ライフサイエンスコーパス: phospholipase

1 TT>deltaG, rs12979860 C>T, and patatin-like phospholipase-3 rs738409 C>G polymorphisms were genotype

2 tinized the unfolded state of outer-membrane phospholipase A (OmpLA) to provide a detailed view of it

3 chniques, we discover that ACT has intrinsic phospholipase A (PLA) activity, and that such activity d

4 Plant phospholipase A (PLA) catalyzes the hydrolysis of PC to

5 The phospholipase A and acyltransferase (PLAAT) family of cy

6 Castor patatin-like phospholipase A IIIbeta facilitates the exclusion of hyd

7 s comprising sequential sn-1 hydrolysis by a phospholipase A(1) (e.g. by patatin-like phospholipase d

8 onoyl-lysophospholipids produced from either phospholipase A(1)-mediated hydrolysis of diacyl arachid

9 semblies of 5-LO and FLAP included cytosolic phospholipase A(2) (cPLA(2)) and were linked to LTB(4) p

10 hain (ETC) derived H(2)O(2) versus cytosolic phospholipase A(2) (cPLA(2)) derived LOOHs in neurogenic

11 y binds to and activates group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) to stimulate the produ

12 Ca(2+)-independent phospholipase A(2) (GVIA iPLA(2)) has gained increasing

13 Lipoprotein associated phospholipase A(2) (Lp-PLA(2)) has been characterized fo

14 uller glia and Xenopus oocytes, but required phospholipase A(2) (PLA(2)) activity exclusively in Mull

15 Recently, a phospholipase A(2) (PLA(2)) encoded by a majority of A.

16 Phospholipase A(2) (PLA(2)) enzyme could be acted as a u

17 ties of 15-lipoxygenase (15-LO) and secreted phospholipase A(2) (sPLA(2)) are needed for the formatio

18 Secreted phospholipase A(2) (sPLA(2)) enzymes release free fatty

19 SAA increases simultaneously with secretory phospholipase A(2) (sPLA(2)), compelling us to determine

20 associated with elevated levels of secreted phospholipase A(2) (sPLA(2)).

21 function through glutathione peroxidase and phospholipase A(2) activity.

22 (VEGFs), angiopoietins (Angs), and secreted phospholipase A(2) enzymes (sPLA(2) ) were evaluated.

23 nditions in which both sphingomyelinases and phospholipase A(2) enzymes are activated, such as during

24 Secretory phospholipase A(2) group IIA (PLA2G2A) is a phospholipas

25 Secretory phospholipase A(2) group IIA enhances the metabolic rate

26 elles; (iv) removal of bound phospholipid by phospholipase A(2) inactivates the cytochrome complex; a

27 ts in remission who tested positive for anti-phospholipase A(2) receptor (PLA2R) antibodies, the decl

28 Antibodies against phospholipase A(2) receptor 1 (PLA(2)R1) are found in 80

29 ed for IL-33 to activate group IVa cytosolic phospholipase A(2) with consequent AA release for synthe

30 ed kinase, an upstream effector of cytosolic phospholipase A(2), which was restored by exogenous PGH(

31 tion in most mammalian cells is initiated by phospholipase A(2)-mediated release of arachidonic acid,

32 the release of arachidonic acid by cytosolic phospholipase A(2)alpha (cPLA(2)alpha) followed by its e

33 protein kinase A, target of rapamycin (TOR), phospholipase A, and ERK1, but does not require the PI3

34 The beta-neurotoxic secreted phospholipases A(2) (sPLA(2)s) block neuro-muscular tran

35 chromatographic-mass spectrometric assay for phospholipases A(2) to perform inhibition analysis using

36 cytosolic, calcium-independent, and secreted phospholipases A(2) were used to establish and validate

37 (WDCL) and enzymatic degumming (EDCL) using phospholipase A1 (PLA1).

38 PLIP1 is a phospholipase A1 In vivo, PLIP1 hydrolyzes polyunsaturat

39 he interaction of the C2 domain in cytosolic phospholipase A2 (cPLA2) with the CARD domain in mitocho

40 released during seizures activates cytosolic phospholipase A2 (cPLA2), resulting in P-gp and BCRP ove

41 mediated activation of the calcium-dependent phospholipase A2 (cPLA2).

42 acid by phospholipase A2, and the cytosolic phospholipase A2 (cPLA2)alpha isoform has been specifica

43 ike 2 protein (PLBL2) and Group XV lysosomal phospholipase A2 (LPLA2).

44 Phospholipase A2 (PLA)-specific B cells were identified

45 For ED, phospholipase C (PLC), phospholipase A2 (PLA2) and a mixture of phospholipases

46 Inhibition of phospholipase A2 (PLA2) has long been considered for tre

47 ions of S1P in vitro In addition, inhibiting phospholipase A2 (PLA2) or lipoxygenase (Lox) blocks che

48 n after lung challenge with S. pneumoniae As phospholipase A2 (PLA2) promotes the release of AA, we i

49 of cancer cells was critically dependent on phospholipase A2 (PLA2) to mobilize lysophospholipids an

50 The antioxidant effect of porcine pancreatic phospholipase A2 (PLA2) was previously demonstrated.

51 Adipose-specific phospholipase A2 (PLA2G16) was recently identified as a

52 ays, we found expression levels of secretory phospholipase A2 (sPLA2), lysophospholipid acyltransfera

53 Increased cytosolic phospholipase A2 activity and lyso-phosphatidylcholine (

54 easurement of prostaglandin E2 and cytosolic phospholipase A2 activity in membrane fractions of fibro

55 Treatment with PEDF activates the phospholipase A2 activity of the PEDF-receptor (PEDF-R)

56 onses are elicited through lipid products of phospholipase A2 activity that acts on the membrane phos

57 ane of eukaryotic cells, where it exerts its phospholipase A2 activity upon interacting with ubiquiti

58 hospholipases, which have been shown to have phospholipase A2 activity.

59 red by the HDL oxidative-inflammatory index; phospholipase A2 activity; and sphingosine-1-phosphate,

60 tion of an intracellular interaction between phospholipase A2 and a mechanosensitive channel present

61 small ubiquitin-like modifier (SUMO) domain, phospholipase A2 and PrsW-family protease domain.

62 Similarly, annexin A5 and phospholipase A2 blocked >95% of myosin-supported activi

63 cid after activation of the CB2 receptor and phospholipase A2 by lenabasum.

64 hile the PmMDV VP sequence lacks a canonical phospholipase A2 domain, the structure of an EDTA-treate

65 Phospholipase A2 enzymes (PLA2) are known to mediate mem

66 d FA production in oilseeds and suggest that phospholipase A2 enzymes rather than LPCAT mediate the h

67 Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived en

68 In patient plasma, we identified phospholipase A2 group IB (PLA2G1B) as the key molecule

69 Cytosolic phospholipase A2 is a key regulator of blood-brain barri

70 long the glomerular basement membrane (GBM), phospholipase A2 receptor (PLA2R) and thrombospondin typ

71 The phospholipase A2 receptor (PLA2R) and thrombospondin typ

72 extracted IgG was determined by ELISA using phospholipase A2 receptor (PLA2R) or Gd-IgA1 as antigen.

73 ting serum autoantibodies against the M-type phospholipase A2 receptor (PLA2R-AB) are a key biomarker

74 The phospholipase A2 receptor (PLA2R1) is the major autoanti

75 tly discovered podocyte antigens: the M-type phospholipase A2 receptor 1 (PLA2R) and thrombospondin t

76 oxisomal trans-2-enoyl-coenzyme A reductase, phospholipase A2 receptor, protein kinase C zeta type, t

77 e ExoU type III secretion enzyme is a potent phospholipase A2 secreted by the Gram-negative opportuni

78 ity to induce prostaglandin E2 and cytosolic phospholipase A2 synthesis in patients' fibroblasts.

79 e protein (hsCRP) and lipoprotein-associated phospholipase A2 were measured 1 month after AMI.

80 ion is the liberation of arachidonic acid by phospholipase A2, and the cytosolic phospholipase A2 (cP

81 gnaling through the NMDA receptor, cytosolic phospholipase A2, COX-2, and mPGES-1 increases P-gp prot

82 (COX-2)/prostaglandin E2 signaling cascade (phospholipase A2, COX-2, multidrug resistance protein 4,

83 adult mice expressed more group 10 secretory phospholipase A2, Wnt5a, and transglutaminase 2 (Tgm2).

84 a loss of function sequence variation in the phospholipase A2-activating protein encoding gene (PLAA)

85 PAF-AH2, an oxidized-phospholipid-selective phospholipase A2.

86 crosis factor-alpha, C-reactive protein, and phospholipase A2.

87 ipid as a novel substrate of honey bee venom phospholipase A2.

88 imulated TRPV4 opening through activation of phospholipase A2.

89 Phospholipase A2/5-lipoxygenase/leukotriene-B4 (PLA2/5-L

90 CR and two isoforms of the allergen Api m 1 (phospholipase A2: PLA2) in HBV.

91 c activity of soluble lipoprotein-associated phospholipase A2; at CYP2F1, with higher plasma interleu

92 Cytosolic phospholipase A2alpha (cPLA2alpha) has been shown to be

93 ding to the activation of Ca(2+)-independent phospholipase A2gamma (iPLA2gamma) and the production of

94 yl chains from CL by the calcium-independent phospholipase A2gamma (iPLA2gamma)-selective inhibitor (

95 phorylation-dependent, allosteric control of phospholipase activation.

96 sure the inhibitory effect of XEN445 on LIPG phospholipase activity and determine its IC50.

97 The endothelial lipase LIPG possesses serine phospholipase activity and is involved in lipoprotein me

98 substrates produced high-resolution maps of phospholipase activity and specificity, which could subs

99 thogen, Pseudomonas aeruginosa Activation of phospholipase activity is induced by protein-protein int

100 anism by which this coactivator enhances the phospholipase activity of ExoU.

101 XEN445, a specific inhibitor targeting LIPG phospholipase activity, impacts on TNBC tumor formation

102 s, myristoylated peptides, and proteins with phospholipase activity.

103 While many pathogen-derived phospholipases also manipulate the immune response, they

104 acute chemogenetic activation of PI-specific phospholipase and 4-kinase.

105 the activation of Bruton's tyrosine kinase, phospholipase and phosphoinositide-3-kinase, calcium, an

106 ocytogenes revealed distinctions between its phospholipases and those previously discovered in other

107 tion in MATRILINEAL (MTL), a pollen-specific phospholipase, and that novel edits in MTL lead to a 6.7

108 Phospholipases are abundant in various types of cells an

109 Parasite-derived patatin-like phospholipases are likely effective drug targets and pro

110 Phospholipase As (PLAs) may be directly involved in the

111 s known to impact biologics product quality, Phospholipase B-like 2 protein (PLBL2) and Group XV lyso

112 Phospholipase B-mediated hydrolysis of phosphatidylcholi

113 m channel currents (G(i)), and activation of phospholipase C (G(q)).

114 product of the phosphatidylcholine-specific phospholipase C (PC-PLC) of L. monocytogenes, is a poten

115 The activation of phosphoinositide-specific phospholipase C (PI-PLC) is one of the earliest response

116 in O (LLO) and phosphatidylinositol-specific phospholipase C (PI-PLC).

117 ototransduction in Drosophila is mediated by phospholipase C (PLC) and Ca(2+)-permeable TRP channels,

118 Stimulating the same receptors activated phospholipase C (PLC) and decreased plasma membrane PI(4

119 te coupling of the receptor to activation of phospholipase C (PLC) but not phospholipase D (PLD).

120 s been shown to activate a calcium-sensitive phospholipase C (PLC) enzyme and to lead to a robust dec

121 Phospholipase C (PLC) enzymes are key virulence factors

122 tein (GP) VI, or the GPVI signaling effector phospholipase C (PLC) gamma2.

123 tors and receptor tyrosine kinases, activate phospholipase C (PLC) isozymes to hydrolyze phosphatidyl

124 the G-protein-coupled receptor (GPCR)-Gq/11-phospholipase C (PLC) pathway.

125 receptors, in which melatonin transactivates phospholipase C (PLC) through 5-HT(2C) .

126 For ED, phospholipase C (PLC), phospholipase A2 (PLA2) and a mix

127 the fibroblast growth factor (FGF) receptor, phospholipase C (PLC), protein kinase C (PKC) and phosph

128 istically, intra-sciatic MBP(84-104) induced phospholipase C (PLC)-driven (females) and phosphoinosit

129 elta) was phosphorylated at threonine 505 by phospholipase C (PLC)-mediated signaling at the early st

130 ily by virtue of its role as a substrate for phospholipase C (PLC).

131 riginate with IP(3) generated from PIP(2) by phospholipase C (PLC).

132 PI(4,5)P(2) hydrolysis is mediated by phospholipase C (PLC).

133 factor (PDGF) requires signaling through the phospholipase C (PLC)/protein kinase C (PKC) pathway.

134 requires G protein alpha q subunit (Galphaq)/phospholipase C (PLC)beta1 activities and protein kinase

135 requires G protein alpha q subunit (Galphaq)/phospholipase C (PLC)beta1/protein kinase C (PKC) activi

136 Phospholipase C (PLC)s degrade phosphatidylinositol-4, 5

137 predicted virulence factors, the presence of phospholipase C (plcC), which is a major virulence facto

138 itment of TRPC3 or phosphoinositide-specific phospholipase C (PLCgamma) to the AT1R-beta-arrestin-1 s

139 Vibration caused phospholipase C activation, transient increases in cytos

140 pathway involving phosphoinositide-specific phospholipase C and diacylglycerol lipase alpha is known

141 A agonist A61603-stimulated phosphoinositide-phospholipase C and myocyte contraction.

142 from intracellular stores via activation of phospholipase C and opening of inositol trisphosphate (I

143 naling pathways activated by CD44, including phospholipase C and phosphoinositide 3-kinase (PI3K), al

144 In contrast, inhibition of phospholipase C and phosphoinositide 3-kinase did not pr

145 se embryo at the 8-cell stage is directed by Phospholipase C and Protein kinase C and occurs in two p

146 ipase C gamma and G protein-coupled receptor/phospholipase C beta activities.

147 eved either by agonist-induced activation of phospholipase C beta or with a rapamycin-inducible syste

148 effect of NAC on Galphaq palmitoylation and phospholipase C beta-mediated signaling in endothelial c

149 ng components (i.e., G-protein gustducin and phospholipase C beta2).

150 sphate counteracted the direct activation of phospholipase C by 2,4,6-trimethyl-N-[3-(trifluoromethyl

151 ed by cAMP (Epac) provokes inhibition of the phospholipase C by an as yet unknown mechanism.

152 a somatic p.S745L (c.2234 G > A) mutation in phospholipase C delta 1 (PLCD1), a proposed tumor suppre

153 ition by the default PI(4,5)P2 lipid sensor, phospholipase C delta 1 pleckstrin homology domain (PLC

154 Phospholipase C Gamma 1 (PLCG1) is frequently mutated in

155 Phospholipase C gamma 1 (Plcgamma1) has been implicated

156 eam of the gene encoding the B cell-specific phospholipase C gamma 2 (PLCG2), a B cell-specific enzym

157 Inhibition of the phospholipase C gamma 2 (PLCG2)/inositol 1,4,5-trisphosp

158 mics depend on both receptor tyrosine kinase/phospholipase C gamma and G protein-coupled receptor/pho

159 GE(2) interfered with the phosphorylation of phospholipase C gamma-1 and extracellular signal-regulat

160 (1) receptors for ATP; and (4) inhibitors of phospholipase C or IP3 receptors.

161 -protein-coupled receptors that activate the phospholipase C pathway, leading to the hydrolysis of ph

162 lation induced by vibration was dependent on phospholipase C pathways, including calcium, protein kin

163 adaptive immune response, integrin, PTEN and phospholipase C signaling, serotonin and tryptophan meta

164 ion of cell-surface receptors that couple to phospholipase C to generate the second messenger inosito

165 ation of phosphatidylcholine biosynthesis by phospholipase C treatment induces the partial nuclear-to

166 Phospholipase C, a key enzyme playing critical roles in

167 Galphaq, on the other hand, signals through phospholipase C, and it remains unclear whether Galphaq-

168 y due to the hydrolytic activity of Sac2 and phospholipase C, becoming undetectable for approximately

169 of the nerves requires the beta3 isoform of phospholipase C, but TRPA1 or other TRP channel are not

170 Inhibition of G (betagamma,) phospholipase C, or protein kinase C mimicked agonist re

171 etabotropic P2Y(1) receptors, recruitment of phospholipase C, release of Ca(2+) from the internal sto

172 in Na/K-ATPase signaling, such as caveolin, phospholipase C, Src, and the IP3 receptor.

173 ototransduction in Drosophila is mediated by phospholipase C, which activates TRP cation channels by

174 gamma subunits, and some Rho family GTPases, phospholipase C-beta (PLC-beta) isoforms hydrolyze phosp

175 This function depends on an alternative phospholipase C-beta enzyme, encoded by PLC21C, presumab

176 rt because of its potentiation downstream of phospholipase C-coupled receptors that regulate phosphoi

177 Direct activation of the human phospholipase C-gamma isozymes (PLC-gamma1, -gamma2) by

178 disclosed many mutations in PLCG2, encoding phospholipase C-gamma(2) (PLCgamma(2)).

179 , leads to the recruitment and activation of phospholipase C-gamma1 (PLC-gamma1), an important effect

180 c, phosphatidylinositol 3-kinase (PI3K), and phospholipase C-gamma1 (PLCgamma1) have all been implica

181 of linker of activation of T cells (LAT) and phospholipase C-gamma1 (PLCgamma1), signaling proteins t

182 osensor based on the tandem SH2 domains from phospholipase C-gamma1 (PLCgamma1), tSH2-WT, has been us

183 the enzymatic action of dPLCXD, an atypical phospholipase C.

184 bnormalities in the PLC/IP3/PKC/ERK pathway (phospholipase C/inositol 1,4,5-triphosphate/protein kina

185 e determinants of pathogenesis: two secreted phospholipases C (PLCs; PlcA and PlcB) and a surface pro

186 ion of IP3 (inositol-1,4,5-trisphosphate) by phospholipase-C and accordingly were not stimulated by p

187 at activation of tropomyosin kinase B (TrkB)-phospholipase-C-gamma-1 (PLCgamma1) signaling induced by

188 rrounding epithelial cells by calretinin and phospholipase C140 immunoreactivity.

189 bidopsis thaliana) phosphoinositide-specific phospholipase C2 functions in the endoplasmic reticulum

190 roduction, here we show that the nonspecific phospholipase C6 (NPC6) promotes seed oil production in

191 aradigmatic mechanism involves activation of phospholipase Cbeta (PLCbeta) enzymes by G protein betag

192 itogenic ERK signaling rather than canonical phospholipase Cbeta (PLCbeta) signaling driven by these

193 pha(q) in Gbetagamma-dependent activation of phospholipase Cbeta (PLCbeta).

194 sponses in cells are mediated by the Galphaq/phospholipase Cbeta (PLCbeta)/phosphatidylinositol 4,5-b

195 The second pathway activates phospholipase Cbeta and induces myosin light chain phosp

196 The functions of phospholipase Cbeta and protein kinase C were required f

197 Phospholipase Cbeta is necessary for OXTR-mediated excit

198 ification cascade that includes a G-protein, phospholipase Cbeta, and the TRP channel, TRPA1.

199 Phospholipase Cbeta1 is activated by Galphaq to generate

200 on potential discharge was largely absent in phospholipase Cbeta3 knockout animals.

201 cation channels requires G(i/o) proteins and phospholipase-Cdelta1 (PLCdelta1) activation by intracel

202 ive G(i/o) proteins, with a co-dependence on phospholipase-Cdelta1 (PLCdelta1).

203 Phospholipase Cepsilon (PLCepsilon) is activated downstr

204 -mediated interference screen, we identified phospholipase Cepsilon 1 (PLCepsilon1) as a crucial regu

205 RhoGTPases (RhoA and Rac1), phospholipases (phospholipases Cepsilon and Cgamma1), and phosphoinositi

206 deficiency did not affect phosphorylation of phospholipase Cgamma or Ca(2+) influx, it was associated

207 o interacts with the p85 subunit of PI3K and phospholipase Cgamma, enzymes that deplete plasma membra

208 Phospholipases Cgamma (PLCgamma) 1 and 2 are a class of

209 Here, we report that mice lacking phospholipase Cgamma1 (PLCgamma1) in the forebrain (Plcg

210 emonstrated that TrkB-mediated activation of phospholipase Cgamma1 is required for epileptogenesis.

211 discovered that TrkB-mediated activation of phospholipase Cgamma1 promotes epileptogenesis.

212 tions in Bruton tyrosine kinase (BTK) and/or phospholipase Cgamma2 (PLCG2) genes.

213 ase)-Syk (spleen tyrosine kinase)-PLCgamma2 (phospholipase Cgamma2) pathway.

214 xperiments revealed that AGB1 interacts with phospholipase Cs (PLCs), and Ca(o) induced InsP3 product

215 release in mouse eggs, including addition of phospholipase Czeta cRNA, which mimics natural fertiliza

216 ns 1 and 2, Miros 1 and 2, and mitochondrial phospholipase D (mitoPLD) all localize to discrete, regu

217 N-Acyl-phosphatidylethanolamine phospholipase D (NAPE-PLD) (EC 3.1.4.4) catalyzes the fi

218 N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) catalyzes the cleavage of mem

219 N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is regarded as the main enzym

220 n of phagocytosis by the FcgammaR stimulates phospholipase D (PLD) activity and triggers the producti

221 Recent evidence suggested the involvement of phospholipase D (PLD) and its product phosphatidic acid

222 gut microorganisms can hydrolyse PC using a phospholipase D (PLD) enzyme and further convert the rel

223 h for imaging physiological PA production by phospholipase D (PLD) enzymes.

224 In animals, the enzyme phospholipase D (PLD) has been shown to generate alcohol

225 Phospholipase D (PLD) hydrolyzes membrane phospholipids

226 hat D-series resolvins (RvD1- RvD5) activate phospholipase D (PLD), a ubiquitously expressed membrane

227 cum virulence factors, arcanolysin (ALN) and phospholipase D (PLD), affect the ability of the bacteri

228 We exploited a microbial phospholipase D (PLD), which produces PA by phosphatidyl

229 nd on EGFR and the newly identified mediator phospholipase D (PLD), which promotes both mTORC1-depend

230 ino acids and growth factors also induce the phospholipase D (PLD)-phosphatidic acid (PA) pathway, re

231 activation of phospholipase C (PLC) but not phospholipase D (PLD).

232 t deletion and pharmacological inhibition of phospholipase D (PLD)2, which generates the signaling li

233 ently reported that the inducible isoform of phospholipase D (PLD1) was significantly increased in sy

234 M-interacting proteins in B cells, including phospholipase D 1 (PLD1), and kinase adaptor proteins AK

235 the individual activities of arcanolysin and phospholipase D affect A. haemolyticum host-pathogen int

236 However, a lipolytic enzyme Phospholipase D alpha1 (OsPLDalpha1) causes rancidity an

237 line to choline was found to be catalysed by phospholipase D enzymes from diverse members of the gut

238 hat increased phosphatidic acid derived from Phospholipase D leads to defects in binary cell-fate dec

239 ndings suggest that A. haemolyticum utilizes phospholipase D primarily for adherence and utilizes arc

240 ysis revealed enrichment of calcium, Wnt and phospholipase D signaling in patients.

241 The sphingomyelinase activity of phospholipase D was necessary to increase bacterial adhe

242 odulation of N-acyl phosphatidylethanolamine phospholipase D).

243 DAG kinases and phospholipase D, the enzymes that produce PA, are identi

244 duction (e.g. PTK2/Focal Adhesion Kinase and Phospholipase D- following chronic RE), TGF-beta signall

245 We propose that Phospholipase D-derived phosphatidic acid promotes ectop

246 ], GPLD1 [phosphate inositol-glycan specific phospholipase D], APOE [apolipoprotein E], IHH [Indian h

247 glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived

248 Here, we evaluated the effects of a phospholipase D1 (PLD1)-selective inhibitor (VU0155069)

249 urane) activate TREK-1 through disruption of phospholipase D2 (PLD2) localization to lipid rafts and

250 We examined the role of phospholipase D2 (PLD2) on acetaminophen (APAP)-induced

251 In this work, we show that phospholipase D2 (PLD2) was overexpressed in colon tumor

252 We show that knockout of phospholipase D2 (PLD2), which generates the signaling l

253 stream of ARF6 small GTPase and its effector phospholipase D2, directly phosphorylating the conserved

254 Phospholipase D3 (PLD3) and phospholipase D4 (PLD4), the

255 Phospholipase D4 (PLD4), a single-pass transmembrane gly

256 Phospholipase D3 (PLD3) and phospholipase D4 (PLD4), the most recently described lys

257 GS1) protein and a lipid-hydrolyzing enzyme, phospholipase Dalpha1 (PLDalpha1), both act as GTPase-ac

258 Carriage of rs738409:G in patatin-like phospholipase domain containing 3 (PNPLA3) is associated

259 oid X receptor [FXR] activity), patatin-like phospholipase domain containing 3 (PNPLA3), and transmem

260 , combining variants in PNPLA3 (patatin-like phospholipase domain containing 3), MBOAT7 (membrane bou

261 genetic modifiers (variants in patatin-like phospholipase domain containing 3, transmembrane 6 super

262 in mitochondria, iPLA(2)gamma (patatin-like phospholipase domain containing 8 (PNPLA8)), possesses s

263 membrane-embedded protein or as a truncated phospholipase domain that remains associated with the ou

264 ent and donor TM6SF2 genotypes, patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 geno

265 ion and genetic variants in the patatin-like phospholipase domain-containing 3 (PNPLA3), transmembran

266 y a phospholipase A(1) (e.g. by patatin-like phospholipase domain-containing 8 (PNPLA8)), direct enzy

267 or four steatogenic alleles in patatin-like phospholipase domain-containing protein 3 (PNPLA3) and t

268 iver disease markers, including patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M

269 A variant (148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is a

270 identified a variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) that

271 Three genetic variants (patatin-like phospholipase domain-containing protein 3 [PNPLA3] p.I14

272 Neither patatin-like phospholipase domain-containing protein 3 rs738409 nor t

273 Emerging evidence suggests that patatin-like phospholipase domain-containing protein-3 (PNPLA3) rs738

274 In this study, two Arabidopsis phospholipase Dzeta genes (AtPLDzeta1 and AtPLDzeta2 ) w

275 ExoU, a type III secreted phospholipase effector of Pseudomonas aeruginosa, serves

276 ls 2 (TREM2) and, more recently, in PLCG2, a phospholipase-encoding gene expressed in microglia.

277 Neither virion requires PLA2G16, a phospholipase essential for entry of other picornaviruse

278 t lipid substrates with secreted lipases and phospholipases for nutrient acquisition, colonization, a

279 ompelling evidence that the active site of a phospholipase from Vibrio vulnificus employs the anion i

280 recent work has demonstrated that the major phospholipase in mitochondria, iPLA(2)gamma (patatin-lik

281 nd characterize the role of Type Vd secreted phospholipases in Gram-negative bacteria.

282 researchers to dissect the complex roles of phospholipases in lipid metabolism, cellular signaling a

283 Studies on the roles of phospholipases in Listeria monocytogenes revealed distin

284 functional redundancy of the B. pseudomallei phospholipases in virulence.

285 nthetic lethality for the yeast sphingolipid phospholipase ISC1, we identified two groups of genes.

286 signaling/metabolic pathways, where specific phospholipases may act as effectors that control key dev

287 e, we show that a P. falciparum patatin-like phospholipase (PfPATPL1) with PLA2 activity plays a key

288 hways, including RhoGTPases (RhoA and Rac1), phospholipases (phospholipases Cepsilon and Cgamma1), an

289 Importantly, we uncovered a role for the phospholipase PLA2G6 (PNPLA9, iPLA2beta), known to metab

290 Gbeta proteins with a specific patatin-like phospholipase, pPLAIIIdelta.

291 Host phospholipase products are involved in stimulating and r

292 C), phospholipase A2 (PLA2) and a mixture of phospholipases Purifine 3G (3G) were used.

293 ExoU is a patatin-like A2 phospholipase requiring the cellular host factors phosph

294 e in gametogenesis, thereby identifying PLA2 phospholipases such as PfPATPL1 as potential targets for

295 Recent work suggests that a phospholipase T6SS effector (TseL) of V. cholerae can in

296 d ethanolamine glycerophospholipids by other phospholipases to generate the corresponding 2-arachidon

297 aeruginosa strains that express this potent phospholipase toxin.

298 ether with biochemical studies with purified phospholipases, we investigate the effect of their enzym

299 phospholipase A(2) group IIA (PLA2G2A) is a phospholipase which has a role in inflammation, atheroge

300 y pathogens contain a family of patatin-like phospholipases, which have been shown to have phospholip