ライフサイエンスコーパス: pigment cell

1 l skeleton, peripheral neurons and glia, and pigment cells.

2 e sensory cell in the close vicinity of dark pigment cells.

3 and also promote specification of NC-derived pigment cells.

4 res a retinol dehydrogenase, PDH, in retinal pigment cells.

5 des with the location of SJs in the cone and pigment cells.

6 al for the development of melanin-containing pigment cells.

7 extual placement of photoreceptors, cone and pigment cells.

8 lature in association with a large number of pigment cells.

9 nd are formed between and among the cone and pigment cells.

10 reased melanogenesis and dendricity in human pigment cells.

11 er cell specification and failure to produce pigment cells.

12 including peripheral neurons, cartilage and pigment cells.

13 on lumenal determinants and conserved in non-pigment cells.

14 pecification of the mesodermal precursors of pigment cells.

15 dihydroxyindole-2-carboxylic acid (DHICA) in pigment cells.

16 yo leading to a loss of neural crest derived pigment cells.

17 no oligonucleotide results in larvae without pigment cells.

18 peripheral neurons, and glia, and iridophore pigment cells.

19 and is expressed and required in the retinal pigment cells.

20 primordia, and subsequently differentiate as pigment cells.

21 g photoreceptor cells by neighboring retinal pigment cells.

22 acial cartilage and bone, smooth muscle, and pigment cells.

23 at these genes are specifically expressed in pigment cells.

24 belong to a differentiation gene battery of pigment cells.

25 ng different classes of neural crest-derived pigment cells.

26 nsert was transfected into immortalized frog pigment cells.

27 luding the epaulets, blastocoelar cells, and pigment cells.

28 t, promotes neuronal fates at the expense of pigment cells.

29 st the photoreceptors, then cone and finally pigment cells.

30 ional (Microphthalmia) gene product lack all pigment cells.

31 e-specific transcription factor of embryonic pigment cells.

32 putative transporter expressed primarily in pigment cells.

33 tely are deposited within the melanosomes of pigment cells.

34 ubsequently, at larval stages, supernumerary pigment cells.

35 em, the retinular cells, the rhabdom, and of pigment cells.

36 in the retinal pigment epithelial and other pigmented cells.

37 r Flk1 expression and contained no obviously pigmented cells.

38 al and nuclear DNA lesions compared with non-pigmented cells.

39 t transdifferentiation of retinal cells into pigmented cells.

40 ylalanine (DOPA) or (-)-epinephrine produced pigmented cells.

41 from homozygous embryos do not give rise to pigmented cells.

42 vesicles and striations of premelanosomes in pigmented cells.

43 y distinct pathways to late endosomes in non-pigmented cells.

44 ized compartments, such as the melanosome of pigmented cells.

45 xpressed in IOCs, and Hbs and Sns in primary pigment cells (1 degrees s).

46 l and Pax3/7 and generate melanin-containing pigment cells, a derivative of the neural crest in verte

47 upal eye led to an excess of interommatidial pigment cells, aberrant cell contacts, and an increase i

48 erated during regeneration or in response to pigment cell ablation.

49 Many pigment cells acquire unique structural properties and g

50 y greater proportion (>90%) than more darkly pigmented cells after culture.

51 roduction of photoreceptors, cone cells, and pigment cells and a corresponding reduction in programme

52 BACE2 is highly expressed in pigment cells and Bace2(-/-) but not Bace1(-/-) mice dis

53 he development of two mesodermal cell types, pigment cells and blastocoelar cells.

54 evelopment of the peripheral nervous system, pigment cells and craniofacial cartilage and bone.

55 est Trpm7 at early stages results in loss of pigment cells and dorsal root ganglion neurons.

56 causes beta-alanine accumulation in retinal pigment cells and impairs carcinine synthesis, leading t

57 reening pigment granules in the two types of pigment cells and in the retinular cells in the equatori

58 (pTpT) stimulates melanogenesis in mammalian pigment cells and intact skin, mimicking the effects of

59 s rise to much of the craniofacial skeleton, pigment cells and peripheral nervous system, yet its spe

60 We discovered unique genes expressed by pigment cells and test their expression with double fluo

61 that is expressed in many tissues, including pigment cells and the hypothalamus.

62 SpPks is expressed exclusively in pigment cells and their precursors starting at blastula

63 ransporter, Sp-ABCC5a (C5a), is expressed in pigment cells and their precursors, which are a subset o

64 ide to albino melanocytes, we detected black-pigmented cells and isolated multiple single clones.

65 or cells, a rhabdom, a thick lens, screening pigment (cells), and in contrast to a modern type, putat

66 ead and trunk, including peripheral neurons, pigment cells, and cartilage.

67 ts in NC-derived lineages such as cartilage, pigment cells, and enteric neurons.

68 dary mesenchyme cells (SMC) that will become pigment cells, and genes that are expressed in portions

69 luble adenylyl cyclase (sAC) is expressed in pigment cells, and its inhibition impairs gastrulation.

70 dy produced migratory peripheral neurons and pigment cells, and that the neural crest evolved through

71 proper formation of craniofacial structures, pigment cells, and the outflow tract of the heart.

72 The objective of this study was to identify pigment cell antigens that are recognized by autoantibod

73 Based on distinctions in pigment cell appearance between mutants, we proposed hyp

74 Vertebrate pigment cells are derived from neural crest cells and ar

75 Vertebrate pigment cells are derived from neural crest, a tissue th

76 ers expressed in sequential fashion when new pigment cells are generated during regeneration or in re

77 vatives, such as melanophore and xanthophore pigment cells are not affected.

78 tion is significantly decreased, even though pigment cells are present in normal amounts and distribu

79 Recent evidence suggests that ascidian pigment cells are related to neural crest-derived melano

80 tor screening pigment granules and screening pigment cells are restricted to the region below the pho

81 ct from the later period of development when pigment cells are specified from neural crest.

82 Pigmented cells are derived from adult nerve, because pi

83 We show that adult pigment cells arise from distinct lineages having distin

84 est showed that lineage-restricted clones of pigment cells arise from medial cells near the neural ke

85 This shift occurs as pigment cells arise from the neural crest and depends on

86 eover, our data implicate Drosophila retinal pigment cells as functioning in the conversion of dietar

87 spective blastocoelar cells, not prospective pigment cells, as was previously believed.

88 Lightly pigmented cells attached and spread in a substantially g

89 In zebrafish, Danio rerio, pigment-cell autonomous interactions generate dark strip

90 sity can be generated when a core network of pigment-cell autonomous interactions is coupled with cha

91 rocess of melanosome transfer has fascinated pigment cell biologists for decades.

92 nts of three classes of neural crest-derived pigment cells: black melanocytes, yellow xanthophores an

93 precise arrangement of three main classes of pigment cells: black melanophores, yellow xanthophores,

94 ere was a marked reduction in the numbers of pigment cells, blastocoelar cells and cells expressing t

95 fication of mesodermal cell types, including pigment cells, blastocoelar cells and muscle cells.

96 ted in the induction of SMC1-positive cells, pigment cells, blastocoelar cells and muscle cells.

97 the lineage choice between neural/glial and pigment cells by repressing MITF during the early phase

98 the potential role of TRPM7 ion channels in pigment cells by studying the phenotype of zebrafish trp

99 te (Teruel, Spain) [9, 10], preserves dermal pigment cells (chromatophores)-xanthophores, iridophores

100 ects, driving the intermingling of all three pigment cell classes and resulting in the loss of stripe

101 attern in D. albolineatus in which all three pigment cell classes are intermingled.

102 In zebrafish, several pigment cell classes interact to generate stripes, yet t

103 es, as well as interactions within and among pigment cell classes, for both pigment pattern developme

104 which comprises several neural crest-derived pigment cell classes, including black melanophores, yell

105 and genetic tools reveal a new way in which pigment cells communicate in zebrafish.

106 tial metabolites found in both variants, the pigmented cells contained anthocyanidins, other flavonoi

107 ve rise to many diverse cell types including pigment cells, craniofacial cartilage and the peripheral

108 ch photoreceptor loss is caused by a retinal pigment cell defect, it argues for an effect related to

109 0 is necessary for development of neural and pigment cell derivatives of the neural crest (NC).

110 we proposed hypotheses as to the process of pigment cell development affected by each mutation.

111 identified roles for thyroid hormone (TH) in pigment cell development and patterning, and in postembr

112 , which controls a set of genes critical for pigment cell development and pigmentation, including dop

113 n turn regulates a set of genes critical for pigment cell development and pigmentation.

114 genes and regulatory mechanisms required for pigment cell development are conserved across vertebrate

115 large set of embryonic mutations that affect pigment cell development from neural crest.

116 Neural crest-derived pigment cell development has been used extensively to st

117 ts provide insights into mechanisms of adult pigment cell development in the strikingly colorful Plat

118 nic bHLH factor Mash1 was expressed early in pigment cell development in transgenic mice from the dop

119 ults demonstrate that the sea urchin GRN for pigment cell development is quite shallow, which is typi

120 Transcription factor genes governing pigment cell development that are associated with spotti

121 ing neural crest development disrupts normal pigment cell development, leading to an increase in the

122 cleavage Delta-Notch signaling, required for pigment cell development, positively regulates SpPks.

123 ine the effects of bHLH factor expression on pigment cell development, the neurogenic bHLH factor Mas

124 Mutations in either Sox10 or Mitf impair pigment cell development.

125 d has not been implicated in neural crest or pigment cell development.

126 studied for their roles in neural crest and pigment cell development.

127 While it is clear that some pigment cells differentiate de novo during pigment patte

128 hyme blastula stage and maintains it through pigment cell differentiation and dispersal.

129 show that SpGsc is required for endoderm and pigment cell differentiation and for gastrulation.

130 Also included are signaling factors and some pigment cell differentiation genes.

131 lating hormone (MSH) plays a crucial role in pigment cell differentiation via cAMP-regulated expressi

132 ey use homologous key components to regulate pigment cell differentiation.

133 a zebrafish homolog of MITF, is required for pigment cell differentiation.

134 ctly activates nacre, which in turn leads to pigment cell differentiation.

135 mous interactions is coupled with changes in pigment cell differentiation.

136 st that Pax6 interacts with Mitf to regulate pigment cell differentiation.

137 ufficient for controlling gene expression in pigment cells during development.

138 , neural crest cells generate three types of pigment cells during embryogenesis: yellow xanthophores,

139 cell shape changes, and the organisation of pigment cells during metamorphosis.

140 Primary pigment cells employ Hibris to function as organizers in

141 ITF do occur, albeit in reduced numbers, and pigmented cells eventually develop in nearly normal numb

142 rtebrates, three types of melanin-containing pigment cells, exert a variety of functional roles inclu

143 eta1 isoform of Na,K-ATPase, whereas the non-pigmented cells express mainly the alpha2beta3 isoform o

144 In the ciliary epithelium of the eye, the pigmented cells express the alpha1beta1 isoform of Na,K-

145 mplicating it as a signal that can influence pigment cell fate directly.

146 d identification of a new mutation affecting pigment cell fate in the zebrafish neural crest.

147 tions in the direct specification of primary pigment-cell fate.

148 d sufficient for neural crest cells to adopt pigment cell fates.

149 al cells of the peripheral nervous system to pigment cells, fibroblasts to smooth muscle cells, and o

150 le case, the regulatory processes underlying pigment cell formation in sea urchin embryos.

151 rogram of these cells from skeletogenesis to pigment cell formation, confirming a direct prediction o

152 blast growth factor signalling, which govern pigment cell formation.

153 A encoding cytoplasmic beta-catenin promotes pigment-cell formation at the expense of neurons and gli

154 endogenous Wnt signalling normally promotes pigment-cell formation by medial crest cells and thereby

155 nhancer activities in iridophores, a type of pigment cells found in egg-spots, suggesting that a cis-

156 his layer lacks the unpigmented gaps between pigment cells found in other darkly colored fishes [9-13

157 Formation of pigment cells from multipotential neural crest cells inv

158 nally preserved fossils [16, 17], and dermal pigment cells generate coloration in numerous reptile, a

159 zebrafish Danio rerio, neural crest-derived pigment cells generate different pigment patterns during

160 This dome-shaped, melanin-pigmented cell generates enormous turgor and applies phy

161 PC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar

162 e that FGF signalling sequentially imposes a pigment cell identity at the expense of anterior neural

163 elinating Schwann cells, enteric neurons and pigment cells in a CHARGE model.

164 , we determine a revised cell lineage of the pigment cells in Ciona intestinalis embryos.

165 Purified BMP-4 reduces the number of pigment cells in culture while increasing the number of

166 s results in the appearance of male-specific pigment cells in otherwise morphologically normal ovarie

167 medium dramatically increases the number of pigment cells in quail neural crest cultures while decre

168 eq (scRNAseq) technology and discovered that pigment cells in the embryo segregated into two distinct

169 be required for development of eye and crest pigment cells in the mouse.

170 tinal pigment layer is directly derived from pigment cells in the overlying retina.

171 ipes generated by the precise positioning of pigment cells in the skin.

172 genetic evidence for a role for the retinal pigment cells in the visual response.

173 articles is already being exploited to treat pigmented cells in dermatology and ophthalmology.

174 l cells and MRP4 to basolateral membranes of pigmented cells in the human eye.

175 ic background, the progressive appearance of pigmented cells in the neural retina, concomitant with l

176 Here, we explore the regulation of pigmented cells in the purple sea urchin Strongylocentro

177 eservation of the dentate nuclei, and of the pigmented cells in the substantia nigra.

178 hese patterns result from several classes of pigment cells including black melanophores and yellow xa

179 biogenesis and macromelanosome formation in pigment cells, including melanocytes and retinal pigment

180 ative model in which evolutionary changes in pigment cell interactions themselves have contributed to

181 s for differentiation state heterogeneity in pigment cell interactions, and an unanticipated morphoge

182 Thus, the presence of pigment cells is a sexually dimorphic trait that is cont

183 an epithelial bilayer consisting of an outer pigmented cell layer (PE) and an inner nonpigmented cell

184 illuminate a physiologic hypoxia response in pigment cells leading to M-MITF suppression, one that su

185 erio, we identified two populations of white pigment cells-leucophores-one of which arises by transdi

186 zed fourth A-P oriented cell division in the pigment cell lineage leads to the generation of the post

187 or expansion of both ERK1/2 activation and a pigment cell lineage marker and subsequently, at larval

188 vior of one type of embryonic stem cell: the pigment cell lineage of the neural crest.

189 n the posterior sister cells, into which the pigment cell lineage segregates.

190 The coordination of adult pigment cell lineage specification and differentiation w

191 f neural crest progenitors fated to form the pigment cell lineage.

192 ucted developmental trajectories, identified pigment cell-lineage specific responses to TH, and asses

193 ell-autonomously to promote the expansion of pigment cell lineages during metamorphosis.

194 rmation, progressive renal disease, aberrant pigment cell localization, precocious mammary lobuloalve

195 GPR143, primarily expressed in pigment cells, localizes exclusively to endolysosomal an

196 iological conditions, and that this leads to pigment cell loss when animals are exposed to intense vi

197 brains were used for a study of neuromelanin pigmented cell loss.

198 ort of cysteine into melanosomes and, in non-pigmented cells, lysosomes.

199 and like these two genes, can induce ectopic pigmented cell masses when overexpressed in developing e

200 Furthermore, the pigmented cells match the retinal pigmented epithelium i

201 tion of lysosome-related organelles, such as pigment cell melanosomes.

202 Neural crest cells that become pigment cells migrate along a dorsolateral route between

203 g of the stromal iris BM zone was found, and pigmented cells migrated out of the iris and covered the

204 n3), encoding a peptide factor that promotes pigment cell migration and differentiation in other vert

205 White (d/d) mutants have defects in pigment cell morphogenesis and differentiation, whereas

206 Pigment cells must be specified; their migration, prolif

207 in most crest-derived cell types, including pigment cells, neurons and specific glia.

208 As neither pigmented extensions of secondary pigment cells, nor pigment granules in the extensions of

209 istic of Hirschsprung's disease with reduced pigment cell number, although the cell biological basis

210 The pigment cells of amphibians and fish have provided excel

211 Mash1 further highlight differences between pigment cells of distinct developmental origins, and sug

212 has opposite effects on neural crest derived pigment cells of the adult stripe pattern, limiting mela

213 fmo family that are expressed selectively in pigment cells of the embryonic and in the coelomic cells

214 t-2 null mutant flies lack the male-specific pigment cells of the reproductive tract sheath and the m

215 BACE2 cleaves the melanocyte protein PMEL in pigment cells of the skin and eye, generating melanin pi

216 asts are the progenitors of melanocytes, the pigment cells of the skin, hair and choroid.

217 ganglia, cartilage and bone of the face and pigment cells of the skin.

218 Pigment cells of the zebrafish, Danio rerio, offer an ex

219 The skin pigment cells of vertebrates, derived from embryonic neu

220 Cone cells and primary pigment cells oppose this signal by supplying a 'life'-p

221 gment pattern formed by neural crest-derived pigment cells, or chromatophores, which include black me

222 stem cell development, and understanding how pigment cells organize into a patterned tissue.

223 csf1ra, however, has adopted unique roles in pigment cell patterning not seen in the second paralogue

224 forms four major categories of derivatives: pigment cells, peripheral neurons, peripheral glia, and

225 lation generated retinas in which neural and pigmented cell phenotypes were co-mingled.

226 ing the rest of the eye lies a thick band of pigment cells (pigment rim; PR).

227 monstrate that parallel neural crest-derived pigment cell populations depend on the activities of two

228 on of Wnt2 within the somatic gonad triggers pigment cell precursor formation from surrounding cells.

229 during late cleavages for the early phase of pigment cell precursor specification.

230 ng gcm output in a cohort of fully specified pigment cell precursors at a relatively early developmen

231 e effects of transcriptional perturbation of pigment cell precursors by Mash1 further highlight diffe

232 embryogenesis but is required for recruiting pigment cell precursors to xanthophore fates, with conco

233 gonad by investigating the formation of the pigment cell precursors, a male-specific cell type in th

234 ingly, we find that sex determination in the pigment cell precursors, as well as the male-specific so

235 ng in the development of amniote and teleost pigment cell precursors.

236 leads to the generation of the post-mitotic pigment cell precursors.

237 The six cell populations were presumptive pigment cells, presumptive neurogenic cells, presumptive

238 is known about the developmental origins of pigment cells produced in adult organisms during tissue

239 lls, we trace and quantitatively compare the pigment cell progenitors at four stages, from embryogene

240 PMEL is a pigment cell protein that forms physiological amyloid in

241 rogenitor cell fates that enables both rapid pigment cell renewal and maintenance of regenerative cap

242 emonstrate that the specification of primary pigment cells requires the reiterative use of the sequen

243 RDHB was expressed in the retinal pigment cells (RPCs), where it promoted the final enzyma

244 n neural input that alters photoreceptor and pigment cell shape, pigment migration, and phototransduc

245 Pmel17 is a approximately 100 kDa pigment cell specific glycoprotein that plays a crucial

246 We identify FGF-dependent and pigment cell-specific factors, including the small GTPas

247 These cells express several pigment cell-specific genes that are thought or have bee

248 Pmel17 is a pigment cell-specific integral membrane protein that par

249 proteolytic fragments derived from Pmel17, a pigment cell-specific integral membrane protein.

250 Proteolytic processing of the pigment cell-specific Melanocyte Protein (PMEL) is also

251 mrk, a mutant egfr gene, that is driven by a pigment cell-specific mitf promoter.

252 acidic dileucine-based sorting signal in the pigment cell-specific protein OCA2 to dissect the relati

253 PMEL is a pigment cell-specific protein that forms a functional am

254 eate their formation in the absence of other pigment cell-specific proteins.

255 used by defects in the gene OCA2, encoding a pigment cell-specific, 12-transmembrane domain protein w

256 Here we show that the pigment-cell-specific cuproenzyme tyrosinase acquires co

257 idence that MEK/ERK signals are required for pigment cell specification until approximately 30min aft

258 Here we analysed the mechanisms underlying pigment cell specification within the CNS of a simple ch

259 sults confirm that this gene is required for pigment cell specification.

260 ixture composed of about 95 and 5% of highly pigmented cells (strain 531Ad) and cells with normal lev

261 ping zebrafish larvae, in vivo monitoring of pigment cells suggested that disturbances in melanocyte

262 ption factor (MITF) is a master regulator of pigmented cell survival and differentiation with direct

263 ally insulated by the pigment rim, a band of pigment cells that circumscribes the eye.

264 pigment rim (PR), which is a thick layer of pigment cells that lies directly adjacent to the HC and

265 l type, but by extensions of the lateral rim pigment cells that penetrate gaps in the BM.

266 cells of the PR are derived from presumptive pigment cells that previously surrounded peripheral omma

267 tiple organelles using Xenopus melanophores, pigment cells that translocate several thousand of pigme

268 er that arises from melanocytes, specialized pigmented cells that are found predominantly in the skin

269 m (RPE) consists of a monolayer of cuboidal, pigmented cells that is located between the retina and t

270 gment epithelial (RPE) cells, a monolayer of pigmented cells that line the subretinal space, an immun

271 l pigment epithelium (RPE) is a monolayer of pigmented cells that requires an active metabolism to ma

272 mily proteins in the 2 degrees and 3 degrees pigment cells throughout the main body of the eye.

273 n which C5a transports sAC-derived cAMP from pigment cells to control late invagination of the hindgu

274 By examining the ability of pigment cells to respond to UV irradiation as part of th

275 cord with the distinct embryology of retinal pigmented cells, transgenic mice with toxigenic ablation

276 -injected embryos show a massive increase in pigment cells (Trp-2-expressing cells).

277 the development of the neural crest-derived pigment cell type common to all vertebrates, the melanoc

278 in iridophores, another neural crest-derived pigment cell type in zebrafish.

279 led and they must differentiate to the final pigment cell type.

280 her, our studies reveal independently arisen pigment cell types and mechanisms of fate acquisition in

281 Interactions between all three pigment cell types are required to form the stripe patte

282 tructural eye descriptions, but knowledge of pigment cell types beneath the retina and basal matrix (

283 hanisms of regulation are similar in the two pigment cell types.

284 ish, which give rise to three distinct adult pigment cell types: melanophores, iridophores, and xanth

285 his results from changed numbers of multiple pigment cell-types in the skin and on scales.

286 In pigmented cells, TYR is trafficked through those organel

287 ea generates porphyrins in its subepithelial pigment cells under physiological conditions, and that t

288 hened receptor complex functions normally in pigment cells was demonstrated by co-transfection with t

289 protein kinase (Sp-CAPK/PKA) is expressed in pigment cells, we examined whether C5a could be involved

290 ecification and differentiation processes of pigment cells, we experimentally analyzed the putative S

291 that express the HNK-1 antigen and form body pigment cells were previously identified in diverse asci

292 ented yeast cells and particles derived from pigmented cells were stable free radicals consistent wit

293 Numerous pigmented cells were visible in the subretinal space at

294 n days posttransplantation, 50% rejection of pigment cells) were infiltrated with a large number of b

295 yme specific genes, expressed exclusively in pigment cells, were isolated from sea urchin embryos usi

296 t SKI-1 is constitutively expressed in human pigment cells with higher SKI activity in seven out of e

297 Treatment of the pigmented cells with proteolytic enzymes, denaturant, an

298 Descriptions of pigment cells within the retina are included in ultrastr

299 d projection corresponded with the amount of pigmented cells within the RPE, but did not correspond w

300 nsplant bed, although there are many heavily pigmented cells within the transplant bed that are Barr