ライフサイエンスコーパス: phosphoribosyl

1 ic acid mononucleotide (NAMN) and PPi from 5-phosphoribosyl 1-pyrophosphate (PRPP) and nicotinic acid

2 de, carbon dioxide, and pyrophosphate from 5-phosphoribosyl 1-pyrophosphate (PRPP) and quinolinic aci

3 d only slightly, whereas those for alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP) are lower by appro

4 ide (NAMN) from nicotinic acid and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP).

5 otide (NAMN) from quinolinic acid (QA) and 5-phosphoribosyl 1-pyrophosphate (PRPP).

6 yrophosphate from quinolinic acid (QA) and 5-phosphoribosyl 1-pyrophosphate (PRPP).

7 ibosyl transferases (ATP-PRT) join ATP and 5-phosphoribosyl-1 pyrophosphate (PRPP) in the first react

8 by the addition of 25 microM GMP, whereas 5-phosphoribosyl-1-diphosphate (PRibPP) at 50-250 microM c

9 GMP and 5-phosphoribosyl-1-diphosphate provided complete protectio

10 This is likely because of depletion of 5-phosphoribosyl-1-pyrophosphate (consumed in the hypoxant

11 ribosyltransferases (PRTases) with alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP) binding to the enz

12 Adenine and alpha-d-5-phosphoribosyl-1-pyrophosphate (PRPP) have K(m) values o

13 ibosyl transferase (ATP-PRT) joins ATP and 5-phosphoribosyl-1-pyrophosphate (PRPP) in a highly regula

14 hosphoribosylation of adenine from alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP) to form AMP and PP

15 ransfer of ribose 5-phosphate from alpha-d-5-phosphoribosyl-1-pyrophosphate (PRPP) to the N1 nitrogen

16 osphate (OMP) from orotic acid and alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP).

17 onophophate (OMP) from orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP).

18 guanine (Gua) and the phosphoribosyl donor 5-phosphoribosyl-1-pyrophosphate (PRPP).

19 PP i) from nicotinamide (NAM) and alpha- d-5-phosphoribosyl-1-pyrophosphate (PRPP).

20 tinate mononucleotide from quinolinate and 5-phosphoribosyl-1-pyrophosphate (PRPP).

21 s: the ribose-phosphate pyrophosphokinase (5-phosphoribosyl-1-pyrophosphate synthetase; PRPP syntheta

22 of a ribosyl phosphate group from alpha-D-5-phosphoribosyl-1-pyrophosphate to the N1 nitrogen of ura

23 ssion decreased the intracellular level of 5-phosphoribosyl-1-pyrophosphate, a product of the pentose

24 d sensitivity to the allosteric activator, 5-phosphoribosyl-1-pyrophosphate, and a loss of UTP inhibi

25 TP, and decreased allosteric activation by 5-phosphoribosyl-1-pyrophosphate, functional changes that

26 se reaction) and subsequent slowing of the 5-phosphoribosyl-1-pyrophosphate-dependent orotate phospho

27 ne diphosphate, 2,3 diphosphoglycerate and 5-phosphoribosyl-1-pyrophosphate.

28 d an increase in the nucleotide precursor, 5-phosphoribosyl-1-pyrophosphate.

29 sion patterns of the single gene encoding 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole

30 The chimera has a single site that binds phosphoribosyl 5'-pyrophosphate (PRPP) with a dissociati

31 esis intermediate and signaling molecule, 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR), f

32 gdoms have NADase activities and can produce phosphoribosyl adenosine monophosphate/diphosphate (pRib

33 The enzyme N(1)-(5'-phosphoribosyl) adenosine-5'-monophosphate cyclohydrolas

34 ation by inclusion of the substrate N(1)-(5'-phosphoribosyl)adenosine 5'-monophosphate; (PR-AMP), whi

35 N1-(5'-Phosphoribosyl)adenosine-5'-monophosphate cyclohydrolase

36 clearly identify the AMP as binding in the 5-phosphoribosyl-alpha-1-pyrophosphate (PRPP)-binding site

37 Phosphoribosyl amine (PRA) is an intermediate in purine

38 Phosphoribosyl amine (PRA) is the first intermediate in

39 has shown that the first common metabolite, phosphoribosyl amine (PRA), can be generated in the abse

40 phoribosyl-glycinamide synthetase (GARs) and phosphoribosyl-aminoimidazole synthetase (AIRs) are fuse

41 o distinct domains, active respectively as a phosphoribosyl-AMP cyclohydrolase (PRA-CH) and phosphori

42 s indicate that the cellular accumulation of phosphoribosyl anthranilate can result in nonenzymatic P

43 The N-1-(5'-phosphoribosyl)-ATP transferase (ATP-PRTase) encoded by

44 The N-1-(5'-phosphoribosyl)-ATP transferase catalyzes the first step

45 The crystal structures of the N-1-(5'-phosphoribosyl)-ATP transferase from Mycobacterium tuber

46 osphoribosyl-AMP cyclohydrolase (PRA-CH) and phosphoribosyl-ATP pyrophosphatase (PRA-PH).

47 quence relationship to the phage T4 dCTPase, phosphoribosyl-ATP pyrophosphatase HisE, NTP pyrophospha

48 Numerous contacts are made both to the phosphoribosyl backbone and to the ordered bases.

49 everal proteins, including apo-citrate lyase phosphoribosyl-dephospho-CoA transferase citX, an Escher

50 hypoxanthine (Hx) and guanine (Gua) and the phosphoribosyl donor 5-phosphoribosyl-1-pyrophosphate (P

51 sphoribosyltransferases that do not form the phosphoribosyl-enzyme intermediate predicted by classic

52 osynthesis and lead to the generation of pro-phosphoribosyl formimino-5-aminoimidazole-4-carboxamide

53 talyzes the Amadori rearrangement of N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide

54 In C. neoformans, phosphoribosyl-glycinamide synthetase (GARs) and phospho

55 Interactions between the enzyme and the phosphoribosyl group anchor the pyrimidine within the ac

56 in poly-Ub chains are either modified with a phosphoribosyl group by PDE domain-containing effectors

57 nes that encode an enzyme that transfers the phosphoribosyl group of nicotinate mononucleotide (NaMN)

58 Compared to k(cat), phosphoribosyl group transfer is rapid in both the forwa

59 thin the active site, helping to explain the phosphoribosyl group's remarkably large contribution to

60 Thus, the effective concentration of the 5'-phosphoribosyl group, in stabilizing the transition stat

61 We observe that the dual-substrate phosphoribosyl isomerase A or priA gene, at which these

62 cterial SidE enzymes catalyzes non-canonical phosphoribosyl-linked (PR) serine ubiquitination and pro

63 e family of bacterial SidE enzymes catalyses phosphoribosyl-linked serine ubiquitination and promotes

64 to a serine residue of target proteins via a phosphoribosyl linker (hence named PR-ubiquitination).

65 et-tRNAMet was almost entirely due to the 2'-phosphoribosyl modification at nucleotide G64, since rem

66 In parallel, phosphoribosyl modification of polyUb, in a region of th

67 s: K63 linkage-specific deubiquitination and phosphoribosyl modification of polyubiquitin (pR-Ub).

68 d by their removal from solvent water, the 1-phosphoribosyl moiety of OMP was replaced with 1-substit

69 tent with the observed binding energy of the phosphoribosyl part of the substrate; and (vi) the presu

70 thetase, carbamoyl phosphate synthetase, and phosphoribosyl pyrophosphate (PRPP) amidotransferase, gu

71 function of PPP in yeast is the synthesis of phosphoribosyl pyrophosphate (PRPP) catalyzed by PRPP-sy

72 fied a critical regulatory enzyme, cytosolic phosphoribosyl pyrophosphate (PRPP) synthetase (PRS4).

73 These mutations result in a loss of phosphoribosyl pyrophosphate (PRPP) synthetase 1 activit

74 y the reaction of 4-hydroxybenzoic acid with phosphoribosyl pyrophosphate (PRPP) to form 4-(beta-d-ri

75 i modulates the levels of the key metabolite phosphoribosyl pyrophosphate (pRpp), decreasing purine s

76 d pyrophosphate from nicotinic acid (NA) and phosphoribosyl pyrophosphate (PRPP).

77 ydroxy-1H-pyrazole-3,5-dicarboxylic acid and phosphoribosyl pyrophosphate (PRPP).

78 function but rather through interaction with phosphoribosyl pyrophosphate amidotransferase (PPAT), th

79 NUDT5 interacted with phosphoribosyl pyrophosphate amidotransferase (PPAT), th

80 ntified in tryptophan synthase and glutamine phosphoribosyl pyrophosphate amidotransferase and are li

81 PRA is normally synthesized by phosphoribosyl pyrophosphate amidotransferase, a high-tu

82 nalyses reveal that decaprenyl phosphate and phosphoribosyl pyrophosphate bind the intramembrane and

83 De novo synthesis of purines and cellular phosphoribosyl pyrophosphate content also were moderatel

84 abortive infection, which is associated with phosphoribosyl pyrophosphate depletion due to PRTase act

85 dicating that purine salvage is activated by phosphoribosyl pyrophosphate replenishment.

86 complex that contains ribosomal protein S1, phosphoribosyl pyrophosphate synthase, RNase R, and YfbG

87 soflurane enhanced the enzymatic activity of phosphoribosyl pyrophosphate synthetase (PRPP-S).

88 The phosphoribosyl pyrophosphate synthetase (PRPS) enzyme ca

89 The toxin specifically modifies phosphoribosyl pyrophosphate synthetase (Prs), an essent

90 Phosphoribosyl pyrophosphate synthetase 1 (PRPS1), the k

91 identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1),

92 Repression of phosphoribosyl pyrophosphate synthetase 1, a target of t

93 of adenosine and inosine, and regulation of phosphoribosyl pyrophosphate synthetase by adenosine dip

94 d adenosine uptake inhibited the activity of phosphoribosyl pyrophosphate synthetase in activated T c

95 O cells: serine hydroxymethyltransferase and phosphoribosyl pyrophosphate synthetase, a known downstr

96 Phosphoribosyl pyrophosphate synthetase-1 (PRPS1) is a k

97 Here, we used a proteomic approach and found phosphoribosyl pyrophosphate synthetases (PRPSs), the es

98 Phosphoribosyl pyrophosphate synthetases (PRPSs), which

99 t catalyses pentosyl phosphate transfer from phosphoribosyl pyrophosphate to decaprenyl phosphate, to

100 sensitive to activation (which depends upon phosphoribosyl pyrophosphate).

101 longer activated by the allosteric effector phosphoribosyl pyrophosphate, although evidence indicate

102 threonine dehydratase (IlvA), threonine, and phosphoribosyl pyrophosphate.

103 sugar pentoses utilization and biogenesis of phosphoribosyl pyrophosphate.

104 ude SmpB, ribosomal protein S1, RNase R, and phosphoribosyl pyrophosphate.

105 AS was able to generate PRA from ammonia and phosphoribosyl pyrophosphate.

106 timated Kis of 25.4 microM against alpha-D-5-phosphoribosyl-pyrophosphate (PRPP) in converting hypoxa

107 We find that a single rate-limiting enzyme, phosphoribosyl-pyrophosphate synthetase 2 (PRPS2), promo

108 he PRA-PH domain shows positioning of the N1-phosphoribosyl relevant to catalysis.

109 d step in the process is the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate to

110 anthranilate, which is then conjugated to a phosphoribosyl sugar in the second step by anthranilate

111 of NAMN formation, indicating that on-enzyme phosphoribosyl transfer chemistry is rate-determining.

112 In contrast, D137N showed slower phosphoribosyl transfer chemistry, although guanine (300

113 a burst in product formation indicating that phosphoribosyl transfer proceeds rapidly relative to som

114 etic mechanism for OPRTase, in which a rapid phosphoribosyl transfer reaction at equilibrium is follo

115 The overall equilibrium for the hypoxanthine phosphoribosyl transfer reaction lies far toward nucleot

116 N within the crystal lattice and undergo the phosphoribosyl transfer reaction to form product.

117 te experiments with K165Q indicated that the phosphoribosyl transfer step was fast in the forward rea

118 (QAPRTase, EC 2.4.2.19) catalyzes an unusual phosphoribosyl transfer that is linked to a decarboxylat

119 denosine/AdoHcy nucleosidase (MTAN), adenine phosphoribosyl transferase (APRT), and pyruvate orthopho

120 as a probe, the Ag precursor gene, adenosine phosphoribosyl transferase (APRT), was isolated by expre

121 Adenine phosphoribosyl transferase (APRTase) and pyruvate orthop

122 viduals with mutations affecting the ADENINE PHOSPHORIBOSYL TRANSFERASE (APT) gene were isolated foll

123 ATP phosphoribosyl transferase (ATP-PRT) joins ATP and 5-pho

124 HisG is an ATP-phosphoribosyl transferase (ATPPRTase) that catalyzes th

125 Hypoxanthine-guanine-xanthine phosphoribosyl transferase (HGXPRTase), an essential enz

126 WTK1 cells at both the hypoxanthine quanine phosphoribosyl transferase (hprt) and the thymidine kina

127 al transgene cassettes into the hypoxanthine phosphoribosyl transferase (HPRT) and Type I collagen (C

128 Utilizing the hypoxanthine guanine phosphoribosyl transferase (HPRT) as a test locus, it wa

129 e through knocking down hypoxanthine-guanine phosphoribosyl transferase (HPRT) expression using RNA i

130 els with the endogenous hypoxanthine-guanine phosphoribosyl transferase (hprt) gene and lacI transgen

131 s the mutation frequency of the hypoxanthine phosphoribosyl transferase (HPRT) gene in a TOP2-depende

132 transgene and of the endogenous hypoxanthine phosphoribosyl transferase (Hprt) gene in mouse embryoni

133 of a 14-kbp duplication in the hypoxanthine phosphoribosyl transferase (HPRT) gene, is elevated in h

134 erage, than that of the hypoxanthine-guanine phosphoribosyl transferase (Hprt) locus in Msh2-deficien

135 ere observed at the single copy hypoxanthine phosphoribosyl transferase (HPRT) locus in normal human

136 single-copy transgene into the hypoxanthine phosphoribosyl transferase (hprt) locus, we find that mi

137 unction mutation at the hypoxanthine guanine phosphoribosyl transferase (hprt) locus.

138 e (neo) into the X-linked human hypoxanthine phosphoribosyl transferase (HPRT) locus.

139 The HPRT assay measures hypoxanthine phosphoribosyl transferase (hprt) mutations, while the V

140 urine metabolic enzyme, hypoxanthine guanine phosphoribosyl transferase (HPRT).

141 inhibition of hypoxanthine-xanthine-guanine phosphoribosyl transferase (HXGPRT) expression by a chim

142 oplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase (HXGPRT) gene by insertional

143 Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting

144 ession of sirtuin 1 (SIRT1) and nicotinamide phosphoribosyl transferase (NAMPT) was lower 5 d followi

145 a pharmacological inhibitor of nicotinamide phosphoribosyl transferase (NAMPT).

146 osynthesis rate-limiting enzyme nicotinamide phosphoribosyl transferase (Nampt).

147 ) - a bifunctional enzyme comprising orotate phosphoribosyl transferase (OPRT) and orotidine monophos

148 pD subunit of the anthranilate synthase (AS)-phosphoribosyl transferase (PRT) complex.

149 king the crc gene are genes encoding orotate phosphoribosyl transferase (pyrE) and RNase PH (rph).

150 Quinolinic acid phosphoribosyl transferase (QAPRTase, EC 2.4.2.19) is a

151 Low placental quinolinate phosphoribosyl transferase (QPRT), the enzyme responsibl

152 lularly and yeast cytosine deaminase: uracil phosphoribosyl transferase (yCD:UPRT) enzyme intracellul

153 This conversion is catalyzed by hypoxanthine phosphoribosyl transferase 1 (HPRT1), which is highly ex

154 est protective effects, whereas nicotinamide phosphoribosyl transferase and nicotinic acid phosphorib

155 The individual orotate phosphoribosyl transferase and orotidine monophosphate d

156 Adenine phosphoribosyl transferase converts adenine to AMP and p

157 sentially all CpGs in the critical guanosine phosphoribosyl transferase core are methylated.

158 omposed of three groups consisting of HPRT1, phosphoribosyl transferase domain containing protein 1 (

159 primarily by oligomerization of the orotate phosphoribosyl transferase domain.

160 The fact that elevated levels of quinolinate phosphoribosyl transferase enhance growth on phthalate s

161 a transgene, the bacterial xanthine guanine phosphoribosyl transferase gene (gpt), differentially ne

162 es de novo genetic mutations of hypoxanthine phosphoribosyl transferase gene in CML and non-CML cells

163 ation during necrotrophy, whereas the uracil phosphoribosyl transferase gene involved in pyrimidine s

164 mit of detection (<10(-3) fg/pg hypoxanthine phosphoribosyl transferase gene; HPRT) in both MRL/+ and

165 me with a gpt gene encoding xanthine-guanine phosphoribosyl transferase in place of the env gene, we

166 bition of NAD -producing enzyme nicotinamide phosphoribosyl transferase increased ciliary length and

167 146 CAG repeats into the murine hypoxanthine phosphoribosyl transferase locus (Hprt(CAG)146), which d

168 rted into the X-linked hypo xanthine-guanine phosphoribosyl transferase locus, resulting in gene inac

169 o gene plus a partially deleted hypoxanthine phosphoribosyl transferase minigene.

170 pathway despite no increase in nicotinamide phosphoribosyl transferase or in the NR transport protei

171 oxanthine phosphoribosyl transferase/adenine phosphoribosyl transferase reaction) and subsequent slow

172 phoribosyl-1-pyrophosphate-dependent orotate phosphoribosyl transferase reaction, which depletes orot

173 hosphoribosyl transferase and nicotinic acid phosphoribosyl transferase showed moderate protective ac

174 tokine signal was normalized to hypoxanthine phosphoribosyl transferase signal obtained from the same

175 is in part due to low expression of adenine phosphoribosyl transferase under high AICAR conditions.

176 A gene coding for an enzyme (quinolinate phosphoribosyl transferase) involved in the biosynthesis

177 uencies at the hemizygous HPRT (hypoxanthine phosphoribosyl transferase) locus, but the mutation spec

178 he Hprt locus (encoding hypoxanthine guanine phosphoribosyl transferase).

179 The gene encodes hypoxanthine-guanine phosphoribosyl transferase, an enzyme involved in purine

180 HPT1 gene, encoding the hypoxanthine guanine phosphoribosyl transferase, enhances cisplatin resistanc

181 teinase 1 (TIMP-1), TIMP-2, and hypoxanthine phosphoribosyl transferase-1 (HPRT1).

182 s using interfering RNA against hypoxanthine phosphoribosyl transferase.

183 -pyrophosphate (consumed in the hypoxanthine phosphoribosyl transferase/adenine phosphoribosyl transf

184 train deficient in both hypoxanthine-guanine phosphoribosyl-transferase (HGPRT) and xanthine phosphor

185 Complete hypoxanthine-guanine phosphoribosyl-transferase (HPRT) deficiency in humans r

186 ssessing a genetically modified hypoxanthine phosphoribosyl-transferase (HPRT) with enhanced substrat

187 To obtain useful hypoxanthine phosphoribosyl-transferase (HPRT)-deficient mouse ES cel

188 evidence that only the ArsA subunit has base:phosphoribosyl-transferase activity, and propose a mecha

189 one polyamine oxidase, and one anthranilate-phosphoribosyl-transferase as candidate genes.

190 Two families of ATP phosphoribosyl transferases (ATP-PRT) join ATP and 5-pho

191 is octameric structure is unique to both the phosphoribosyl transferases and the aminoacyl-tRNA synth

192 biquitination directly on host targets or on phosphoribosyl-Ub conjugated to host targets by Sde.

193 rse PR-ubiquitination by specific removal of phosphoribosyl-Ub from substrates.

194 lla pneumophila coordinate the conversion of phosphoribosyl ubiquitin (PR-Ub) released by reversal of

195 ion in a process that involves production of phosphoribosyl ubiquitin (PR-Ub).

196 Legionella effector SdeA, an unconventional phosphoribosyl ubiquitin ligase, by adding glutamate mol

197 R) rearrangements that are tightly linked to phosphoribosyl-ubiquitin (pR-Ub) modification of Reticul

198 ch group of translocated proteins, catalyzes phosphoribosyl-ubiquitin (pR-Ub) modification of target

199 Legionella pneumophila encodes a family of phosphoribosyl ubiquitination ligases (SidE) essential f

200 several cellular processes through a unique phosphoribosyl ubiquitination mechanism that bypasses th

201 ed to other host substrates via Sde-mediated phosphoribosyl-ubiquitination.