ライフサイエンスコーパス: phosphoinositide phosphatase

1 cloning and was found to encode a Sac1p-like phosphoinositide phosphatase.

2 mechanism uncovered INP53, a gene encoding a phosphoinositide phosphatase.

3 II secreted Salmonella effector protein with phosphoinositide phosphatase activity and a distinct GTP

4 In cell-free assays, reduced phosphoinositide phosphatase activity correlated with in

5 ty protein phosphatase and also possesses D3-phosphoinositide phosphatase activity on phosphatidylino

6 re, we show that SopB/SigD, an effector with phosphoinositide phosphatase activity, has anti-apoptoti

7 c1 proteins individually defective in either phosphoinositide phosphatase activity, or in recycling o

8 It acts as a phosphoinositide phosphatase and consists of an amino-te

9 In addition, we show that the phosphoinositide phosphatase and tensin homolog deleted

10 , we addressed the reverse process driven by phosphoinositide phosphatases and uncovered a key negati

11 ng enzymes, including phospholipase C (PLC), phosphoinositide phosphatase, and diacylglycerol (DAG) k

12 enzymes involved in PIP metabolism--Sac1p, a phosphoinositide phosphatase, and Vps34p and Pik1p, a PI

13 al that the main domains of VSPs and related phosphoinositide phosphatases are intrinsically modular

14 have previously identified synaptojanin 2, a phosphoinositide phosphatase, as an effector of Rac1.

15 (mtm), a Drosophila melanogaster MTM1/MTMR2 phosphoinositide phosphatase, as necessary and sufficien

16 ase (PLIP), which defines a new subfamily of phosphoinositide phosphatases clearly distinct from PTEN

17 Salmonella recruited ARNO via Arf6 and the phosphoinositide phosphatase effector SopB-induced PIP3

18 as identified and shown to encode a putative phosphoinositide phosphatase, Fig4.

19 r survival outcome in AML independent of its phosphoinositide phosphatase function.

20 ase domain of synaptojanin 1 (SJ1/PARK20), a phosphoinositide phosphatase implicated in synaptic vesi

21 tested the hypothesis that synaptojanin 1, a phosphoinositide phosphatase implicated in the endocytos

22 Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin unco

23 ng a new perspective on the function of this phosphoinositide phosphatase in health and development.

24 magnesium-activated PtdIns(3,5)P2-selective phosphoinositide phosphatase in vitro.

25 The biological relevance of most of these phosphoinositide phosphatases in acute myeloid leukemia

26 family of disease-related myotubularin (MTM) phosphoinositide phosphatases includes catalytically ina

27 ddition to recombinant versions of the Sac1p phosphoinositide-phosphatase indicated that PI(4)P was r

28 tream of PIK3CA in a manner dependent on the phosphoinositide phosphatase INPP4B.

29 ns that lack expression of synaptojanin 1, a phosphoinositide phosphatase involved in clathrin-coated

30 In LNCaP prostate cancer cells, the PTEN phosphoinositide phosphatase is inactivated, leading to

31 Synaptojanin (Synj), a phosphoinositide phosphatase, is known to play an import

32 hosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein co

33 INPP5E is a ciliary phosphoinositide phosphatase mutated in ciliopathies lik

34 Sac1 is a phosphoinositide phosphatase of the endoplasmic reticulu

35 In contrast to previously characterized phosphoinositide phosphatases, PLIP has a preference for

36 egatively targeting the tumor suppressor and phosphoinositide phosphatase PTEN (phosphatase and tensi

37 gand found within the C-terminal tail of the phosphoinositide phosphatase PTEN revealed two discrete

38 s activated by loss of the tumour suppressor phosphoinositide phosphatase PTEN.

39 we describe a defect in expression of the D3 phosphoinositide phosphatase, PTEN, in Jurkat and JTAg T

40 FIG4 encodes a phosphoinositide phosphatase required for regulation of

41 We identified the conserved phosphoinositide phosphatase Sac1 as a Drosophila VAP (D

42 functions between Sac1p and other homologous phosphoinositide phosphatases, sac1(ts) mutant cells lac

43 We analyzed the primary role of the phosphoinositide phosphatase Sac1p in Saccharomyces cere

44 ns are known to physically interact with the phosphoinositide phosphatase Sac1p.

45 The 5-phosphoinositide phosphatase Sac3, in which loss-of-func

46 and gene ablation in mice suggested that two phosphoinositide phosphatases, SH2 domain-containing ino

47 Here, we report that the phosphoinositide phosphatase SopB, a Salmonella Typhimur

48 his PPB-independent mechanism depends on the phosphoinositide phosphatase SUPPRESSION OF ACTIN 9 (SAC

49 , we functionally characterized the putative phosphoinositide phosphatase SUPPRESSOR OF ACTIN9 (SAC9)

50 s required for proper neurotransmission, the phosphoinositide phosphatase synaptojanin 1 is a key reg

51 philin also binds the GTPase dynamin and the phosphoinositide phosphatase synaptojanin and is thought

52 ially suppressed by removing one copy of the phosphoinositide phosphatase synaptojanin, suggesting a

53 g diameters, we show that the major synaptic phosphoinositide phosphatase, synaptojanin 1 (Synj1), ac

54 Fig4 is a phosphoinositide phosphatase that converts PI3,5P2 to PI

55 Here, we found that SopB, a phosphoinositide phosphatase that is delivered into host

56 The tumor suppressor gene PTEN is a phosphoinositide phosphatase that is inactivated by dele

57 FIG4 is a phosphoinositide phosphatase that is mutated in several

58 Myotubularin is a 3-phosphoinositide phosphatase that is mutated in X-linked

59 Here, we screen for phosphoinositide phosphatases that influence autophagy i

60 EN suppresses tumor formation by acting as a phosphoinositide phosphatase to limit signaling by phosp

61 Synaptojanin1 (synj1) is a phosphoinositide phosphatase with dual SAC1 and 5'-phosp