ライフサイエンスコーパス: phosphorylation site

1 reonine at position 152 of tau confers a new phosphorylation site.

2 The mutation led to loss of a conserved phosphorylation site.

3 ibrium of the beta3-alpha3 loop close to the phosphorylation site.

4 of which lacks the key regulatory serine 472 phosphorylation site.

5 site, and another disrupted a predicted CK1 phosphorylation site.

6 harboring a cyclin-dependent kinase 2 (CDK2) phosphorylation site.

7 newly evolved H2A variant lacking a mitotic phosphorylation site.

8 howed modified fibrillation that depended on phosphorylation site.

9 firm that Ser-331 is a primary and preferred phosphorylation site.

10 ing dependent on the integrity of its TbDYRK phosphorylation site.

11 horylation and identified 10 high-confidence phosphorylation sites.

12 identification and localization of histidine-phosphorylation sites.

13 ), a proline-rich region (PRR), and multiple phosphorylation sites.

14 be mono-phosphorylated on any one of 14 CDK phosphorylation sites.

15 diated through different and non-overlapping phosphorylation sites.

16 hat 32 of these sites are likely direct AMPK phosphorylation sites.

17 f mTORC1, we were able to identify six T-bet phosphorylation sites.

18 nism likely dependent on TRPV1 S502 and T704 phosphorylation sites.

19 itative phosphoproteomics identified 229 PKA phosphorylation sites.

20 nd Thr-227, matching previous in vivo-mapped phosphorylation sites.

21 containing nuclear localization sequence and phosphorylation sites.

22 rotein pellet with 4,792 proteins with 1,072 phosphorylation sites.

23 human TRPC6 identified several novel serine phosphorylation sites.

24 vely phosphorylated, and we precisely assign phosphorylation sites.

25 expressing FUS mutated in the EGFR-targeted phosphorylation sites.

26 has several predicted protein kinase A (PKA) phosphorylation sites.

27 kout cells and discovered 160 AMPK-dependent phosphorylation sites.

28 manner in mitosis and identify several novel phosphorylation sites.

29 cated that GLI3 processing depends on the 19 phosphorylation sites (849, 852, 855, 856, 860, 861, 864

30 zymes and show that they carry a total of 75 phosphorylation sites, 92 acetylation sites, and two ubi

31 e phosphorylation of I1 at its PKA consensus phosphorylation site (a threonine residue in position 35

32 g fragment of RPT1 carries a PfPKG consensus phosphorylation site; a peptide carrying this consensus

33 , point mutations of the BIN2-mediated CESA1 phosphorylation site abolished BIN2-dependent regulation

34 Comparison of katanin and kif2a phosphorylation sites across a variety of species reveal

35 While the inventory for phosphorylation sites across different species has rapid

36 Here we map in vitro and in-cell phosphorylation sites across FUS LC We show that both ph

37 T238, T248, and T256, and mutations of these phosphorylation sites alter GLK1 protein stability and D

38 Our data suggest that PfPKG has a distinct phosphorylation site and that PfPKG directly phosphoryla

39 ng-range CheY allosteric network between D57 phosphorylation site and the FliM(N) interface, namely t

40 was needed for the deposition as a positive phosphorylation site and the last five amino acids in th

41 which has substitutions of various potential phosphorylation sites and a substitution of the conserve

42 pproach, we mutated 11 confirmed or presumed phosphorylation sites and assessed the impact on overall

43 ent helices, which are found away from known phosphorylation sites and could play a key role in the s

44 ations in phospholemman in the region of the phosphorylation sites and performed analyses within 2 hu

45 , all of which occur close to two regulatory phosphorylation sites and the catalytic site on human Ca

46 dicates that substitution of these potential phosphorylation sites and the tyrosine residue result in

47 a challenge owing to the multiple potential phosphorylation sites and their clustering in the Tau se

48 lcineurin activates the TF, but the specific phosphorylation sites and their roles in the activation/

49 Single point mutations at the phosphorylation sites and truncations of the N-terminal

50 FUS contains EGFR-targeted phosphorylation sites and, in Itgalpha1-null cells, acti

51 tional ECT2 BRCT domain and the UBF1 Ser-412 phosphorylation site are required for UBF1-mediated ECT2

52 We show that evolutionarily conserved MCV LT phosphorylation sites are constitutively recognized by c

53 Phosphorylation sites are hyperabundant in the eukaryoti

54 Only a limited number of PP2A-regulated phosphorylation sites are known.

55 e regulatory sites while the lower abundance phosphorylation sites are more densely populated at the

56 y a version of Cmb in which known Rho kinase phosphorylation sites are mutated.

57 k1(AF) knockin mice, in which two inhibitory phosphorylation sites are replaced by the non-phosphoryl

58 Akl1 has two Fpk1 phosphorylation sites (Ark1 and Prk1 have none) and is h

59 otein stability in response to site-specific phosphorylation sites, as well as trends related to prot

60 uman SMG1-8-9 kinase complex bound to a UPF1 phosphorylation site at an overall resolution of 2.9 ang

61 We identified a phosphorylation site at residue Ser(237) of TRIP8b that

62 The phosphorylation site at serine 14 of TRPC6 is embedded i

63 d CTCF mass spectrometry, identified a novel phosphorylation site at Serine 224 (Ser(224)-P), and dem

64 beling method, we defined a PP1/2A-sensitive phosphorylation site at Thr-48 in human DAT, a residue t

65 tandem mass spectrometry, we identified two phosphorylation sites at the distal C-terminal tail of t

66 type tyrosine phosphatases contain potential phosphorylation sites at their C termini, we propose tha

67 Conversion of the phosphorylation sites at Thr-70 and Ser-166 to Ala resul

68 tion of PLK4, or mutation of the NEK7 Ser204 phosphorylation site, augments NEK7 interaction with NLR

69 hosphoproteomic analysis show relatively few phosphorylation sites being affected by PPM5C deletion i

70 Deletion of all four conserved phosphorylation sites but not individual ones affected t

71 runcation mutant (DeltaP242) that lacked all phosphorylation sites but retained a previously suggeste

72 There are thousands of known cellular phosphorylation sites, but the paucity of ways to identi

73 ne, which is predicted to be a potential PKA phosphorylation site by at least one prediction tool, wh

74 actin-modulating proteins and located their phosphorylation sites by mass spectrometry.

75 ly encoded melanopsin lacking all C-terminal phosphorylation sites (C terminus phosphonull) leads to

76 r Tyrosine that could potentially retain the phosphorylation site capacity.

77 P-binding site, RAD51-interacting domain, or phosphorylation site causes excessive binding of RAD51 t

78 model predicts that a cdr2 mutant in an Ssp1 phosphorylation site (cdr2-T166A) [4] should form nodes

79 Despite a shared upstream kinase and similar phosphorylation sites, Cdr2 and Ssp2 have distinct regul

80 P83 as a bona fide TTBK2 substrate with four phosphorylation sites characterized.

81 entify new Aurora kinase substrates based on phosphorylation site clustering, protein localization, p

82 The results show that all 11 phosphorylation sites contribute, in varying degrees, to

83 over 170,000 carefully curated nonredundant phosphorylation sites covering 18,610 proteins.

84 Importantly, we showed that the phosphorylation site - D58 is at the interface of RssB-s

85 e protein-centric PTM networks, quantitative phosphorylation site data from over 10 different quantit

86 Mutation of the putative PKA phosphorylation sites did not change the inhibitory effe

87 have employed a 25-mer novel peptide, MARCKS phosphorylation site domain sequence (MPS), to determine

88 attenuation of MARCKS using the MPS (MARCKS phosphorylation site domain) peptide synergistically int

89 ics and high throughput screening identified phosphorylation sites downstream of Cdk5.

90 ults presented here with previously reported phosphorylation sites downstream of ERK showed a limited

91 gnaling components and C-terminal tail GluA1 phosphorylation sites exhibited a permissive role, limit

92 An RPA32 mutant lacking phosphorylation sites fails to recruit PRP19 and support

93 Arg-354 or Ser-357, which forms a consensus phosphorylation site for basophilic kinases, markedly re

94 of histone 2A (H2A) that lacks the conserved phosphorylation site for kinetochore-associated Bub1 kin

95 of a Thr residue potentially creates a novel phosphorylation site for Ser/Thr kinases and because Nav

96 no acid sequence of mammalian Cx36 harbors a phosphorylation site for the Ca(2+)/calmodulin-dependent

97 ion, and forward and reverse transport, with phosphorylation sites for these kinases being linked to

98 horylation induces dissociation of the Par-3 phosphorylation site from aPKC's kinase domain but does

99 enabled quantitative analysis of over 20 000 phosphorylation sites from human pancreatic islets treat

100 inhibiting the ISR by mutating the eIF2alpha phosphorylation site, genetically(11) and pharmacologica

101 Although tens of thousands of phosphorylation sites have been identified in human cell

102 LTCC phosphorylation sites identified and studied to date are

103 he C terminus of ArnB, which harbors all the phosphorylation sites identified to date and is importan

104 Among the 17 candidate phosphorylation sites identified, the mutation of Ser68

105 Of 19 native NaV1.5 phosphorylation sites identified, two C-terminal phospho

106 conclusion, we have characterized a tyrosine phosphorylation site in Aplysia cortactin that plays a m

107 In contrast, only one E2 tyrosine phosphorylation site in BPV-1 (tyrosine 102) and one in

108 ther, these findings establish that a single phosphorylation site in Drp1 can regulate mitochondrial

109 we identified Ser(22) as an additional AMPK phosphorylation site in FOXO1's N terminus, with Ser(22)

110 We report the relative importance of each phosphorylation site in inducing a functionally active o

111 complexes, by a mechanism that requires S28 phosphorylation site in LIN52.

112 nces of targeted elimination of the Drp1S600 phosphorylation site in progression of diabetic nephropa

113 is, Ser-164 was identified as a major serine phosphorylation site in SIRT1 in obese, but not lean, mi

114 PKA phosphorylates TCF4 directly and a PKA phosphorylation site in TCF4 is necessary for its transc

115 ) that lies adjacent to Thr(288), a critical phosphorylation site in the activation segment.

116 Antibodies against a tyrosine phosphorylation site in the intracellular juxtamembrane

117 Here we identify a CDK phosphorylation site in the shelterin subunit at Ser365

118 ia coli identified S837 as another potential phosphorylation site in vivo Mutation of all five potent

119 ssible to identify and quantify thousands of phosphorylation sites in a given cell type (phosphoprote

120 teomics techniques can identify thousands of phosphorylation sites in a single experiment, the majori

121 e out a role for all conserved consensus PKA phosphorylation sites in alpha1C in beta-adrenergic stim

122 We characterize several phosphorylation sites in ATM that are targets of DNA-PKc

123 Moreover, loss of Jak3-mediated phosphorylation sites in beta-catenin abrogated its AJ l

124 brafish studies indicated three PKC-specific phosphorylation sites in beta-catenin that are required

125 Furthermore, we identified five phosphorylation sites in beta-tubulin that serve as subs

126 Mutations of Mps1 phosphorylation sites in Bub1 or Mad1 abrogate the spind

127 ssays, we show here that mutation of the CK1 phosphorylation sites in Cx43 reduces the levels of tota

128 Our results show that the Plk1 phosphorylation sites in FoxM1b serve as a regulator for

129 thylation, and that is regulated by the Plk1 phosphorylation sites in FoxM1b.

130 emonstrate that 14-3-3 binds to two pairs of phosphorylation sites in IRSp53.

131 Here, we identify three conserved phosphorylation sites in NLRP3 and demonstrate that NLRP

132 Moreover, we identified regulated phosphorylation sites in numerous proteins that function

133 logos generated from significantly decreased phosphorylation sites in PKA-intact and PKA-null cells b

134 oxM1b identified a critical role of the Plk1 phosphorylation sites in regulating the binding of FoxM1

135 was proposed to involve a central cluster of phosphorylation sites in Ste5.

136 site in vivo Mutation of all five potential phosphorylation sites in the activation loop decreased,

137 Our screens identify phosphorylation sites in the cancer target ADAM17 that a

138 site, T479, is among the highly constrained phosphorylation sites in the coding regions of the gene

139 The phosphorylation sites in the D1R intracellular loop 3 ar

140 luated by the ability to predict Ser/Thr/Tyr phosphorylation sites in the disordered proteome.

141 MS analysis identified 14 phosphorylation sites in the Gle1A isoform, six of which

142 Of note, mutating the phosphorylation sites in the MAD1(CTD), including Thr-71

143 domains of TOPBP1 selectively bind conserved phosphorylation sites in the N-terminus of 53BP1.

144 nalyses to identify and quantify in situ the phosphorylation sites in the NaV1.5 proteins purified fr

145 hypothesize that positive selection of novel phosphorylation sites in the protein NS4B of the Brazili

146 Phosphorylation sites in the region between the CRIB-PR

147 Identification of regulatory phosphorylation sites in TRPC6 and corresponding protein

148 55, Thr-159, and Ser-280 as the main mitotic phosphorylation sites in Vgll4.

149 t that the corresponding tyrosines are known phosphorylation sites in vivo in many cases.

150 This study identified several IkappaBzeta phosphorylation sites, including a conserved cluster of

151 Mutation of all potential phosphorylation sites, including a highly conserved tyro

152 We identify a set of 115 phosphorylation sites increased during G2, termed 'early

153 evaluating the relative importance of direct phosphorylation site interactions remains challenging.

154 a mutant lacking the 5 protein kinase A or C phosphorylation sites interfered with its ability to sti

155 Tumors also showed a reduction of phosphorylation sites involved in transcription and RNA

156 odorant-guided behaviors in Drosophila This phosphorylation site is conserved in other insects, incl

157 ties, resulting from multiple interdependent phosphorylation sites is required for a GC-A conformatio

158 including a 27-residue sequence and Aurora B phosphorylation sites, is both necessary and sufficient

159 tbetagamma binding surface and contains both phosphorylation sites, is restrained within the central

160 lts indicate different functional classes of phosphorylation sites: 'key sites' required for arrestin

161 the literature and major public databases of phosphorylation sites, kinases, and disease associations

162 The specific phosphorylation sites leading to these abnormalities hav

163 cells suggest that kinase binding motifs and phosphorylation sites line up to maximize MAPK based co-

164 Akt, protein kinase A, and protein kinase C phosphorylation sites located in the vicinity of the ZO-

165 ectly phosphorylates Cdc55 and Igo/ENSA, and phosphorylation site mapping and mutagenesis indicate th

166 We hypothesized that this phosphorylation site may serve as a molecular switch, in

167 phosphorylation motifs indicated that these phosphorylation sites may be regulated directly by HAI1

168 indicate that Thr(264) in TRPV3 is a key ERK phosphorylation site mediating EGFR-induced sensitizatio

169 y charged amino acid instead of the putative phosphorylation site mimics the effect on voltage gating

170 increased the overall number of quantifiable phosphorylation sites more than 4-fold.

171 We systematically determined the phosphorylation-site motifs for the entire Nek kinase fa

172 Finally, we show that the phosphorylation-site motifs for the mitotic kinases Nek6

173 in vivo, we genetically altered a major PKC phosphorylation site, mouse TRPV1 S801, to alanine.

174 scued by wild-type p47(phox), but not by the phosphorylation site mutant of p47(phox) In agreement wi

175 n vitro, but with one exception, none of the phosphorylation site mutants had a selective impact on t

176 of D836 to alanine in the activation loop of phosphorylation site mutants nearly completely abolished

177 nces in tyrosine import could be detected in phosphorylation site mutants showing that if tyrosine tr

178 Single phosphorylation site mutants still support induction of

179 -galactosidase reporter activated by Hac1(i) Phosphorylation site mutants survive low levels of endop

180 and inactivation of Ire1 are not affected by phosphorylation site mutants.

181 cell lines could highly reproduce oncogenic phosphorylation site mutations identified in primary tum

182 s mutant could be complemented by expressing phosphorylation site mutations of MKP1.

183 The phosphorylation-site mutations confer DNA damage sensiti

184 having a phosphomimetic substitution in the phosphorylation site of alpha-Tpm (S283D).

185 -1 E2 mutant lacking a previously identified phosphorylation site of interest (Y102).

186 The phosphorylation site of NFAT3 was critical for epidermal

187 rmacologic manipulation of the serine (S)184 phosphorylation site of the proapoptotic Bcl2 family mem

188 s suggest that elimination of inhibitory Ser phosphorylation sites of IRS2 exerts short-term benefici

189 Here, we identified phosphorylation sites of PER-bound TIM by mass spectrome

190 Here, we examined whether the PKA phosphorylation sites of SIK1 and SIK2 are involved in s

191 er tissues and (iv) associations among multi-phosphorylation sites of the same protein.

192 A key phosphorylation site on RsbR (T209) is partially hidden

193 Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E

194 meostatic upscaling can be gated by a single phosphorylation site on the GluA2 subunit.

195 Here we identify serine 80 (S80) as a phosphorylation site on the p50 subunit of NF-kappaB, an

196 lysis identified 699 significantly regulated phosphorylation sites on 441 proteins.

197 nine experiments we identified 7827 class I phosphorylation sites on 4960 proteins.

198 1 and, furthermore, found 76 CD147-dependent phosphorylation sites on 57 proteins.

199 of FFA4-L as well as the effects of loss of phosphorylation sites on beta-arrestin recruitment and E

200 e cell cycle, yet mutation of Pkc1-dependent phosphorylation sites on Cdc55 and Igo2 did not cause de

201 However, the YopO phosphorylation sites on gelsolin and the consequences o

202 The results suggest that phosphorylation sites on globular, as distinct from diso

203 te (Asp), glutamate (Glu) and cysteine (Cys) phosphorylation sites on human proteins by mass spectrom

204 Moreover, we identified new phosphorylation sites on IAV-encoded proteins.

205 ned with point mutations abrogating specific phosphorylation sites on KIT.

206 By mapping PKC phosphorylation sites on LB3 and testing the effects of

207 ich resource for prioritizing the effects of phosphorylation sites on protein lifetime in the context

208 ee highly conserved growth factor-responsive phosphorylation sites on RagC, a component of the Rag he

209 we mapped the position of the TBK1 dependent phosphorylation sites on Raptor in vitro.

210 Mutation of DORN1 phosphorylation sites on RBOHD eliminates the ability of

211 M(3SA); phospholemman [FXYD1] in which the 3 phosphorylation sites on serines 63, 68, and 69 are muta

212 ence of reports in the literature on mapping phosphorylation sites on sPPases, a database survey of v

213 Alanine mutations of all 11 phosphorylation sites on the C terminus of MORs almost c

214 Previous studies identified numerous phosphorylation sites on TRPM7, but very little is known

215 d new functional regions, characterised with phosphorylation sites or distinct hydrophilic properties

216 2 (HER2)- pY(1196) site, but not other HER2 phosphorylation sites or other known PTPN12 substrates.

217 titative data for 10,000 proteins and 55,000 phosphorylation sites (p-sites) from 125 CCLs.

218 genomic ATG13 -8SA allele lacking key TORC1 phosphorylation sites partially bypasses the macroautoph

219 and suggested that residues surrounding the phosphorylation site play roles in PP2A substrate specif

220 In silico methods for phosphorylation site prediction can provide a useful and

221 and sequence features significantly improves phosphorylation site prediction performance across all k

222 provides a powerful tool for improvement of phosphorylation site prediction.

223 and tested peptide libraries to identify its phosphorylation site preferences.

224 kinase 4 (MST4) largely interconverted their phosphorylation site preferences.

225 ds on DAT residue Thr-53, a proline-directed phosphorylation site previously implicated in AMPH-stimu

226 From a total of 14,139 phosphorylation sites quantified, we found that 571 and

227 -1, thus elucidating the molecular basis for phosphorylation site recognition.

228 eptor C-termini, the functional role of each phosphorylation site remains obscure.

229 These phosphorylation sites represent potential new targets fo

230 osures of odor, and contains a candidate PKG phosphorylation site required to tune odor sensitivity.

231 Mutating these phosphorylation sites reverses 14-3-3-dependent inhibiti

232 ntify the substrates directly and to map the phosphorylation site(s) of plant symbiotic receptor-like

233 utation of SIM2s at one of the predicted ATM phosphorylation sites (S115) reduces HR efficiency throu

234 n increasingly positive charge in a critical phosphorylation site, S318, progressively amplifies OPS

235 t on Slack channels in which a conserved PKC phosphorylation site (S407) that regulates the current a

236 lack a well-conserved protein kinase A (PKA) phosphorylation site, S551, showed longer non-rapid eye

237 g the main CDK (sae2-S267A) or Mec1 and Tel1 phosphorylation sites (sae2-5A) with sae2Delta and Mre11

238 ated calcium response depended on the P2Y(2) phosphorylation sites Ser-243, Thr-344, and Ser-356, whi

239 Phosphorylation of the sole AMELX phosphorylation site (Ser-16) in vitro greatly enhances

240 ctrometry analysis, we discovered a distinct phosphorylation site, Ser-176, on YBX1.

241 was eliminated by mutating two PKC-targeted phosphorylation sites, Ser-502 and Ser-800, indicating i

242 In this binding mode, the phosphorylation site Ser366 in the STING tail cannot rea

243 ivated by dephosphorylation of an inhibitory phosphorylation site, Ser637.

244 odulin-dependent protein kinase II-dependent phosphorylation site (serine 2814) mutated to alanine (S

245 These data identify a set of HAI1-affected phosphorylation sites, show that HAI1-regulated phosphor

246 ins, and the functional analysis of selected phosphorylation sites showed that they either support (N

247 f thousands of proteins, phosphoproteins and phosphorylation sites specific to each tissue source, to

248 We used peptide arrays to define the phosphorylation site specificity for the majority of STE

249 Our findings further suggest that phosphorylation site specificity is both necessary and s

250 FUS's PrLD and observed that mimicking a few phosphorylation sites strongly inhibited FUS solid-phase

251 DEP1 also harbors the primary PKA phosphorylation site, suggesting that an improved unders

252 Finally, we identified a specific OCT4 phosphorylation site (T343) responsible for mediating Au

253 Here, we show that the proposed Munc18-1 phosphorylation site, T479, is among the highly constrai

254 analyses identified around 15-20% additional phosphorylation sites than control experiments without F

255 H. boettgeri kif2a possesses an activating phosphorylation site that is absent from X. laevis.

256 Serine 384 (S384) is the critical cyclin E phosphorylation site that stimulates Fbw7 binding and cy

257 now identified CaS(S875) as the missing PKC phosphorylation site that, together with CaS(T888), shap

258 Hic-5, identified critical motifs as well as phosphorylation sites that are required for the formatio

259 Here, we report that Arc GAG also acquired phosphorylation sites that can acutely regulate its syna

260 We identified >6,000 protein phosphorylation sites that can be used to infer >1,500 k

261 Analysis of the 838 phosphorylation sites that changed significantly, sugges

262 phoproteomic measurements further identified phosphorylation sites that were examined using phosphomi

263 In addition we identified 26 phosphorylation sites that were only responsive to dabra

264 This included 54 phosphorylation sites that were significantly down-modul

265 Mass spectroscopic analysis identified 20 phosphorylation sites, the majority of which were specif

266 RPA and to determine the effects of two UNG2 phosphorylation sites (Thr(6) and Tyr(8)) located within

267 Alanine substitution of the phosphorylation site Thr166 promoted incorporation of mu

268 e, we have analyzed the effect of a new Cytc phosphorylation site, threonine 58, which we mapped in r

269 We subsequently map this X. laevis LB3 phosphorylation site to a conserved site in mammalian la

270 Activation of FoxO3 by mutating phosphorylation sites to enhance its nuclear expression

271 AKAP79, its signaling components, and GluA1 phosphorylation sites to induce CP-AMPARs under conditio

272 nteracts with Brg1, and mutation of putative phosphorylation sites to non-phosphorylatable (Ser to Al

273 otential phosphorylation switches by mapping phosphorylation sites to protein-protein interactions of

274 omatographic tandem mass spectrometry to map phosphorylation sites to the otherwise divergent amino-t

275 fferent specificities for cMyBP-C's multiple phosphorylation sites, to show that individual sites are

276 By precisely removing a unique PKC phosphorylation site (TRPV1 S801) in mice through CRISPR

277 masses, mice in which a putative C-terminal phosphorylation site, Tyr(399), in endogenous PTPROt was

278 This allele disrupts an inhibitory phosphorylation site (Tyr15) for the kinase WEE1.

279 Alanine mutagenesis of each of the six phosphorylation sites was tested for the ability to impa

280 Among the 12 TIM phosphorylation sites we identified, at least two of the

281 and revealed that ablation of the three PKC phosphorylation sites weakens their interaction.

282 Phosphorylation sites were also identified on a subset o

283 predictions indicated that the MIC-regulated phosphorylation sites were chiefly modified by mTOR, as

284 Novel phosphorylation sites were found on IAV-encoded proteins

285 Moreover, a high proportion of the regulated phosphorylation sites were found on proteins that are as

286 The validated phosphorylation sites were found to be involved in actin

287 Importantly, however, these phosphorylation sites were not required for an insulin-i

288 A(6D) variant (in which six putative Ser/Thr phosphorylation sites were substituted with Asp) perturb

289 ures could be trained as a motif detector of phosphorylation sites when no kinase-specific phosphoryl

290 orylation profile and identified S685 as one phosphorylation site where one ASD-linked variant has be

291 Tau contains ~85 potential phosphorylation sites, which can be phosphorylated by va

292 CD site and exposure of the activation loop phosphorylation sites, which likely account for the decr

293 ing multi-omics data, we identify 789 (~17%) phosphorylation sites with circadian oscillations.

294 sites quantified, we found that 571 and 263 phosphorylation sites with significant changes in abunda

295 Surprisingly, 1,915 phosphorylation sites with the motif x-(S/T)-P showed in

296 it also reveals the importance of conserved phosphorylation sites within the DNA-binding domain of t

297 We discovered that Reelin regulates several phosphorylation sites within the positively charged seri

298 ed with antibodies directed against tyrosine phosphorylation sites within the receptor kinase domain.

299 e, we identified a single cortactin tyrosine phosphorylation site (Y499) to be important for the form

300 howed variations in the accessibility of the phosphorylation site Y701, which corresponded to the los