ライフサイエンスコーパス: photolabile

1 multifunctional chemicals, many of which are photolabile.

2 We report the synthesis of a radioactive, photolabile 2'-O-methyloligoRNA probe, 2258-53/52(SAz)-4

3 We report the synthesis of radioactive, photolabile 2'-O-methyloligoRNAs, PHONTs 1 and 2, comple

4 adjacent 2'-hydroxyl group protected as the photolabile 2'-O-o-nitrobenzyl or 2'-O-alpha-methyl-o-ni

5 The photolabile 2-nitrobenzyl protecting group is most appro

6 Photolabile 3',5'-dimethoxybenzoin-based linkers are adv

7 esis of DNA strands in capillaries utilizing photolabile 3-nitrophenylpropyloxycarbonyl (NPPOC) chemi

8 herapy employing the synergistic effect of a photolabile Abeta ligand and molecular light emerges as

9 In contrast, the relatively less photolabile AFO is reduced by both O(2)(*)(-) and LMCT.

10 Here, we describe a new photolabile alanine derivative based on protection of al

11 rt the synthesis and characterization of new photolabile amine protecting groups that are active unde

12 The novel photolabile amino acid was incorporated into substance P

13 the cholecystokinin (CCK) receptor, using a photolabile analogue of CCK having a blocked amino termi

14 in their native membranes, we synthesized a photolabile analogue of D-aspartate, 4-methoxy-7-nitroin

15 tions of Ca(2+) decreased the binding of the photolabile analogues to the C-terminal phosphoinositide

16 oceans could result in up to 13 Tg of highly photolabile and aerobically biolabile groundwater dissol

17 viously reported cleavable linkers including photolabile and disulfide linkers have restricted their

18 The species, assigned to TiOOH (eta(2)), is photolabile and is very efficiently converted to a titan

19 lysis; byproducts were found to be even less photolabile and more toxic (via the Microtox test).

20 estrict the site of covalent attachment of a photolabile and radiolabeled derivative of substance P (

21 OS from sulfidic sediments is preferentially photolabile and solar irradiation can be a potential mec

22 spectrometry (FT-ICR-MS) identified both the photolabile and the photoproduced DON from both natural

23 ) states based on interpretation of FeFeco's photolabile and thermolabile E(1) isomers (Inorg.

24 These effects were not photolabile and were present also when a 'blocking solut

25 Very photolabile "antivitamins B12" would also represent part

26 d derivatization reagents that incorporate a photolabile aryl iodide that is selectively activated by

27 coenzyme B12 and methylcobalamin, are highly photolabile, as are other alkylcobalamins.

28 gment 6 of the receptor, using probes with a photolabile benzoyl-phenylalanine on each end.

29 ity labeling the secretin receptor through a photolabile benzoyl-phenylalanine residue in position 13

30 of cholecystokinin (CCK) that incorporates a photolabile benzoylphenylalanine (Bpa) moiety in the mid

31 with a CCK analogue probe incorporating dual photolabile benzoylphenylalanine (Bpa) residues as sites

32 ized a cholecystokinin (CCK) analogue with a photolabile benzoylphenylalanine (Bpa) sited in position

33 probes that simultaneously incorporated two photolabile benzoylphenylalanines as sites of covalent a

34 ogen bromide to demonstrate that both of the photolabile benzoylphenylalanines within a single probe

35 he laser-pulse photolysis technique, using a photolabile, biologically inert ligand (caged carbamoylc

36 ad its DNA binding activity inhibited with a photolabile blocking reagent.

37 h a releasable linker, either a disulfide or photolabile bond.

38 critical for function, we also positioned a photolabile Bpa as an amino-terminal extension, in posit

39 e also developed a new probe incorporating a photolabile Bpa at position 26 of secretin, closer to it

40 57BL/6 mouse beta-cells were loaded with the photolabile Ca(2+) chelator NP-EGTA, the UV flash photol

41 ore efficient, selective, and pH-insensitive photolabile Ca(2+) chelators.

42 Relaxation was initiated using diazo-2, a photolabile Ca2+ chelator that has low Ca2+ binding affi

43 n of either photostable labeling reagents or photolabile cage compounds.

44 stal structures of wild-type IDH soaked with photolabile caged isocitrate and Mg2+ and void of nicoti

45 ir cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal c

46 A new photolabile caging group, 6-nitropiperonyloxymethyl (NPO

47 Photolabile caging groups, including the 1-(2-nitropheny

48 Light-driven uncaging of the photolabile calcium chelator DMNP-EDTA stimulates rapid

49 New salicyl alcohol derived photolabile carbonyl protecting groups have been develop

50 e 1-isocyTPQA ligand positioned trans to the photolabile CH3CN ligand in 2, suggesting the presence o

51 ous sites on BFCAs yields novel bifunctional photolabile chelating agents (BFPCAs) that are useful fo

52 Photolabile chelating cages or protecting groups need co

53 Two photolabile cholecystokinin analogues were developed and

54 to produce flakes as thin as bilayers, with photolabile CO ligands on the exfoliated surface.

55 Herein we demonstrate that a photolabile, colored moiety could be incorporated in a c

56 Our approach, featuring the use of novel photolabile compounds targeting the membrane-spanning re

57 Brief exposure of cells loaded with the photolabile conjugates to UVA light released free substr

58 Efforts to make photolabile coordination complexes of 14 and 21 with par

59 Stoppers were assembled by first binding photolabile coumarin-based molecules to the nanoparticle

60 In this study, we present the use of a photolabile curcumin-diazirine analogue, CRANAD-147, to

61 NIR-nanogels feature a photolabile cyanine cross-linker (Cy780-Acryl) that can

62 The synthesis and characterization of a photolabile derivative of beta-alanine, caged beta-alani

63 A biologically inactive photolabile derivative of isocitrate has been synthesize

64 e the synthesis and characterization of four photolabile derivatives of urea in which alpha-substitut

65 ase with two diazene analogues: diazirine, a photolabile diazene containing the azo (-N=N-) group in

66 Synthetic highlights of the study are a photolabile dimethoxynitrobenzyl-protected glutamic acid

67 creased the similarity due to the removal of photolabile DOS formulas not present in the ocean.

68 The photolabile effect of CO only upon afferent neural disch

69 hydroxy-2-nitrobenzhydryl (BHNB) groups in a photolabile ester bond were synthesized.

70 , high pCO (>300 Torr) causes Ca2+-dependent photolabile excitation of chemosensors in the carotid bo

71 the concentration of the dissolved and more photolabile Fe(III)-SRFA complex present in equilibrium

72 Our results show that the photolabile Fe(III)SRFA complex is reduced rapidly by LM

73 ic and electronic structural features of two photolabile {FeNO}(6) complexes where the compounds diff

74 We have identified a series of photolabile fluorescently quenched cassettes that displa

75 haracterized two high affinity, full-agonist photolabile GLP1 probes having sites for covalent attach

76 We developed two high-affinity, full agonist photolabile GLP1 probes having sites of covalent attachm

77 Incorporation of a photolabile group on the amine precursor obviates the ne

78 d by Michael addition chemistry to install a photolabile group.

79 us work, we demonstrated that coumarin-based photolabile groups could be used to cage tertiary amine

80 In these cases, the photolabile groups have been typically depicted as modif

81 Diazo-based precursors of photolabile groups have been used extensively for modify

82 dified at the carboxamide with o-nitrobenzyl photolabile groups is demonstrated as well as their pote

83 Herein, we refine and extend the concept of photolabile groups, synthesizing the first Ca(2+) -sensi

84 lays a much smaller role for the more highly photolabile halogenated forms.

85 R8, a plant photoreceptor protein that forms photolabile homodimers, to engineer the first light-trig

86 tochemically inert but can be converted into photolabile hydroquinones by mild reduction in situ.

87 A series of trityl-based photolabile hydroxyl protecting groups have been examine

88 ime course analyses and careful isolation of photolabile intermediates with support from DFT calculat

89 e technique to kainate and AMPA receptors, a photolabile kainate precursor in which a caging group, t

90 eneration from oligonucleotides containing a photolabile ketone suggests that such issues could be ad

91 photolysis of oligonucleotides containing a photolabile ketone, and were characterized by gel electr

92 The photolabile latch is based on adducts of C-nucleophiles

93 dinate high-spin heme species was reversibly photolabile, leading to a pentacoordinate high-spin ferr

94 loxyazo compounds 8a,b, which are themselves photolabile, leading to both radical and ionic decomposi

95 This photolabile ligand bound specifically and with high affi

96 By fuelling the system with the photolabile ligand, the conformation of G4 DNA was switc

97 uctures of photoremovable protecting groups, photolabile linkages, as well as a broad array of target

98 Strong-base stability of the photolabile linker allowed on-column nucleobase and phos

99 , 112,000 over 2.67 h) functionalized with a photolabile linker and pepstatin A into picoliter-scale

100 atent-active approach enabled by a traceless photolabile linker that allows for bidirectional AGA and

101 Here, we describe a traceless photolabile linker used to prepare carbohydrates with a

102 et (UV) laser has been applied to eliminate "photolabile" linkers without affecting the overall cryst

103 a biotinylated reagent that contains both a photolabile linking group and a thiol specific capture a

104 Bulky photolabile masked alkyne equivalents (MAEs) are needed

105 Here, we report a family of three photolabile material crosslinkers that respond rapidly a

106 This study aims to elucidate the fate of photolabile methionine in the presence of three CDOM sur

107 Photolabile moieties have been utilized in applications

108 d a series of five new probes, incorporating photolabile moieties into positions 2, 15, 20, 24, and 2

109 Three separate photolabile moieties that can be distinguished based upo

110 entification of a site of attachment for the photolabile moiety of the antagonist probe deep within t

111 On the right wavelength: Photolabile molecular units that undergo photocleavage u

112 e oxidoreductase (POR) forms an aggregate of photolabile NADPH-POR-protochlorophyllide (Pchlide) tern

113 Photolabile nighttime radical reservoirs, such as nitrou

114 id construct transfers the pH sensitivity of photolabile NIR cyanine dyes to highly emissive and long

115 The cleavage of a photolabile nitroveratryloxycarbonyl protecting group, w

116 To apply the technique to NMDA1 receptors a photolabile NMDA precursor (beta-DNB NMDA) was synthesiz

117 Using photolabile NO and O(2) carriers, we recently found that

118 by UV-light induced release of GTP from the photolabile NPE-GTP substrate.

119 (4) are generated at specific sites using a photolabile nucleotide precursor.

120 Photolabile nucleotides that disrupt nucleic acid struct

121 roscopy using the CO flow-flash approach and photolabile O(2) and NO carriers.

122 us in the absence and presence of CO using a photolabile O(2)-carrier.

123 A series of photolabile o-nitrobenzyl derivatives of serotonin (cage

124 ge site of the Na(+)-specific DNAzyme with a photolabile o-nitrobenzyl group, we achieved controlled

125 rotransmitters have been developed using the photolabile o-nitrobenzyl group.

126 We report the synthesis of a radioactive, photolabile oligodeoxyribonucleotide probe and its explo

127 We report the synthesis of a radioactive, photolabile oligodeoxyribonucleotide probe and its explo

128 ite-specifically photolabeled by radioactive photolabile oligoDNA probes targeted toward the 530 loop

129 proteolysis with chimeric molecules bearing photolabile or photoswitchable motifs.

130 of the secretin receptor that incorporates a photolabile p-benzoyl-L-phenylalanine (Bpa) into the pos

131 nalogue of human motilin that incorporated a photolabile p-benzoyl-l-phenylalanine (Bpa) residue into

132 6,Tyr10]rat secretin-27) that incorporates a photolabile p-benzoyl-L-phenylalanine (Bpa) residue into

133 ing to determine spatial approximations with photolabile p-benzoyl-l-phenylalanine (Bpa) residues sit

134 The first probe incorporated a photolabile p-benzoyl-l-phenylalanine into the position

135 o human calcitonin analogues incorporating a photolabile p-benzoyl-l-phenylalanine residue in the mid

136 robe incorporated the same fluorophore and a photolabile p-benzoylphenylalanine at the amino terminus

137 ithiane-based approach to synthesis of novel photolabile phospholipids is developed.

138 Photolabile phosphotriester derivatives of cyclic AMP an

139 Here, we show that PIF1 and related photolabile PIFs (but not photostable PIF7) promote the

140 Phytochrome A (phyA) is the photolabile plant light receptor that mediates broad spe

141 We describe a detailed procedure to create photolabile, polyethylene glycol (PEG)-based hydrogels a

142 The synthesis and characterization of a new photolabile precursor of glycine (caged glycine) is desc

143 The synthesis and characterization of a new photolabile precursor of glycine (coumarin-caged glycine

144 tered within milliseconds by photolysis of a photolabile precursor.

145 lesion released from single diastereomers of photolabile precursors by 1H NMR indicates that isomeriz

146 choline, or of gamma-aminobutyric acid, from photolabile precursors did not have this effect.

147 ,2-bis(diphenylphosphino)ethane, are used as photolabile precursors for metallonitrenes, an important

148 control experiments, photolytic release from photolabile precursors of carbamoylcholine, a stable and

149 a coli by flash photorelease of leucine from photolabile precursors.

150 eurotransmitters via photolysis of inactive, photolabile precursors.

151 intermediates is based on the irradiation of photolabile precursors.

152 h constraint now obtained with a position 16 photolabile probe was inconsistent with this model.

153 In this work, we design and implement a photolabile probe, which upon irradiation strengthens th

154 contact points derived from incorporation of photolabile probes (p-benzoylphenylalanine (Bpa)) into S

155 eveloped, characterized, and applied two new photolabile probes for this receptor, with sites for cov

156 o high-affinity, full-agonist, secretin-like photolabile probes having sites for covalent attachment

157 We have prepared two new photolabile probes incorporating a p-benzoyl-l-phenylala

158 evelopment of new classes of cell-compatible photolabile probes using a wide variety of extended pai-

159 binding, using a novel series of fluorescent photolabile probes, receptor proteolysis, and rapid high

160 ine interactions, we engineered an efficient photolabile proligand (OptoIso) to trigger betaAR signal

161 We report on a photolabile protecting (caging) group that is new for ca

162 The synthesis and characterization of a new photolabile protecting group (caging group) for carboxyl

163 hylaminobenzyl (DEABn) group as an effective photolabile protecting group (PPG).

164 e conjugated to and released in vitro from a photolabile protecting group and a commonly used catheps

165 The synthesis of a new photolabile protecting group for carboxylic acids, alpha

166 he development and characterization of a new photolabile protecting group for the carboxyl group of n

167 patible photoinduced electron transfer based photolabile protecting group has been developed for the

168 The photolabile protecting group increases the chemical stab

169 e-derived chiral BP synthons incorporating a photolabile protecting group.

170 Photolabile protecting groups (or "photocages") enable p

171 Photolabile protecting groups (PPGs) enable the precise

172 A group of robust and easy-to-make photolabile protecting groups (PPGs) for carbonyl compou

173 stituents on the photochemical properties of photolabile protecting groups (PPGs) has been studied.

174 The use of photolabile protecting groups is a versatile and well-es

175 The new photolabile protecting groups presented here complement

176 By installing two different photolabile protecting groups, so-called caging groups,

177 phthalenes that can be used to develop novel photolabile protecting groups.

178 ns suggests that these esters can be used as photolabile protecting groups.

179 nformation by blocking hydrogen bonding with photolabile protection groups.

180 n important source of nitrous acid (HONO), a photolabile radical precursor, yet in situ measurements

181 We also incorporated the photolabile radical precursors into dinucleoside monopho

182 lorine-based cleaner was a source of several photolabile reactive chlorine compounds, including ClNO(

183 r such as amines and halide ions, to produce photolabile reactive iodine species such as HOI and IX (

184 ve TM1 (the first transmembrane domain) by a photolabile residue at the carboxyl terminus of CCK.

185 We reported previously that a photolabile residue within the carboxyl-terminal half (r

186 Here, we developed probes having photolabile residues at the amino terminus of secretin t

187 Like probes incorporating individual photolabile residues in these positions,1,2 the two Bpa

188 iously used a series of probes incorporating photolabile residues into positions 6, 12, 13, 14, 18, 2

189 to establish spatial approximations between photolabile residues within a ligand and its receptor.

190 ying the time of laser exposure and ratio of photolabile/robust linkers.

191 ase preparation of the 3',5'-dialkoxybenzoin photolabile safety-catch linker 16 is described.

192 This second generation of benzoin photolabile safety-catch linkers provides greater contro

193 ops, we developed another probe that has its photolabile site of labeling within the amino-terminal h

194 Intermediate 3 is photolabile, so, in lieu of a Raman spectrum, IR was use

195 and 3'-hydroxyl groups were obtained using a photolabile solid-phase synthesis support (2) and a comm

196 c acids or 3'-alkylamines were obtained from photolabile solid-phase synthesis supports (1 and 4).

197 This includes the discovery of two novel, photolabile SPGs, para-methoxybenzyl Rongalite and ortho

198 We installed a photolabile structural cage on the hydroxy group of D-F0

199 making a diverse set of mass-differentiated photolabile tags readily available for combinatorial enc

200 tional photorelease of externally sensitized photolabile tags.

201 nating the formaldehyde byproduct and giving photolabile tertiary amine drugs with Phi(u) > 20%-a 35-

202 Analogues containing a photolabile tether have also been prepared as a compleme

203 position as DOS molecular formulas were more photolabile than those without sulfur.

204 ll-studied subfamily of CBCRs proceeds via a photolabile thioether linkage to a second cysteine fully

205 ccurs from triplet excited-state (3)PS* to a photolabile triplet state of Mn2(CO)10, which, like unde

206 All of these phytoestrogens were found to be photolabile under certain conditions.

207 addition is not clear, the formation of more photolabile weakly complexed Fe(III)SRFA is most consist

208 it is well known that the disulfide bond is photolabile when exposed to ultraviolet C (UVC) radiatio