ライフサイエンスコーパス: photodamage

1 fold, probably protecting it from UV-induced photodamage.

2 ults, who are at highest risk of ultraviolet photodamage.

3 al stress on skin, causing acute and chronic photodamage.

4 tion may lead to enhanced protection from UV photodamage.

5 ure by the photosynthetic antenna to prevent photodamage.

6 ndonuclease that makes an incision 5' to the photodamage.

7 ted by death receptors, lipid mediators, and photodamage.

8 dants may counteract and prevent UVR-induced photodamage.

9 e higher plant photosynthetic apparatus from photodamage.

10 alanced state of photomorphogenesis to avoid photodamage.

11 -type Bcl-2 with respect to localization and photodamage.

12 ion over 20-30 min without photobleaching or photodamage.

13 sensitization of mitochondrial membranes to photodamage.

14 asia and considerably reduced penetration of photodamage.

15 maximizing the ability of the plant to avoid photodamage.

16 ibution of laser-induced hyperthermia to the photodamage.

17 indicate the level of protection against DNA photodamage.

18 tributed to the higher bax:bcl-2 ratio after photodamage.

19 against psoralen plus ultraviolet A-induced photodamage.

20 n disorders and recommendations for reducing photodamage.

21 aging and avoids out-of-focus background and photodamage.

22 hotochemical efficiency and/or resilience to photodamage.

23 track the lifetime changes in S cones after photodamage.

24 ly luminescence, and reductive repair of DNA photodamage.

25 throughput and increases photobleaching and photodamage.

26 e requirement while minimizing laser-induced photodamage.

27 g must also be balanced against the risks of photodamage.

28 ght drives photosynthesis but can also cause photodamage.

29 ort wavelengths, however, causes significant photodamage.

30 loyed DNA damage as a sensitive indicator of photodamage.

31 enables low-dose IR imaging of skin without photodamage.

32 at very low light levels to protect against photodamage.

33 ainst overdose of irradiance and to minimize photodamage.

34 olution while minimizing image artifacts and photodamage.

35 also the mechanisms for this new pathway to photodamage.

36 fficient force, short working distances, and photodamage.

37 , minimizing light absorption and preventing photodamage.

38 during 24 h time-lapse imaging with minimal photodamage.

39 e the efficiency of photosynthesis and avoid photodamage.

40 ng up to 26%, without increasing the risk of photodamage.

41 organisms due to its high speed and reduced photodamage.

42 ture is in preventing biologically momentous photodamage.

43 the photochemical pathways leading to uracil photodamage.

44 tiphoton microscope while limiting potential photodamage.

45 ent a novel prophylactic approach to corneal photodamage.

46 t their photosynthetic efficiency and induce photodamage.

47 oninvasive and label-free and does not cause photodamage.

48 in the mutant is not strictly the result of photodamage.

49 effects on the rate of photosystem II (PSII) photodamage.

50 tes, producing singlet oxygen and subsequent photodamage.

51 ht to optimize light capture and to minimize photodamage.

52 , and lipid vesicles, without any detectable photodamage.

53 stunted growth and accumulation of apparent photodamage.

54 st be balanced to prevent photoinhibition or photodamage.

55 icated that these plants experience stronger photodamage.

56 atial resolution, low photobleaching and low photodamage.

57 to protect the photosynthetic system against photodamage.

58 thylakoid membranes and repair of PSII after photodamage.

59 omain, spread diffusely in cells and was not photodamaged.

60 Bcl-2 missing alpha-helices 5/6 was also not photodamaged.

61 ic reticulum, and nuclear membranes and were photodamaged.

62 on interact with sunlight and can induce DNA photodamages.

63 had significantly less clinical evidence of photodamage (0% graded 6-8 on a photonumeric scale) than

64 action center protein is the main target for photodamage(2), with repair involving the selective degr

65 ntation group A (XPA) to sites of nuclear UV photodamage, accelerating clearance of UV-induced photol

66 s of RNA folding and catalytic behavior, but photodamage accrued during ultraviolet (UV) shadowing st

67 Our data also showed that DNA photodamage accumulates in both skin types with repeated

68 In plants, D1 photodamage activates translation of chloroplast psbA mR

69 Overall, 22 men with significant photodamage and a high number of AKs were enrolled in th

70 (5)/alpha(6) region of Bcl-2 is required for photodamage and cross-linking, and domain-dependent phot

71 mechanisms like photoprotection can prevent photodamage and ensure treatment safety.

72 requires high-sensitivity actuators to avoid photodamage and heating.

73 volumetric acquisition, leading to increased photodamage and inability to capture fast cellular and t

74 n short wavelength visible light, leading to photodamage and incompatibility with large-scale reactio

75 ntrol of DNA damage/repair and prevention of photodamage and nonmelanoma skin cancer in vitiligo.

76 luorescence and self-absorption, and reduced photodamage and photobleaching and therefore is particul

77 By mitigating concerns regarding photodamage and photobleaching associated with high-inte

78 However, susceptibility to photodamage and photobleaching, particularly when high-i

79 cutaneous melanocytes which protects against photodamage and photocarcinogenesis.

80 ynthetic ERbeta agonist inhibited UV-induced photodamage and skin wrinkle formation in a murine model

81 us, which could be a cause for the increased photodamage and subsequent D1 degradation.

82 the vulnerability of all genetic material to photodamage and subsequent mutations.

83 minated by D1a Symbiodinium experienced less photodamage and symbiont loss compared to control corals

84 th the redox state of the stroma rather than photodamage and that CGL71 functions under atmospheric O

85 similar action spectra for erythema and DNA photodamage and that erythema is a clinical surrogate fo

86 ndicate that the cpUPR mitigates chloroplast photodamage and that manipulation of this pathway is a p

87 y induce nonphotochemical quenching to avoid photodamage and trigger expression of "photoprotective"

88 Line-shaped illumination mitigates photodamage and, alongside refined spatial gating, maxim

89 nvestigated type I procollagen production in photodamaged and sun-protected human skin.

90 radiation as quickly as possible to prevent photodamages and corruption of the carried genetic infor

91 include efficient background rejection, low photodamage, and improved depth discrimination.

92 by endogenous chromophores, minimized tissue photodamage, and improved tissue penetration, highlighti

93 htforward to implement, free of radiation or photodamage, and provide ample multiplexing capability,

94 Although gene expression and photodamage are dynamic over the diurnal cycle, Chlamydo

95 e biologically relevant molecular targets of photodamage are still uncertain.

96 erable assembly complexes are protected from photodamage are unknown.

97 igmentation using erythema and epidermal DNA photodamage as endpoints.

98 dard course of fluorouracil on the extent of photodamage as measured using 4 photonumeric scales.

99 on, indicative that NRC forms in response to photodamage as part of the PSII repair process.

100 Pc 4-PDT photodamages Bcl-2 and Bcl-xL, antiapoptotic proteins in

101 nt of fluorescence leads to the reduction of photodamage, because the sample can be illuminated with

102 tistically significant changes were found in photodamage between baseline and 6 months (Griffiths sca

103 y, upon comparing the efficiency of membrane photodamage between two of these MgPzs (with the highest

104 To assess DNA photodamage, biopsies were taken and prepared for paraff

105 PSII is particularly sensitive to photodamage but benefits from a large diversity of photo

106 synthetic apparatus of plants and algae from photodamage by dissipating as heat the energy absorbed i

107 ulation of photosynthesis, and in preventing photodamage by excess light.

108 se strategies minimize photosystem II (PSII) photodamage by keeping the photosynthetic electron trans

109 The molecular mechanisms of photodamage by ultraviolet A, the sunlight's major ultra

110 pecially in areas in which safety issues and photodamage by UV light are of concern.

111 at a substantial reduction of these types of photodamage can be achieved by imaging samples on covers

112 h as light scattering, autofluorescence, and photodamage can be reduced.

113 mporal resolution of and/or reduce potential photodamage caused by optical imaging in live neural tis

114 ed rate of damage entails an accumulation of photodamaged centers (80% of all PSII) and the formation

115 lants to intense light, NBR1 associates with photodamaged chloroplasts independently of ATG7, a core

116 We postulate that, as photodamaged chloroplasts lose envelope integrity, cytos

117 SCAPE 2.0's significantly lower photodamage compared to point-scanning techniques is als

118 of the nanoparticles and may further repair photodamaged conjugated polymer.

119 Using a new photodamage criterion based on morphological changes of

120 g its gene product, D1, as needed to replace photodamaged D1 in Photosystem II.

121 Photodamaged D1 must be replaced with nascent D1 to main

122 stem II, likely by affecting turnover of the photodamaged D1 polypeptide.

123 tion as a protease in the degradation of the photodamaged D1 protein, they also are required, either

124 for in all organisms by enzymatic repair of photodamaged DNA.

125 nd a six- to 20-fold decrease in the rate of photodamage during calcium imaging of rat hippocampal br

126 tosynthesis and protect against ROS-mediated photodamage during high light exposure or desiccation.

127 (2)), thus minimizing the risk for nonlinear photodamage effects.

128 e to study cellular processes because of low photodamage, efficient background rejection, and improve

129 xygenase system is a risk factor for retinal photodamage, especially in individuals with Stargardt di

130 onents in the thylakoid membrane following a photodamage event.

131 hibition is always observed when the rate of photodamage exceeds the rate of D1 repair.

132 The action spectrum for photodamage exhibits minima at 830 and 970 nm, and maxim

133 uous pigmented facial macules and 12 control photodamaged facial areas were included in the study.

134 titative benchmarks for acceptable levels of photodamage, facilitating the optimisation of imaging pr

135 The photodamage focally increased the duration of microglia-

136 The rate of photodamage for 0615 and 0518 is 3.5 and 2.5 times that

137 ctions as a rapid and sensitive model of UVA photodamage for the identification and comparison of com

138 ( approximately 65 and 57%, respectively) in photodamaged forearm skin compared to sun-protected hip

139 ced capacity of skin fibroblasts in severely photodamaged forearm skin to synthesize procollagen, or

140 non-repeatable processes or systems prone to photodamage from prolonged laser exposure.

141 Photodamage from this pigment is minimized by its short

142 if oral pomegranate consumption will reduce photodamage from UVB irradiation and alter the compositi

143 UVA photodamage has been attributed to photosensitization by

144 pe I and type III procollagen are reduced in photodamaged human skin.

145 transformative approach designed to mitigate photodamage in biological and biomedical studies, enabli

146 l fluorescence measurements revealed no PSII photodamage in chilled leaves of either genotype.

147 orward electron transfer, back-reactions and photodamage in Chl-f-PSII, Chl-d-PSII, and Chl-a-PSII.

148 e have determined the action spectra for DNA photodamage in different human epidermal layers in situ.

149 Histologically, there was less evidence of photodamage in ETR than in TP, which had wispy collagen

150 different spectral profiles, to inhibit DNA photodamage in human epidermis in situ.

151 decreasing the severity of acute and chronic photodamage in human skin.

152 This agent induces photodamage in irradiated cells and simultaneously ident

153 r: transient growth arrest and repair of DNA photodamage in keratinocytes (KCs); elimination of KCs w

154 ave established that optical tweezers induce photodamage in live cells, the effects of trap irradiati

155 PSI structure and photochemistry to mitigate photodamage in response to changes in electron utilizati

156 We tested for laser-induced photodamage in several ways.

157 gh light-acclimated cells partially overcome photodamage in the latter half of the day prior to cell

158 poptotic member of the Bcl-2 family, was not photodamaged in Pc 4-PDT-treated human carcinoma cells M

159 ebiotic environment, UV-induced formation of photodamages in polymeric nucleic acids, such as cyclobu

160 es the stability of protein-OSC complexes to photodamage, increasing the lifetime of the chromophores

161 However, previous assessments of photodamage induced by imaging may have failed to measur

162 A on the apoptotic response to mitochondrial photodamage induced by photodynamic therapy (PDT).

163 developed to quantify ATR-pS435, measure XPA-photodamage interactions, and assess NER function.

164 nge for Acropora muricata with no measurable photodamage is defined based upon polyp expansion, coral

165 te and penetration depth, as well as reduced photodamage is detected.

166 s higher plant photosynthetic machinery from photodamage, is triggered by acidification of the thylak

167 ages such as deep light penetration, minimal photodamage, low autofluorescence, and high spatial reso

168 go a repair and reassembly process following photodamage, many facets of which remain unknown.

169 ng time range with respect to unraveling the photodamage mechanism, including the formation of the mo

170 This finding has implications for disease/photodamage mechanisms and interventions.

171 ting components of solar light and therefore photodamage mechanisms and photoprotection interventions

172 ing technology, signal generation rates, and photodamage mediation are bringing us closer to the goal

173 To prevent photodamage, molecules relax from electronic excited sta

174 Photodamage, observed on Western blots as the loss of th

175 a new perspective on the photostability and photodamage of biological systems.

176 ed stomach mucosa of anesthetized mice while photodamage of gastric epithelial surface cells created

177 ast psbA mRNA in angiosperms is activated by photodamage of its gene product, the D1 subunit of photo

178 This causes photodamage of labeled proteins and rapid photobleaching

179 iated with structural changes resulting from photodamage of PSII.

180 ansport is blocked, which, in turn, leads to photodamage of PSII.

181 evel of PSI does not result from accelerated photodamage of the PSI centers in var1 or var2 under mod

182 200 micro m) into tissue slices with minimal photodamage of tissue and photobleaching of label.

183 roaming atoms are radicals that can lead to photodamage, offering a new perspective on the photostab

184 f photoprotection by examining the effect of photodamage on the behavior of a switchable mutant of ki

185 submicron resolution and little out-of-focus photodamage or bleaching, its ability to record fast ele

186 be attributable to a true lack of effect in photodamage or limitations of the photonumeric scales in

187 mful back reactions, favouring resilience to photodamage over efficiency of light usage.

188 x that also serves to protect Rubpy dye from photodamaging oxidation, the Rubpy-dye-doped nanoparticl

189 D1 is susceptible to oxidative photodamage, particularly under high light, and protecti

190 erobic conditions, implicating oxygen in the photodamage pathway.

191 m effectors of gastric restitution following photodamage (PD) to single cells within the gastric orga

192 zing, and thereby minimizing the dynamics of photodamage (PD), a frequent limiting factor in the opti

193 Photodamage peaks in the UV-B part of the spectrum, but

194 To avoid photodamage, photosynthetic organisms are able to therma

195 This was accompanied by repair of photodamaged photosystem II (PSII) reaction centers, acc

196 and processes associated with the repair of photodamaged photosystem II complexes is discussed.

197 unassembled thylakoid membrane proteins and photodamaged photosystem II D1 protein.

198 n, may render it vulnerable to unprecedented photodamage, possibly involving nonadjacent bases that a

199 ependent analysis revealed not only the high photodamaging potential of both natural DNA modification

200 erior reaction yields, but also resolves the photodamage problem, regardless of whether they are sing

201 ore photoproduct or SP) is the exclusive DNA photodamage product in bacterial endospores.

202 ore photoproduct or SP) is the exclusive DNA photodamage product in bacterial endospores.

203 his study we pursue a closer analysis of the photodamage promoted on giant unilamellar vesicles membr

204 PSII) core complex, and may act in repair of photodamaged PSII complexes.

205 vo biosynthesis and/or assembly of D1 in the photodamaged PSII template.

206 The accumulation of photodamaged PSII under irradiance stress reflects a chl

207 Repair of photodamaged PSII was not affected by gabaculine.

208 ns as a degradation and disassembly zone for photodamaged PSII.

209 I) reaction center protein D1 upon repair of photodamaged PSII.

210 with a rate over five times higher than its photodamage rate and has a maximum reaction yield exceed

211 vel target for the prevention of UVB-induced photodamage regardless of p53 status.

212 In plant chloroplasts, D1 photodamage regulates D1 synthesis by modulating transla

213 While essential to avoid photodamage, regulation of photosynthesis results in dis

214 We posit that D1 photodamage relieves a repressive cotranslational intera

215 resses translation initiation in cis, and D1 photodamage relieves this repression.

216 l to fully understand the photostability and photodamage repair mechanisms in proteins.

217 lumination, suggesting that Deltapsi-induced photodamage represents a previously unrecognized limitin

218 ing photosynthetic efficiency while avoiding photodamage requires equally rapid regulation of photopr

219 mplex (OEC) synthesis, and resynthesis after photodamage, requires significantly higher Cl(-) concent

220 n-limited shot noise, but photobleaching and photodamage restrict the number and duration of simultan

221 Localized photodamage resulted in rapid cell exfoliation coinciden

222 markedly reduces overall photobleaching and photodamage, resulting in extended viability of biologic

223 Modeling of retinal photodamage revealed that plasma-mediated effects do not

224 mine, circumvents the limitations imposed by photodamage, scattering, and indiscriminate background e

225 To better understand DNA photodamage, several nucleosides were studied by femtose

226 gen, or whether contextual influences within photodamaged skin act to down-regulate type I procollage

227 For these studies, fibroblasts from photodamaged skin and matched sun-protected skin were es

228 d underlie the loss of collagen synthesis in photodamaged skin and, to a lesser extent perhaps, in ag

229 Pigmented facial macules on photodamaged skin are a clinical, dermoscopic, and histo

230 False-positives obtained with RCM in photodamaged skin are due to the presence of basal melan

231 In contrast, cells in photodamaged skin are often in contact with fragmented c

232 therefore, that factors within the severely photodamaged skin may act in some manner to inhibit proc

233 n of partially degraded collagen observed in photodamaged skin may inhibit, by an as yet unidentified

234 Collagen synthesis is reduced in severely photodamaged skin relative to collagen synthesis in corr

235 ollagen is approximately 3.6-fold greater in photodamaged skin than in sun-protected skin, and some f

236 udy of ambiguous pigmented facial macules on photodamaged skin was conducted in a tertiary referral c

237 confocal microscopy improves LM diagnosis in photodamaged skin with good histopathologic correlation

238 In photodamaged skin, collagen fibrils are shortened, thinn

239 Melanoma arising in chronically photodamaged skin, especially on the head and neck, is o

240 es in collagen structure in vivo in aged and photodamaged skin.

241 ches were used to assess collagen changes in photodamaged skin.

242 f these patients, there is neither increased photodamage/skin aging nor a higher incidence for sun-in

243 re susceptible to all-trans-retinal-mediated photodamage than are the major proteins from the rod out

244 ton fluorescence microscopy causes much less photodamage than conventional confocal microscopy, expan

245 chloroplasts exhibit greater photosystem II photodamage than is observed in the wild type, particula

246 skin (MED) is a more useful predictor of DNA photodamage than is racial/ethnic origin or skin phototy

247 ochondria was considerably more sensitive to photodamage than was Bcl-xL in the cytosol, indicating t

248 titute a previously unrecognized type of DNA photodamage that may interfere with telomere replication

249 hat erythema is a clinical surrogate for DNA photodamage that may lead to skin cancer.

250 RBD1 is central to the perception of the D1 photodamage that triggers D1 synthesis and that it activ

251 able deep subsurface penetration and reduced photodamage, there are few luminescent probes that can b

252 to UV radiation are subject to irreversible photodamage through covalent modification of tryptophans

253 Employing this assay, we characterized photodamage throughout the near-infrared region favored

254 Photodamage to ABCR causes it to aggregate in SDS gels a

255 We now observe Pc 4-PDT-induced photodamage to all Bcl-xL-related proteins, except the 3

256 r a modification of this approach, confining photodamage to arteries on the cortical surface (artery-

257 mage and cross-linking, and domain-dependent photodamage to Bcl-2 offers a unique mechanism for activ

258 (TC50 > 400 muM) and high ability to induce photodamage to endothelial cells (EA.hy926) without prei

259 At a 50 mJ/cm2 light dose, photodamage to MCF-10A/bcl-2 resulted in a greater loss

260 Photosynthetic organisms avoid photodamage to photosystem II (PSII) in variable light c

261 enotype of npq1 lor1 was not due to enhanced photodamage to photosystem II but rather to a less local

262 Photodamage to phycobilisomes in vitro and in living cel

263 hich presumably diminishes the likelihood of photodamage to reaction centers that have either lost an

264 CF136 and RBD1 as the signal that reports D1 photodamage to regulate psbA translation rate as needed

265 r and protein in the complex or irreversible photodamage to the aptamer.

266 tions of very low light intensities to avoid photodamage to the cell and rapid photobleaching.

267 activation yield by suppressing irreversible photodamage to the cofactor-free apo-WOC-PSII (photoinhi

268 that acute disruption of synaptic ribbons by photodamage to the ribbon markedly reduced both sustaine

269 abling faster image acquisition with reduced photodamage to the sample.

270 ly focused laser beam can further reduce the photodamages to the target object.

271 Tumors and photodamaged tumor-free "margin" skin were obtained from

272 e to the large penetration depth and reduced photodamage, two-photon imaging is an highly promising t

273 Plants prevent photodamage under high light by dissipating excess energ

274 timal low light, and are highly sensitive to photodamage under moderate light levels.

275 analyzed the amount and distribution of DNA photodamage using RIAs and immunofluorescence micrograph

276 arison of cell shape in 1-microm sections of photodamaged versus healthy skin at the light microscopi

277 d antenna complexes become protected against photodamage via shortening of the excited-state lifetime

278 experiments collected under conditions where photodamage was avoided.

279 Photodamage was determined to be negligible by observing

280 in Outcomes and Measures: Resolution of skin photodamage was evaluated on clinical examination.

281 The intensity dependence for photodamage was linear, supporting a single-photon proce

282 thesis, life expectancy was <40 y; long-term photodamage was not a concern; and vitamin D(3) deficien

283 High-intensity 730-nm light (two-photon photodamage) was used to cause single-cell damage in gas

284 lity of these mice as a model of UVA-induced photodamage, we administered four lotions to the skin of

285 To characterize the requirements for photodamage, we transiently transfected epitope-tagged B

286 Their skin photodamage were also improved or resolved completely on

287 Plants are vulnerable to photodamage when exposed to light intensities that excee

288 The RNA nucleobase uracil can suffer from photodamage when exposed to UV light, which may lead to

289 oscopy, we demonstrate substantially reduced photodamage when imaging rapid morphological changes in

290 of ribosomes to psbA mRNA is triggered by D1 photodamage, whereas the global stimulation of translati

291 esults confirm existing literature values of photodamage, whereas we now quantified the susceptibilit

292 Several mechanisms exist to avoid photodamage, which are collectively referred to as nonph

293 omplex consisting of AKAP12-ATR-pS435-XPA at photodamage, which is essential for cAMP-enhanced NER.

294 rce is crucial for protection of PSI against photodamage, which occurred particularly during the high

295 ltraviolet (UV) light, bears the majority of photodamage, which results in skin thinning, wrinkling,

296 The location of DNA photodamage within the epidermis is crucial as basal lay

297 hat there may be specific protein targets of photodamage within the outer segment, and they may be es