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1 icrovilli, which are interdigitated with the photoreceptor outer segment.
2 gue, Rom-1, to maintain the integrity of the photoreceptor outer segment.
3 in the light-sensitive disc membranes of the photoreceptor outer segment.
4 rans-retinal to all-trans-retinol within the photoreceptor outer segment.
5 ation and maintenance of the light-sensitive photoreceptor outer segment.
6 A prime example is the turnover of the rod photoreceptor outer segment.
7 idate genes involved in the formation of the photoreceptor outer segment.
8 re the RetGC1:GCAP1 complex is formed in the photoreceptor outer segment.
9 pecifically detected at the proximal part of photoreceptor outer segment.
10 unknown function surrounding the base of the photoreceptor outer segment.
11 epithelium and inner retina but an abnormal photoreceptor outer segment.
12 pace K(+) homeostasis in the vicinity of the photoreceptor outer segment.
13 ible for impeding their transport to the rod photoreceptor outer segment.
14 the choroid, retinal pigment epithelium, and photoreceptor outer segments.
15 omplex was observed on endothelial cells and photoreceptor outer segments.
16 showed abnormal disc stacking and shortened photoreceptor outer segments.
17 embly and morphogenesis of the rim region of photoreceptor outer segments.
18 2cr4 verified its expression in the discs of photoreceptor outer segments.
19 nsory cilia formation and the development of photoreceptor outer segments.
20 nd by imaging the fluorescence of retinol in photoreceptor outer segments.
21 l that exceeds the reductive capacity of the photoreceptor outer segments.
22 ase 9 (HDAC9) proteins were detected in cone photoreceptor outer segments.
23 idinium bisretinoid (A2PE) that forms within photoreceptor outer segments.
24 ze the mobility of all-trans retinol in frog photoreceptor outer segments.
25 as revealed progressive vacuolization of the photoreceptor outer segments.
26 CAR was expressed in retina except in photoreceptor outer segments.
27 d the structural and functional integrity of photoreceptor outer segments.
28 but not maintained, producing the absence of photoreceptor outer segments.
29 and GCAP1 immunostaining was absent from the photoreceptor outer segments.
30 pherin/rds protein to the disc rim region of photoreceptor outer segments.
31 ly normal CRX activity, led to shortening of photoreceptor outer segments.
32 ch localized correctly to the axoneme of the photoreceptor outer segments.
33 small extracellular compartment surrounding photoreceptor outer segments.
34 disruption of the normal organization of the photoreceptor outer segments.
35 on in the delivery of 11-cis-retinoid to the photoreceptor outer segments.
36 nt of reactive Muller glia into the layer of photoreceptor outer segments.
37 or other genes that affect the integrity of photoreceptor outer segments.
38 ed to be derived primarily from phagocytosed photoreceptor outer segments.
39 neration slow (rds) mutation completely lack photoreceptor outer segments.
40 um, thus facilitating rhodopsin transport to photoreceptor outer segments.
41 ansplants did not develop parallel layers of photoreceptor outer segments.
42 minently to the microvilli that surround the photoreceptor outer segments.
43 are expressed in the retina and enriched in photoreceptor outer segments.
44 se (PDE) mediates signal transduction in the photoreceptor outer segments.
45 Anti-Yb1 also reacted with photoreceptor outer segments.
46 C-1) is a membrane guanylyl cyclase found in photoreceptor outer segments.
47 on fragments to remodel synapses and recycle photoreceptor outer segments.
48 marked functional defects in phagocytosis of photoreceptor outer segments.
49 ons in the gene for the ABCA4 transporter in photoreceptor outer segments.
50 photoreceptor function and abnormally shaped photoreceptor outer segments.
51 matrix at the interface between the RPE and photoreceptor outer segments.
52 cells primarily through phagocytosis of the photoreceptor outer segments.
53 e ABCA4 gene encodes a protein localizing to photoreceptor outer segments.
54 g of PDE6 and GRK1 to their destination, the photoreceptor outer segments.
55 eflectances appeared dim, suggesting loss of photoreceptor outer segments.
56 es and endfeet, photoreceptor terminals, and photoreceptor outer segments.
57 rate that IFT proteins extracted from bovine photoreceptor outer segments, a modified sensory cilium,
58 resulted in atypical accumulation of Rpgr in photoreceptor outer segments, abnormal photoreceptor mor
60 creased at night by at least two mechanisms: photoreceptor outer segment activity decreases and synap
61 he optical path length have been observed in photoreceptor outer segments after a flash stimulus via
62 r studies suggest that Grb14 translocates to photoreceptor outer segments after photobleaching of rho
63 f adhesion between RPE apical microvilli and photoreceptor outer segments also declined during peak a
64 nal membrane guanylyl cyclase (RetGC) in the photoreceptor outer segment and suppresses RetGC activat
65 n the cause of acute vision loss to the cone photoreceptor outer segment and will refocus the search
66 luded lamination defects, failure to develop photoreceptor outer segments and a small eye phenotype,
67 Rp1 is required for normal morphogenesis of photoreceptor outer segments and also may play a role in
68 lls are responsible for daily degradation of photoreceptor outer segments and are thus particularly s
69 ce of vacuolar structures that distorted rod photoreceptor outer segments and became more prominent w
70 e and monitor the free Mg2+ concentration in photoreceptor outer segments and examine whether the fre
71 nd their discrete localization in developing photoreceptor outer segments and ganglion cells suggests
72 of mice is associated with nondevelopment of photoreceptor outer segments and gradual death of photor
73 cle in homozygous rds/rds retinas which lack photoreceptor outer segments and heterozygous rds/+ reti
74 alled the retinoid cycle, takes place in the photoreceptor outer segments and in the retinal pigmente
75 us studies have shown that RDH8 localizes to photoreceptor outer segments and is a strong candidate f
76 have highly disorganized, short, fragmented photoreceptor outer segments and lack both rod and cone
78 osition of debris composed of unphagocytosed photoreceptor outer segments and lipofuscin granules in
79 in RPE further prompted the loss of adjacent photoreceptor outer segments and photoreceptor death, wh
80 receptors-result in blindness from shortened photoreceptor outer segments and progressive photorecept
82 thogenic PRPH2 variants, primarily affecting photoreceptor outer segments and retinal pigment epithel
83 parameters of the retinal nerve fiber layer, photoreceptor outer segments and retinal pigment epithel
84 or the retinal nerve fiber layer's features, photoreceptor outer segments and retinal pigment epithel
86 ter scale due to the unique structure of the photoreceptor outer segments and sequential stimulation.
88 Only minimal staining was detected in the photoreceptor outer segments and the optic nerve pia and
89 alled the retinoid cycle, takes place in the photoreceptor outer segments and the retinal pigment epi
91 nges; RPE were vacuolated and separated from photoreceptor outer segments, and choriocapillaris fenes
92 cerebrospinal fluid transport, generation of photoreceptor outer segments, and hedgehog signaling.
93 ibroblasts, in all retinal layers except the photoreceptor outer segments, and in the fascicles and a
94 nt disc flattening only minimally alters the photoreceptor outer segment architecture beyond the site
98 ed changes in the optical path length of the photoreceptor outer segment as a response to an optical
99 ning the function and/or organization of the photoreceptor outer segment as reflected by the species-
100 ding cassette (ABC) family that functions in photoreceptor outer segments as a flipase of all-trans r
101 function leads to shortening and loss of the photoreceptor outer segments as observed for various inh
102 as able to reinstate phagocytosis of labeled photoreceptor outer segments at a reduced, but significa
105 aminins at photoreceptor synapses and around photoreceptor outer segments; both molecules are express
107 ldehyde all-trans retinal is released in rod photoreceptor outer segments by photoactivated rhodopsin
108 a, circadian phagocytosis and degradation of photoreceptor outer segments by the postmitotic retinal
110 The concentration of all-trans retinol in photoreceptor outer segments can be monitored from its f
111 highly enriched in retina, and localizes to photoreceptor outer segments, ciliary complex, and horiz
112 lysosomal pH with these treatments enhanced photoreceptor outer segment clearance, demonstrating fun
115 Consequently, STGD1 RPE cells have reduced photoreceptor outer segment degradation and abnormal acc
118 F220C mice exhibited minor disruptions of photoreceptor outer segment dimensions without any mislo
119 is a membrane glycoprotein essential for the photoreceptor outer segment disc morphogenesis and maint
121 lexiform layer simultaneously with the first photoreceptor outer segment discs at 60 hpf; functional
123 rin/rds), which is inserted into the rims of photoreceptor outer segment discs in a complex with rom-
125 ase A(2) plays a role in the phagocytosis of photoreceptor outer-segment discs by the retinal pigment
127 se results indicate that a rhythm of retinal photoreceptor outer segment disk shedding exists in the
128 Here, we report that the phagocytosis of photoreceptor outer segment disks by the retinal pigment
130 ficient mice revealed abnormal morphology of photoreceptor outer segments during the time at which th
132 lar pseudodrusen were deposits juxtaposed to photoreceptor outer segments extending through the outer
133 etinal space developed parallel layers, with photoreceptor outer segments facing the host pigment epi
134 ciliary ectosomes in building the elaborate photoreceptor outer segment filled with hundreds of tigh
135 A2-PE, the A2E precursor, are formed within photoreceptor outer segments following light-induced rel
136 ithelium (RPE), a cell layer adjacent to the photoreceptor outer segments, form the well-established
137 raflagellar transport (IFT) is essential for photoreceptor outer segment formation and maintenance, a
138 lacking ift80 function exhibited defects in photoreceptor outer segment formation and photoreceptor
139 tablish that nephrocystin-5 is essential for photoreceptor outer segment formation but is dispensable
142 iurnal bursts of RPE phagocytosis that clear photoreceptor outer segment fragments (POS) shed in a ci
143 ta5 integrin-dependent phagocytosis of spent photoreceptor outer segment fragments by the retinal pig
144 he retinal pigment epithelium (RPE) of spent photoreceptor outer segment fragments is critical for vi
146 apical projections to shield light-sensitive photoreceptor outer segments from photobleaching when fi
149 reviously reported and that preincubation of photoreceptor outer segment homogenates with ATP or its
150 is tightly associated with the membranes of photoreceptor outer segments; however, the nature of thi
151 on belt around the basolateral region of the photoreceptor outer segment in humans, and that defects
152 fetal retina can develop parallel layers and photoreceptor outer segments in contact with host pigmen
153 scopic examination confirmed the presence of photoreceptor outer segments in the areas affected by tr
154 al results showed Tgamma c localized to cone photoreceptor outer segments in the normal retina, where
155 required for the elaboration of rod and cone photoreceptor outer segments in the vertebrate retina; i
156 kewise, the autofluorescence of phagocytosed photoreceptor outer segments increased by lysosomal alka
161 pe 1 (ROS-GC1), originally identified in the photoreceptor outer segments, is a member of the subfami
162 binding protein which is highly expressed in photoreceptor outer segments, is also located in 6p21.1.
165 a dome-shaped hyper-reflective lesion at the photoreceptor outer segment layer disrupting the ellipso
167 pigment epithelium (RPE) to phagocytize shed photoreceptor outer segments leads to a progressive loss
169 mong the 32 eyes with subretinal detachment, photoreceptor outer segment length was significantly cor
170 mean EZ-RPE thickness (i.e., a surrogate for photoreceptor outer segment length) and central RFI were
172 in absence of subretinal drusenoid deposits, photoreceptor outer segment loss, RPE drusen complex vol
173 the RPE resulted in an aberrant assembly of photoreceptor outer segments, loss of fine subcellular u
175 vestigators and is recognized as an index of photoreceptor outer segment maturity, yet its antigen re
176 )-2 is a Ca2+-binding protein that regulates photoreceptor outer segment membrane guanylate cyclase (
177 ultifunctional molecule that participates in photoreceptor outer segment membrane recognition, oxidan
178 demonstrated that the formation of A2-PE in photoreceptor outer segment membrane was augmented by ex
179 -retinal and phosphatidylethanolamine in the photoreceptor outer segment membrane; (ii) further react
180 found that compartmentalization of GCAP-2 in photoreceptor outer segment membranes is Ca2+- and ionic
184 n the retina, Rbpr2 loss resulted in shorter photoreceptor outer segments, mislocalization and decrea
185 naling pathways that guide the modulation of photoreceptor outer segment morphogenesis by RPE during
186 nd to light and displayed severely disrupted photoreceptor outer segment morphology and ciliary defec
191 er than controls in the outer retina (ONL to photoreceptor outer segments). OCT-based retinal sublaye
198 rogressive rod-cone degeneration (PRCD) is a photoreceptor outer segment (OS) disc-specific protein w
203 marginal zone (CMZ) cell death and decreased photoreceptor outer segment (OS) length, as well as gros
204 irst, the disease-related deformation of the photoreceptor outer segment (OS) may reduce its ability
207 spanin protein that plays a pivotal role for photoreceptor outer segment (OS) structure and is involv
208 highly-regulated, biological process wherein photoreceptor outer segment (OS) tips are cyclically pha
212 ions in the gene for ABCA4, a transporter in photoreceptor outer segments (OS) that clears retinaldeh
213 ipitate-like alterations at the level of the photoreceptor outer segments (OS) to choroidal neovascul
215 sters are generated by and accumulate in the photoreceptor outer segments (OS), which is the retinal
219 - animals showed progressive degeneration of photoreceptor outer segments (OSs) and increased apoptos
221 the retinal pigment epithelium (RPE) of shed photoreceptor outer segments (OSs), a tissue with one of
222 for the formation of the disc/lamella rim in photoreceptor outer segments (OSs), but plays a differen
223 2 (PRPH2) is essential for the formation of photoreceptor outer segments (OSs), where it functions i
230 r early disease features, such as a delay in photoreceptor outer segment (POS) clearance and accumula
231 of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a m
232 es; and horizontal extent of the ONL and the photoreceptor outer segment (POS) interdigitation zone (
234 pendently inhibited RPE cell phagocytosis of photoreceptor outer segments (POS) and activated AMP-act
235 of apoptotic cells by macrophages and spent photoreceptor outer segments (POS) by retinal pigment ep
237 retina, life-long renewal of light-sensitive photoreceptor outer segments (POS) involves circadian sh
238 fficiency of phagocytosis and degradation of photoreceptor outer segments (POS) necessary for photore
239 at underpin the daily phagocytic turnover of photoreceptor outer segments (POS) required for maintena
240 ed epithelium (RPE) is the clearance of shed photoreceptor outer segments (POS) through a multistep p
241 A main function of RPE is to phagocytose photoreceptor outer segments (POS) which are rich in the
242 ly phagocytosis and lysosomal degradation of photoreceptor outer segments (POS) within the retinal pi
243 its effects measured on the uptake of bovine photoreceptor outer segments (POS), proteolysis of POS r
247 ere they participated in the phagocytosis of photoreceptor outer segments (POSs) and contributed to a
248 ) cells are disorganized and contact between photoreceptor outer segments (POSs) and the RPE apical s
251 In the absence of phagocytic challenge with photoreceptor outer segments, postconfluent RPE cultures
252 s (53.3%), irregular hyporeflectivity in the photoreceptor outer segments (PROS) was observed in 17 e
253 he previously characterized ROS-GC1 from the photoreceptor outer segments (PROS), and its new modulat
254 synaptic proteins are correctly trafficked, photoreceptor outer segment proteins fail to be transpor
255 dherin, a known interactor of PROM1, and rod photoreceptor outer segment proteins, including rhodopsi
257 he light-activated currents generated at the photoreceptor outer segment provide an easily observed r
258 feration and migration, RPE atrophy, loss of photoreceptor outer segments, reactive gliosis, retinal
259 ific human retinal pigment epithelial (HRPE) photoreceptor outer segment recognition and oxidant prod
260 equired for morphogenesis and maintenance of photoreceptor outer segments, regions that collect light
263 fish consisting of disorganized rod and cone photoreceptor outer segments resulting in abnormal visua
265 nterestingly, although it is associated with photoreceptor outer segments, retbindin's expression is
268 RPE) and plays a role in the phagocytosis of photoreceptor outer segments (ROS), a function critical
269 ated in in vitro models of lipid rafts, from photoreceptor outer segments (ROS), and the localization
272 ess to the confined space within the retinal photoreceptor outer segment signaling compartment and di
273 xhibited small eyes, kidney cysts, and short photoreceptor outer segments, some of which were disorga
274 this degeneration on the localization of two photoreceptor outer segment-specific integral membrane p
276 5 photoreceptor-specific knock-out mice, the photoreceptor outer segment structure was severely impai
277 mt-deficient mice trafficked normally to the photoreceptor outer segment, suggesting that the failure
278 tinal pigment epithelium (RPE) with adjacent photoreceptor outer segments that are essential for visi
279 hich are crucial for forming and maintaining photoreceptor outer segments that are PUFA-enriched cili
280 fluorescent spots appeared to originate from photoreceptor outer segments that were arranged within r
281 f key signaling proteins into and out of the photoreceptor outer segment, the cellular compartment wh
282 matographies of a cytosolic fraction of frog photoreceptor outer segments, the Pgamma kinase activity
283 stinct scattering bands corresponding to the photoreceptor outer segment tips, RPE, and Bruch's membr
285 the second procedure showed that exposure of photoreceptor outer segments to light resulted in the in
288 olved in binding and internalization of shed photoreceptor outer segments was subjected to changes in
289 rans-retinal to all-trans-retinol within the photoreceptor outer segment, was the first visual cycle
293 histochemistry localizes the PHR1 protein to photoreceptor outer segments where chemical extraction s
294 dX) is a polytopic membrane protein found in photoreceptor outer segments where it is the principal e
295 otoreceptors, rather than at the base of the photoreceptor outer segments, where PROM1 is normally lo
296 and reduction to all-trans-retinol occur in photoreceptor outer segments whereas enzymatic esterific
297 affect the structure of the light-sensitive photoreceptor outer segment, which is composed of a stac
298 lial (RPE) cells phagocytize and digest shed photoreceptor outer segment, which provides a rich sourc
300 ght exposure promotes "oxidative tagging" of photoreceptor outer segments with structurally defined c