiepileptic drug Phenytoin, with no use of any harmful organic solvent.

299 ic administration of the antiepileptic agent phenytoin would reduce its occurrence.

300 hypothesis that sodium channel blockade with phenytoin would result in neuroprotection of retinal gan