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1 ma interacts with its regulators, Galpha and phosducin.
2 d ethanol-responsive gene, is a homologue of phosducin, a known major regulator of Gbetagamma signali
3 sponse, while also investigating the role of phosducin, a phosphoprotein binding transducin betagamma
4  A key component in dark/light adaptation is phosducin, a phosphorylatable protein that modulates the
5 e also show that Tbetagamma association with phosducin, a photoreceptor-specific protein of unknown p
6             We suggest that the mechanism of phosducin action is based on the reduction of transducin
7 transducin beta gamma subunits interact with phosducin along their entire intracellular translocation
8  the abundant photoreceptor-specific protein phosducin and found that the ON-bipolar cell responses i
9 udy, we identify new isoforms of the retinal phosducin and investigate the expression of the phosduci
10                                              Phosducin and its isoforms are widely distributed in bod
11 otoreceptor transduction proteins, cytosolic phosducin and membrane-bound rhodopsin, by the same enzy
12                                              Phosducin and phosducin-like protein (PhLP) bind G prote
13 d the functional roles of the two domains of phosducin and phosducin-like protein in binding retinal
14                                              Phosducin and phosducin-like protein regulate G protein
15 ice to unravel the function of recoverin and phosducin and to further define the role of the gamma su
16 ansgenic mouse models expressing full-length phosducin, and phosducin lacking phosphorylation sites s
17                                    Mammalian phosducins are known to bind G protein betagamma subunit
18  kinase 2 or membrane-targeted myristoylated-phosducin-attenuated or abolished Cav2.3 modulation.
19 al change upon interaction of betagamma with phosducin (beta1H311Agamma2, beta1R314Agamma2, and beta1
20           Together, these data indicate that phosducin binding to transducin beta gamma subunits faci
21  the Gtalpha binding surface, explaining how phosducin blocks Gtbetagamma's interaction with Gtalpha.
22 ng surface plasmon resonance showed that: 1) phosducin bound G(t)betagamma with a 2.5-fold greater af
23                           Phosphorylation of phosducin by Ca(2+)/calmodulin-dependent protein kinase
24                     These data indicate that phosducin can selectively regulate early signaling event
25 onformational change when the dimer binds to phosducin (conformational change mutants).
26 gamma dimer and two regions of defined Gbeta/phosducin contact points.
27 hosducin-like protein; 2) phosphorylation of phosducin decreased its affinity by 3-fold, principally
28 ovine retinal protein phosphatase 2A (PP2A), phosducin dephosphorylation activity peaks coelute with
29  with the B alpha regulatory subunit have no phosducin dephosphorylation activity.
30  the cytosolic fraction of mouse retina, the phosducin dephosphorylation of which occurs rapidly.
31 tein with limited homology to members of the phosducin family that associates with baculovirus Op-IAP
32 sducin and investigate the expression of the phosducin family, showing that an isoform, PhLP1, has se
33 omparable results were observed when the GST-phosducin fusion proteins selectively sequestered Gbeta
34 chemical mechanism for the regulation of the phosducin-Gt beta gamma interaction.
35                            However, although phosducin has a well characterized role in retinal photo
36                                              Phosducin has two domains that wrap around Gtbetagamma t
37            These results support the role of phosducin in regulating signaling in the rod outer segme
38             We also found that the amount of phosducin in rods is sufficient to interact with practic
39  retina neurons and transgenic expression of phosducin in rods of phosducin knock-out mice rescued th
40  lines of evidence in support of the role of phosducin in transducin translocation.
41           Here we describe two homologues of phosducin in yeast, called PLP1 and PLP2.
42 nificant clusters of identity with mammalian phosducin, including a domain corresponding to a highly
43              Although the molecular basis of phosducin interaction with G proteins is well understood
44                                              Phosducin is a major phosphoprotein of rod photoreceptor
45                                              Phosducin is a photoreceptor-specific protein known to i
46 lls and that the subcellular distribution of phosducin is consistent with that of a soluble protein e
47  likely to be photoreceptor specific because phosducin is not expressed in other retina neurons and t
48 s may be generalized to other Gbetagamma and phosducin isoforms as well.
49    To test the functional interaction of all phosducin isoforms with Gbeta gamma in vitro, a glutathi
50 ransgenic expression of phosducin in rods of phosducin knock-out mice rescued the rod-specific phenot
51 from the sensitivity of phototransduction in phosducin knock-out rods being affected to a much lesser
52                       Second, we generated a phosducin knockout mouse and found that the degree of li
53 models expressing full-length phosducin, and phosducin lacking phosphorylation sites serine 54 and 71
54                           We have identified phosducin-like 3 (PDCL3, also known as PhLP2A), through
55                                          The phosducin-like orphan proteins (PhLOPs) fail to bind Gbe
56 ma binding capability, whereas two isoforms (phosducin-like orphan proteins, PhLOPs) share sequence h
57               A proposed function of PDC and phosducin-like protein (PDCL) is the sequestration of "f
58                                Phosducin and phosducin-like protein (PhLP) bind G protein betagamma s
59                                              Phosducin-like protein (PhLP) is a broadly expressed mem
60                                              Phosducin-like protein (PhLP) is a widely expressed bind
61                                              Phosducin-like protein (PhLP) is a widely expressed bind
62                          Phosducin (Pdc) and phosducin-like protein (PhLP) regulate G protein-mediate
63                                              Phosducin-like protein (PhLP), a widely expressed ethano
64 is facilitated by the ubiquitously expressed phosducin-like protein (PhLP), which is thought to act a
65 rotein-1 ring complex (TRiC)/Hsc70, and TRiC-phosducin-like protein 1 (PhLP1) chaperone complexes, th
66 rotein-1 ring complex (TRiC)/Hsc70, and TRiC/phosducin-like protein 1 (PhLP1) chaperone complexes.
67  cytosolic chaperonin CCT and a cochaperone, phosducin-like protein 1 (PhLP1) for dimer formation.
68 f Gbetagamma, recent studies have shown that phosducin-like protein 1 (PhLP1) works as a co-chaperone
69  in complex with its accessory co-chaperone, phosducin-like protein 1 (PhLP1), in the process of fold
70  (CCT; also called TRiC) and its cochaperone phosducin-like protein 1 (PhLP1).
71                                We identified phosducin-like protein 2, Plp2p (=PLP2), as an ATP-eluta
72  alpha, one G beta, one G gamma subunits and phosducin-like protein BDM-1 that have important roles i
73 al roles of the two domains of phosducin and phosducin-like protein in binding retinal G(t)betagamma.
74  association of the Gbeta-GPSM3 complex with phosducin-like protein PhLP and T-complex protein 1 subu
75                                Phosducin and phosducin-like protein regulate G protein signaling path
76  A proteomics search for binding partners of phosducin-like protein, a co-chaperone for the cytosolic
77 agamma with a 2.5-fold greater affinity than phosducin-like protein; 2) phosphorylation of phosducin
78 rtners with cochaperones prefoldin (PFD) and phosducin-like proteins (PhLPs) to facilitate folding of
79                                              Phosducin-like proteins are conserved regulatory compone
80            Given that the regulatory role of phosducin-like proteins may be influenced by protein kin
81 ter closing the channels by dark adaptation, phosducin or inactive Galphao (both sequester Gbetagamma
82 cells is confined to photoreceptors and that phosducin participates in the underlying molecular mecha
83  (PhLP) is a broadly expressed member of the phosducin (Pd) family of G protein betagamma subunit (Gb
84                                              Phosducin (Pd) is a Gbetagamma-binding protein that is h
85                                              Phosducin (Pd) is a widely expressed phosphoprotein that
86                           The phosphoprotein phosducin (Pd) regulates many guanine nucleotide binding
87                                              Phosducin (Pd), a small protein found abundantly in phot
88                                              Phosducin (Pdc) and phosducin-like protein (PhLP) regula
89                                              Phosducin (PDC) has been shown in structural and biochem
90                                              Phosducin (Pdc) is a conserved phosphoprotein that, when
91                                              Phosducin (Pdc) is a G protein beta gamma dimer (G beta
92                                              Phosducin (Pdc), a highly conserved phosphoprotein invol
93                                              Phosducin (Pdc), a highly conserved phosphoprotein, play
94       From the subtraction library, cDNA for phosducin (PDC), a member of the phototransduction pathw
95 n or rod- and cone-specific proteins such as phosducin, peripherin/rds, and ROM1.
96                                              Phosducin (Phd) and Phd-like proteins (PhLPs) selectivel
97      We found that in the dark-adapted rods, phosducin phosphorylated at serine 54 is compartmentaliz
98                                 In contrast, phosducin phosphorylated at serine 71 is present in all
99                                The degree of phosducin phosphorylation in the dark appeared to be les
100                                       In the phosducin phosphorylation mutants, the transducin alpha
101 this process is accelerated significantly by phosducin phosphorylation.
102 ion of phosducin; thus, it was proposed that phosducin plays a role in the light adaptation of G prot
103 icance of light-dependent phosphorylation of phosducin remains largely hypothetical.
104 s Ser-73, which when phosphorylated inhibits phosducin's function, points away from Gtbetagamma, towa
105                     This transition disrupts phosducin's interface with Gt beta gamma, leading to the
106                                              Phosducin's Ser-73, which when phosphorylated inhibits p
107 pal light-regulated phosphorylation sites of phosducin, serine 54 and 71.
108 biquitin-proteasome pathway and suggest that phosducin serves to protect Tbetagamma following the lig
109 on by labeling with antibodies to rod opsin, phosducin, synaptophysin, calbindin D, and glial fibrill
110 -dependent protein kinase II, which inhibits phosducin-Tbetagamma complex formation, completely resto
111 netics, and contained approximately 50% more phosducin than wild-type controls.
112 e regulatory function proposed for mammalian phosducin, the genetic data presented in this report sug
113          Light promotes dephosphorylation of phosducin; thus, it was proposed that phosducin plays a
114                            3) The binding of phosducin to G(t)betagamma diminishes the membrane parti
115                    In mice expressing normal phosducin, transducin alpha and betagamma subunits retur
116  redistribution to the plasma membrane, less phosducin upregulation, and fewer calbindin D-labeled ho
117                In pursuit of the function of phosducin, we tested the hypothesis that it regulates th
118  Gbetagamma increases the current, whereas m-phosducin, which binds Gbetagamma without affecting the
119                            The exception was phosducin, which localized to both rods and cones and, i
120                                    Moreover, phosducin, which produces dissociation of G(t)betagamma
121 ansducin's betagamma subunits complexed with phosducin, which regulates Gtbetagamma activity, has bee
122 ilon subunit, greatly prefers phosphorylated phosducin, with an activity several hundred times those

 
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