ライフサイエンスコーパス: phospholipase C beta

1 s the activities of PKC, IP(3) receptor, and phospholipase C beta.

2 iting G alpha(q) stimulation of the effector phospholipase C beta.

3 alpha protein responsible for activation of phospholipase C beta.

4 om Galpha(q) to the nucleus independently of phospholipase C-beta.

5 rotein signaling pathways such as Galpha and phospholipase C-beta.

6 pha) from activating its downstream effector phospholipase C-beta.

7 aused a decrement in its ability to activate phospholipase C-beta.

8 mer had no effect on its ability to activate phospholipase C-beta.

9 y protein kinase C, possibly at the level of phospholipase C-beta.

10 hatidylinositol (4,5)-bisphosphate (PIP2) by phospholipase C beta 1 (PLC beta 1) and PLC beta 2 in mi

11 Phospholipase C beta 1 (PLCbeta1), highly expressed in t

12 NHERF2 simultaneously binds phospholipase C beta 1 and an atypical, carboxyl-termina

13 Although phospholipase C-beta 1 deficiency has not previously bee

14 tile spasms were analysed for linkage to the phospholipase C-beta 1 gene locus.

15 ated with a loss-of-function mutation in the phospholipase C-beta 1 gene.

16 Phospholipase C-beta 1 has important functions in both h

17 the promoter element and exons 1, 2 and 3 of phospholipase C-beta 1 in the index case.

18 Linkage to the phospholipase C-beta 1 locus was excluded in the 12 othe

19 Thus, the discovery of a phospholipase C-beta 1 mutation allows us to propose a n

20 q alpha and the single Cys mutants activated phospholipase C-beta 1 normally, while the double Cys mu

21 er, the ETA receptor and downstream effector phospholipase C-beta 1 were co-localized within T-tubule

22 ailed to alter interactions of Gq alpha with phospholipase C-beta 1, the G protein beta gamma subunit

23 yte contractility by activating ETA receptor-phospholipase C-beta 1-PKC-epsilon signaling complexes p

24 es of purified phosphatidylinositol-specific phospholipases C-beta 1 and C-beta 2 to membranes of var

25 ng affinity of phosphatidylinositol-specific phospholipases C-beta 1, even though alpha 11 is a poten

26 Phosphatidic acid (PA) stimulates phospholipase C-beta(1) (PLC-beta(1)) activity and promo

27 role of phosphatidic acid (PA) in regulating phospholipase C-beta(1) (PLC-beta(1)) activity was deter

28 ivity of mammalian phosphoinositide-specific phospholipase C beta 2 (PLC-beta 2) is regulated by the

29 din 1, delta-like 4, BclII modifying factor, phospholipase C, beta 2, adrenergic receptor, beta 1, ac

30 association of phosphatidylinositol-specific phospholipases C-beta 2 even though these subunits stron

31 ype and mutant Gbetagamma subunits activated phospholipase C beta(2) with similar potencies; however,

32 d protein chimeras in which the PH domain of phospholipase C-beta(2) (PLC-beta(2)), which is regulate

33 hmerle (she) encodes a zebrafish ortholog of Phospholipase C, beta 3 (Plcbeta3) required in cranial n

34 Phospholipase C-beta 3 (PLC beta 3) is an important effe

35 tract stimulated P2Y(2) receptors coupled to phospholipase C beta(3), leading to activation of multip

36 As compared to PLC-beta(1), the phospholipase C-beta(3) (PLC-beta(3)) isoform was less s

37 ing-10; G-protein coupled receptor kinase-2; phospholipase C beta-3; arrestin) is predicted and valid

38 ipase C gamma and G protein-coupled receptor/phospholipase C beta activities.

39 a(q) and regulation of G alpha(q)-stimulated phospholipase C beta activity when introduced into full-

40 Phospholipase C-beta activity was similar in depressed s

41 R activated NF-kappaB without an increase in phospholipase C-beta activity, and the response was only

42 activation was paralleled by an increase in phospholipase C-beta activity, and was blocked by pharma

43 the NHERF2 PTH1R complex markedly activates phospholipase C beta and inhibits adenylyl cyclase throu

44 ma(2) were 10-fold less potent in activating phospholipase C-beta and adenylyl cyclase than beta(1)ga

45 ptors couple preferentially to activation of phospholipase C-beta and in some cells to stimulation of

46 timulates CREB transcriptional activity in a phospholipase C-beta and protein kinase C (PKC)-dependen

47 l light-activated ion channels, the effector phospholipase C-beta and protein kinase C.

48 nity and was unable to mediate activation of phospholipase C-beta and the p42/44 mitogen-activated pr

49 s well established that adenylyl cyclase and phospholipase C-beta are two proximal signal effectors f

50 uroactive substances increased the amount of phospholipase C-beta associated with membranes, G(alphaq

51 AGS8 rescued phospholipase C beta binding and regulation by an inacti

52 had no effect, whereas U-73122 inhibition of phospholipase C-beta blocked the response.

53 y inhibited Galpha(q)-mediated activation of phospholipase C-beta both in vitro and in cells, possibl

54 more, these RGS proteins block activation of phospholipase C beta by guanosine 5'-(3-O-thio) triphosp

55 lated HUVEC migration and proliferation in a phospholipase C beta-dependent fashion and decreased Gal

56 hototransduction pathway, which requires the phospholipase C-beta encoded by norpA (no receptor poten

57 This function depends on an alternative phospholipase C-beta enzyme, encoded by PLC21C, presumab

58 examined in three assays: activation of pure phospholipase C-beta in lipid vesicles; activation of re

59 A kinase defective protein kinase D and a phospholipase C beta inhibitor blocked receptor-induced

60 NHERF-mediated assembly of PTH1R and phospholipase C beta is a unique mechanism to regulate P

61 xamined for their ability to stimulate three phospholipase C-beta isozymes and type II adenylyl cycla

62 effect of NAC on Galphaq palmitoylation and phospholipase C beta-mediated signaling in endothelial c

63 Here, we show that TRP forms a complex with phospholipase C-beta (NORPA), rhodopsin (RH1), calmoduli

64 eved either by agonist-induced activation of phospholipase C beta or with a rapamycin-inducible syste

65 , there were no differences in the levels of phospholipase C-beta or protein kinase C-alpha in the tw

66 to the A1 adenosine receptor and to activate phospholipase C-beta or type II adenylyl cyclase.

67 annels that are not only activated by the Gq-phospholipase C beta pathway (receptor-activated Ca entr

68 + entry in response to stimulation of the Gq-phospholipase C beta pathway, which is similar to that m

69 Phosphatidylinositide-specific phospholipase C-betas play a key role in Ca2+ signaling

70 of forskolin-stimulated adenylyl cyclase and phospholipase C beta (PLC beta) activation was measured

71 n through G alpha(q) involves stimulation of phospholipase C beta (PLC beta) that results in increase

72 Ligand binding, phospholipase C-beta (PLC-beta) activation, inositol 1,4

73 t protein kinases inhibit agonist-stimulated phospholipase C-beta (PLC-beta) activity and inositol 1,

74 Activation of phospholipase C-beta (PLC-beta) by G protein-coupled rec

75 Members of the phospholipase C-beta (PLC-beta) family of proteins are a

76 Phospholipase C-beta (PLC-beta) has been implicated to c

77 e have demonstrated that G-protein-activated phospholipase C-beta (PLC-beta) interacts with cell pola

78 ignaling from G protein-coupled receptors to phospholipase C-beta (PLC-beta) is regulated by coordina

79 Phospholipase C-beta (PLC-beta) isoenzymes are key effec

80 Mammalian phospholipase C-beta (PLC-beta) isoforms are stimulated

81 gamma subunits, and some Rho family GTPases, phospholipase C-beta (PLC-beta) isoforms hydrolyze phosp

82 G proteins to activation of an unidentified phospholipase C-beta (PLC-beta) isozyme and inhibition o

83 Phospholipase C-beta (PLC-beta) isozymes hydrolyze the m

84 the cells with ACh and an m2 antagonist, the phospholipase C-beta (PLC-beta) response to CCK-8 and SP

85 trate that US28/1-314 exhibits a more potent phospholipase C-beta (PLC-beta) signal than does wild-ty

86 nhibition or activation of Ca2+ channels and phospholipase C-beta (PLC-beta), the enzyme responsible

87 uction which include the essential effector, phospholipase C-beta (PLC-beta), which is also known as

88 GPCR activation to the enzymatic activity of phospholipase C-beta (PLC-beta).

89 Phosphatidylinositol-specific phospholipase C-betas (PLC-betas) are the only PLC isofo

90 ported the coupling of dopamine signaling to phospholipase C beta (PLCbeta) both in vitro and in vivo

91 and one of its downstream signal transducer phospholipase C beta (PLCbeta) can differentially affect

92 with the specific inhibitors of Gbetagamma, phospholipase C-beta (PLCbeta), or PKC, but not of prote

93 he major GNAQ/11 effector pathways, YAP, and phospholipase C-beta (PLCbeta)-ERK was also investigated

94 ha(q)- and Gbetagamma-mediated activation of phospholipase C-beta (PLCbeta).

95 Phospholipase C-betas (PLCbetas) catalyze the hydrolysis

96 eptor antagonist, chemical disruptors of the phospholipase C-beta, protein kinase A, c-Src and epider

97 he presence of phosphatidylinositol-specific phospholipases C-beta s' major physiological substrate,

98 thway that involved histamine receptor 1 and phospholipase C beta signaling.

99 MCMV is an activator of CREB, NF-kappaB, and phospholipase C-beta signaling pathways and has been imp

100 ) is more potent and effective in activating phospholipase C-beta than either the beta1 gamma1 (farne

101 As was the case with phospholipase C-beta, the beta1gamma2-L71S dimer was les

102 Phospholipase C-beta, the principal effector protein reg

103 CC3 domain inhibited PAR1 signaling to G(q)-phospholipase C-beta through coiled-coil interactions wi

104 PMT activates phospholipase C-beta through G(q)alpha, and the activati

105 om the plasma membrane through the action of phospholipase C-beta, triggering translocation of tubby

106 and to activate type II adenylyl cyclase or phospholipase C-beta was examined.

107 The beta5 gamma2HF dimer activated phospholipase C-beta with a potency and efficacy similar