ライフサイエンスコーパス: phosphorylate

1 ne residues, several of which are reportedly phosphorylated.

2 h GSK3beta was restored, and GSK3beta became phosphorylated.

3 ntified residues within CHT7 are also likely phosphorylated.

4 t the C terminus of RRS1-R but not RRS1-S is phosphorylated.

5 ylated-pyrroles, -furans, -thiophenes, and 4-phosphorylated 2,5-dihydropyridazines is reported.

6 s the first synthetic method for accessing 4-phosphorylated 2,5-dihydropyridazines.

7 These M3Ks phosphorylate a specific SnRK2/OST1 site, which is indis

8 found that cyclin-dependent kinase 1 (CDK1) phosphorylated a threonine residue on the catalytic subu

9 ophosphorylation on Thr and Tyr residues and phosphorylates a classical eukaryotic protein kinase sub

10 is a key regulator of energy metabolism that phosphorylates a wide range of proteins to maintain cell

11 PKG stimulated purified 26S proteasomes by phosphorylating a different 26S component than is modifi

12 at alpha-Syn colocalizes with PIP(2) and the phosphorylated active form of the clathrin adaptor prote

13 -binding surface of the DBD and the multiple phosphorylated AD2 motifs within the tetramer.

14 ent is harnessed by a rotary ATP synthase to phosphorylate adenosine diphosphate to ATP.

15 ed activation of heme oxygenase-1 (HO-1) and phosphorylated adenosine monophosphate-activated protein

16 ervation was coupled to a 6-fold increase in phosphorylated adenosine nucleotide abundance.

17 Although many phosphorylated AGC kinases are sensitive to phosphatase-

18 Interestingly, Aldob directly interacts with phosphorylated Akt (p-Akt) and promotes the recruitment

19 the underlying mechanism of the inability of phosphorylated AKT to phosphorylate GSK3beta remains unk

20 rmediate and basal cell apoptosis, likely by phosphorylated AKT, and drives phosphorylated ERK-mediat

21 The increase in phosphorylated Akt, S6, and STAT1, as well as immature N

22 in exacerbated motor deficits and increased phosphorylated alpha-syn deposits.

23 lysis, we demonstrate that in the absence of phosphorylated AMELX, KI enamel lacks enamel rods, the h

24 irected mutagenesis of previously identified phosphorylated amino acids within CHT7.

25 l lobe epilepsy cases, hippocampal levels of phosphorylated amyloid precursor protein, its pro-amyloi

26 e sensor kinases that detect DNA lesions and phosphorylate an extensive network of substrates.

27 CDK5 promotes cell invasiveness by directly phosphorylating an intermediate filament protein, viment

28 es containing protein kinases A and C, which phosphorylate and activate PLD1 to produce phosphatidic

29 High levels of Cdk1 in ESCs phosphorylate and partially inactivate Dot1l, the H3K79

30 l model of RB regulation is that cyclin-CDKs phosphorylate and render RB inactive in late G1/S, promo

31 uction, the deubiquitinase VCPIP1/VCIP135 is phosphorylated and activated by ATM/ATR.

32 nt than rapamycin, and robustly downregulate phosphorylated and insoluble tau, consequently reducing

33 ed forks in BRCA2-deficient cells accumulate phosphorylated and ubiquitinated replication protein A (

34 CK1delta prevents termination by phosphorylating and inhibiting SSUP-72.

35 ith a near-infrared dye selectively binds to phosphorylated Annexin A2 (pANXA2), with high affinity a

36 not uniform, as different substrates become phosphorylated at different times as cells proceed throu

37 We found that EGFR is predominantly phosphorylated at multiple sites, yet phosphorylation at

38 thin PERK's kinase domain, which is, itself, phosphorylated at multiple sites.

39 We examined whether plasma tau phosphorylated at residue 181 (pTau181) could differenti

40 In Alzheimer's disease (AD), human Tau is phosphorylated at S199 (hTau-S199-P) by the protein kina

41 Here, we report that RRM1 is phosphorylated at Ser 559 by CDK2/cyclin A during S/G2 p

42 t of the DNA-damage response, SMURF2 becomes phosphorylated at Ser(384) by ataxia telangiectasia muta

43 educed the production of insoluble alpha-syn phosphorylated at Ser-129 (pS129-alpha-syn).

44 14-3-3 proteins bound TET2 when it was phosphorylated at Ser-99.

45 endogenous alpha-syn to become insoluble and phosphorylated at Ser129 to a greater extent than monome

46 ng mass spectrometry, we found that ACTN4 is phosphorylated at serine (S) 159 in human podocytes.

47 and activator of transcription 3 (STAT3) is phosphorylated at the warmer, female-producing temperatu

48 synthesis pathway in Arabidopsis thaliana is phosphorylated at Threonine 101 (T101).

49 in, and neurofilament light chain (NFL); tau phosphorylated at threonine 181 (p-tau), and NFL in cere

50 ons of amyloid-beta1-42 peptide, tau protein phosphorylated at threonine 181, total tau, and the rati

51 Expression of SFK phosphorylated at Y416 (SFK_pY416(+)) in tumor cells was

52 We report that CHK2 binds to and phosphorylates Beclin 1 at Ser90/Ser93, thereby impairin

53 Thr55 is constitutively phosphorylated, becomes dephosphorylated upon DNA damage

54 e multiprotein destruction complex binds and phosphorylates beta-cat and transfers it to the SCF-TrCP

55 Given the centrality of phosphorylated biomolecules in metabolic, structural, an

56 stabilized when the activation loop is fully phosphorylated but is again stabilized with ATP-Mg(2+) b

57 In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, whic

58 se substrates, a nucleotide analogue must be phosphorylated by cellular kinases which is rate-limitin

59 rora B substrates at the kinetochore are not phosphorylated by centromere-localized pools of Aurora B

60 PHF8 is phosphorylated by CK2, which regulates binding of PHF8 t

61 kinase 2 (UCK2) for activation, 2'-AzCyd is phosphorylated by deoxycytidine kinase (dCK), and we fin

62 ly, upon growth factor stimulation, Exo70 is phosphorylated by ERK1/2, which in turn suppresses its p

63 esides being overexpressed, is substantially phosphorylated by family with sequence similarity 20, me

64 Here, we report that beta1 subunits are phosphorylated by FYN kinase.

65 tiple residues in the C terminus of eIF6 are phosphorylated by GSK3 in a sequential manner.

66 The P protein is phosphorylated by host kinases, and its phosphorylation

67 substrate screen and identified that EGFR is phosphorylated by HUNK.

68 the N-terminus of the protein, which can be phosphorylated by MAPKs.

69 tivating protein 1 transcription factors are phosphorylated by mitogen-activated protein kinases (MAP

70 a prolyl-isomerase, Ppia, which is directly phosphorylated by MLK3 to increase its isomerase activit

71 lysosomal biogenesis and autophagy(4,5), is phosphorylated by mTORC1 via a substrate-specific mechan

72 ramide, generates sphingosine, which is then phosphorylated by sphingosine kinase to produce the pros

73 GluN2A harbors tyrosine residues that, when phosphorylated by Src family kinases, potentiate NMDAR a

74 factors GLK1 and GLK2 interact with and are phosphorylated by the BRASSINOSTEROID insensitive2 (BIN2

75 ported that tyrosine (Y) 138 of HPV-31 E2 is phosphorylated by the fibroblast growth factor receptor

76 otential phosphorylation sites, which can be phosphorylated by various kinases because the unfolded s

77 Similarly, betaarr1 in complex with only a phosphorylated C-terminal tail of the vasopressin 2 rece

78 aluated by MTT assay, apoptosis/necrosis and phosphorylated-cAbl (cAbl-p).

79 expression of IP(3)R1 (IP(3)R-type 1) and of phosphorylated CaMKII (immunohistochemistry and immunobl

80 In this study, we report that DNA-PK phosphorylates cGAS and suppresses its enzymatic activit

81 s is necessary for high levels of activated (phosphorylated) Chk1.

82 oreover, Mec1 is more efficient than Tel1 at phosphorylating chromatin in trans-at distant undamaged

83 blation coincides with sustained activity of phosphorylated components of signaling pathways includin

84 g in the rapid generation of the more active phosphorylated conformer.

85 in PAGR1 (also known as PA1) cooperates with phosphorylated CREB and ligand-activated glucocorticoid

86 CREB activity (phosphorylated CREB) was also increased by DHA and EPA b

87 1-RAD50-NBS1 (MRN) complex and its cofactor, phosphorylated CtIP.

88 However, the E3 ligase that regulates phosphorylated cyclin D3 and whether a stabilized, phosp

89 on of SCF-Fbxl8 as the E3 ligase for Thr-283 phosphorylated cyclin D3.

90 w that the protein DYRK1A interacts with and phosphorylates cyclin L2.

91 e results suggest that a spatial gradient of phosphorylated CYK4 around the central spindle patterns

92 n human hepatocellular carcinoma (HCC) cells phosphorylates cytosolic phosphoenolpyruvate carboxykina

93 l striatum of CHL1-deficient mice, levels of phosphorylated DARPP32 were reduced.

94 Diacylglycerol kinase (DGK) produces PA by phosphorylating diacylglycerol, a crucial step in PA met

95 motifs help cyclin-dependent kinases (CDKs) phosphorylate different substrates at different stages,

96 This study shows that HUNK directly phosphorylates EGFR at T654 to promote metastasis and is

97 Our studies show that HUNK phosphorylates EGFR at T654, enhancing receptor stabilit

98 Phosphorylated eIF2 (p-eIF2) in turn sequesters the eIF2

99 orylated PERK at Thr(980) Subsequently, PERK phosphorylated eIF2alpha at Ser(51), upregulating its do

100 stress pathways besides the UPR converge on phosphorylated eIF2alpha in the integrated stress respon

101 l reduction of UPR signaling at the level of phosphorylated eIF2alpha is neuroprotective and avoids t

102 S63del neuropathy despite reduced levels of phosphorylated eIF2alpha.

103 In response to nutrient deprivation, Gcn2 phosphorylates eIF2alpha, thereby repressing general tra

104 ollectively, our findings indicate that EGFR phosphorylates ELK1 to activate GDH1 transcription and g

105 cells appear to be enriched for the glucose phosphorylating enzyme glucokinase and for genes encodin

106 activates the Sult1e1 promoter by recruiting phosphorylated ERalpha in the liver as observed with PB-

107 cell endoreplication associated with absent phosphorylated ERK staining and decreased p53 expression

108 is, likely by phosphorylated AKT, and drives phosphorylated ERK-mediated KRT5(+)/KRT14(-) cell prolif

109 e significantly attenuated or ablated spinal phosphorylated ERK.

110 s stimuli prompt dedicated stress kinases to phosphorylate eukaryotic initiation factor 2 (eIF2).

111 codes a kinase (protein kinase R [PKR]) that phosphorylates eukaryotic translation initiation factor

112 IQGAP1 was phosphorylated exclusively on Tyr-1510 under conditions

113 ization but only slightly reduced downstream phosphorylated extracellular signal-regulated kinase (ER

114 ineation of the pathway revealed that CDK4/6 phosphorylated EZH2 in keratinocytes, thereby triggering

115 Accordingly, TORC1 can phosphorylate Fab1 proximal to its PI3P-interacting FYVE

116 ted in a significantly superior reduction of phosphorylated FLT3 and transcriptional suppression of g

117 In addition, the active phosphorylated form of AMP kinase was significantly incr

118 GH-responsive cells were detected via the phosphorylated form of the signal transducer and activat

119 (TLN1), integrin beta 1 (ITGB1), as well as phosphorylated forms of paxillin (pPXN) and focal adhesi

120 d with enriched levels of trimethyl H3K4 and phosphorylated forms of RNA polymerase (Pol) II at the p

121 with a bell-shaped distribution; the highly phosphorylated fraction P(h) had 14 P(i) (+/- 6).

122 The medium phosphorylated fraction P(m) showed overall occupancies

123 NK-binding kinase 1 (TBK1), that efficiently phosphorylates full-length and N-terminal HTT fragments

124 Src is activated under DNA damage stress and phosphorylates GAPDH at Tyr41.

125 Furthermore, BIN2 phosphorylates GLK1 at T175, T238, T248, and T256, and m

126 ealed that GCBCs generate significantly less phosphorylated glucose and little lactate.

127 We show that phosphorylated glycogen phosphorylase (GPa), glycogen sy

128 en together, these data demonstrate that the phosphorylated GPCR tail interaction with betaarr1 is ne

129 sm of the inability of phosphorylated AKT to phosphorylate GSK3beta remains unknown.

130 POLD1 and POLD2 each colocalize with phosphorylated H2AX at ionizing radiation-induced DSBs b

131 MmuPV1 infection induced the expression of phosphorylated H2AX, but not degradation of proapoptotic

132 esidue-level information was used to develop phosphorylated hCT analogs that showed modified fibrilla

133 arks of DNA damage is the rapid spreading of phosphorylated histone H2A (gamma-H2AX) around a DNA dou

134 n as Haspin), a serine/threonine kinase that phosphorylates histone H3 at Thr-3 during mitosis.

135 The kinase Haspin phosphorylates histone H3 at threonine-3 (H3T3ph), creat

136 by activating Ataxia Telangiectasia Mutated, phosphorylating histone H2AX, and localizing RAD51 to th

137 he expression of Fyn, a tyrosine kinase that phosphorylates hnRNPA2, reduces neurodegeneration associ

138 trate that p21-activated kinase 4 (PAK4) can phosphorylate ICAP1 at Ser-10 both in vitro and in cultu

139 In B cell leukaemia, oncogenic kinases phosphorylate IFITM3 at Tyr20, which causes constitutive

140 and pathway activation by more than 50% (of phosphorylated IGF1R, phosphorylated protein kinase B, a

141 ing enzyme UBE2D to its recruited substrate, phosphorylated IkappaBalpha.

142 SFKs are key kinases phosphorylating immunoreceptor tyrosine-based activation

143 osphorylation, rendering it "constitutively" phosphorylated in cells.

144 directly binds only to BDNF promoter IV, is phosphorylated in response to BDNF-TrkB signaling, and a

145 Previously, we showed that GRK1 is phosphorylated in the dark at Ser21 in a cAMP-dependent

146 to a varying degree in all samples but only phosphorylated in TNBC tumor cells that expressed SFK_pY

147 We show that Y155 is phosphorylated in vitro by the Tyr kinase domain of epid

148 yzed for sugars, organic acids, amino acids, phosphorylated intermediates, minerals, starch, protein,

149 is a single-cell-based technique to measure phosphorylated intracellular proteins, providing a more

150 AKT3 directly bound and phosphorylated IRF3 at Ser385, together with TBK1-induce

151 We furthermore show that ROCK2 phosphorylates IRF4 and that the ROCK2-mediated phosphor

152 The levels of phosphorylated IRF7 and NF-kappaB inversely correlated w

153 Furthermore, we observed several phosphorylated isoforms of CHT7 under these conditions.

154 irectly binding of AMPKalpha2 in nucleus and phosphorylating it at Thr172 residue.

155 toplasmic surface of endosomal membranes, it phosphorylates its substrate lipid (phosphatidylinositol

156 se MBK-2, which is activated during meiosis, phosphorylates Katanin at multiple serines.

157 Aurora B kinase phosphorylates kinetochore substrates to correct imprope

158 ra B kinase corrects improper attachments by phosphorylating kinetochore components and so releasing

159 65) in the C-terminal tail (CTT) of STING is phosphorylated, leading to induction of type I interfero

160 Phosphorylated levels of c-Jun were overexpressed in hum

161 enic genes, and orexin treatment induced the phosphorylated levels of ERK1/2(Thr202/Tyr204), but not

162 Src signaling, including the upregulation of phosphorylated Lyn (pTyr507) and Fyn (pTyr530).

163 Cdk1 phosphorylates many proteins involved in epigenetic regu

164 IGF1R, phosphorylated protein kinase B, and phosphorylated MAPK kinase), suggesting the complementar

165 Phosphorylated metabolites regulate key cellular process

166 Substance P (SP), S100beta, GFAP, and phosphorylated mitogen-activated protein kinase 1 (pERK)

167 ated with increased phosphorylated RIPK1 and phosphorylated MLKL but not active caspase-3 expression.

168 Cells lacking cyclin B can enter mitosis and phosphorylate most mitotic proteins, because of parallel

169 acrophages, and increased immunostaining for phosphorylated mothers against decapentaplegic homolog 2

170 We confirm that Dyrk1a phosphorylates Munc18-1 at T479.

171 es of activated beta-arrestin2 stabilized by phosphorylated muOR bound to the morphine and D-Ala(2),

172 find that the beta-arrestin2 couples to the phosphorylated muOR by forming strong polar interactions

173 AURKB directly phosphorylates MYC at serine 67, counteracting GSK3beta-

174 oncogenes, including MYC We report that BRD4 phosphorylates MYC at Thr58, leading to MYC ubiquitinati

175 iatum and SN N-glycans with the detection of phosphorylated N-glycans in SN which were not detected i

176 At day 3, the abundance of NHE3 normalized, phosphorylated NCC levels decreased, and cleavage and ap

177 activates MST1, which selectively binds and phosphorylates netrin receptor UNC5B on T428 residue, pr

178 TP) despite the reaction requiring neither a phosphorylated nor an adenylated intermediate.

179 The cellular kinase CK1alpha phosphorylates NSP2 on serine 313, triggering the locali

180 which was correlated with serum zonulin and phosphorylated nuclear factor-kappaB expression.

181 unction of RSK1, migrating to the nucleus to phosphorylate nucleoprotein (NP), the major constituent

182 Tyr-172, Tyr-654, Tyr-855, and Tyr-1510 were phosphorylated on IQGAP1 when phosphotyrosine phosphatas

183 be the simplest scenario, when a protein is phosphorylated on only two sites in a strict, well-defin

184 f Collagen-I by HSCs incubated with either a phosphorylated or nonphosphorylated form of recombinant

185 o 1%; p<=0.022) and increases in H3K9ac+ and phosphorylated P-TEFb in CD4 + T cells compared to place

186 Hoxd3 promoter is a direct target of phosphorylated (p) SMAD1, a mediator of BMP signaling.

187 n-3 transgenic mice have decreased levels of phosphorylated (p)-Ezrin (Thr567) and Yap, increased Hip

188 ntrol values and abolished oscillations, but phosphorylated (p)-rC0C7-sc did not completely rescue th

189 Because phosphorylated (p)-rC0C7-sc was less effective at dampin

190 accumulation of both lytic EBV proteins and phosphorylated p53 in cell lines that contain a wild-typ

191 In vitro, COL6 promoted steady-state phosphorylated paxillin levels and reduced cell density

192 to vaccination identified 53 differentially phosphorylated peptides when comparing low responders wi

193 irect FAM20C-binding partner and that FAM20C phosphorylates Periostin in vitro.

194 nsient activation of VEGFR2, which, in turn, phosphorylated PERK at Thr(980) Subsequently, PERK phosp

195 Exogenous application of phosphorylated PHS (PHS-P) induces stomatal closure and

196 LCBK1 phosphorylates phytosphingosine (PHS).

197 LCBK1 phosphorylates phytosphingosine and thereby promotes sto

198 cule that acts as receptor for mono- and bis-phosphorylated PIPs in a cell free environment.

199 ression of PP2Ac, leading to accumulation of phosphorylated PRAS40 and mTORC1-mediated activation of

200 AMPK phosphorylated proapoptotic caspase-6 protein to inhibit

201 hat is suited for nucleocapsid assembly, and phosphorylated protein forms a liquid-like compartment f

202 n by more than 50% (of phosphorylated IGF1R, phosphorylated protein kinase B, and phosphorylated MAPK

203 ation of soluble alpha-synuclein protein and phosphorylated protein kinase Calpha, as well as reduced

204 teome analysis identified 310 differentially phosphorylated proteins (DP) from 350 phosphopeptides wi

205 small interfering RNA to deplete a subset of phosphorylated proteins not previously linked to thrombi

206 first global method for the preparation of 3-phosphorylated-pyrroles, -furans, -thiophenes, and 4-pho

207 t the PBL13 receptor-like cytoplasmic kinase phosphorylates RBOHD's C-terminus and two phosphorylated

208 uding binding of the N domain of betaarr1 to phosphorylated receptor residues and insertion of the fi

209 se phosphorylates RBOHD's C-terminus and two phosphorylated residues (S862 and T912) affect RBOHD act

210 substrate of CK1delta/epsilon with up to 38 phosphorylated residues in vitro and in vivo.

211 These phosphorylated residues were dispensable for CHT7 functi

212 tivation of the mTOR pathway, as assessed by phosphorylated ribosomal protein S6 expression.

213 d complex of nucleotide-free Galpha bound to phosphorylated Ric-8A at near atomic resolution by cryo-

214 ial cell death was associated with increased phosphorylated RIPK1 and phosphorylated MLKL but not act

215 ced occupancy of NF-kB, P-TEFb, and serine 2 phosphorylated RNA Polymerase II on the HEXIM1 gene.

216 Moreover, we observed that human cMLCK phosphorylates rodent cTnI to a much smaller extent in v

217 that HNF4alpha formed a complex with Ser 100-phosphorylated RORalpha, as shown by supershifted comple

218 of RUNX2 stability, as Casein kinase 2 (CK2) phosphorylates RUNX2, recruiting the deubiquitinase herp

219 s, the core components of the Hippo pathway, phosphorylate S606 of Raptor, an essential component of

220 ates its second kinase-domain, which in turn phosphorylates sarcoplasmic/endoplasmic reticulum calciu

221 ow SMG1 and perhaps other PIKKs specifically phosphorylate Ser/Thr-containing motifs with a glutamine

222 ween three of its BRCT domains and conserved phosphorylated Ser/Thr residues at the C-terminus of the

223 es Cys18 of the toxin), TglT/TakA (antitoxin phosphorylates Ser78 of the toxin), and HepT/MntA (antit

224 CDK11 phosphorylates serine 2 (Ser2) of the carboxy-terminal d

225 e protein tyrosine phosphatase SHP2 binds to phosphorylated signaling motifs on regulatory immunorece

226 from 350 phosphopeptides with a total of 399 phosphorylated sites.

227 upon phosphorylation of these mostly singly phosphorylated sites.

228 o regulated by protein kinase A (PKA), which phosphorylates SK2 in its C-terminal domain, facilitatin

229 Tacrolimus-induced phosphorylated SMAD1/5 acts in synergy with metabolic st

230 , promoted ubiquitination and degradation of phosphorylated SMAD3 and impaired a SMAD3/beta2SP-depend

231 Liver phosphorylated SMAD5 and the SMAD1/5/8 target inhibitor

232 esponds to diverse stimuli by differentially phosphorylating specific substrates is poorly understood

233 eration of mice in which eIF2alpha cannot be phosphorylated specifically in Schwann cells.

234 se 1 (SphK1), one of the two isoenzymes that phosphorylate sphingoid bases, was markedly reduced in b

235 We find that Polo phosphorylates Spindly and impairs its ability to bind t

236 ' cells with JAK inhibitors in vitro reduced phosphorylated STAT1 to normal.

237 (APT2, also known as LYPLA2) depalmitoylates phosphorylated STAT3 (p-STAT3) and enables it to translo

238 ed levels of plasma IL-6, TNF, IL-1beta, and phosphorylated STAT3 as well as swift lymphocyte restora

239 ficantly higher in BIA-ALCL, as indicated by phosphorylated STAT3 immunohistochemistry.

240 uman PDAC tissues had higher levels of IL22, phosphorylated STAT3, and markers of the epithelial-mese

241 cade recruiting TRAF6 and TBK-1, while TBK-1 phosphorylates STAT3 on S727.

242 sed a time-dependent reduction in the active phosphorylated state of AMPK and of its downstream targe

243 in levels and activity of cGAS (based on the phosphorylated STING and phosphorylated TBK1 levels), an

244 gests that Lck confinement was not caused by phosphorylated substrates.

245 The saccharopine pathway intermediates and phosphorylated sugars are abundant when cellular express

246 GDH are comparable, while nicotinate and non-phosphorylated sugars are when DHTKD1 expression is orde

247 h enable two example kinases-AMPK and PKC-to phosphorylate target proteins that are not otherwise sub

248 ated proteins beta-amyloid (Abeta) and hyper-phosphorylated tau (p-tau) in Vero and glioblastoma cell

249 pathological hallmarks: amyloid plaques (A), phosphorylated tau (T), and accompanying neurodegenerati

250 SF) biomarkers (amyloid beta1-42, total tau, phosphorylated tau 181) were also assessed.

251 c human tau is enriched in synapses, whereas phosphorylated tau accumulates predominantly in cell bod

252 ormal levels of baseline cerebrospinal fluid phosphorylated tau and subthreshold Abeta were associate

253 c Alzheimer's disease; standard cut-offs for phosphorylated tau and total tau may thus result in misc

254 The pathological actions of phosphorylated tau are mediated by surrounding neuronal

255 Here, we found a prominent accumulation of phosphorylated tau in GABAergic interneurons in the dent

256 Network analysis showed that the phosphorylated tau interactome was enriched in proteins

257 rehensive understanding of the proteins that phosphorylated tau interacts with in Alzheimer's disease

258 Accumulation of phosphorylated tau is a key pathological feature of Alzh

259 ly, Cr and Ni treatments increased total and phosphorylated tau levels in both cell types, implicatin

260 beta peptide 42 levels, 15 with elevated CSF phosphorylated tau levels, mean age of 62.705 +/- 4.628

261 amyloid-beta peptide 42 (amyloid-beta42) and phosphorylated tau on the patterns of functional connect

262 t threonine 181, total tau, and the ratio of phosphorylated tau to amyloid-beta1-42.

263 tangles interacted with PHF1-immunoreactive phosphorylated tau.

264 hich of these proteins specifically bound to phosphorylated tau.

265 onstrating the pathogenic role of abnormally phosphorylated tau.

266 Thus, active GSK3beta phosphorylates Tau aberrantly.

267 as performed to measure levels of total-Tau, phosphorylated-Tau (pTau), amyloid precursor protein (AP

268 disease than either the ATN framework or the phosphorylated-tau/amyloid-beta1-42 ratio.

269 Plasma phosphorylated-tau181 (p-tau181) is a promising blood-ba

270 cGAS (based on the phosphorylated STING and phosphorylated TBK1 levels), and the expression and ribo

271 AMP-activated protein kinase (AMPK) directly phosphorylates Tda1 to govern Tda1 activity, while CK2 r

272 r mitotic kinase that drives the cell cycle, phosphorylates the Ask1 component of the Dam1c to increa

273 PK localizes in the mitochondrial matrix and phosphorylates the catalytic alpha subunit of PDHc (PDHA

274 family kinase (SFK) Src42A,(3) which in turn phosphorylates the damage receptor Draper.

275 show that the mitotic Polo-like kinase PLK-1 phosphorylates the lamin LMN-1 to promote timely lamina

276 we show that upon cell stress, JNK directly phosphorylates the microtubule rescue factor CLIP-170 in

277 Mechanistically, Pak1 phosphorylates the Mid1 N-terminus to promote its associ

278 Hog1 phosphorylates the nucleolar protein Net1, altering its

279 ing T cell development and activation, as it phosphorylates the TCR/CD3 complex to initiate TCR signa

280 These kinases terminate IL-17 signaling by phosphorylating the adaptor ACT1 leading to the release

281 ands around the transcription start site and phosphorylating the C-terminal domain for RNA polymerase

282 ermed nonsense-mediated mRNA decay (NMD), by phosphorylating the NMD factor UPF1.

283 in which SFKs autoinhibit their activity by phosphorylating their C-terminal tyrosine residues.

284 otential circadian kinases to participate in phosphorylating these sites, including 7 previously know

285 liberates the nucleotide, which can then be phosphorylated to become the pharmacologically active tr

286 inase C (PKC) activity, which is proposed to phosphorylate TRPC1 proteins to promote channel opening

287 interacts with TSC2 via its death domain and phosphorylates TSC2 via its kinase domain to mediate mTO

288 te that the nonreceptor tyrosine kinase Pyk2 phosphorylates tyrosine 131 in the E2 transactivation do

289 dopaminergic loss, whereas blockade of MST1 phosphorylating UNC5B suppresses neuronal apoptosis.

290 strate that P2K2 and P2K1 interact and cross-phosphorylate upon extracellular ATP treatment.

291 SHP2 was also phosphorylated upon engagement of the extracellular matr

292 OSCA1.3 is rapidly phosphorylated upon perception of pathogen-associated mo

293 NAD(+), its phosphorylated variant NAD(P)(+), and its reduced forms

294 dues were dispensable for CHT7 function, but phosphorylated variants of CHT7 persisted, indicating th

295 c detail limited to the suggestion that CDK1 phosphorylates VPS34.

296 Once Tyr88 is phosphorylated, we observe a coupling to a second site,

297 display a shorter lifetime when CLIP-170 is phosphorylated, we propose that instead of acting at the

298 ring that corona-localised MAD1 can still be phosphorylated when MPS1 activity is low.

299 vation when they also induce accumulation of phosphorylated, wild-type p53.

300 It can also phosphorylate zidovudine and ganciclovir to toxic moieti