ライフサイエンスコーパス: phosphatidylinositol 3,5-bisphosphate

1 C2 is a Na(+)-selective channel activated by phosphatidylinositol 3,5-bisphosphate.

2 s, phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,5-bisphosphate.

3 ylating phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate.

4 atidylinositol-5-phosphate (PI(5)P) or d-myo-phosphatidylinositol-3,5-bisphosphate.

5 PTase11 also hydrolyzes the 5-phosphate from phosphatidylinositol (3,5) bisphosphate.

6 onal marker) and its upstream molecule FIG4 (phosphatidylinositol (3,5)-bisphosphate 5-phosphatase) a

7 4 localized to lysosomes and associated with phosphatidylinositol (3,5)-bisphosphate, a key component

8 altered phosphoinositide levels [increase in phosphatidylinositol (3,5)-bisphosphate and decrease in

9 janins leads to increased cellular levels of phosphatidylinositol (3,5)-bisphosphate and phosphatidyl

10 rlay assay showed specific binding of SVB to phosphatidylinositol 3,5-bisphosphate and phosphatidylin

11 emonstrate that mVps24p selectively binds to phosphatidylinositol 3,5-bisphosphate and phosphatidylin

12 e data provide the first direct link between phosphatidylinositol 3,5-bisphosphate and the protein ma

13 This phase depends on the production of phosphatidylinositol-3,5-bisphosphate and the Fab1 compl

14 PIKfyve is a lipid kinase that generates phosphatidylinositol-3,5-bisphosphate and, directly or i

15 phatidylinositol 3-phosphate and its product phosphatidylinositol 3, 5-bisphosphate, and a WIPI-bindi

16 phatidylinositol 3-phosphate and synthesizes phosphatidylinositol 3,5-bisphosphate, and plays a criti

17 rylating phosphatidylinositol-3-phoshate and phosphatidylinositol-3,5-bisphosphate, and some members

18 It is accelerated by the PI(3)P- and phosphatidylinositol 3,5-bisphosphate-binding protein At

19 osphate in the identification of a mammalian phosphatidylinositol 3,5-bisphosphate-binding protein, m

20 erentially with maturing macropinosomes in a phosphatidylinositol 3,5-bisphosphate-dependent manner a

21 Kfyve modulates phagosome maturation through phosphatidylinositol-3,5-bisphosphate-dependent activati

22 Phosphatidylinositol 3,5-bisphosphate enables transport

23 n with synthetic biotinylated derivatives of phosphatidylinositol 3,5-bisphosphate in the identificat

24 inic acid adenine dinucleotide phosphate and phosphatidylinositol-3,5-bisphosphate, induce ion flux t

25 Phosphatidylinositol 3,5-bisphosphate is a membrane lipi

26 t synthesizes the endosomal phosphoinositide phosphatidylinositol-3,5-bisphosphate, is an essential r

27 hat the Vac14 protein, like Vac7p, regulates phosphatidylinositol 3,5-bisphosphate levels and possibl

28 FIG4 is a ubiquitously expressed phosphatidylinositol 3,5-bisphosphate phosphatase that r

29 The PPI phosphatidylinositol (3,5)-bisphosphate (PI(3,5)P2) is e

30 In light of this, the effect of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)) on v

31 hosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)) regu

32 Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)), an

33 The signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)), lik

34 e V(O) a-subunit ortholog Vph1 and the lipid phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)).

35 tor cortactin as a direct binding partner of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) and de

36 Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is a l

37 Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is the

38 Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2), a rec

39 he low-level endo-lysosomal signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2), is re

40 ity and assembly require the signaling lipid phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2).

41 igand-gated channel that can be activated by phosphatidylinositol 3,5-bisphosphate [PI(3,5)P(2)] as w

42 that the rare late endosomal signaling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P(2)] dire

43 use defects in levels of the signaling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P(2)] lead

44 Phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] is a l

45 itive to the levels of the low abundant PIP, phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], becau

46 signaling lipids phosphatidic acid (PA) and phosphatidylinositol(3,5)bisphosphate [PI(3,5)P2].

47 We show that the signaling lipid phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] is req

48 other groups, claiming mammalian TPCs to be phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2]-activa

49 VPA compromised the dynamics of phosphatidylinositol 3,5-bisphosphate (PI3,5P2) and grea

50 I), phosphatidylinositol-3-phosphate (PI3P), phosphatidylinositol-3,5-bisphosphate (PI3,5P2), and a r

51 The mammalian phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P(2)

52 se (PIKfyve), a lipid kinase which generates phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P(2)

53 smotic stress induces a dramatic increase in phosphatidylinositol 3,5-bisphosphate (PtdIns 3,5-P(2))

54 rter GLUT4 onto the cell surface require the phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P(2))

55 The phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P(2))

56 Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P(2))

57 Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) he

58 Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is

59 the budding yeast Saccharomyces cerevisiae, phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is

60 Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a

61 Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), m

62 Perturbations in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)-sy

63 Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P(2))

64 Phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P(2))

65 analysis, the TRPML1 structure reveals that phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) bi

66 smotically stressed, they rapidly synthesize phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) by

67 the localization and regulation of mammalian phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2), a

68 -abundance and LEL-enriched signalling lipid phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2), w

69 Recently, two novel phosphoinositides, phosphatidylinositol-3,5-bisphosphate (PtdIns-3,5-P2) an

70 hatidylinositol 3-phosphate [PtdIns(3)P] and phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P(2)]

71 Phosphatidylinositol-3,5-bisphosphate [PtdIns(3,5)P(2)]

72 PIKfyve is essential for the synthesis of phosphatidylinositol-3,5-bisphosphate [PtdIns(3,5)P2] an

73 wollen endosomal membranes is abrogated when phosphatidylinositol 3,5-bisphosphate synthesis is block

74 s involved in 5' messenger RNA decapping and phosphatidylinositol 3,5-bisphosphate synthesis were als

75 ive Vps34 drives certain pathways, including phosphatidylinositol-3,5-bisphosphate synthesis and retr

76 Tritiated arachidonic acid and phosphatidylinositol 3,5-bisphosphate were used to demon

77 For phosphatidylinositol 3,5-bisphosphate, where the two pho

78 ane association (dependent on interaction of phosphatidylinositol 3,5-bisphosphate with the N-termina