ライフサイエンスコーパス: phosphagen

1 Measurement of the phosphagen and metabolite profile of freeze-clamped arte

2 phosphoryl transfer reactions involving both phosphagens and other biochemically important "high-ener

3 Eight different phosphagens (and corresponding phosphagen kinases) are f

4 Phosphagens are phosphorylated guanidino compounds that

5 largely unexplored, despite evidence linking phosphagen deficits to behavioural and learning impairme

6 p a selective covalent inhibitor of creatine phosphagen energetics, CKi.

7 Phosphagen energy-buffering systems play an essential ro

8 family of phosphoryl transfer enzymes called phosphagen (guanidino) kinases which play a central role

9 family of phosphoryl transfer enzymes called phosphagen (guanidino) kinases.

10 ms and tissue-specific expression of certain phosphagens in an evolutionary and functional context.

11 The role of phosphagens in regulation of intracellular Pi levels lik

12 bond is central to the physiological role of phosphagens involving phosphoryl transfer reactions impo

13 re we knocked down expression of the primary phosphagen kinase (arginine kinase 1 (ArgK1)) in Drosoph

14 ke Schistosoma mansoni (SmTK) belongs to the phosphagen kinase (PK) family and catalyzes the reversib

15 GK is a member of the phosphagen kinase enzyme family and appears to have evol

16 Lombricine kinase is a member of the phosphagen kinase family and a homolog of creatine and a

17 ase is an annelid enzyme that belongs to the phosphagen kinase family of which creatine kinase and ar

18 Arginine kinase is a member of the phosphagen kinase family that includes creatine kinase a

19 Glycocyamine kinase (GK), a member of the phosphagen kinase family, catalyzes the Mg(2+)-dependent

20 The phosphagen kinase family, including creatine and arginin

21 ginine kinase (AK), which is a member of the phosphagen kinase family, serves as a model system for s

22 ion and position of these enzymes within the phosphagen kinase family.

23 meric ancestral protein closely related to a phosphagen kinase homologue, arginine kinase (AK).

24 Knockdown of the primary phosphagen kinase in Drosophila larval motor neurons (MN

25 or body-wall contractions were unaffected by phosphagen kinase knockdown.

26 Thermodynamic poise of the phosphagen kinase reaction profoundly impacts this capac

27 Phosphagen kinase reactions function in temporal ATP buf

28 Phosphagen kinase reactions show differences in thermody

29 gy state and ATP hydrolysis by corresponding phosphagen kinase reactions: phosphagen + MgADP + H(+) <

30 Another phosphagen kinase, creatine kinase (CK), is found in spo

31 The performance deficits we observe in phosphagen kinase-deficient Drosophila MNs phenocopy def

32 ficient Drosophila MNs phenocopy deficits in phosphagen kinase-deficient mouse muscle fibres, where t

33 ophila and mice to be heavily decorated with phosphagen kinases - a key element in an energy storage

34 All phosphagen kinases contain a conserved cysteine residue

35 our understanding of how the active sites of phosphagen kinases have evolved to recognize their respe

36 By knocking down phosphagen kinases in fruit fly motor nerve terminals, a

37 e, pH and Ca(2+) , we demonstrate a role for phosphagen kinases in stabilizing presynaptic ATP levels

38 adopt the same overall fold as that of other phosphagen kinases of known structure (the homodimeric c

39 Phosphagen kinases undergo a segmented closing on substr

40 Substrate binding synergy observed in many phosphagen kinases was reduced or eliminated in mutant e

41 of these new CK sequences with other CKs and phosphagen kinases yielded a consensus tree containing a

42 ght different phosphagens (and corresponding phosphagen kinases) are found in the animal kingdom dist

43 To probe the early evolution of phosphagen kinases, we have amplified the cDNAs for AKs

44 TP levels in muscles and we demonstrate that phosphagen kinases, which support such phosphagen system

45 ficity and catalysis in CK and other related phosphagen kinases.

46 mbricine kinase is limited compared to other phosphagen kinases.

47 re analyzed and compared with other selected phosphagen kinases.

48 and compared with available data for annelid phosphagen kinases.

49 an to the substrate-bound forms of the other phosphagen kinases.

50 y corresponding phosphagen kinase reactions: phosphagen + MgADP + H(+) <--> guanidine acceptor + MgAT

51 echanism by which an arginine residue of the phosphagen specificity loop is crucial for substrate spe

52 ural substrates are among the largest of the phosphagen substrates.

53 presynaptic bioenergetics indicates that the phosphagen system's contribution to MN performance is li

54 vertebrates, is the most extensively studied phosphagen system.

55 This review evaluates the distribution of phosphagen systems and tissue-specific expression of cer

56 Phosphagen systems are crucial for muscle bioenergetics

57 Phosphagen systems are known to buffer ATP levels in mus

58 Phosphagen systems are well characterized in muscle, but

59 trate that, as in muscle fibres, MNs rely on phosphagen systems during activity that imposes intense

60 These data indicate that the maintenance of phosphagen systems in motor neurons, and not just muscle

61 that phosphagen kinases, which support such phosphagen systems, also localize to mitochondria in mot

62 differences in thermodynamic poise, and the phosphagens themselves differ in terms of certain physic

63 rformed on a model N-phosphorylguanidine, or phosphagen, to understand the stereoelectronic factors c