ライフサイエンスコーパス: phototransduction

1 oes a calcium-myristoyl switch during visual phototransduction.

2 receptors that influences the sensitivity of phototransduction.

3 s well as mutants with disrupted opsin-based phototransduction.

4 -gated (CNG) channels play a pivotal role in phototransduction.

5 into neuronal signals in a process known as phototransduction.

6 r cells, PDE6, is the key effector enzyme in phototransduction.

7 nown whether this mutant pigment can mediate phototransduction.

8 ubunit (CNGA1), a PM component essential for phototransduction.

9 death in light damage caused by constitutive phototransduction.

10 of genes, specifically those associated with phototransduction.

11 eptors by the guanylate cyclase/PDE6 pair in phototransduction.

12 e compared with fast, norpA-dependent visual phototransduction.

13 ike opsins for the complex process of visual phototransduction.

14 oreceptor degenerate as a result of abnormal phototransduction.

15 level of metabolic activity associated with phototransduction.

16 ing evidence for TRPA1 function in mammalian phototransduction.

17 lutionary-based theoretical model of humoral phototransduction.

18 nts for the acceleration of translocation by phototransduction.

19 -gated (CNG) channels play a pivotal role in phototransduction.

20 e guanylate cyclase) is a vital component of phototransduction.

21 in-loaded stacked membrane disks that enable phototransduction.

22 s the channels for their specialized role in phototransduction.

23 is expressed in HEMs and contributes to UVR phototransduction.

24 A phospholipase C which mediates rhabdomeric phototransduction.

25 e discrete PDE6 enzymes that are crucial for phototransduction.

26 ng PDE families and is central to vertebrate phototransduction.

27 the signal transduction apparatus mediating phototransduction.

28 n to gain some insight into the mechanism of phototransduction.

29 licate the function of a 'taste receptor' in phototransduction.

30 n age-dependent impairment in termination of phototransduction.

31 d function in ROS-GC1 signaling, linked with phototransduction.

32 signaling events alternative to the classic phototransduction.

33 he local regulation of PIP(2) and PLC during phototransduction.

34 ma-subunit (Pgamma) is pivotal in vertebrate phototransduction.

35 h response, a measure of the initial gain of phototransduction.

36 hat schizo in photoreceptors is required for phototransduction.

37 ns, or if they form a photopigment and drive phototransduction.

38 sor proteins with their targets operating in phototransduction.

39 outer segment, which is the primary site of phototransduction.

40 revealing these responses to be triggered by phototransduction.

41 egeneration, suggesting potential defects in phototransduction.

42 nd to affect other signaling cascades beyond phototransduction.

43 ess, whereas in light they use it to support phototransduction.

44 Cyclic-GMP is a second messenger in phototransduction, a G-protein signaling cascade that co

45 Loss of cone phototransduction accompanies the compromised integrity

46 Phototransduction accounted for essentially all of the r

47 A physiologically based model of rod phototransduction activation was used to determine photo

48 al, and was blocked by uncoupling opsin from phototransduction, all indicating opsin as its source.

49 alysis of the retinal metabolome showed that phototransduction also influences steady-state concentra

50 then measured neuronal electrophysiological phototransduction and behavioral responses to light.

51 ealed the dysregulation of genes involved in phototransduction and cholesterol metabolism.

52 r segments despite near normal expression of phototransduction and cilia genes.

53 ne signaling deficits arising from disrupted phototransduction and cone loss rather than from synapti

54 tochondrial Ca(2+) uptake via MCU influences phototransduction and energy metabolism in photoreceptor

55 Phosphodiesterase-6 (PDE6) is key to both phototransduction and health of rods and cones.

56 he cell death pathway caused by constitutive phototransduction and identify the unfolded protein resp

57 al cone photoreceptor terminals and to probe phototransduction and its diverse regulatory mechanisms

58 Ca(2+) to regulate many functions, including phototransduction and neurotransmission.

59 and ON-bipolar cells, Gbeta3 is essential in phototransduction and ON-bipolar cell signaling.

60 ent; electroretinography was used to measure phototransduction and outer retinal function; electron m

61 xpression of UAS-shi(ts1) causes decelerated phototransduction and reduced neurotransmitter release.

62 Mutations in phototransduction and retinal signaling genes are implic

63 S9 reaction into the conventional scheme for phototransduction and show that this augmented scheme ca

64 Cone phototransduction and survival of cones in the human mac

65 iples of G-protein signaling from studies of phototransduction and to relate these signals to downstr

66 DE6), which is a pivotal effector enzyme for phototransduction and vision because it hydrolyzes cGMP.

67 ochondrial oxidative phosphorylation for its phototransduction and visual function.

68 OS) is a sensory compartment specialized for phototransduction, and it shares many features with prim

69 ow and why RGS9 concentration matters in rod phototransduction, and they provide a framework for unde

70 ve pressure in the genes involved in retinal phototransduction, and traces of this selective pressure

71 system, recombination, lipid metabolism, and phototransduction are enriched for positively selected g

72 spares the trafficking of key structural and phototransduction-associated proteins.

73 h KK mouse rods displayed markedly decreased phototransduction, biochemical studies of the mutant rho

74 demonstrate that P23H mutant Rho can trigger phototransduction but Rho(P23H/P23H) rods are approximat

75 r light intensities that activate melanopsin phototransduction, but not at dimmer light intensities t

76 In worm neurons, P23H isorhodopsin initiated phototransduction by coupling with the endogenous Gi/o s

77 lowed retinal degeneration, whereas blocking phototransduction by crossing KK mice with GNAT1-deficie

78 ing differential reliance upon cone-mediated phototransduction by ipRGC subpopulations.

79 be replenished during the recovery phase of phototransduction by photoreceptor guanylate cyclases (G

80 tended cylindrical structure specialized for phototransduction called the outer segment (OS).

81 that of the wild-type, suggesting that cone phototransduction can function efficiently without a Gbe

82 eceptor potential channel (TRP), but how the phototransduction cascade accelerates Arr2 translocation

83 enzyme-linked immunoassay was used to assess phototransduction cascade activity by measurement of lig

84 mRGCs are activated both by their intrinsic phototransduction cascade and by the rods and cones.

85 lex controls signal amplification of the rod phototransduction cascade and is critical for the abilit

86 erase 6 (PDE6) is the effector enzyme in the phototransduction cascade and is critical for the health

87 rt powerful modulation on the mammalian cone phototransduction cascade and play an important role in

88 de the cone outer segment, thus exposing the phototransduction cascade and subsequent downstream effe

89 ponents to suppress random activation of the phototransduction cascade and thus increases the signali

90 ch leads to a constitutive activation of the phototransduction cascade as revealed by in vitro bioche

91 The visual phototransduction cascade begins with a cis-trans photoi

92 ts, where they are capable of regulating the phototransduction cascade by the active targeting signal

93 etic mutations affecting the proteins in the phototransduction cascade cause blinding disorders in hu

94 Sensory cilia of photoreceptors regulate phototransduction cascade for visual processing.

95 Our results identify a phototransduction cascade in C. elegans and implicate th

96 n repetitive light exposure, and an impaired phototransduction cascade in ppr mutants results in exce

97 e-6 (PDE6) is the key effector enzyme of the phototransduction cascade in rods and cones.

98 k loop that increases the sensitivity of the phototransduction cascade in rods.

99 ase) is critical for the deactivation of the phototransduction cascade in vertebrate photoreceptors.

100 anylate cyclase 1 (GC1), a key member of the phototransduction cascade involved in modulating the pho

101 Calcium ions (Ca(2+)) modulate the phototransduction cascade of vertebrate cone photorecept

102 o effect on SOCE, the sensitivity of the rod phototransduction cascade or synaptic transmission at ro

103 retinal degeneration with mislocalization of phototransduction cascade proteins.

104 f light sensitive visual pigments, and other phototransduction cascade signaling proteins expressed i

105 pear to be driven through an ancient type of phototransduction cascade similar to that in rhabdomeric

106 The Drosophila phototransduction cascade terminates in the opening of t

107 of rhodopsin, but not signaling through the phototransduction cascade, and is not based on direct Gr

108 ying mechanism functions downstream from the phototransduction cascade, as evident from the sensitivi

109 hodiesterase 6 (PDE6) is a key enzyme of the phototransduction cascade, consisting of PDE6alpha, PDE6

110 melanopsin protein, an extraordinarily slow phototransduction cascade, divisions of labor even among

111 CAP1, and GCAP2) operating in the vertebrate phototransduction cascade, over variations in Ca(2+) con

112 rotein involved in the regulation of retinal phototransduction cascade, transcriptional control, and

113 In the G-protein-coupled receptor phototransduction cascade, visual Arrestin 1 (Arr1) bind

114 trigger further downstream reactions of the phototransduction cascade.

115 gle photons using a stochastically operating phototransduction cascade.

116 o the G-protein transducin and activates the phototransduction cascade.

117 vity, but not on the subsequent steps of the phototransduction cascade.

118 ccurs independently of known elements of the phototransduction cascade.

119 isks, which capture photons and scaffold the phototransduction cascade.

120 athway, which is distinct from the classical phototransduction cascade.

121 d cone Talpha couple equally well to the rod phototransduction cascade.

122 ) is the effector molecule in the vertebrate phototransduction cascade.

123 hout affecting their vision or the canonical phototransduction cascade.

124 sities both at the front and back end of the phototransduction cascade.

125 ve changes arising from processes within the phototransduction cascade.

126 defective association of crucial players in phototransduction cascade.

127 s in genes encoding proteins involved in rod phototransduction cascade; night blindness is the only s

128 olved in either the photoreceptor structure, phototransduction cascades, or visual cycle are expresse

129 How constitutive phototransduction causes photoreceptor cell death is poo

130 erone that stabilizes the effector enzyme of phototransduction, cGMP phosphodiesterase 6 (PDE6).

131 , control several sensory functions, such as phototransduction, chemosensation, and thermosensation,

132 lor (which is absent in animals lacking cone phototransduction; Cnga3(-/-)) aligns with natural chang

133 rved cellular mechanism exists to create the phototransduction compartments by examining the function

134 of photoreceptor cells into their respective phototransduction compartments.

135 In rod photoreceptors, several phototransduction components display light-dependent tra

136 y between 2 and 4 weeks postnatally, but the phototransduction components including rhodopsin traffic

137 Translocation of phototransduction components out of the OS may protect r

138 The delivery and organization of the phototransduction components within and along the cilium

139 Despite the expression of homologous phototransduction components, the molecular basis for di

140 tigate the hypothesis that signaling through phototransduction controls production of energy in mouse

141 pon photoactivation, the second messenger of phototransduction, cyclic GMP, is rapidly degraded and m

142 ivity and speeded the rate-limiting step for phototransduction deactivation, causing rod photorespons

143 duced ATP level in ppr mutants underlies the phototransduction defect, leading to increased Rhodopsin

144 gh we did not observe other developmental or phototransduction defects in cones with mislocalized nuc

145 lag, combined with the approximately 100 ms phototransduction delay at photopic light levels, gave a

146 lacking KIF3A, membrane proteins involved in phototransduction did not traffic to the outer segments

147 acid rich proteins (GARPs) are required for phototransduction, disk morphogenesis, and rod structura

148 This result indicates that phototransduction does not play a direct role in the lig

149 e catalytic domain of PDE6C, a cone-specific phototransduction enzyme associated with achromatopsia i

150 acaque caused by homozygous mutations in the phototransduction enzyme PDE6C.

151 A negative phototransduction feedback in rods and cones is critical

152 appears to extend the operating range of rod phototransduction following pigment bleaching.

153 g CRY and mutants with disrupted opsin-based phototransduction for behavioral and electrophysiologica

154 s of fast Ca2+ feedback to cGMP synthesis in phototransduction for GCAPs-/- mice increases the magnit

155 model of rod phototransduction suggests that phototransduction gain adjustments and bleaching adaptat

156 ff's law reveals that complete activation of phototransduction generates a potentially harmful 20% in

157 e, through adaptive evolutionary analyses of phototransduction genes by using a variety of approaches

158 Six of 20 phototransduction genes evaluated had gene-level selecti

159 nd evidence for the expression of opsins and phototransduction genes known to play a role in light de

160 ssed in subsets of photoreceptors to that of phototransduction genes that are expressed broadly, in a

161 The level of recent positive selection in phototransduction genes was evaluated and compared to a

162 Pph13 regulates Rh2 and Rh6, and other phototransduction genes, demonstrating that Pph13 and Ot

163 ptor transcription factors Crx, Nrl, and rod phototransduction genes.

164 cupancy of NonO at rhodopsin and a subset of phototransduction genes.

165 in turn results from expressional tuning of phototransduction genes.

166 Free opsin activates phototransduction; however, the link between constitutiv

167 type and various mutant worms, we found that phototransduction in ASJ is a G protein-mediated process

168 The GCAP mode plays a vital role in phototransduction in both rods and cones and the S100B m

169 molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear.

170 tion in vitamin A-deprived Xenopus rods with phototransduction in constitutively active mammalian rod

171 Cone photoreceptors carry out phototransduction in daylight conditions and provide the

172 Ca(2+)-free solutions.SIGNIFICANCE STATEMENT Phototransduction in Drosophila is mediated by phospholi

173 Phototransduction in Drosophila is mediated by phospholi

174 Phototransduction in Drosophila microvillar photorecepto

175 plausible model for circadian photoreception/phototransduction in Drosophila.

176 st identified as membrane proteins mediating phototransduction in fruit flies.

177 ology and could provide insights into visual phototransduction in humans.

178 onventional signaling mechanisms: melanopsin phototransduction in ipRGCs and output by the neuropepti

179 This cascade differs from phototransduction in mammalian rods and cones, but is re

180 Phototransduction in microvillar photoreceptors is media

181 cascade, as evident from the sensitivity of phototransduction in phosducin knock-out rods being affe

182 he calcium feedback mechanisms that modulate phototransduction in rods have been studied extensively.

183 s of neural processes acting downstream from phototransduction in scotopic lights, (2) rod response k

184 No receptor protein directly mediating phototransduction in skin has been identified.

185 receptors are specialized neurons that drive phototransduction in the mammalian retina.

186 Separate pools of Ca(2+) regulate phototransduction in the outer segment, metabolism in th

187 This low amplification is in contrast to rod phototransduction in vision, the best-quantified G-prote

188 n of retinal guanylyl cylcase (RetGC) during phototransduction in vision.

189 Contrasting phototransduction in vitamin A-deprived Xenopus rods wit

190 igated the functional role of CNG-modulin in phototransduction in vivo in morpholino-mediated gene kn

191 nct isoforms of PDE6, the effector enzyme in phototransduction, in these differences.

192 nd that Nckx2(-/-) cones exhibit compromised phototransduction inactivation, slower response recovery

193 Phototransduction is a G-protein signal transduction cas

194 Drosophila phototransduction is a model system for the ubiquitous p

195 Phototransduction is carried out by a signaling pathway

196 Phototransduction is initiated when the absorption of li

197 GPCR signaling, including rhodopsin-driven phototransduction, is terminated by receptor phosphoryla

198 Interestingly, phototransduction kinetics are normal in single rods and

199 a genetic variant exhibiting extremely slow phototransduction kinetics, yet normal sensitivity.

200 ysiological processes acting downstream from phototransduction limit sensitivity to high frequencies

201 These novel photoreceptors use phototransduction machinery distinct from other photorec

202 lyl cyclase (RetGC1), a key component of the phototransduction machinery in photoreceptors.

203 supply energy for protein synthesis and the phototransduction machinery in the outer segment, as wel

204 Phototransduction machinery in vertebrate photoreceptors

205 a highly modified primary cilium containing phototransduction machinery necessary for light detectio

206 xpand the apical membrane to accommodate the phototransduction machinery, exemplified by the cilia-ba

207 Their phototransduction mechanisms are essentially identical.

208 uanylyl cyclase is potentially a key step in phototransduction modulation.

209 le for meckelin in intraciliary transport of phototransduction molecules and their effects on subsequ

210 PA1 and H2O2 production but not conventional phototransduction molecules.

211 gmatic, particularly since these cells use a phototransduction motif that allows invertebrates like D

212 ell as crossbred Gnat1(-/-) mice lacking rod phototransduction (n = 110) were gavaged weekly for 6 mo

213 equently became integrated with higher plant phototransduction networks.

214 ches have led to inconsistent expositions of phototransduction noise performance.

215 ying genetics of evolutionary adaptations in phototransduction not only allows greater understanding

216 channels play crucial physiological roles in phototransduction, olfaction, and cardiac pace making.

217 do not exhibit significant defects in either phototransduction or the visual cycle, suggesting that m

218 receptors via the intrinsic melanopsin-based phototransduction pathway and as a relay for rod/cone in

219 n kinetics of the intrinsic melanopsin-based phototransduction pathway and its contribution to severa

220 ere, we report that ROS generated by the UVA phototransduction pathway are critical cellular messenge

221 luding Crx, Nr2E3, NeuroD, and RXRgamma, and phototransduction pathway components, including transduc

222 TRPA1 is essential for a unique extraocular phototransduction pathway in human melanocytes that is a

223 We recently identified a UVA phototransduction pathway in melanocytes that is mediate

224 is the key effector enzyme of the vertebrate phototransduction pathway in rods and cones.

225 ted expression of the visual opsins from the phototransduction pathway in the skin translates illumin

226 Reduced expression of genes involved in the phototransduction pathway indicates altered photorecepto

227 In the phototransduction pathway responsible for vertebrate vis

228 cone PDE6 can effectively couple to the cone phototransduction pathway to mediate visual signaling.

229 analyses of the vision genes involved in the phototransduction pathway to predict the diel activity p

230 a decline in queen vision by perturbing the phototransduction pathway within 24-48 hr.

231 for genes related to visual perception, the phototransduction pathway, and numerous retina and photo

232 ies on either CRY or the canonical rhodopsin phototransduction pathway, which requires the phospholip

233 role in regulating rhythmic elements in the phototransduction pathway.

234 PDE6alpha' can couple effectively to the rod phototransduction pathway.

235 catalytic subunits from coupling to the cone phototransduction pathway.

236 Circadian and phototransduction pathways are enriched in our results.

237 Clock control of phototransduction pathways remained robust across a rang

238 dopsis plants is complex, in part due to its phototransduction pathways, which are themselves under c

239 6) plays a central role in both rod and cone phototransduction pathways.

240 mone and retinoic acid signaling, as well as phototransduction pathways.

241 hare similar structures, and closely related phototransduction polypeptides.

242 uman cells show Maritigrella xenopsin drives phototransduction primarily by coupling to Galphai.

243 aptation in cones that is independent of the phototransduction process.

244 y photoreceptor model, which mimics the real phototransduction processes, has elucidated how light ad

245 Because the expression of other phototransduction proteins did not increase, transducin

246 ation is profoundly slowed in mutants of key phototransduction proteins including phospholipase C (PL

247 s with stacked membrane discs that house the phototransduction proteins necessary for sight.

248 toreceptors use similar but distinct sets of phototransduction proteins to achieve different function

249 Upon illumination several phototransduction proteins translocate between cell body

250 cone OS may maximize density or proximity of phototransduction proteins, but is not required for OS f

251 In addition, phototransduction proteins, such as rhodopsin, arrestin,

252 ed normal levels of RetGC isozymes and other phototransduction proteins, with the exception of GCAP2,

253 egulation of genes encoding key rod and cone phototransduction proteins.

254 inner segment and reduction in selected rod phototransduction proteins.

255 enes and nineteen patients with mutations in phototransduction (PT) genes were analyzed.

256 ), and the speed and recoverability of their phototransduction reactions.

257 s three physiological functions: it quenches phototransduction, reduces sensitivity during light adap

258 ct, as neither photoreceptor neurons nor the phototransduction regulators NORPA and INAF are required

259 In addition, we found that C. elegans phototransduction requires LITE-1, a candidate photorece

260 cond, there was an age-dependent loss in rod phototransduction sensitivity; the lack of dietary carot

261 this is mediated, directly or indirectly, by phototransduction signaling in rod and cone photorecepto

262 esses of G protein-coupled receptor-mediated phototransduction signaling, these photoreceptors have b

263 r segments for terminating G-protein coupled phototransduction signaling.

264 kout (TKO) mice lack essential components of phototransduction signalling pathways present in rods, c

265 l, it is not important for supporting normal phototransduction.SIGNIFICANCE STATEMENT Phospholipids c

266 ic flux in mouse retinas, we also found that phototransduction slows metabolic flux through glycolysi

267 or transepithelial ion transport, olfaction, phototransduction, smooth muscle contraction, nociceptio

268 l system to compensate for the slow speed of phototransduction so that a moving object can be accurat

269 the pigment-to-transducin/phosphodiesterase phototransduction step, especially in L cones, apo-opsin

270 ansmission, photoreceptor morphogenesis, and phototransduction, suggesting that the miR-183/96/182 cl

271 A model of rod phototransduction suggests that phototransduction gain a

272 Therefore, it is unclear how phototransduction suppresses dark bump production arisin

273 had little effect on photoreceptor survival, phototransduction, synaptic transmission, and visual beh

274 ce of recent positive selection in the human phototransduction system at single nucleotide polymorphi

275 rmine the relative contributions of distinct phototransduction systems, we tested mutants lacking CRY

276 but did slightly accelerate the rate of cone phototransduction termination.

277 signaling cascades, especially those such as phototransduction that are turned on and off with great

278 h exerts a well studied negative feedback on phototransduction that includes calcium-dependent inhibi

279 of the rod-specific G-protein transducin in phototransduction, the physiological function of the aux

280 This is particularly so for visual phototransduction, the process responsible for convertin

281 thways, including photoreceptor development, phototransduction, the retinoid cycle, cilia, and outer

282 is family, RGS9-1, in controlling vertebrate phototransduction, the roles and organizational principl

283 Nonetheless, phototransduction-the mechanism by which absorbed photon

284 Phototransduction--the process in which absorbed photons

285 d TRP have previously characterized roles in phototransduction, their function in cool avoidance appe

286 ich calcium exerts negative feedback on cone phototransduction through recoverin and GRK1 are not wel

287 by fit of a model of the activation of cone phototransduction to the a-waves.

288 nvolved in a variety of processes, including phototransduction, transcriptional regulation, cell adhe

289 ectron transfer reactions do not affect dCRY phototransduction under bright or dim light in vivo as m

290 ntrinsic and extrinsic noise in invertebrate phototransduction using minimum mean squared error recon

291 rm n-3 fatty acid deficiency on rod and cone phototransduction was investigated in the rhesus monkey.

292 Cone phototransduction was not altered by n-3 deficiency.

293 The ability of the mutant to initiate phototransduction was tested using a radioactive filter

294 ever, genes important in eye development and phototransduction were downregulated in oil-exposed larv

295 otein-coupled receptors including Drosophila phototransduction where light sensitive channels are act

296 the downregulated genes were associated with phototransduction, whereas upregulated genes were associ

297 d (CNG) channels play a pivotal role in cone phototransduction, which is a process essential for dayl

298 a fully constrained spatiotemporal model of phototransduction, which we used to determine the effect

299 rs is mediated by apo-opsin, which activates phototransduction with effective activity 10(5)- to 10(6

300 rd current evoked by blue light derives from phototransduction within the outer segment of the S cone