ライフサイエンスコーパス: photoreceptor cell

1 f photoreceptive units (e.g., assemblages of photoreceptor cells).

2 This accumulation can damage the photoreceptor cell.

3 rolysis, leading to hyperpolarization of the photoreceptor cell.

4 based photosensitive organelle of Drosophila photoreceptor cells.

5 inal ganglion cells and connecting cilium of photoreceptor cells.

6 transport in specialized cilia of vertebrate photoreceptor cells.

7 products to the RPE and dispose of the dying photoreceptor cells.

8 associate in the outer segments of mouse rod photoreceptor cells.

9 bit signs of retinal stress and rapidly lose photoreceptor cells.

10 participate in the transport of proteins in photoreceptor cells.

11 indicated that vitamin E treatment protected photoreceptor cells.

12 previously under-appreciated S1R presence in photoreceptor cells.

13 2A (IVS1-2A>G mutation) in the BBS8 gene to photoreceptor cells.

14 thus eliminating the protein specifically in photoreceptor cells.

15 of 11-cis-retinal that can be marshalled in photoreceptor cells.

16 ge-gated Ca(2+) channels (Cav1.4) in retinal photoreceptor cells.

17 ng the first example of dispersed high-order photoreceptor cells.

18 ontinuously supply 11-cis-retinal to retinal photoreceptor cells.

19 are the most abundant transport vesicles in photoreceptor cells.

20 sponse during visual signaling in vertebrate photoreceptor cells.

21 le to long wavelength-sensitive (M/LWS) cone photoreceptor cells.

22 eneration of visual pigments in rod and cone photoreceptor cells.

23 yanine green may have a late toxic effect on photoreceptor cells.

24 to loss of insm1a expression than were cone photoreceptor cells.

25 ution, and possible plasticity of animal eye photoreceptor cells.

26 er retinal layers toward the RPE and loss of photoreceptor cells.

27 rmination of photoactivated rhodopsin in rod photoreceptor cells.

28 ted ommatidial lattice and reduced number of photoreceptor cells.

29 s involved in generating a light response in photoreceptor cells.

30 essive production of bisretinoid by impaired photoreceptor cells.

31 ormally fast kinetics of Ca(2+) elevation in photoreceptor cells.

32 s conserved between rhabdomeric and ciliated photoreceptor cells.

33 in terminally differentiated epithelial and photoreceptor cells.

34 proper development of hair cells and retinal photoreceptor cells.

35 role in retinal pigment epithelial (RPE) and photoreceptor cells.

36 characterized by progressive loss of retinal photoreceptor cells.

37 of mechanosensitive channels introduced into photoreceptor cells.

38 e to white light to assess protection of the photoreceptor cells.

39 sing exclusively the mutant rhodopsin in rod photoreceptor cells.

40 ct on RHD12, a protein found specifically in photoreceptor cells.

41 er conditions that fully bleach rod and cone photoreceptor cells.

42 ndent superoxide production in epithelia and photoreceptor cells.

43 major blood supply for the outer retina and photoreceptor cells.

44 n mechanism in olfactory sensory neurons and photoreceptor cells.

45 he most important regulatory factors for the photoreceptor cells.

46 covery of the retinal pigment epithelium and photoreceptor cells.

47 on found in the light-sensitive membranes of photoreceptor cells.

48 y revealed differentiating outer segments of photoreceptor cells.

49 es of Muller glia in the phagocytosis of rod photoreceptor cells.

50 sis of a limited population of dying or dead photoreceptor cells.

51 iocapillaris, the vascular supply of retinal photoreceptor cells.

52 itical component of the viability of RPE and photoreceptor cells.

53 dness caused by the dysfunction and death of photoreceptor cells.

54 p of Mendelian disorders primarily affecting photoreceptor cells.

55 hows properties of both retinal ganglion and photoreceptor cells.

56 tate with the outer segments of rod and cone photoreceptor cells.

57 Postmortem human eyes and mouse-derived photoreceptor cells (661W) were examined for Fas express

58 acity of Xenopus laevis retina to regenerate photoreceptor cells after cyclic light-mediated acute ro

59 The removal of ARL13B in adult rod photoreceptor cells after maturation of OS resulted in l

60 unappreciated role of IRBP in protecting the photoreceptor cells against the cytotoxic effects of acc

61 We found here that, in macaque photoreceptor cells, all USH1 proteins colocalized at me

62 WDR81 is expressed in Purkinje cells and photoreceptor cells, among other CNS neurons, and like t

63 cilia-based outer segment of the vertebrate photoreceptor cell and the microvilli-based rhabdomere o

64 characterized by progressive degeneration of photoreceptor cells and a strongly decreased light respo

65 hyde (bisretinoids) form nonenzymatically in photoreceptor cells and accumulate in retinal pigment ep

66 visual photopigments are housed within these photoreceptor cells and are sensitive to a wide range of

67 However, ribbon synapses of photoreceptor cells and bipolar neurons in the retina ex

68 Ribbon synapses of photoreceptor cells and bipolar neurons in the retina si

69 ons in genes associated with BBS affect only photoreceptor cells and cause nonsyndromic retinitis pig

70 yer in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role f

71 te of elongase ELOVL4, which is expressed in photoreceptor cells and generates very long chain (>/=C2

72 In vitro systems of isolated photoreceptor cells and intact neural retina were used.

73 is constitutive activity can desensitize rod photoreceptor cells and lead to night blindness.

74 lp1 gene in mouse (Mus musculus) retinal rod photoreceptor cells and measured the effects on G-protei

75 voked rapid PLC-mediated contractions of the photoreceptor cells and modulated the activity of mechan

76 E8 function is necessary for the survival of photoreceptor cells and NHE8 is important for RPE cell p

77 characterized by degeneration of the retinal photoreceptor cells and progressive loss of vision.

78 eurons that receive synaptic input from cone photoreceptor cells and provide the output of the first

79 onstrate a novel transport mechanism between photoreceptor cells and RPE that does not involve canoni

80 Ribbon synapses of photoreceptor cells and second-order bipolar neurons in

81 Two retinal cell types, photoreceptor cells and the adjacent retinal pigmented e

82 The demanding physiologic functions of photoreceptor cells and the retinal pigmented epithelium

83 quential biochemical reactions that occur in photoreceptor cells and the retinal pigmented epithelium

84 nderstanding better the interactions between photoreceptor cells and the RPE, and may help in the dev

85 However, precise roles of BBS proteins in photoreceptor cells and the underlying mechanisms of pho

86 sulted in activation of Muller glia, loss of photoreceptor cells, and an increase in phosphorylated t

87 rmal ciliogenesis and differentiation in the photoreceptor cells, and that ttc26 is required for norm

88 additional visible light to the rod and cone photoreceptor cells, and thereby improve the visual syst

89 n about the function of DICER1 in mature rod photoreceptor cells, another retinal cell type that is s

90 led that chrysophanol attenuated MNU-induced photoreceptor cell apoptosis and inhibited the expressio

91 3 and Ascl1a proteins following rod and cone photoreceptor cell apoptosis.

92 In the eyes, the outer segments of photoreceptor cells appeared shortened or absent, wherea

93 ions that generate a photoreceptor and a non-photoreceptor cell are decreased in favor of symmetric t

94 The newly integrated photoreceptor cells are light-responsive with dim-flash

95 The outer segments (OS) of rod and cone photoreceptor cells are specialized sensory cilia that c

96 ning localized to the inner segments (IS) of photoreceptor cells, as well as the outer segments (OS)

97 In photoreceptor cells, associated neurons, and radial glia

98 Microarray analysis revealed loss of photoreceptor cell-associated transcripts, with preserva

99 orrelated with a significant preservation of photoreceptor cells at 4 and 10 weeks PI.

100 in coexpressed with rhabdomeric-opsin in eye photoreceptor cells bearing both microvilli and cilia in

101 on, indicating an essential role for Numb in photoreceptor cell biology.

102 retinal membrane guanylyl cyclase (RetGC) in photoreceptor cells, blocks RetGC catalytic activity and

103 e in the fly retina, where they are found in photoreceptor cell bodies and surrounding pigment glial

104 f the disorder, phagocytic clearance of dead photoreceptor cell bodies has a protective role by preve

105 ne metabolites between perisynaptic glia and photoreceptor cell bodies to mediate a novel, long-dista

106 t 6 months of age, the treated eyes retained photoreceptor cell bodies, while there were no detectabl

107 ght according to the adaptation state of the photoreceptor cells by shifting the detection limit to h

108 question remains whether transplantation of photoreceptor cells can actually improve vision.

109 Cone photoreceptors cells can use 11-cis-retinal from the RPE

110 , which are destined to produce amacrine and photoreceptor cells, can be re-programmed into RGCs when

111 Retinal photoreceptor cells contain the highest concentration of

112 Mature rod photoreceptor cells contain very small nuclei with tight

113 The vertebrate photoreceptor cell contains an elaborate cilium that inc

114 se (PDE6) involved in visual transduction in photoreceptor cells contains two inhibitory gamma-subuni

115 In photoreceptor cells, dark activation of G(q)alpha molecu

116 Photoreceptor cell death accompanying many retinal degen

117 dly observed in blinding disorders caused by photoreceptor cell death and are thought to occur in res

118 inherited retinal disorder characterized by photoreceptor cell death and genetic heterogeneity.

119 d surrounding commotio retinae with specific photoreceptor cell death and sparing of cells in the oth

120 Retinal degenerative diseases caused by photoreceptor cell death are major causes of irreversibl

121 PE atrophy, choroidal neovascularisation and photoreceptor cell death associated with severe visual l

122 The photoreceptor cell death associated with the various gen

123 indness are caused by mutations that lead to photoreceptor cell death but spare second- and third-ord

124 h pathways will be more effective at slowing photoreceptor cell death caused by elevated cGMP.

125 The extent of photoreceptor cell death declined and necrosis progresse

126 loss of transducin in rd10 mice also led to photoreceptor cell death in darkness.

127 uture investigation into retbindin's role in photoreceptor cell death in models of retinal degenerati

128 d chromatin accessibility and stress-induced photoreceptor cell death in our mouse model.

129 pportunity to longitudinally monitor retinal photoreceptor cell death in preclinical studies.

130 in-coupled receptor is causing light-induced photoreceptor cell death in rd10 mice.

131 Dysfunctional RPE may ultimately lead to photoreceptor cell death in the NHE8 mutants.

132 t critical pathobiological factor leading to photoreceptor cell death in these animals is insufficien

133 Irreversible photoreceptor cell death is a major cause of blindness i

134 How constitutive phototransduction causes photoreceptor cell death is poorly understood.

135 Photoreceptor cell death is the proximal cause of blindn

136 Photoreceptor cell death is the ultimate cause of vision

137 In rd10 mice, photoreceptor cell death occurs with exposure to normal

138 Increased photoreceptor cell death was observed when retinas lacki

139 a-1(+) cells in the subretinal space, severe photoreceptor cell death, and increased Ccl4 expression

140 and retinal pigmented epithelium, early cone photoreceptor cell death, and reduced lengths of rod out

141 group of disorders which lead to progressive photoreceptor cell death, resulting in blindness.

142 Retinal degeneration leads to progressive photoreceptor cell death, resulting in vision loss.

143 Using an inducible model of photoreceptor cell death, we investigated the prevalence

144 sregulation is thought to cause rod and cone photoreceptor cell death.

145 ative vitreoretinopathy, and protect against photoreceptor cell death.

146 s and mutations in Drosophila PNPLA6 lead to photoreceptor cell death.

147 tive optics images does not necessarily mean photoreceptor cell death.

148 proliferating Muller glia without affecting photoreceptor cell death.

149 emistry were observed after the onset of rod photoreceptor cell death.

150 hin the endoplasmic reticulum (ER) and cause photoreceptor cell death.

151 e only model of retinal trauma with specific photoreceptor cell death.

152 e fate of misfolded P23H rhodopsin linked to photoreceptor cell death.

153 nucleotide gated channels to cGMP and causes photoreceptor cell death.

154 n activity as a key event during primary rod photoreceptor cell death.

155 ine retinas from light- and disease-mediated photoreceptor cell death.

156 t FTY720 serves an active role in preventing photoreceptor cell death.

157 e to mutant rhodopsin that ultimately limits photoreceptor cell death.

158 reduced photoreceptor function and increased photoreceptor cell death.

159 tion of intracellular mechanisms, leading to photoreceptor cell death.

160 Deoxysphingolipids caused photoreceptor-cell death in retinal organoids, but not i

161 te Dicer1 from cone cells, we show that cone photoreceptor cells degenerate and die in the Dicer-dele

162 inal degeneration mutants, and light-induced photoreceptor cell degeneration models), the use of Tb(3

163 system functions in patients who suffer from photoreceptor cell degeneration or related retinal disea

164 iers and affected males demonstrated RPE and photoreceptor cell degeneration.

165 rogressive disease involving RPE atrophy and photoreceptor cell degeneration.

166 The further reduction of photoreceptor cell demise by co-treatment with calpastat

167 stress responses that together contribute to photoreceptor cell demise.

168 pmental apoptotic pathway is not involved in photoreceptor cell demise.

169 Rod photoreceptor cells depend completely on the output of 1

170 Photoreceptor cells depolarized normally following light

171 ds to retina-specific enhancers and controls photoreceptor cell development.

172 nstrate that Notch signaling is required for photoreceptor cell differentiation and retinal organizat

173 several developmental genes involved in the photoreceptor cell differentiation suggest that a role o

174 Circadian shedding of retinal photoreceptor cell discs with subsequent phagocytosis by

175 ominant retinal degeneration, in rhabdomeric photoreceptor cells disrupts morphogenesis in ways paral

176 The mechanism by which RPGR mutations cause photoreceptor cell dysfunction is not well understood.

177 Photoreceptor cells encode light signals over a wide ran

178 ve units expressed multiple opsins, while UV photoreceptor cells expressed single opsins; 2) most of

179 ort the 'transcriptional dominance' model of photoreceptor cell fate determination and provide insigh

180 Here we show that Abl is required for photoreceptor cell fate maintenance, as Abl mutant photo

181 ether in gene regulatory networks to control photoreceptor cell fate specification.

182 The mechanisms that specify photoreceptor cell-fate determination, especially as reg

183 trinsic activity to suppress the alternative photoreceptor cell fates of early retinal progenitors by

184 37 donors examined, there was marked loss of photoreceptor cells for variable distances distal from t

185 the need to identify approaches to generate photoreceptors cells for future replacement therapies.

186 istered noninvasively to efficiently protect photoreceptor cells from oxidative damage.

187 tumor that expresses several markers of cone photoreceptor cells has been described earlier.

188 Retinal rod photoreceptor cells have double membrane discs located i

189 The two fundamental types of photoreceptor cells have evolved unique structures to ex

190 s between the photoreceptors and RPE because photoreceptor cells have very high energy demands, large

191 thelium (RPE), a monolayer of cells vital to photoreceptor cell health.

192 Muller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenera

193 , organization and function of brain and eye photoreceptor cells in bilaterian animals.

194 r a new way for maintaining and regenerating photoreceptor cells in neurodegenerative diseases.

195 dies against TTLL5 stained the basal body of photoreceptor cells in rat and the centrosome of the spe

196 results point to a potential way to generate photoreceptor cells in situ in adult mammalian eyes.

197 Photoreceptor cells in the eyes of Bilateria are often c

198 dent light reception in the compound eye and photoreceptor cells in the Hofbauer-Buchner eyelet.

199 adults and ultimately leads to the death of photoreceptor cells in the macular area of the neural re

200 ith two r-opsins in depolarizing rhabdomeric photoreceptor cells in the pigmented eyes of Platynereis

201 Postmitotic neurons, such as photoreceptor cells in the retina and epithelial cells i

202 ations in dogs characterised by depletion of photoreceptor cells in the retina, which ultimately lead

203 tures of outer segments between rod and cone photoreceptor cells in the vertebrate retina.

204 Spectral absorbance of the photoreceptor cells in these sharks revealed the presenc

205 and thickening of Bruch's membrane, loss of photoreceptors, cells in subretinal space, and a reducti

206 f cells and at the connecting cilium (CC) of photoreceptor cells, indicating that SPATA7 is a ciliary

207 enesis of these compartments is integral for photoreceptor cell integrity and function.

208 atic RPE cell signaling that aims to sustain photoreceptor cell integrity and reveal potential therap

209 n in photoreceptors and RPE, thus preserving photoreceptor cell integrity.

210 al membranes of the two fundamental types of photoreceptor cells into their respective phototransduct

211 ve outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hund

212 antial fraction of the visual pigment in our photoreceptor cells is bleached.

213 y of a gene playing an essential function in photoreceptor cells is derived with high specificity and

214 Phototransduction in Drosophila microvillar photoreceptor cells is mediated by a G protein-activated

215 ial reduction of RPGRIP1 levels at the CC of photoreceptor cells is observed, suggesting that SPATA7

216 e protein from the retinal Muller glia (RMG)/photoreceptor cell junction.

217 In the retina, the photoreceptor cell layer showed the strongest beta-galac

218 n: increased migration, translocation to the photoreceptor cell layer, proliferation, and phagocytosi

219 assist in maintaining homeostasis across the photoreceptor cell layer.

220 A photoreceptor cell line, 661W, derived from a mouse reti

221 duced cell death in 661W cells, a mouse cone photoreceptor cell line, shown to express both estrogen

222 ne 661W, a mouse SV-40 T antigen transformed photoreceptor cell line.

223 deposits, severe reduction in ERG responses, photoreceptor cell loss and gliosis.

224 can help inhibit the inflammation-associated photoreceptor cell loss in late AMD, including geographi

225 inal pigment epithelium (RPE) and late-onset photoreceptor cell loss in the mutant retina.

226 Minor photoreceptor cell loss occurred in adult Mfsd2a KO mice

227 age, indicated by a significant reduction in photoreceptor cell loss, and restoration of the alpha-tr

228 ession of retinoic acid-responsive genes and photoreceptor cell loss, overall leading to a reduction

229 including abnormal RPE cells and late-onset photoreceptor cell loss.

230 t, as well as Purkinje cell degeneration and photoreceptor cell loss.

231 s of these ER stress markers correlated with photoreceptor cell loss.

232 AMD in a proportion of cases and imply that photoreceptor-cell loss may contribute to the functional

233 slow progressive degeneration, with ~30% of photoreceptor cells lost by the age of 6 months.

234 for ocular retinoid production required for photoreceptor cell maintenance and visual function.

235 es in regulating epithelial polarity and, in photoreceptor cells, morphogenesis and stability.

236 l1 disruption caused abnormal positioning of photoreceptor cell nuclei early in development.

237 elease, marked apoptosis was detected in the photoreceptor cell nuclei of the retina.

238 In addition, there was a reduction in cone photoreceptor cell number and cone b-wave amplitude.

239 Additionally, four weekly IVIs increased the photoreceptor cell number in the retinae of Rho(P23H/+)

240 This rule is broken by rod photoreceptor cells of nocturnal mammals, in which the t

241 sin ciliary trafficking, was mislocalized in photoreceptor cells of rpgrip1 mutants.

242 native rod outer segment disc membranes from photoreceptor cells of the retina in mice.

243 ffort to understand genetic disorders of the photoreceptor cells of the retina, we have focused on in

244 ctivation of visual pigments in rod and cone photoreceptor cells of the retina.

245 uestion, we expressed cone PDE6alpha' in the photoreceptor cells of the retinal degeneration 10 (rd10

246 that it could sustain the responsiveness of photoreceptor cells, particularly cones, even under brig

247 , ey>CHMP2B(Intron5) flies showed defects in photoreceptor cell patterning and phototactic behavior.

248 The cGMP phosphodiesterase of rod photoreceptor cells, PDE6, is the key effector enzyme in

249 rosophila melanogaster larvae, which have 12 photoreceptor cells per hemisphere, are attracted to dis

250 Accumulating evidence suggests that photoreceptor cells play a previously unappreciated role

251 o the third instar larval eye disc while the photoreceptor cells (PR) are differentiating.

252 early functional deficiencies (ERG) without photoreceptor cell (PRC) death and identified early insu

253 significant advance for the understanding of photoreceptor cell (PRC) evolution and development and f

254 esterase gene Pde6beta and lose rod and cone photoreceptor cells (PRC) within the first 6 wk of life,

255 The photoreceptor cell progeny are exclusively cone photorec

256 tein common to both rhabdomeric and ciliated photoreceptor cells, Prominin.

257 For instance, different classes of photoreceptor cells (PRs) are distributed stochastically

258 and HP1a are required for differentiation of photoreceptor cells R1, R6 and R7.

259 In vertebrate photoreceptor cells, rapid recovery from light excitatio

260 Here we show that Ca(2+) homeostasis in the photoreceptor cell relies on the protein calphotin.

261 echanisms underlying the progressive loss of photoreceptor cells remains therefore crucial.

262 he safety and efficiency of patient-specific photoreceptor cell replacement in humans.

263 Significant obstacles to advancement of photoreceptor cell-replacement include low migration rat

264 Photoreceptor cell-replacement may hold the potential fo

265 The outer segment of a vertebrate photoreceptor cell represents the most elaborate of all

266 Formation of membrane discs in photoreceptor cells requires evagination of its ciliary

267 and consequent removal from Muller glial and photoreceptor cells, results in severe and progressive r

268 ikely corresponded to histologically visible photoreceptor cell rosettes.

269 in other cell types in previous reports, in photoreceptor cells S1R was found in the nuclear envelop

270 Every day, shortly after light onset, photoreceptor cells shed approximately a tenth of their

271 Emerging evidence has linked photoreceptor cell-specific nuclear receptor (PNR/NR2E3)

272 These intronic sequences are sufficient for photoreceptor-cell-specific splicing of heterologous exo

273 ic opsins are employed by different kinds of photoreceptor cells, such as ciliary vertebrate rods and

274 cally and immunohistochemically recognizable photoreceptor cells, suggesting that the mutations in th

275 thways and adenylate cyclases (ACs) improved photoreceptor cell survival, preserved photoreceptor fun

276 tion of guanylate cyclase (GC) signaling and photoreceptor cell survival.

277 osis (LCA) is a neurodegenerative disease of photoreceptor cells that causes blindness within the fir

278 sin is the G protein-coupled receptor in rod photoreceptor cells that initiates vision upon photon ca

279 specialized morphological features of mature photoreceptor cells, the fundamental question remains wh

280 signaling proteins to the sensory cilium of photoreceptor cells, the outer segment.

281 n of the phototransducing compartment of the photoreceptor cells-the rhabdomeres, reminiscent of the

282 storation of the mutant gene in all diseased photoreceptor cells, thereby ensuring sufficient transdu

283 ate PKM2 to provide a metabolic advantage to photoreceptor cells, thereby promoting cell survival.

284 (all-trans-retinol) from the circulation and photoreceptor cells to produce the esterified substrate

285 d protein complex, and that apoptosis of rod photoreceptor cells triggered by protein mislocalization

286 in mediating layer-specific targeting of one photoreceptor cell type in the Drosophila visual system.

287 ployment of this protein in a highly plastic photoreceptor cell type of mixed microvillar/ciliary org

288 Drosophila photoreceptor cells use the ubiquitous G-protein-mediate

289 the Abca4(-/-) mice corresponded to reduced photoreceptor cell viability as reflected in ONL thinnin

290 y GDF-11 knockout, but a slight reduction in photoreceptor cells was observed by GDF-15 knockout in t

291 hese cilia, as well as in cilia of mouse rod photoreceptor cells, was reduced significantly when KIF3

292 To determine the importance of ARL3 in rod photoreceptor cells, we generated transgenic mice expres

293 As both RPE and photoreceptor cells were affected, these cell types may

294 Rod photoreceptor cells were more sensitive to loss of insm1

295 Guanine nucleotide homeostasis is central to photoreceptor cells, where cGMP is the signal transducin

296 process of vision is impossible without the photoreceptor cells, which have a unique structure and s

297 egulation or function of these lipids in rod photoreceptor cells, which have highly active membrane d

298 sion, that vertebrate eyes have two types of photoreceptor cells with differing sensitivity: rods for

299 e evolved from the primary cilium to provide photoreceptor cells with vast membrane surfaces for effi

300 te retina lacking the outer nuclear layer of photoreceptor cells would allow the survival, maturation