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1 ast strains carrying mutations in individual phosphoinositide kinases.
2 tidylinositol and its derivatives are termed phosphoinositide kinases.
3 nerated by the tightly regulated activity of phosphoinositide kinases.
4 opment of potent and selective inhibitors of phosphoinositide kinases.
5  A2 (PLA2), but its action is independent of phosphoinositide kinase 3 (PI3K) and PI4K.
6 B2s did not result in hyperactivation of the phosphoinositide kinase-3/AKT or mitogen-activated prote
7 uction of prosurvival pathways, most notably phosphoinositide kinase-3/Akt, after oxaliplatin.
8 s5P)-4-kinases (PIP4Ks) are stress-regulated phosphoinositide kinases able to phosphorylate PtdIns5P
9               These two chimeras also showed phosphoinositide kinase activity in vitro when immunoads
10 most abundant and widely expressed mammalian phosphoinositide kinase activity is contributed by phosp
11 -organizing system consisting of a bacterial phosphoinositide kinase and its opposing phosphatase tha
12 target inhibitory activity against the human phosphoinositide kinases and MINK1 and MAP4K kinases, wh
13 a co-factor which stimulates the activity of phosphoinositide kinases and phospholipase C (PLC) by pr
14  site of use by the concerted actions of the phosphoinositide kinases and PLC.
15 examples of how we have used HDX-MS to study phosphoinositide kinases and the protein kinase Akt.
16                         The PI5P4K family of phosphoinositide kinases and their substrates and produc
17       GTP-binding proteins, protein kinases, phosphoinositide kinases, and protein phosphatases all p
18 e ATP-binding core and demonstrates that all phosphoinositide kinases belong to one superfamily.
19 membrane-bound substrate and ATP shows how a phosphoinositide kinase can phosphorylate its substrate
20                         We show that diverse phosphoinositide kinases can be assayed using this appro
21      Finally, we show that several different phosphoinositide kinases colocalize with PTP-MEG2, thus
22 eceptor responsiveness, we overexpressed the phosphoinositide kinase domain of PI3K (which disrupts b
23                                              Phosphoinositide kinases, extending beyond the well-know
24  current understanding of the lesser-studied phosphoinositide kinase families, PI4K and PIPK, focusin
25 about the substrate selectivity of different phosphoinositide kinase families.
26  is phosphorylated by protein kinases of the phosphoinositide kinase family, including ATM, ATR or DN
27 PtdIns(3,5)P(2)-synthesizing enzyme PIKfyve (phosphoinositide kinase for position 5 containing a FYVE
28      Apilimod dimesylate is a first-in-class phosphoinositide kinase, FYVE-type zinc finger-containin
29                       Our data indicate that phosphoinositide kinases have multiple roles in the regu
30 plasma membranes, where it can interact with phosphoinositide kinases implicated in actin assembly re
31 f the molecular basis for the involvement of phosphoinositide kinases in disease and assesses the pre
32 ealed opportunities for targeting almost all phosphoinositide kinases in human diseases, including ca
33 we identified and validated the tyrosine and phosphoinositide kinase inhibitor PP121 as a robust indu
34 y tetanus toxin and by phenylarsine oxide, a phosphoinositide kinase inhibitor.
35  the preclinical and clinical development of phosphoinositide kinase inhibitors.
36                      SMG1 is a member of the phosphoinositide kinase-like kinase family of proteins t
37                  Recent studies suggest that phosphoinositide kinases may participate in intracellula
38                          Adenoviral-mediated phosphoinositide kinase overexpression significantly inc
39 hair cells and that, in conjunction with the phosphoinositide kinase PI-4Kbeta1, RHD4 regulates the a
40 ublications have reported the implication of phosphoinositide kinase PI3Kbeta in PTEN-deficient cell
41     By interacting with betaARK1 through the phosphoinositide kinase (PIK) domain, phosphoinositide 3
42  three other cortical structures, eisosomes, phosphoinositide kinase (PIK) patches, and the TORC2 com
43 itment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches.
44                                The mammalian phosphoinositide kinase PIKfyve catalyzes the synthesis
45         Here we have examined whether the 5'-phosphoinositide kinase PIKfyve, reported previously to
46 rotein) in yeast-two hybrid screens with the phosphoinositide kinase PIKfyve.
47  carcinoma cell line (TCCSUP) identified the phosphoinositide kinase, PIKfyve, as a potential compone
48                                              Phosphoinositide kinases play central roles in signal tr
49 fying enzymes including sphingomyelinase and phosphoinositide kinases regulate the generation and deg
50 known as mTOR and RAFT-1) is a member of the phosphoinositide kinase related kinase family.
51                                              Phosphoinositide kinases such as PI3-kinase synthesize l
52  the preclinical and clinical development of phosphoinositide kinase-targeting molecules.
53                                   PI4KA is a phosphoinositide kinase that is highly expressed in the
54 linositol 5-phosphate 4-kinase (dPIP4K) as a phosphoinositide kinase that regulates growth during lar
55            Here we report that PI5P4Kbeta, a phosphoinositide kinase that regulates PI(5)P levels, de
56                       PI5P4Ks are a class of phosphoinositide kinases that phosphorylate PI-5-P to PI
57 otein determines an important novel class of phosphoinositide kinases that seems to be targeted to sp
58 ce that cell volume increases also stimulate phosphoinositide kinases, the purpose of these studies w