ライフサイエンスコーパス: phorbol ester

1 ve to Rol, while retaining responsiveness to phorbol ester.

2 , a mediator of the cell death effect by the phorbol ester.

3 ive C1 domains and has been reported to bind phorbol ester.

4 of the two MRCK isoforms alpha and beta with phorbol ester.

5 tion as well as a weaker initial response to phorbol ester.

6 y 30% at baseline and after stimulation with phorbol ester.

7 ercome by signals bypassing the TCR, such as phorbol ester.

8 matory lesions after topical applications of phorbol ester.

9 , and displayed translocation in response to phorbol ester.

10 in the deltaC1b domain conferred response to phorbol ester.

11 arkers and was not slowed in the presence of phorbol ester.

12 RI or combination of Ca (2)(+) ionophore and phorbol ester.

13 rotein kinase C (PKC)-Ras-Erk signaling with phorbol esters.

14 y inhibit the dephosphorylation triggered by phorbol esters.

15 lation and down-regulation of PKC induced by phorbol esters.

16 n but also as a consequence of activation by phorbol esters.

17 kinase activation and cannot be triggered by phorbol esters.

18 through a heterologous mechanism mediated by phorbol esters.

19 P1 KO cells even after 60 min of exposure to phorbol esters.

20 affinity to diacylglycerol analogs like the phorbol esters.

21 in the absence of chemical inducers such as phorbol esters.

22 second messenger diacylglycerol (DAG) or the phorbol esters.

23 lglycerol and its ultrapotent analogues, the phorbol esters.

24 lglycerol and its ultrapotent analogues, the phorbol esters.

25 ated the levels of isozymes that cannot bind phorbol esters.

26 cytes induced to differentiate by calcium or phorbol esters.

27 ow extracellular calcium and facilitation by phorbol esters.

28 cal structure and the medicinal potential of phorbol esters.

29 d in the absence of promoting agents such as phorbol esters.

30 ubiquitination or endocytosis in response to phorbol esters.

31 0 micromol/L) and phorbol myristate acetate (phorbol ester, 10 micromol/L), and inhibited by H-89 (pr

32 sing ex vivo retinal explants, we found that phorbol ester 12-myristate 13-acetate and insulin-like g

33 surface localization of GLUT1 induced by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA

34 -)/Tg.AC mice exposed to the proinflammatory phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)

35 on that is reversed with the addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA,

36 o extracellular stimuli (serum, EGF, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate) that

37 an mediate Ras activation in response to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, a we

38 Forced depletion of Cx43, by tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate, is a

39 y 80%) produced following promotion with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

40 Cleavage was stimulated by phorbol ester (12-O-tetradecanoylphorbol-13-acetate (TPA

41 and current responses to the TRPV4 agonists phorbol ester 4alpha-phorbol 12,13-didecanoate (4alphaPD

42 dulatory domains, including a diacylglycerol/phorbol ester [4beta-phorbol-12, 13-dibutyrate (PDBu)] b

43 ligation of the BCR or after treatment with phorbol esters (a diacylglycerol mimetic).

44 Using NIH 3T3 cells, we show that phorbol esters, acting through protein kinase C-delta (P

45 the alpha-subtype of PKC as the mediator of phorbol ester action on FR recycling and provide evidenc

46 ignaling versus the chronic hyperactivity of phorbol ester-activated PKC.

47 In Aplysia, there are two major phorbol ester-activated PKCs, Ca2+-activated PKC Apl I a

48 Signal was increased by a phorbol ester activator of glucose transport.

49 otein kinase C activity, whose activation by phorbol ester also promoted ERRalpha protein loss.

50 Activation of PKC by phorbol esters also resulted in phosphorylation of the s

51 ) and erbB2/4-Akt pathways was mimicked by a phorbol ester and blocked by pharmacological inhibition

52 PKCdelta upon stimulation by ligands of the phorbol ester and bryostatin classes.

53 e depressed in mice in vivo and in humans to phorbol ester and calcium ionophore stimulation in vitro

54 re-B cells are inhibited by a combination of phorbol ester and calcium ionophore, agents that bypass

55 ctors could be restored after treatment with phorbol ester and calcium ionophore.

56 gh levels of superoxide when stimulated with phorbol ester and efficiently ingest immunoglobulin (Ig)

57 tained oxidative burst upon stimulation with phorbol ester and fMLP, Gsr-deficient neutrophils displa

58 effects of NADH and NAD+ were mimicked by a phorbol ester and forskolin, respectively.

59 Cells were stimulated with phorbol ester and ionomycin in the presence of brefeldin

60 factor alpha gene expression in response to phorbol ester and ionophore, while signal-responsive gen

61 Phorbol ester and moderate alpha1A-AR stimulation enhanc

62 a and endotoxin) or tumor promoters (such as phorbol ester and okadaic acid), 3-FC suppressed NF-kapp

63 Phorbol ester and RTA transgene induction were used to i

64 tic cycle in EBV-positive AGS/BX1 cells with phorbol ester and sodium butyrate treatment led to a tra

65 s independent of Src and can be triggered by phorbol esters and 2) agonist-stimulated activation in t

66 ds diacylglycerol as well as tumor-promoting phorbol esters and a catalytic GAP domain that inactivat

67 Although structurally related to phorbol esters and a protein kinase C activator, topical

68 igand shedding by two commonly used stimuli, phorbol esters and calcium influx.

69 in alpha2-chimaerin that restricts access of phorbol esters and DAG, thereby limiting its activation.

70 PKC isozymes and responsible for binding of phorbol esters and diacylglycerol, interact with the Gol

71 Phorbol esters and Group I metabotropic glutamate recept

72 otection was enhanced by PKD activation with phorbol esters and limited by PKD inhibition with CID756

73 ometry of ~50% and was strongly increased by phorbol esters and protein phosphatase inhibitors, demon

74 enous Pcyt2 were dramatically increased with phorbol esters and reduced by specific PKC inhibitors.

75 cells undergo apoptosis upon treatment with phorbol esters and related analogs, an effect primarily

76 internalization was observed in response to phorbol esters and sphingosine 1-phosphate.

77 itutively active PKCdelta can substitute for phorbol esters and support exocytosis.

78 Both phorbol esters and tetanic stimulation potentiate synapt

79 we used the stimulation of MLP29 cells with phorbol esters and the in vivo activation after partial

80 ta2-chimaerin is that it can be activated by phorbol esters and the lipid second messenger diacylglyc

81 erins possess a C1 domain capable of binding phorbol esters and the lipid second messenger diacylglyc

82 hage-like cells (D-U1) by costimulation with phorbol esters and urokinase-type plasminogen activator.

83 eceptor-mediated signaling pathways (but not phorbol esters) and differs from signaling at plasma mem

84 aB activation induced by lipopolysaccharide, phorbol ester, and cigarette smoke, was also abolished i

85 phosphorylated in response to high glucose, phorbol esters, and analogs of cAMP, all key insulin sec

86 promoting function of their potent ligands, phorbol esters, and the prevalence of their mutations.

87 Phorbol ester- and TNF-alpha-dependent activation of the

88 Phorbol esters, anti-immunoglobulin G (anti-IgG), and, s

89 assays to study directional cell migration, phorbol esters are frequently used as a chemotactic agen

90 Phorbol esters are without effect in BHK cells.

91 e second messenger diacylglycerol and of the phorbol esters, are classified as typical (ligand-respon

92 e vesicles for fusion, which are targeted by phorbol esters, are different for the spontaneous and ev

93 if the C1 domains of MRCK are to respond to phorbol ester at concentrations comparable with those th

94 lacental trophoblast cells revealed that the phorbol ester (beta-PMA)-induced phosphorylation of NET

95 We show that stolonidiol binds to the phorbol ester binding site of protein kinase C (PKC), in

96 Phorbol ester binding with C1b alone activates classical

97 th the mutated C1 domains also showed strong phorbol ester binding, albeit modestly weaker than that

98 reduced acidic phospholipid requirement for phorbol ester binding.

99 GRP3 is redistributed upon diacylglycerol or phorbol ester binding.

100 ta C1b (deltaC1b) conferred high potency for phorbol ester binding.

101 e gene encoding Munc13-2, which has calcium-/phorbol ester-binding domains and controls presynaptic f

102 identified as a genomic region important for phorbol ester biosynthesis.

103 sponse and partially reduced the response to phorbol ester but not to forskolin.

104 rotein kinase C regulator, and plant-derived phorbol esters, but each ligand induces different activi

105 deltaC1a and deltaC1b domains potently bound phorbol esters, but the binding of [(3)H]phorbol 12,13-d

106 ent signaling response to diacylglycerol and phorbol esters by protein kinase C (PKC) and by several

107 ctroscopy, we dissect the contribution of DG/phorbol esters (C1 ligand) and PS in driving the associa

108 -delta, and -epsilon) were down-regulated by phorbol ester, cells remained responsive to FGF2 with Er

109 We also show that the affinity for phorbol ester-containing membranes is 2 orders of magnit

110 affinity of the C1b domain for DAG- (but not phorbol ester-) containing membranes.

111 The diacylglycerol (DG)/phorbol ester-dependent translocation of conventional pr

112 sesses Rac-GAP activity and a C1 domain with phorbol ester/diacylglycerol-binding capability.

113 Interestingly, phorbol esters did not accelerate endocytosis of axonal

114 ab downregulates cell-surface CD33 by 80% in phorbol-ester differentiated U937 cells, at concentratio

115 diacylglycerol (DAG) signaling pathways with phorbol esters dramatically enhances Ca2+-triggered exoc

116 l-length RasGRP2 with the mutated C1 domain, phorbol ester enhanced the ability of the mutated RasGRP

117 equired 50-100-fold higher concentrations of phorbol ester for induction of membrane translocation.

118 activation, as did calcium ionophore A23187, phorbol ester, forskolin, 8-bromo-cyclic AMP, and the Ep

119 fibrosarcoma cells and that proinflammatory phorbol esters further enhanced this effect.

120 inases are major targets for tumor-promoting phorbol esters, G protein-coupled receptors, and activat

121 mediated by endogenous CD44 in response to a phorbol ester gradient.

122 ession is essential for chemotaxis towards a phorbol ester gradient.

123 Na(+)/H(+) exchange activity in response to phorbol esters, growth factors or protein phosphatase in

124 PKC) activators including diacylglycerol and phorbol ester have previously been reported to increase

125 isplayed properties indistinguishable from a phorbol ester in a proliferation/attachment assay.

126 that the activation of viral replication by phorbol ester in latently infected monocytic cells requi

127 he recognition module for diacylglycerol and phorbol esters in protein kinase C, Ras guanine nucleoti

128 decreased effectiveness of DG compared with phorbol esters in retaining the C1 domain on membranes c

129 e to the limitation posed by the presence of phorbol esters in toxic varieties.

130 IGF-1 and phorbol ester increased hBVR/PKCdelta binding; hBVR was

131 enylephrine or direct activation of PKC with phorbol ester increased HERG channel protein abundance a

132 ng cells expressing low levels of Wnt5A with phorbol ester increased Snail expression inhibiting PKC

133 Angiotensin II and phorbol ester increased superoxide/H2O2 generation in PM

134 on of a melanocyte-lineage signature, drives phorbol ester-independent growth in vitro, and promotes

135 ular production of HOCl when stimulated with phorbol ester, indicating that CF neutrophils had the no

136 However, in p53-null K562 cells, phorbol esters induce miR-34a expression independently o

137 ) as well as the protein kinase C activator, phorbol ester, induce rapid phosphorylation of hSphK2 wh

138 In addition, PKC activation by phorbol ester induced agonist-independent KOPR phosphory

139 In addition, phorbol esters induced a Shh-regulated reporter gene.

140 Enzastaurin specifically inhibits phorbol ester-induced activation of PKC isoforms, as wel

141 e known biological actions of PKD1 including phorbol ester-induced class IIa histone deacetylase 5 nu

142 s after PE stimulation, but had no effect on phorbol ester-induced CPI-17 phosphorylation.

143 sphorylation sites (S396A, S402A) were used, phorbol ester-induced desensitization of the calcium res

144 CRYP-alpha was downregulated during the phorbol ester-induced differentiation of BM2 cells.

145 Ets-2 also increased dramatically following phorbol ester-induced differentiation of the v-Myb-trans

146 mechanism to protect cells from ischemia and phorbol ester-induced down-regulation of channel conduct

147 orter degradation fragments and to increased phorbol ester-induced down-regulation, further supportin

148 In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activation in LNCa

149 urnover is further slowed in the presence of phorbol ester-induced ERK activation, resulting in Mcl-1

150 SSeCKS suppressed phorbol ester-induced ERK1/2 activity only if it encoded

151 a cells was associated with constitutive and phorbol ester-induced expression and secretion of active

152 a unique and critical role in wound healing, phorbol ester-induced hyperplasia, and tumor development

153 UNX-1-containing multiprotein complexes from phorbol ester-induced L8057 murine megakaryoblastic cell

154 miR-34a is strongly up-regulated during phorbol ester-induced megakaryocyte differentiation, but

155 Conversely, KLF4 knockdown blocked phorbol ester-induced monocyte differentiation.

156 armacologic inhibition of Akt also abrogated phorbol ester-induced O(2)(-) production, which was unaf

157 Phorbol ester-induced sequential phosphorylation of both

158 Mouse CD163 resisted endotoxin- and phorbol ester-induced shedding, and ex vivo analysis of

159 n attenuates P2X(7) agonist-induced, but not phorbol ester-induced, ERK1/2 phosphorylation.

160 Cyclopropylmethanol inhibited phorbol-ester-induced PKCdelta activity, but failed to d

161 ely, activation of myosin II or treatment of phorbol ester induces macropinocytosis in the axons and

162 domains of the atypical PKC members are DAG/phorbol ester-insensitive.

163 ition of HSF1 attenuated latency reversal by phorbol ester+ionomycin but not by anti-CD3+anti-CD28.

164 D2 confers PLD activity that is activated by phorbol ester, ionomycin, and okadaic acid.

165 kat and primary human T cells activated with phorbol ester/ionomycin or antibodies against CD3/CD28.

166 C (PKC) attendant to prolonged activation by phorbol esters is a widely described property of this ke

167 collagen XVII shedding was not stimulated by phorbol esters, known activators of ADAM17, (b) constitu

168 ressing the IL-1 family member, IL-1F6, with phorbol ester leads to an inflammatory condition with ma

169 d stimulation of protein kinase C (PKC) with phorbol esters led to sequestration of recycling endosom

170 rticipation in the action of tumor-promoting phorbol esters like 12-O-tetradecanoylphorbol-13-acetate

171 ponse, however, does not distinguish between phorbol ester-like and bryostatin-like behavior.

172 eration and cell attachment assays displayed phorbol ester-like and/or toxic behavior, including WN-8

173 iated TGF-beta activation can be enhanced by phorbol esters, likely because of the increased activity

174 This signature was normalized by specific phorbol esters, making them promising therapeutic candid

175 The phorbol ester-mediated dephosphorylation of the hydropho

176 etic depletion of RINCK had no effect on the phorbol ester-mediated down-regulation and, additionally

177 n of PKC occurs independently of the classic phorbol ester-mediated down-regulation: genetic depletio

178 ucture-function studies of this inhibitor of phorbol ester-mediated ornithine decarboxylase induction

179 infection of fibroblast cells and following phorbol ester-mediated reactivation from a latently infe

180 TSP1 causes a significant increase in phorbol ester-mediated superoxide generation from differ

181 Phorbol ester mimicked the effect of M-CSF, activating E

182 PKC activation by phorbol ester mimicked Wnt5A effects, and Wnt5A treatmen

183 For these studies, we examined phorbol ester modulation of GABA(A) and glycine receptor

184 When stimulated with phorbol ester, nonlytic TIL bind purified ICAM-1 equival

185 Moreover, treatment with a phorbol ester or a calmodulin inhibitor induces Pmel17 s

186 We show here that phorbol ester or angiotensin II-induced proteolytic rele

187 sed cutaneous inflammation following topical phorbol ester or CFA injection.

188 out 30%), but increases after application of phorbol ester or during PTP.

189 racellular release of superoxide elicited by phorbol ester or formyl-methionyl-leucyl-phenylalanine (

190 Treatment of cells with phorbol ester or histone deacetylase inhibitors triggere

191 glucagon-like peptide 1 and KCl, but not by phorbol ester or nerve growth factor.

192 a release upon pro-inflammatory priming with phorbol ester or Toll-like receptor stimulation.

193 ingestible beta-glucan-containing particles, phorbol esters or live yeast hyphae.

194 nated following activation induced by either phorbol esters or natural agonists.

195 and BCL2A1, mediate the apoptotic effect of phorbol esters or the chemotherapeutic agent etoposide i

196 Phorbol esters or the engagement of the T cell antigen r

197 tor molecules constitutively, in response to phorbol esters or through bystander activation by innate

198 with mitochondria following stimulation with phorbol esters or, in L6 myocytes, with insulin via a me

199 i of ectodomain cleavage--hypertonic stress, phorbol ester, or activation of G-protein-coupled recept

200 y, spermatozoa exposed to calcium ionophore, phorbol ester, or H(2)O(2) exhibited superoxide anion pr

201 n with vasoactive intestinal peptide (V) and phorbol ester (P) synergistically activated viral infect

202 The phorbol ester PDBu, which blocks ClC-3-mediated Cl- curr

203 o study the complex regulation of NCC by the phorbol ester (PE) 12-O-tetradecanoylphorbol-13-acetate

204 A phorbol ester phorbol 12,13-dibutyrate (PDBu) (a diacylg

205 By activating PKC with the phorbol ester phorbol 12,13-dibutyrate (PDBu) or a natur

206 SOCs stimulated by CPA, BAPTA-AM and the phorbol ester phorbol 12,13-dibutyrate (PDBu) were reduc

207 inhibitor chelerythrine and activated by the phorbol ester phorbol 12,13-dibutyrate (PDBu), the diacy

208 strate that direct activation of PKC via the phorbol ester phorbol 12-myristate 13-acetate (PMA) mimi

209 f IL-23R was induced by stimulation with the phorbol ester phorbol 12-myristate 13-acetate (PMA), but

210 s in which PKC was directly activated by the phorbol ester phorbol 12-myristate 13-acetate (PMA).

211 Epidermal growth factor or the phorbol ester phorbol 12-myristate 13-acetate caused rap

212 d muscarinic receptor mimetic carbachol, the phorbol ester phorbol 12-myristate 13-acetate, the Ca(2+

213 on in B95-8 marmoset lymphoblastoid cells by phorbol ester phorbol-12-myristate-13-acetate (TPA).

214 Activation of protein kinase C (PKC) by the phorbol ester (phorbol 12-myristate 13-acetate) induces

215 lasts displayed increased relative basal and phorbol ester (phorbol 12-myristate 13-acetate)-induced

216 ed the ability of AJH-836 and a prototypical phorbol ester (phorbol 12-myristate 13-acetate, PMA) to

217 PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced

218 ort that COX-2 expression is up-regulated in phorbol ester (phorbol myristate acetate, PMA)-different

219 Phorbol ester [phorbol 12-myristate 13-acetate (PMA)] tr

220 ome-like structures after stimulation with a phorbol ester, phorbol-12,13-dibutyrate (PDBu).

221 ort induced by unprocessed PKCs activated by phorbol ester, PKCalpha-CT directly drives HDAC cytosoli

222 l receptor (TCR) cross-linking antibodies or phorbol ester plus ionomycin.

223 r187 in the enhancement of exocytosis by the phorbol ester PMA (phorbol 12-myristate 13-acetate).

224 In contrast, the phorbol ester PMA (phorbol-12-myristate-13-acetate, a ph

225 activation of protein kinase C (PKC) by the phorbol ester PMA has been shown to down-regulate cell s

226 al transactivator region is inducible by the phorbol ester PMA, a potent activator of the protein kin

227 The typical phorbol ester PMA, in contrast to bryostatin 1, had no e

228 In contrast, the PKC-activating phorbol ester PMA, often used as a strong inducer of ADA

229 sion after induction of differentiation with phorbol ester (PMA) and transduction with the full-lengt

230 promoter activity was stimulated by IBMX and phorbol ester (PMA) in Raw264.7 monocytes, but only by I

231 In this study, we show that phorbol ester (PMA)-induced internalization of the LPA(1

232 regulated in a rapid and transient manner in phorbol ester (PMA)-stimulated B-1a cells, whereas cycli

233 ciates upon activation of gene expression by phorbol ester (PMA).

234 Activating PKC with the phorbol ester, PMA, enhanced Ca(2+) entry, and potentiat

235 Phorbol esters predominantly activate ADAM17, thereby tr

236 Although phorbol esters promote a strong apoptotic response in LN

237 following exposure to a tumor initiator and phorbol ester promoter.

238 The non-tumor-inducing phorbol esters prostratin and 12-deoxyphorbol-13-phenyla

239 upon sustained stimulation (30-60 min) with phorbol esters, protein kinase C (PKC) alpha and betaII

240 As the predominant cellular receptor for phorbol esters, protein kinase C (PKC) is assumed to pla

241 ucleotide exchange factor and diacylglycerol/phorbol ester receptor expressed in mast cells (MCs) and

242 Like other DAG/phorbol ester receptors, including protein kinase C isoz

243 we found that short-term exposure of CAFs to phorbol esters reduced the number of stress fibers and t

244 array using RNAi depletion of diacylglycerol/phorbol ester-regulated PKCs.

245 Diacylglycerol (DAG)/phorbol ester-regulated protein kinase C (PKC) isozymes

246 Optimal stimulation of the u-PAR promoter by phorbol ester required this enhancer.

247 in the 9-kb promoter did not affect Dex and phorbol ester responses.

248 ntial homology to that of the diacylglycerol/phorbol ester-responsive C1 domains and has been reporte

249 endently of p53 by activating an alternative phorbol ester-responsive promoter to produce a longer pr

250 Cepsilon (PKCepsilon), a diacyglycerol- and phorbol ester-responsive serine-threonine kinase, has be

251 hus, PS drives the initial encounter, and DG/phorbol esters retain the domain on membranes.

252 Thus, the phorbol esters selectively regulate the activity-depende

253 Compared with the DAG/phorbol ester-sensitive C1 domains, the rim of the bindi

254 PMA and active phorbol esters stimulate the proliferation of various tu

255 Additionally, phorbol ester stimulated the production of abnormal PrP

256 In this study, two distinct models, phorbol ester-stimulated adhesion of U937 monocytoid cel

257 ion is integrin mediated, but in contrast to phorbol ester-stimulated adhesion, it is not dependent o

258 ping yet distinct from clusters based on the phorbol ester-stimulated B cell reactivation time course

259 during de novo fibroblast infection and upon phorbol ester-stimulated B cell reactivation, highlighti

260 ase activities were successfully detected in phorbol ester-stimulated neutrophils and eosinophils usi

261 CAT-1 ubiquitination and endocytosis in phorbol ester-stimulated porcine aorthic endothelial and

262 ADAM17, even though ADAM17 is essential for phorbol ester-stimulated shedding of these EGFR-ligands.

263 nts, only the C1B domain is required for the phorbol ester-stimulated translocation of PKCdelta to ot

264 h NHERF-1 in live cells that is triggered by phorbol ester stimulation and, importantly, differs stri

265 rsistent activation of PKC family members by phorbol ester stimulation in cells leads to phosphorylat

266 We show that complexinI/II deficiency or phorbol ester stimulation indeed affects responses to hy

267 Finally, phorbol ester stimulation of PEA-15-null lymphocytes res

268 duced at the plasma membrane (PM) induced by phorbol ester stimulation of PLD were rapidly internaliz

269 ancer cells undergo apoptosis in response to phorbol ester stimulation via PKCdelta-mediated release

270 orm in controlling the induction of genes by phorbol ester stimulation, whereas PKCepsilon predominan

271 in cells growing in serum or in response to phorbol ester stimulation.

272 s of lysosomal function showed that specific phorbol esters, such as PEP005, reduced alpha-synuclein

273 a) had no apparent effect on the response to phorbol esters, suggesting that the specific position of

274 D (PKD) is a family of novel diacylglycerol/phorbol ester targets that regulate many important cellu

275 nducing agents, like activating cytokines or phorbol esters that stimulate host cell signal transduct

276 However, when treated with phorbol ester, the conjugation frequency of nonlytic TIL

277 Upon cell stimulation with phorbol ester, the NF-kappaB soluble complex exchanges F

278 nger sn-1,2-diacylglycerol (DAG) and for the phorbol esters, the C1 domain has been an important targ

279 Consistent with the ability of phorbol ester to induce translocation of the full-length

280 stitutions was reduced in cells treated with phorbol ester to the levels detected in nonstimulated ce

281 veral JNK upstream activators, including the phorbol ester TPA, anisomycin and MAPK kinase kinase-1 (

282 n transcription in 8-bromo-cAMP, insulin and phorbol ester-treated cells.

283 cell rounding and/or decreased apoptosis in phorbol ester-treated LNCaP, LNCaP-C4-2, and MAT-LyLu pr

284 Inactivation of transport activity by phorbol ester treatment of intact platelets relocates SE

285 for APP when TACE activity was enhanced via phorbol ester treatment or if APP was modified such that

286 trigger compensation by the other form, and phorbol ester treatment rescued the endocytotic activity

287 Our results show that phorbol ester treatment stimulated the formation of pall

288 d enhanced ubiquitination of mutant PKC upon phorbol ester treatment.

289 1 HIR fibroblast cells more than insulin and phorbol ester treatment.

290 nd impaired stratum corneum thickening after phorbol ester treatment.

291 down of PHLPP expression reduces the rate of phorbol ester-triggered dephosphorylation of the hydroph

292 mbrane-sensing role of the C2 domain, causes phorbol ester-triggered redistribution of PKCalpha to ot

293 The phorbol ester tumor promoter induced higher mitogenic an

294 econd messenger diacylglycerol (DAG) and the phorbol ester tumor promoters.

295 pharmacological differences with the typical phorbol ester tumor promoters.

296 mulated by growth factors or tumor-promoting phorbol esters, we analyzed its role in amino acid-depen

297 lastic and inflammatory responses to topical phorbol ester were significantly suppressed, suggesting

298 A 10 min application of either 5-HT or phorbol ester, which activates PKC, produced persistent

299 e protein kinase C pathway by treatment with phorbol ester, which has been shown previously to result

300 active compounds were identified, including phorbol esters, which likely act through protein kinase

301 lycerol-binding site, such as bryostatin and phorbol esters, which produce prolonged down-regulation,